Effect of Aerobic Exercise in Water on Serum Estrogen and C - Reactive Protein and Body Mass Index Level in Obese and Normal Weight Postmenopausal Women

Objective: Cathepsin S has been suggested provide a mechanistic link between obesity and atherosclerosis, possibly mediated via adipose tissue-derived inflammation. Previous data have shown an association between circulating cathepsin S and inflammatory markers in the obese, but to date, community-based reports are lacking. Accordingly, we aimed to investigate the association between serum levels of cathepsin S and markers of cytokine-mediated inflammation in a community-based sample, with prespecified subgroup analyses in nonobese participants. Methods: Serum cathepsin S, C-reactive protein (CRP), and IL-6 were measured in a community-based cohort of elderly men (Uppsala Longitudinal Study of Adult Men; mean age 71 years, n = 991). CRP and IL-6 were also measured at a reexamination after 7 yr. Results: After adjustment for age, body mass index, fasting plasma glucose, diabetes treatment, systolic blood pressure, diastolic blood pressure, hypertension treatment, serum cholesterol, serum high-density lipoprotein cholesterol, prior cardiovascular disease, smoking, and leisure time physical activity, higher cathepsin S was associated with higher CRP (regression coefficient for 1 sd increase, 0.13; 95% confidence interval 0.07–0.19; P < 0.001) and higher serum IL-6 (regression coefficient for 1 sd increase, 0.08; 95% confidence interval 0.01–0.14; P = 0.02). These associations remained similar in normal-weight participants (body mass index <25 kg/m2, n = 375). In longitudinal analyses, higher cathepsin S at baseline was associated with higher serum CRP and IL-6 after 7 yr. Conclusions: These results provide additional evidence for the interplay between cathepsin S and inflammatory activity and suggest that this association is present also in normal-weight individuals in the community.

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The relation between high-sensitivity C-reactive protein and maximum body mass index in patients with psoriasis

British Journal of Dermatology ◽

10.1111/j.1365-2133.2008.08467.x ◽

2008 ◽

Vol 158 (5) ◽

pp. 1141-1143 ◽

Cited By ~ 15

Author(s):

T. Ohtsuka

Keyword(s):

Body Mass Index ◽

Body Mass ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

Maximum Body

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Combined body mass index with high-sensitivity C-reactive protein as independent predictors for chronic kidney disease in a relatively healthy population in Taiwan

European Journal of Clinical Nutrition ◽

10.1038/ejcn.2016.28 ◽

2016 ◽

Vol 70 (7) ◽

pp. 766-771 ◽

Cited By ~ 1

Author(s):

Y-W Tsai ◽

M-C Lu ◽

Y-H Lin ◽

Y-C Lee ◽

W-C Li ◽

...

Keyword(s):

Body Mass Index ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Body Mass ◽

High Sensitivity ◽

Healthy Population ◽

C Reactive Protein ◽

Reactive Protein

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Body Mass Index, but Not Physical Activity, Is Associated with C-Reactive Protein

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000074565.79230.ab ◽

2003 ◽

Vol 35 (7) ◽

pp. 1160-1166 ◽

Cited By ~ 85

Author(s):

ERIC S. RAWSON ◽

PATTY S. FREEDSON ◽

STAVROULA K. OSGANIAN ◽

CHARLES E. MATTHEWS ◽

GEORGE REED ◽

...

Keyword(s):

Physical Activity ◽

Body Mass Index ◽

Body Mass ◽

C Reactive Protein ◽

Reactive Protein

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Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index

Annals of the Rheumatic Diseases ◽

10.1136/ard.2009.125260 ◽

2010 ◽

Vol 69 (11) ◽

pp. 1976-1982 ◽

Cited By ~ 46

Author(s):

Hanneke J M Kerkhof ◽

Sita M A Bierma-Zeinstra ◽

Martha C Castano-Betancourt ◽

Moniek P de Maat ◽

Albert Hofman ◽

...

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Genetic Variation ◽

Body Mass ◽

Analysis Of Covariance ◽

C Reactive Protein ◽

Knee Oa ◽

Reactive Protein ◽

Serum Crp ◽

The Relationship

ObjectiveTo study the relationship between serum C reactive protein (CRP) levels, genetic variation in the CRP gene and the prevalence, incidence and progression of radiographic osteoarthritis (ROA) in the Rotterdam Study-I (RS-I). A systematic review of studies assessing the relationship between osteoarthritis (OA) and CRP levels was also performed.MethodsThe association between CRP levels and genetic variation in the CRP gene and ROA was examined in 861 patients with hand OA, 718 with knee OA, 349 with hip OA and 2806 controls in the RS-I using one-way analysis of covariance and logistic regression, respectively. PubMed was searched for articles published between January 1992 and August 2009 assessing the relationship between CRP levels and OA.ResultsIn RS-I the prevalence of knee OA, but not hip OA or hand OA, was associated with 14% higher serum CRP levels compared with controls (p=0.001). This association disappeared after adjustment for age and especially body mass index (BMI) (p=0.33). Genetic variation of the CRP gene was not consistently associated with the prevalence, incidence or progression of OA within RS-I. The systematic review included 18 studies (including RS-I) on serum CRP levels and the prevalence, incidence or progression of OA. Consistently higher crude CRP levels were found in cases of prevalent knee OA compared with controls. No association was observed between serum CRP levels and the prevalence of knee OA following adjustment for BMI (n=3 studies, meta-analysis p value=0.61).ConclusionThere is no evidence of association between serum CRP levels or genetic variation in the CRP gene with the prevalence, incidence or progression of OA independent of BMI.

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C-reactive Protein, Body Mass Index, and Diabetic Retinopathy

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.09-4939 ◽

2010 ◽

Vol 51 (9) ◽

pp. 4458 ◽

Cited By ~ 49

Author(s):

Laurence Shen Lim ◽

E. Shyong Tai ◽

Paul Mitchell ◽

Jie Jin Wang ◽

Wan Ting Tay ◽

...

Keyword(s):

Body Mass Index ◽

Diabetic Retinopathy ◽

Body Mass ◽

Protein Body ◽

C Reactive Protein ◽

Reactive Protein

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The Metabolic Phenotype of Prader-Willi Syndrome (PWS) in Childhood: Heightened Insulin Sensitivity Relative to Body Mass Index

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2010-1733 ◽

2011 ◽

Vol 96 (1) ◽

pp. E225-E232 ◽

Cited By ~ 46

Author(s):

Andrea M. Haqq ◽

Michael J. Muehlbauer ◽

Christopher B. Newgard ◽

Steven Grambow ◽

Michael Freemark

Keyword(s):

Body Mass Index ◽

Insulin Sensitivity ◽

Body Mass ◽

Density Lipoprotein ◽

High Sensitivity ◽

Metabolic Phenotype ◽

Prader Willi Syndrome ◽

C Reactive Protein ◽

Reactive Protein ◽

Total Adiponectin

Context: Insulin sensitivity is higher in patients with Prader-Willi syndrome (PWS) than in body mass index-matched obese controls (OCs). Factors contributing to the heightened insulin sensitivity of PWS remain obscure. We compared the fasting levels of various hormones, cytokines, lipids, and liver function tests in 14 PWS patients and 14 OCs with those in 14 age- and gender-matched lean children (LC). We hypothesized that metabolic profiles of children with PWS are comparable with those of LC, but different from those of OCs. Results: Leptin levels were comparable in PWS patients and OCs, suggesting comparable degrees of adiposity. Glucose levels were comparable among groups. However, fasting insulin concentrations and homeostasis model assessment insulin resistance index were lower in PWS patients than in OCs (P < 0.05) and similar to LC. Moreover, high-density lipoprotein levels were lower and triglycerides higher in OCs (P < 0.05) but not PWS patients. Total adiponectin, high-molecular-weight (HMW) adiponectin and the HMW to total adiponectin ratio were higher in PWS patients (P < 0.05) than in OCs and similar to LC. High-sensitivity C-reactive protein and IL-6 levels were higher in OCs than in PWS patients or LC (P < 0.05). Nevertheless, PAI-1 levels were elevated in both OC and PWS patients. There were no group differences in glucagon-like peptide-1, macrophage chemoattractant protein-1, TNFα, IL-2, IL-8, IL-10, IL-12p40, IL-18, resistin, total or low-density lipoprotein cholesterol, aspartate aminotransferase, or alanine aminotransferase. Conclusions: The heightened insulin sensitivity of PWS patients relative to OCs is associated with higher levels of adiponectin and lower levels of high-sensitivity C-reactive protein and IL-6. Future studies will determine whether PWS children are protected from obesity comorbidities such as type 2 diabetes, hyperlipidemia, and nonalcoholic fatty liver disease.

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