scholarly journals Histopathological study of lower gastrointestinal tract lesions

2021 ◽  
Vol 7 (4) ◽  
pp. 194-200
Author(s):  
Dr. Vibhaben Kantilal Patel ◽  
◽  
Dr. Anjali Deepak Goyal ◽  
Keyword(s):  
Gastrointestinal Tract ◽  
Treatment Options ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Lower Gastrointestinal Tract ◽  
Tertiary Care Centre ◽  
Intestinal Lesions ◽  
Neoplastic Lesions ◽  
Malignant Lesions ◽  
And Gender

Background: The benign lesions of the lower gastrointestinal tract are responsible for a largenumber of morbidities. The microscopic examination of and determination of histological types ofmalignant lesions help to decide treatment options and to predict prognosis. The histopathologicalstudy is the Gold standard for the diagnosis of intestinal lesions. Aims and Objectives: To studythe prevalence of various lower gastrointestinal tract lesions site-wise, age-wise and gender-wiseand to compare the obtained results with other studies. Materials and methodology: Aretrospective study of 600 various lower gastrointestinal tract lesions sent for histopathologicalexamination at Pathology department of tertiary care centre, VS General Hospital, Ahmedabad iscarried out. Results: Among all the 600 cases, non-neoplastic lesions 572 (95.34%) are far morecommon than neoplastic lesions 28 (4.66%). Conclusion: Non-neoplastic lesions are common in thesmall intestine, while the large intestine harbors most malignant lesions.

scholarly journals Histopathological Study of Lower Gastrointestinal Tract Biopsies in 600 Cases

2021 ◽  
Author(s):  
Jasmin Haridas Jasani ◽  
Shivani Bhaveshbhai Vora ◽  
Nidhi Amrutlal Patel
Keyword(s):  
Small Intestine ◽  
Gastrointestinal Tract ◽  
Large Intestine ◽  
Histopathological Examination ◽  
Microscopic Analysis ◽  
Histopathological Study ◽  
Lower Gastrointestinal Tract ◽  
Delay In Diagnosis ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions

Introduction: Broadly the whole gastrointestinal tract can be divided into upper and lower segments by taking the insertion of ligament of Treitz as a landmark. The disorders of Lower Gastrointestinal Tract (LGIT) are responsible for a great number of morbidity. The microscopic analysis and the determination of histological types are thus helpful in deciding treatment options, predicting prognosis and conducting epidemiological studies and research. Delay in diagnosis causes direct as well as distant metastasis leading to advanced stage of the disease. Aim: To emphasise the usefulness of LGIT biopsy in diagnosing the conditions, thus helping the surgeons to decide further management prior to resection, especially in malignant cases. Materials and Methods: An observational retrospective study of various LGIT biopsies sent for Histopathological Examination (HPE) at Pathology department of Sumandeep Vidyapeeth, Vadodara, Gujarat, India was carried out. The study was based on the HPE of lesions received in the duration from June 2019 to September 2020. In this study, the records of LGIT specimens including small intestine, large intestine, rectum and anus were included. Due importance was paid to brief clinical history with patient’s age, inpatient number and presenting signs and symptoms. A total of 600 specimens were analysed. Results: Non-neoplastic lesions were more common than neoplastic lesions cases out of the total 600 cases. Lesions were more common in 2nd to 5th decades with male preponderance. Among non-neoplastic lesions, majority of non-neoplastic lesion were of appendiceal lesion (247) followed by non-specific inflammation (138). Out of 30 neoplastic lesions; most common were of adenocarcinoma (15 cases). Conclusion: A wide variety of neoplastic and non-neoplastic lesions were diagnosed in the present study. In small intestine, non-neoplastic lesions were common while most of the malignant lesions were common in large intestine. The most common non-neoplastic lesion was appendicitis followed by non-specific inflammation and the most common neoplastic lesion was adenocarcinoma.

scholarly journals Pattern of neoplastic and non-neoplastic lesions of ovary: a five-year study in a tertiary care centre of rural india

2018 ◽  
Vol 6 (7) ◽  
pp. 2418
Author(s):  
Geeta Maurya ◽  
Sanjeev Kumar Singh ◽  
Pinki Pandey ◽  
Vineet Chaturvedi
Keyword(s):  
Tertiary Care ◽  
Female Genital Tract ◽  
Mucinous Cystadenoma ◽  
Histopathological Study ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Serous Adenocarcinoma ◽  
Follicular Cyst ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions

Background: Most common ovarian lesions include benign non-neoplastic lesions including functional cysts and neoplastic lesions. While among cancers of female genital tract, the incidence of ovarian cancer ranks below only carcinoma of cervix and endometrium. The aim of this study was to observe and evaluate the frequency and morphological pattern of different ovarian pathologies encountered in this tertiary care centre of rural India.Methods: This was a retrospective five years observational study (2012-16) and conducted at Department of Pathology of UPUMS, Saifai. The study material included 264 histopathology specimens received in our department.Results: Total 264 cases of ovarian pathologies were studied, in which 147 cases were non-neoplastic while remaining 117 cases were neoplastic. The most common non-neoplastic lesion was follicular cyst (51.7%), followed by corpus luteal cyst (30.61%), endometriosis (15.64%). Among 117 neoplastic cases, 87 cases (74.35%) were benign, 5 cases (4.27%) were borderline tumours and 25 cases (21.36%) were diagnosed malignant. Serous cystadenoma was most common benign tumour with 53 cases (45.29%) followed by 20 cases (17.09%) of dermoid cyst and 12 cases (10.25%) of mucinous cystadenoma. While in malignant tumours, serous adenocarcinoma were most common (4.27%) followed by mucinous adenocarcinoma (2.56%).Conclusions: In our study, non-neoplastic ovarian lesions were more commonly seen than neoplastic lesions. Surface epithelial tumours were most common histologic type in all age groups. While serous adenocarcinoma was most common ovarian malignancy seen. Both non-neoplastic as well as neoplastic lesions of ovary often present with similar clinical and radiological features. So histopathological study is essential to diagnose ovarian tumours. 

A study of histopathological spectrum of gastrointestinal tract lesions in a rural tertiary care centre

2019 ◽  
Vol 12 (3) ◽  
pp. 153-160
Author(s):  
Neha Mukesh Goel ◽  
◽  
Abhay Y Desai ◽  
Waghmare Rohan Mohan ◽  
Vijay D Dombale ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre

A prospective observational study on the effectiveness of risk of malignancy index score (RMI 3) in a tertiary care centre in Eastern India

2020 ◽  
Vol 11 (5) ◽  
pp. 54-60
Author(s):  
Apurba Mandal ◽  
Shibram Chattopadhyay ◽  
Sushanta Mondal ◽  
Arunava Biswas
Keyword(s):  
Ovarian Cancer ◽  
Adnexal Mass ◽  
Malignant Tumors ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Ca 125 ◽  
Tertiary Care Centre ◽  
Gynecology And Obstetrics ◽  
Risk Of Malignancy ◽  
Malignant Lesions

Background: Adnexal mass is a common presentation in today’s gynecological practice. The incidence of ovarian cancer is increasing day by day and diagnosis is often difficult to be made pre operatively with inadequate surgical exploration is a regular occurrence. Aims and Objectives: To assess and validate the importance of RMI-3 score as pre-operative diagnostic tool of differentiating benign from malignant adnexal mass for starting first line therapy of ovarian cancer and to find out the incidences of ovarian malignancy among study population. Material and Methods: The study was conducted in the Department of Gynecology and Obstetrics on (n=115) patients attending GOPD and indoor with adnexal mass fulfilling the inclusion and exclusion criteria using purposive sampling technique. All the selected cases underwent ultrasonography and serum CA- 125 level estimation necessary for calculating RMI score. A score of >200 was taken as suggestive of malignancy and confirmatory diagnosis was performed by histopathological examination obtained from staging laparotomy of adnexal mass. The individual scores were then correlated with final outcomes with statistical analyses. Results: The study revealed benign ovarian tumors are more under 50 years (78.46%) and patients with normal BMI are diagnosed with maximum of malignancy (n = 28). History of tubal ligation carried less risk of malignancy (p<0.0001). Histologically malignant tumors found mostly in 71.4% postmenopausal group whereas 94.1% benign pathology were present in perimenopausal group and there is no association found between parity and histopathology (p=0.058). Bilateral (p=0.013), multilocular (p=0.000) tumors with solid areas (p<0.0001) and thick papillary projections (p<0.0001) had statistically significant association with malignant lesions. RMI score (>200) had more efficacy than serum CA-125 level (>46) in differentiating malignant lesions from benign one in terms of specificity (96% vs 83.87%) and positive predictive value (95% vs 79.17%). Conclusions: RMI-3 score is a simple, reliable and effective tool in differentiating benign from malignant adnexal masses thereby help in quick referral and management of cases with increase chances of survival of the patients.

Histopathological Study of Cystoscopic Bladder Biopsies in a Tertiary Care Center

2021 ◽  
Vol 6 (1) ◽  
pp. 1310-1314
Author(s):  
Rachana Dhakal ◽  
Hem Nath Joshi ◽  
Ramesh Makaju ◽  
Shailendra Sigdel
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Pathological Condition ◽  
Care Center ◽  
Tertiary Care ◽  
University Hospital ◽  
World Health ◽  
Histopathological Study ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions

Introduction: Non-neoplastic urinary bladder lesions are not life threatening, but are an important source to cause clinical symptoms and signs. However, neoplasms of the bladder are a source of morbidity, mortality, and exhibit more clinical challenges. Cystoscopy provides overall information about an anatomical/pathological condition of the urinary bladder which will be helpful for patients' management. A cystoscopic biopsy is a primary diagnostic tool for diagnosing urinary bladder cancer. Objectives: The objective of the study was to find the frequency and histomorphological characteristics of urinary bladder lesions in Dhulikhel Hospital, to find the clinical presentation of urinary bladder lesions and to grade the urothelial tumors based on the World Health Organization (WHO)/ International Society of Urological Pathology (ISUP) classification 2004. Methodology: This was a retrospective, cross-sectional, observational study carried out in the Department of Pathology, Dhulikhel Hospital-Kathmandu University Hospital. Convenient sampling was done. All cystoscopy biopsies received from January 2014 to December 2018 were studied. All tissue blocks were retrieved, cut, and stained with Hematoxylin and Eosin. The stained slides were examined under a light microscope by the primary investigator. Result: A total of 70 cystoscopic biopsies were analyzed. The majority of patients 20 (28.6%) were in the age group between 60 and 69 years and males were predominant 43 (61.4%). The neoplastic lesions constituted 40 (57.1%) of all bladder lesions, among them urothelial carcinoma accounted for 38 (54.2%). Similarly, chronic cystitis 27(38.6%) was the most common non-neoplastic lesion. Conclusion: The study found that the neoplastic lesions were commonly encountered in urinary bladder lesions. Among them, lowgrade urothelial carcinoma was the most common bladder tumor. However, most of the non-neoplastic lesions were inflammatory in origin. Cystoscopy combined with histomorphological examination helps in the early detection of bladder lesions. 

Histopathological Study of Lesions of the Nasal Cavity, Paranasal Sinuses and Nasopharynx in a Tertiary Care Centre, Visakhapatnam over a Period of 2 Years

2021 ◽  
Vol 8 (33) ◽  
pp. 3054-3059
Author(s):  
Rajendra Prasad Jagannadham ◽  
Lakshmi Latchupatula ◽  
Sravani Ponnada ◽  
Neelima Lalam ◽  
Raghunadhababu Gudipudi ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Malignant Tumours ◽  
Tertiary Care Centre ◽  
Female Ratio ◽  
Male Predominance

BACKGROUND A variety of non - neoplastic and neoplastic conditions involve the nasal cavity, paranasal sinuses and nasopharynx and these are very common lesions encountered in clinical practice. Histopathological examination of these lesions is the gold standard for diagnosis because management and prognosis vary among different lesions. The aim of the present study was to evaluate the histopathological study of the lesions of the nasal cavity, paranasal sinuses and nasopharynx in relation to their incidence, age, gender and site wise distribution and to compare the results with the available data. METHODS A study of 88 cases was conducted for a period of 2 years from August 2017 to July 2019. After fixation, Processing and Haematoxylin and Eosin staining and special stains histopathological diagnosis was made. RESULTS Among 88 total cases, 58 were males and 30 were females. A male predominance was observed with a male to female ratio of 1.93 : 1. They were more common in third, fourth and fifth decade of life. Malignant nasal lesions were seen after fourth decade of life. Nasal lesions were more common in nasal cavity (67.05 %), followed by paranasal sinuses (18.18 %) and nasopharynx (14.75). Out of 88 total cases, 39 (44.32 %) were non - neoplastic, 30 (34.09 %) were benign and 19 (21.59 %) were malignant nasal lesions. CONCLUSIONS Sinonasal lesions and nasopharyngeal lesions can have various differential diagnoses. A complete clinical, radiological and histopathological correlation helps to categorize these sinonasal lesions into various non - neoplastic and neoplastic types. But histopathological examination remains the mainstay of definitive diagnosis. KEYWORDS Nasal Cavity, Paranasal Sinuses, Nasopharynx, Benign Tumours, Malignant Tumours, Histopathological Examination

scholarly journals IV Paracetamol for closure of patent ductus arteriosus in preterm neonates admitted to a tertiary care centre

2018 ◽  
Vol 5 (2) ◽  
pp. 294 ◽  
Author(s):  
Sunil B. ◽  
Shruthi Patel ◽  
Girish N.
Keyword(s):  
Side Effects ◽  
Preterm Infants ◽  
Ductus Arteriosus ◽  
Treatment Options ◽  
Tertiary Care ◽  
Current Treatment ◽  
Preterm Neonates ◽  
Tertiary Care Centre ◽  
Vascular Connection ◽  
Intravenous Paracetamol

Background: Ductus arteriosus is a vascular connection between the pulmonary artery and descending aorta. The incidence is inversely related to birth weight and gestational age (GA). In preterm infants it varies between 40% and 60% on the third day of life. At present, the choice of treatment of clinically significant PDA is with either ibuprofen or indomethacin, but they carry many contraindications and potential side effects. Hence it is important to consider that paracetamol may be used as an alternative to other non steroidal anti-inflammatory drugs and is effective in ductal closure with minimal side effects.Methods:Thirty six preterm infants with hemodynamically significant PDA(hs-PDA) were treated with intravenous paracetamol and subsequent closure was evaluated clinically and by follow-up 2D-Echo.Results: PDA closure following intravenous paracetamol was evident in 27 babies (75%). There were no significant side effects noted with paracetamol therapy.Conclusions: This study shows that paracetamol could offer favourable safety profile in comparison to current treatment options. Therefore, paracetamol may be accepted as a first-line drug treatment for PDA in preterm infants. 

scholarly journals CLINICOPATHOLOGICAL STUDY OF CARCINOMA ORAL CAVITY & PATTERN OF METASTASIS- EXPERIENCE IN A TERTIARY CARE CENTRE

2020 ◽  
pp. 1-3
Author(s):  
Bijan Basak ◽  
Soutrik Kumar ◽  
Kaustuv Das Biswas ◽  
Sayan Hazra ◽  
Debarshi Jana
Keyword(s):  
Indian Subcontinent ◽  
Treatment Options ◽  
Tertiary Care ◽  
Neck Surgery ◽  
Tertiary Care Centre ◽  
Major Health Problem ◽  
Node Metastases ◽  
Long Term Prognosis ◽  
Head Neck Surgery ◽  
Head Neck

Oral cancer (code 145.9, ICD 9) encompasses all malignancies originating in oral tissues & it is a major health problem in many parts of the world. Although incidence is relatively low in the western countries, in the Indian subcontinent & other parts of Asia it remains one of the commonest cancers. The study was conducted on the patients attending the ENT & HEAD-NECK SURGERY OPD at the INSTITUTE OF OTORHINOLARYNGOLOGY & HEAD-NECK SURGERY, IPGME&R, Kolkata during a period of 1 year from 1st March 2019 to 29th February 2020. Buccal mucosa was the commonest site & most cases presented in late stage with cervical lymph node metastases entailing poorer prognosis. People should be made aware of the warning symptoms, need for early diagnosis & treatment options available through IEC (information, education & communication programmes) in order to provide better treatment outcomes, improved long term prognosis & thereby reducing the morbidity & mortality of people at large.

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