scholarly journals Prevalence of non-albicans Candida species versus Candida albicans in critical care patients of a tertiary care hospital

2016 ◽  
Vol 2 (3) ◽  
pp. 89-93
Author(s):  
Dr. Poonam Sharma ◽  
◽  
Dr. Jasvir Kaur ◽  
Dr. Sarbjeet Sharma ◽  
◽  
...  
Keyword(s):  
Critical Care ◽  
Candida Albicans ◽  
Candida Species ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Critical Care Patients

CHARACTERISATION AND ANTIFUNGAL SUSCEPTIBILITY PATTERNS OF CANDIDA SPECIES ISOLATED IN TERTIARY CARE HOSPITAL IN NORTH INDIA.

2021 ◽  
pp. 7-8
Author(s):  
Meenakshi Sharma ◽  
Chaudhary BL
Keyword(s):  
Candida Albicans ◽  
Candida Species ◽  
Tertiary Care Hospital ◽  
Antifungal Susceptibility ◽  
Tertiary Care ◽  
Diffusion Method ◽  
Individual Species ◽  
Care Hospital ◽  
Clinical Specimens ◽  
Susceptibility Patterns

Candida is usually considered a commensal with the potential to cause opportunistic infections ranging from supercial mucosal infections to lifethreatening invasive infections. This study was aimed to determine antifungal susceptibility patterns of Candida species isolated from various clinical specimens from a tertiary care hospital. Isolation and identic Material and Methods: ation of Candida species were done by morphological examination, pseudohyphae, and chlamydospore production on cornmeal agar, germ tube test, and HiCrome Candida differential agar. The antifungal susceptibility of Candida strains was performed by the disk diffusion method as per the CLSI M44-A2 protocol. A Result: total of 96 Candida species were isolated from various clinical specimens. The isolation rate was more in the older age group and female patients(52%). Most frequently isolated from urine 41.67% followed by sputum 19.79%, Blood 16.67%, and least from vaginal swab 2.08%. Four species of Candida were isolated among them Candida albicans was most common 59.37% followed by Candida prapsilosis and Candida krusei 15.62%, and Candida tropicalis 9.37%. In antifungal susceptibility testing, Itraconazole was the most sensitive drug and Fluconazole was the least sensitive one with only 58.33% susceptibility among individual species. Concussion: Urinary tract infection was common due to Candida albicans, and Itraconazole was the most susceptible drug.

scholarly journals Characterisation and Isolation of Candida Species from ICU Patients in Nobel Medical College Teaching Hospital, Biratnagar

2016 ◽  
Vol 5 (1) ◽  
pp. 61-65
Author(s):  
Bigu Kumar Chaudhari ◽  
Ganesh K. Singh ◽  
Kamal Prasad Parajuli ◽  
Kewal Shrestha ◽  
Dharmendra Shah
Keyword(s):  
Candida Albicans ◽  
Teaching Hospital ◽  
Candida Species ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Antifungal Drugs ◽  
Clinical Samples ◽  
Care Hospital ◽  
Sensitivity Testing ◽  
Medical College

Background Fungi have emerged as major causes of human diseases. Intensive Care Units (ICU), harbor almost all the risk factors for opportunistic fungal infections. Among these, Candida infections are very common with recent trends being rise in the non-Candida albicans (NCA) species along with an increase in resistance of these species to antifungal drugs. Increament in invasive Candidasis during last three decades have been reported in several studies, among all Candida species the Candida albicans is considered as the most common infectious agent the other non-albicans like C. Tropicalis, C. glabrata, C. parapsilosis C. krusei, and C. dubliniensis were raised as infectious agents. The aim of current study is to characterize the candida species from the clinical specimens of patients admitted in the ICU of Tertiary Care hospital in Eastren Nepal and to perform their antifungal susceptibility.Material and Methods The study was carried out in the tertiary care hospital Nobel Medical College and Teaching Hospital Biratnagar Nepal over a period of 6 monthsbetween September 2015 to February 2016. The following techniques were employed to characterize the isolates in the study – Gram’s stain, culture on Sabouraud’s Dextrose Agar, Germ Tube test, morphology in Cornmeal Agar and chromogenic agar media, sugar fermentation and sugar assimilation tests, and the results were interpreted by using standard protocols.Results Out of 50 candida isolates from different clinical samples including 37 blood samples, 9 urines and 4 Endo Tracheal (ET) tube, the most common species was C.albicans (44%) followed by C.tropicalis (26%), C.Glabrata (18%), C.Parapsilosis (08%), C.Krusei (02%), and C.Dubliniensis(02%).Conclusion The purpose of the study is to show the value of species isolation, identification and antimicrobial sensitivity testing of the ICU & NICUs patients.Journal of Nobel Medical CollegeVolume 5, Number 1, Issue 8, January-July 2016, 61-65

scholarly journals Prevalence of Candidemia with Susceptibility Pattern in a Tertiary Care Hospital in North India

2021 ◽  
Vol 8 (16) ◽  
pp. 1041-1046
Author(s):  
Ashish William ◽  
Aroma Oberoi ◽  
Divya Dsouza ◽  
Arpit Oberoi
Keyword(s):  
Candida Albicans ◽  
Candida Species ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Blood Stream ◽  
Blood Cultures ◽  
North India ◽  
Care Hospital ◽  
Susceptibility Pattern ◽  
Candida Infections

BACKGROUND Blood stream infections (BSI) caused by various candida species have been reported from many countries worldwide and are a significant cause of morbidity and mortality in hospitalised patients. The alarming increase in infections with multidrug resistant bacteria is due to overuse of broad-spectrum antimicrobials, which leads to over growth of candida species; thus, enhancing its opportunity to cause the disease. During recent decades, there has been a change in the epidemiology of candida infections, characterised by a progressive shift from a predominance of Candida albicans to non-albicans candida species. This study was conducted to determine the prevalence of candidemia in blood stream and the susceptibility pattern in a tertiary care hospital in North India. METHODS This is retrospective study which has been conducted for a period of 1.5 years form April 2015 to October 2016. All blood cultures received during this period by BACTEC automated culture system and Becton Dickinson were included in the study. The culture was done on positive blood culture bottles and were cultured on Sabouraud dextrose agar. Recovered candida isolates were speciated and antifungal susceptibility testing was performed as per Clinical and Laboratory Standards Institute guidelines (CLSI). RESULTS A total of 80 out of 8020 blood cultures were culture positive for candida species. Therefore, the overall prevalence rate of isolation of candida species was 0.99 % in our study. The incidence of blood stream infection caused by non albicans candida species (73.8 %) was higher than Candida albicans (26.2 %). Among NAC species, Candida tropicalis (44 %) was the most common, followed by Candida parapsilosis (24 %), Candida glabrata (17 %), Candida krusei (8.5 %), Candida guilliermondii (5 %) and Candida dubliniensis (1.5 %). Candidemia was predominantly observed in ICU patients. Resistance was significantly higher among non-albicans candida species (NAC), amphotericin B, fluconazole, ketoconazole, itraconazole and clotrimazole - 96.72 %, 59.84 %, 51.23 %, 19.44 %, and 56.15 % respectively. CONCLUSIONS With an ever-expanding array of non-candida species-related infections in highly compromised and terminally ill patients, understanding the activity of the antifungal agents used against both C. albicans and nonalbicans species becomes mandatory. Continued surveillance of candida infections will be required to document changes in epidemiology and antifungal susceptibilities. KEYWORDS Bloodstream Infections, Candidemia, Non Albicans Candida (NAC)

scholarly journals Species identification of Candida isolated from clinical specimens in a tertiary care hospital

2016 ◽  
Vol 9 (1) ◽  
pp. 20 ◽  
Author(s):  
Lsmet Nigar ◽  
Shirin Tarafder ◽  
Rehana Razzak Khan ◽  
S. M. Ali Ahmed ◽  
Ahmed Abu Saleh
Keyword(s):  
Candida Albicans ◽  
Candida Species ◽  
Tertiary Care ◽  
Clinical Manifestations ◽  
Common Species ◽  
Blood Stream ◽  
Care Hospital ◽  
Emerging Pathogens ◽  
Predisposing Factor ◽  
Clinical Specimens

<p><strong>Background:</strong> Candida species are responsible for various clinical manifestations from mucocutaneous overgrowth to blood stream infections especially in immunocompromized situations. Although C. albicans is the most prevalent species, high incidence of non-albicans Candida species with antifungal resistance are emerging which is posing a serious threat to the patients care.</p><p><strong>Objective:</strong> This study aimed to isolate and identify different species of Candida from different clinical specimens. Methods: A total of 100 different clinical specimens were studied of which 35 were oral swab, 28 were high vaginal swab, 15 were urine, 14 were nail, 04 were bronchoalveolar lavage and peritoneal fluid were 04. Among 100 clinical specimens, Candida isolates were identified in 64 specimens. Isolation of Candida species was done by primary culture in SDA. Subsequent identification of species were performed by germ tube test, subculture in chromo­genic agar medium and carbohydrate assimilation test with commonly used twelve sugars.</p><p><strong>Results:</strong> Out of 64 isolated Candida species, Candida albicans were 51.56% and the non-albicans Candida species were 48.44%. The most prevalent Candida species was C. albicans 33 (51.53%) followed by C. tropicalis 17 (26.56%). C. glabrata 4 (6.25%), C. parapsilo­sis 4 (6.25%), C. krusei 3 (4.68%) and C. guilliermondii 2 (3.2%). One of the isolated Candida species was unidentified.</p><p><strong>Conclusion:</strong> Though Candida albicans was found as the most common species, but non-albicans Candida species are appearing as emerging pathogens as well. Exposure to chemotherapy appeared to be the commonest predisposing factor for Candida infection followed by indwelling urinary catheter in situ for prolong period.</p>

scholarly journals A Predominance of Clade 17 Candida albicans Isolated From Hemocultures in a Tertiary Care Hospital in Thailand

2019 ◽  
Vol 10 ◽  
Author(s):  
Linh Thi Truc Pham ◽  
Sujiraphong Pharkjaksu ◽  
Piriyaporn Chongtrakool ◽  
Kamol Suwannakarn ◽  
Popchai Ngamskulrungroj
Keyword(s):  
Candida Albicans ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital

Prevalence of Sudden Speechlessness in Critical Care Units

2011 ◽  
Vol 20 (4) ◽  
pp. 439-447 ◽  
Author(s):  
Loris A. Thomas ◽  
Carmen S. Rodriguez
Keyword(s):  
Critical Care ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Hospital Data ◽  
Care Environment ◽  
Critical Care Units ◽  
Clinical Diagnoses ◽  
Unit Characteristic

Sudden speechlessness (SS) is commonly experienced by patients admitted to critical care units. Although literature findings document challenges associated with periods of SS, the prevalence is unknown. The purpose of this study is to determine the prevalence and characteristics of adult SS patients in four critical care units at a university-affiliated tertiary care hospital. Data are collected on 9 randomly selected days over a 4-month period. The daily prevalence of SS ranges from 16% to 24% in each unit. Characteristic data collected includes patient age, gender, medical diagnosis related to SS episode, type of speechlessness, days since SS began, and communication strategies in use. Respiratory intubation related to various clinical diagnoses is the main cause for SS. Use of multiple specific strategies to convey needs during SS periods are identified. Follow-up studies to further define the prevalence of SS in settings beyond the critical care environment are recommended.

Critical Care Nurses’ Knowledge of Sedation and Its Management in Mechanically Ventilated Patients at a Tertiary Care Hospital in Pakistan

2020 ◽  
Vol 14 (1) ◽  
pp. 7-18
Author(s):  
Samuel Masih ◽  
Khairunnisa Aziz Dhamani ◽  
Sadia Farhan Khan
Keyword(s):  
Critical Care ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Critical Care Nurses ◽  
Good Knowledge ◽  
Care Hospital ◽  
Poor Knowledge ◽  
Mechanically Ventilated ◽  
Mechanically Ventilated Patients ◽  
Ventilated Patients

BackgroundSedation assessment and management is an essential part of critical care nursing. The patients are at significant risks of undersedation and oversedation. Critical care nurses must possess sufficient knowledge about sedation assessment and its management.AimThis study aimed to determine critical care nurses’ knowledge of sedation and its management in mechanically ventilated patients in Pakistan.MethodologyA cross-sectional descriptive study was conducted. The participants were recruited from three critical care units of a tertiary care hospital using a consecutive sampling technique. Data were collected using a self-administered questionnaire.FindingsIn total, 91 critical care nurses participated in this study. Most of them had less than 2 years of experience as registered nurses and as intensive care unit nurses. The majority of them had insufficient knowledge (poor knowledge 18.7% and fair knowledge 63.7%), whereas only 17.6% had good knowledge of sedation and its management. The average correct response rate for general knowledge of sedation management practices was 71.3%. Almost half of the participants (51.6%) had poor knowledge of assessing undersedation and oversedation. Overall, 67% of nurses had good knowledge of managing sedative drugs.ConclusionThe majority of critical nurses lacked sufficient knowledge related to sedation and its management in mechanically ventilated patients. This poses risks to patients’ safety and quality of care.

Sign in / Sign up

Export Citation Format

Share Document