scholarly journals Therapy challenges in patients with Mycoplasma genitalium infection of the urogenital tract: clinical observations

2021 ◽  
Vol 22 (4) ◽  
pp. 86-91
Author(s):  
V. B. Stoyanov ◽  
V. A. Molochkov ◽  
T. B. Semenova ◽  
O. B. Zhukov
Keyword(s):  
Inflammatory Diseases ◽  
Mycoplasma Genitalium ◽  
Nucleic Acid Amplification ◽  
Multiple Drug ◽  
Antimicrobial Drugs ◽  
Urogenital Infections ◽  
Clinical Observations ◽  
Multiple Drug Resistant ◽  
Clinically Significant ◽  
Drug Resistant Strains

Mycoplasma genitalium is a clinically significant intracellular bacterium from the family of genital mycoplasmas; it absolutely dominates in persistent/recurrent nongonococcal urethritis, causes chronic inflammatory diseases of the urogenital organs which dictates the necessity of treating this infection. The study presents observations of 2 patients with chronic recurrent urethritis caused by multiple drug resistant strains of M. genitalium. None of the administered schemes of antibacterial treatment covered in the international protocols on treatment of M. genitalium infection allowed to achieve clinical or microbiological cure in these patients. Practicing doctors require development and improvement of nucleic acid amplification methods with antimicrobial testing for M. genitalium resistance and new antimicrobial drugs with improved chemical and pharmacological characteristics for treatment of patients with intracellular urogenital infections.

Anatomic distribution of Neisseria gonorrhoeae, Chlamydia trachomatis and Mycoplasma genitalium infections in men who have sex with men

Sexual Health ◽  
2013 ◽  
Vol 10 (3) ◽  
pp. 199 ◽  
Author(s):  
N. Reinton ◽  
H. Moi ◽  
A. O. Olsen ◽  
N. Zarabyan ◽  
J. Bjerner ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Neisseria Gonorrhoeae ◽  
Mycoplasma Genitalium ◽  
Nucleic Acid Amplification ◽  
Multiple Drug ◽  
Multiple Drug Resistant ◽  
Sexually Transmissible Infections ◽  
Anatomic Distribution ◽  
Sex With Men ◽  
Drug Resistant Strains

Background New cases of gonorrhoea (Neisseria gonorrhoeae) and chlamydia (Chlamydia trachomatis) infections have been steadily increasing in Scandinavian countries over the last decade. There is a particular urgency in reducing new infections as isolation of multiple drug resistant strains of gonorrhoea is becoming more frequent. The aim of this study was to determine the prevalence and sites of infection of common sexually transmissible infections (STIs) in men who have sex with men (MSM). Methods: We have performed a retrospective analysis of the three major STIs, gonorrhoea, chlamydia and Mycoplasma genitalium in urogenital, anorectal and oropharyngeal samples from MSM that attended two STI clinics in Oslo. Results: One hundred and thirty-six men (6.0%) out of 2289 MSM tested were found to be positive for gonorrhoea using a porA gene targeted nucleic acid amplification test (NAAT). Of these, 106 (77.9%) would not have been identified through testing first-void urine alone. Two hundred and twenty eight (10.0%) patients from 2289 tested were found to be positive for chlamydia, 164 (71.9%) of which were identified through anorectal specimens. Ninety-one (5.1%) patients from 1778 tested were found to be positive for M. genitalium, with 65 (71.4%) identified through testing of anorectal specimens. Conclusions: Our results supports the European findings that the MSM population carries a high burden of STIs and that testing the anorectum and oropharynx will identify a significantly higher percentage of infected patients and reservoirs of STIs.

scholarly journals Vancomycin Sensitivity of Clinical Isolates of Staphylococcus aureus from Patients in Dhaka City, Bangladesh

2012 ◽  
Vol 15 (2) ◽  
pp. 159-163 ◽  
Author(s):  
Mohammad Shahriar ◽  
Sanjida Shahid ◽  
Khusbu Khalil Katha ◽  
Waheeda Nasreen ◽  
Mohiuddin Ahmed Bhuiyan
Keyword(s):  
Staphylococcus Aureus ◽  
Pharmaceutical Journal ◽  
Clinical Isolates ◽  
Diffusion Method ◽  
Multiple Drug ◽  
Beta Lactamase ◽  
Antimicrobial Drugs ◽  
Multiple Drug Resistant ◽  
Vancomycin Resistant ◽  
Drug Resistant Strains

Methicillin-resistant Staphylococcus aureus (MRSA), resistant to all antibiotics including vancomycin, has been reported in Japan, USA, Canada and Brazil. Hence, the main objective of this study was to evaluate the possible presence of vancomycin resistant or intermediate Stap. aureus in Dhaka. A total of 122 clinical isolates were collected from different hospitals, clinics and diagnostic centers of the city for about 12 months starting from August 2010 to July 2011.They were identified using standard bacteriological methods. Sensitivity to recommended antibiotics was determined by disc diffusion method. In the present study 74% of total isolates were found to be betalactamase producers by iodometric methods, whereas with Nitrocefin® sticks 80% of the isolates were found to be beta-lactamase producers. All the multiple drug resistant strains were beta-lactamase producers. Out of 122 isolates, although no strains were found vancomycin resistant, 93.44% were found intermediate and only 6.56% showed sensitivity. This study reveals the growing antimicrobial resistance in Bangladesh and refers not to use the antimicrobial drugs that show insufficient sensitivity against Stap. aureus to prevent resistance and associated treatment failure. DOI: http://dx.doi.org/10.3329/bpj.v15i2.12582 Bangladesh Pharmaceutical Journal 15(2): 159-163, 2012

scholarly journals Microbial quality of herbal juices sold at sport complex in Washim

2017 ◽  
Vol 5 (11) ◽  
pp. 4946 ◽  
Author(s):  
Nikhilesh Kulkarni ◽  
Jayshree Narwade ◽  
Rachana Pachori ◽  
Prithviraj Sadar
Keyword(s):  
Age Groups ◽  
Human Consumption ◽  
Multiple Drug ◽  
Microbial Quality ◽  
The People ◽  
Multiple Drug Resistant ◽  
Resistant Strains ◽  
Human Infections ◽  
Drug Resistant Strains

Background: Herbal juices are gaining global attention due to their medicinal properties, nutritive and antioxidant activity. They are frequently consumed by the people of all age groups in the form of health drinks. However, many outbreaks of human infections have been reported to be associated with the consumption of contaminated herbal juices. Hence, microbial quality assessment of herbal juices is utmost important.Methods: The present study was undertaken to detect the existence of enteric pathogens as well as coliforms in the herbal juices sold at sport complex in Washim city area. The antimicrobial susceptibility testing was also performed to evaluate the MDR status of the isolates.Results: The results showed that most of the herbal juices are contaminated with Salmonella, Shigella and Coliforms. The pathogens were found to be multiple drug resistant strains which pose an alarming threat for the consumers.Conclusions: Regular monitoring of the quality of herbal juices for human consumption is recommended to avoid disease outbreak.

scholarly journals Antibacterial activity of combined medicinal plants extract against multiple drug resistant strains

2015 ◽  
Vol 5 ◽  
pp. S151-S154
Author(s):  
Rafiqul Islam ◽  
Md. Shahedur Rahman ◽  
Riad Hossain ◽  
Nazmun Nahar ◽  
Belal Hossin ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Medicinal Plants ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Multiple Drug Resistant ◽  
Resistant Strains ◽  
Drug Resistant Strains ◽  
Plants Extract

scholarly journals Studies on the effects of 3-acetyl-4"-isovaleryltylosin against multiple-drug resistant strains of Staphylococcus aureus.

1981 ◽  
Vol 34 (3) ◽  
pp. 305-312 ◽  
Author(s):  
MASAMI TSUCHIYA ◽  
KAYOKO SUZUKAKE ◽  
MAKOTO HORI ◽  
TSUTOMU SAWA ◽  
TOMIO TAKEUCHI ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Multiple Drug Resistant ◽  
Resistant Strains ◽  
Drug Resistant Strains

scholarly journals Factors associated with typhoid relapse in the era of multiple drug resistant strains

2011 ◽  
Vol 5 (10) ◽  
pp. 727-731 ◽  
Author(s):  
Kaashif Aqeeb Ahmad ◽  
Liaqat Hayat Khan ◽  
Bakht Roshan ◽  
Zulfiqar Ahmed Bhutta
Keyword(s):  
Enteric Fever ◽  
Medical Center ◽  
Reticuloendothelial System ◽  
Multiple Drug ◽  
Clinical Relapse ◽  
Drug Resistant ◽  
Factors Associated ◽  
Multiple Drug Resistant ◽  
Drug Resistant Strains ◽  
Subsequent Relapse

Introduction: Typhoid has an estimated global burden of greater than 27 million cases per annum with a clinical relapse rate of 5% to 20%.  Despite the large relapse burden, the factors associated with relapse are largely unknown.  Methodology: We have followed a protocol for the diagnosis and management of pediatric typhoid since 1988.  We report factors associated with relapse of culture-proven enteric fever in 1,650 children presenting to the Aga Khan University Medical Center,  Karachi, Pakistan, over a 15-year period.  Results: In those infected with multiple drug resistant (MDR) strains, factors associated with subsequent relapse include constipation at presentation and presentation within 14 days of fever onset.  Diarrhoea in those children infected with drug sensitive strains had an association with decreased subsequent relapse, as was quinolone therapy. Conclusions: Multiple clinical factors at presentation are associated with subsequent typhoid fever relapse.  These factors may be postulated to be associated with subsequent relapse due to alterations in the reticuloendothelial system organism load.  These data will be valuable in developing algorithms for clinical follow-up in children infected with MDR enteric fever.

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