Dysmenorrhea and endometriosis in teenage girls (review)

Most adolescents experience discomfort during menstruation. Usually, girls are diagnosed with primary dysmenorrhea in the early reproductive period and respond well to symptomatic treatment with non-steroidal anti-inflammatory or hormonal drugs. If first-line therapy does not improve the symptoms of dysmenorrhea, transabdominal ultrasonography is indicated. Most often, these patients are diagnosed with endometriosis, which is the main cause of secondary dysmenorrhea in adolescents. Endometriosis should be assumed in patients with persistent, clinically pronounced dysmenorrhea that does not respond to treatment with hormonal drugs and non-steroidal anti-inflammatory drugs, especially if no other cause of chronic pelvic pain or secondary dysmenorrhea is detected on the basis of history, physical examination, and ultrasonography of pelvic organs. The aim of the therapy is to relieve symptoms, suppress disease progression, and protect future fertility.

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Nonopioid, Multimodal Analgesia as First-line Therapy After Otolaryngology Operations: Primer on Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Otolaryngology ◽

10.1177/0194599820947013 ◽

2020 ◽

pp. 019459982094701

Author(s):

John D. Cramer ◽

Michael L. Barnett ◽

Samantha Anne ◽

Brian T. Bateman ◽

Richard M. Rosenfeld ◽

...

Keyword(s):

Postoperative Pain ◽

Multimodal Analgesia ◽

Cochrane Library ◽

First Line ◽

Opioid Prescribing ◽

First Line Therapy ◽

Line Therapy ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Effective Analgesia

Objective To offer pragmatic, evidence-informed advice on nonsteroidal anti-inflammatory drugs (NSAIDs) as first-line therapy after surgery. This companion to the American Academy of Otolaryngology–Head & Neck Surgery (AAO-HNS) clinical practice guideline (CPG), “Opioid Prescribing for Analgesia After Common Otolaryngology Operations,” presents data on potency, bleeding risk, and adverse effects for ibuprofen, naproxen, ketorolac, meloxicam, and celecoxib. Data Sources National Guidelines Clearinghouse, CMA Infobase, National Library of Guidelines, NICE, SIGN, New Zealand Guidelines Group, Australian National Health and Medical, Research Council, TRIP database, PubMed, Guidelines International Network, Cochrane Library, EMBASE, CINAHL, BIOSIS Previews, ISI Web of Science, AHRQ, and HSTAT. Review Methods AAO-HNS opioid CPG literature search strategy, supplemented by PubMed/MEDLINE searches on NSAIDs, emphasizing systematic reviews and randomized controlled trials. Conclusion NSAIDs provide highly effective analgesia for postoperative pain, particularly when combined with acetaminophen. Inconsistent use of nonopioid regimens arises from common misconceptions that NSAIDs are less potent analgesics than opioids and have an unacceptable risk of bleeding. To the contrary, multimodal analgesia (combining 500 mg acetaminophen and 200 mg ibuprofen) is significantly more effective analgesia than opioid regimens (15 mg oxycodone with acetaminophen). Furthermore, selective cyclooxygenase-2 inhibition reliably circumvents antiplatelet effects. Implications for Practice The combination of NSAIDs and acetaminophen provides more effective postoperative pain control with greater safety than opioid-based regimens. The AAO-HNS opioid prescribing CPG therefore prioritizes multimodal, nonopioid analgesia as first-line therapy, recommending that opioids be reserved for severe or refractory pain. This state-of-the-art review provides strategies for safely incorporating NSAIDs into acute postoperative pain regimens.

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NAPROXEN INDUCED ERYTHEMA MULTIFORME-A RARE CASE REPORT

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2017v9i3.14903 ◽

2017 ◽

Vol 9 (3) ◽

pp. 294 ◽

Cited By ~ 1

Author(s):

Sai Keerthana P. C. ◽

Anila K. N. ◽

Reshma Reji

Keyword(s):

Erythema Multiforme ◽

Lupus Erythematosus ◽

Rare Case ◽

Symptomatic Treatment ◽

Girl Child ◽

Rare Case Report ◽

History Of ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Custodial Parents

Erythema multiforme (EM) is a hypersensitivity reaction characterized by varying degrees of blisters and ulcerations. We report a case of 4 y old girl child born for Non-custodial parents who has a history of seizures and a known case of carbamazepine-induced SLE (Systemic Lupus Erythematosus) when treated with anti-inflammatory drugs developed EM. The offending drug was identified and withdrawn. Steroid was given as a part of symptomatic treatment. Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed groups of drugs for a variety of indications. The patient gradually improved and got discharged.

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ANTI-INFLAMMATORY THERAPY OF THROAT DISEASES

Folia Otorhinolaryngologiae et Pathologiae Respiratoriae ◽

10.33848/foliorl23103825-2019-25-3-53-59 ◽

2019 ◽

Vol 25 (3) ◽

pp. 53-59

Author(s):

O.M. Kolesnikova ◽

◽

S.A. Karpishchenko ◽

Y.V. Legkova ◽

◽

...

Keyword(s):

Quality Of Life ◽

Respiratory Tract ◽

Antibiotic Therapy ◽

Symptomatic Treatment ◽

Diagnostic Methods ◽

Active Life ◽

Systemic Antibiotic Therapy ◽

Inflammatory Drugs ◽

Anti Inflammatory

Sore throat is one of the most common complaints faced by doctors of various specialties. This symptom accompanies many diseases of the pharynx and larynx, and may be a manifestation of certain diseases that are not associated with the respiratory tract. When choosing therapy, it is necessary by doctors to rationally use the criteria for the appointment of systemic antibiotic therapy. However, local anti-inflammatory therapy as a symptomatic treatment should be selected before accurate confirmation of the etiology of the disease. This provides patients with a quick return to an active life and an improvement in the quality of life in general. The article discusses the etiology and pathogenesis of pain in diseases of the pharynx, modern diagnostic methods and optimal tactics for treating patients. As a symptomatic treatment, to reduce inflammation in the pharynx, the drug Vertum LOR, which belongs to the group of non-steroidal anti-inflammatory drugs of local action, may contain benzidamine as an active substance.

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Biological Basis for the Use of Botanicals in Osteoarthritis and Rheumatoid Arthritis: A Review

Evidence-based Complementary and Alternative Medicine ◽

10.1093/ecam/neh117 ◽

2005 ◽

Vol 2 (3) ◽

pp. 301-308 ◽

Cited By ~ 117

Author(s):

Salahuddin Ahmed ◽

Jeremy Anuntiyo ◽

Charles J. Malemud ◽

Tariq M. Haqqi

Keyword(s):

Rheumatoid Arthritis ◽

Symptomatic Treatment ◽

Cartilage Explants ◽

Unknown Etiology ◽

Joint Diseases ◽

History Of ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Systemic Nature

Osteoarthritis (OA) of the knee and hip is a debilitating disease affecting more women than men and the risk of developing OA increases precipitously with aging. Rheumatoid arthritis (RA), the most common form of inflammatory joint diseases, is a disease of unknown etiology and affects ∼1% of the population worldwide, and unlike OA, generally involves many joints because of the systemic nature of the disease. Non-steroidal anti-inflammatory drugs (NSAIDs) are the first drugs of choice for the symptomatic treatment of both OA and RA. Because of the risks associated with the use of NSAIDs and other limitations, the use of alternative therapies, such as acupuncture and medicinal herbs, is on the rise and according to reports ∼60–90% of dissatisfied arthritis patients are likely to seek the option of complementary and alternative medicine (CAM). This paper reviews the efficacy of some of the common herbs that have a history of human use and their anti-inflammatory or antiarthritic properties have been evaluated in animal models of inflammatory arthritis, in studies employing well defined and widely acceptedin vitromodels that use human chondrocytes/cartilage explants or in clinical trials. Available data suggests that the extracts of most of these herbs or compounds derived from them may provide a safe and effective adjunctive therapeutic approach for the treatment of OA and RA. This, in turn, argues for trials to establish efficacy and optimum dosage of these compounds for treating human inflammatory and degenerative joint diseases.

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Frontiers in Gastroenterology

Journal of Pharmacy Practice ◽

10.1106/9v9t-paul-w05m ◽

2002 ◽

Vol 15 (3) ◽

pp. 241-249

Author(s):

Joseph Reilly ◽

Edmund J. Bini

Keyword(s):

Pegylated Interferon ◽

The United States ◽

Published Data ◽

First Line ◽

Ulcer Disease ◽

First Line Therapy ◽

Line Therapy ◽

Inflammatory Drugs ◽

Irritable Bowel ◽

Bleeding Ulcers

There have been a number of exciting advancements and changes in the gastroenterology field over the last few years. A new mesalamine formulation, balsalazide disodium, is now available for the treatment of ulcerative colitis (UC). Balsalazide may be utilized as first line therapy for patients with UC, or patients who are intolerant to other mesalamine preparations. In the area of irritable bowel syndrome, alosetron was removed from the market after reports that it was associated with severe constipation and death, although a causal relationship could not be established. Published data examines the risk of certain medications and the development of reflux disease and esophageal adenocarcinoma. Also, new proton pump inhibitors (PPIs) are available, esomeprazole, as well as alternate methods of administration for others. The first intravenous PPI, pantoprazole, is available in the United States, although currently there is a paucity of data regarding its efficacy. Peptic ulcer disease is also discussed, including Helicobacter pylori resistance, nonsteroidal anti-inflammatory drugs, and the treatment of bleeding ulcers. With pegylated interferon, progress in the treatment of hepatitis C offers promise for many patients. This review will highlight many recent changes in gastroenterology an offer a perspective on how disease management has changed.

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Chronic mandible inflammation as the first symptom of chronic recurrent multifocal osteomyelitis (CRMO) – a case report

Nowa Stomatologia ◽

10.25121/ns.2018.23.2.72 ◽

2018 ◽

Vol 23 (2) ◽

Author(s):

Ewa Krasuska-Sławińska ◽

Paulina Piekarska ◽

Piotr Gietka ◽

Anna Wieteska-Klimczak ◽

Mirela Wadecka ◽

...

Keyword(s):

Clinical Symptoms ◽

Chronic Recurrent Multifocal Osteomyelitis ◽

Unknown Aetiology ◽

First Line ◽

First Line Therapy ◽

Line Therapy ◽

Soft Tissue Swelling ◽

Multifocal Osteomyelitis ◽

Inflammatory Drugs ◽

Mild Fever

Chronic recurrent multifocal osteitis (CRMO) is a rare disease of an unknown aetiology, occurring mainly in children aged 4-14 years. It is characterised by recurring episodes of osteitis, with no detectable cause, lasting from several months up to a few years. It usually affects the metaphysis of long bones. Primary lesions in the form of isolated focuses rarely occur in the mandible. The clinical symptoms of CRMO include ostealgia, soft tissue swelling (oedema), skin reddening, and mild fever. The diagnosis is difficult. It involves numerous laboratory and radiological investigations. In order to exclude infectious and neoplastic aetiology, it is advisable to perform a tissue biopsy. The disease is long-lasting with exacerbations and remissions. The prognosis is uncertain. Non-steroidal anti-inflammatory drugs and empirical antibiotic therapy are a recommended first-line therapy; if no improvement is observed, corticosteroids should be used. The analysed case concerns a 10-year-old boy with mandible inflammation as the first symptom of chronic recurrent multifocal osteitis (CRMO). Mandibular lesions may be the first symptom of chronic recurrent multifocal osteitis. The non-specific onset and variable clinical picture delay the diagnosis. Early diagnosis enables early treatment, which prevents complications.

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Corticosteroids for Acute and Recurrent Idiopathic Pericarditis: Unexpected Evidences

Cardiology Research and Practice ◽

10.1155/2019/1348364 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7

Author(s):

Antonio Perrone ◽

Anna Castrovilli ◽

Giuseppina Piazzolla ◽

Sabina Savino ◽

Alessia D’Introno ◽

...

Keyword(s):

Recurrence Rate ◽

Low Dose ◽

Common Disease ◽

High Dose ◽

Efficacy And Safety ◽

Emergency Room Visits ◽

First Line ◽

First Line Therapy ◽

Line Therapy ◽

Inflammatory Drugs

Pericarditis is a common disease, often postviral or “idiopathic,” diagnosed in about 5% of emergency room visits for non-ischemic chest pain. Although pericarditis often occurs as a benign and self-limiting disease, it may present recurrences. The first-line therapy includes aspirin/nonsteroidal anti-inflammatory drugs (ASA/NSAIDs) plus colchicine. Steroids especially at high-dose have been associated with a higher recurrence rate. In this retrospective study, we evaluated efficacy and safety of ASA/NSAIDs and prednisone in the treatment of acute or recurrent idiopathic pericarditis (colchicine was off-label in the period of the study). The cohort included 276 patients diagnosed with acute idiopathic pericarditis. Mean age was 45.4 ± 12.7 years, and males were significantly higher in number and younger than females. Sixty-one patients (22.1%) were treated with prednisone and 215 with ASA/NSAIDs (77.9%). 171 patients experienced at least one recurrence (62%). No difference in recurrence rate was observed (p=0.257) between the groups treated with prednisone (55.7%) vs. ASA/NSAIDs (63.7%). The recurrences were treated with steroids at low doses and very gradual tapering, and the dose reduction was slower as the number of relapses was higher. Steroids alone were administered to about 80% of patients, while in the remaining 20% of cases, they were associated with ASA/NSDAIDs or colchicine. Approximately 90% of patients had a very favorable course, that is no more than 2 relapses and no patients presented serious side effects. Steroids at low dose, did not act, surprisingly, as an independent risk factor for recurrences and therefore may be considered a successful and safe treatment for acute and recurrent idiopathic pericarditis.

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Disease-Modifying Effects of Long-Term and Continuous Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Spondyloarthritis

Advances in Pharmacological Sciences ◽

10.1155/2019/5324170 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Rebecca S. Y. Wong

Keyword(s):

Pain Relief ◽

Adverse Effects ◽

Musculoskeletal System ◽

First Line ◽

Disease Research ◽

Inflammatory Drugs ◽

Disease Modifying ◽

Anti Inflammatory ◽

Continuous Use

Spondyloarthritis or spondyloarthropathy (SpA) is a group of related rheumatic disorders, which presents with axial and nonaxial features, affecting structures within the musculoskeletal system, as well as other bodily systems. Both pharmacological and nonpharmacological therapeutic options are available for SpA. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) have been used as the first-line drugs to treat the disease. Research has shown that other than pain relief, NSAIDs have disease-modifying effects in SpA. However, to achieve these effects, continuous and/or long-term NSAID use is usually required. This review will give an overview of SpA, discuss NSAIDs and their disease-modifying effects in SpA, and highlight some of the important adverse effects of long-term and continuous NSAID use, particularly those related to the gastrointestinal, renal, and cardiovascular systems.

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Use of Nonsteroidal Anti-Inflammatory Drugs for Symptomatic Treatment of Episodic Headache

Pain Practice ◽

10.1111/papr.12461 ◽

2016 ◽

Vol 17 (3) ◽

pp. 392-401 ◽

Cited By ~ 15

Author(s):

Giannapia Affaitati ◽

Paolo Martelletti ◽

Mariangela Lopopolo ◽

Claudio Tana ◽

Francesca Massimini ◽

...

Keyword(s):

Symptomatic Treatment ◽

Episodic Headache ◽

Inflammatory Drugs ◽

Anti Inflammatory

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Impact of Medication with Diclofenac Sodium vs. Etoricoxibum in Patients with Inflammatory Reumatic Pathology, Prosthetic Complications and Algo-dysfunctional Syndrome

Revista de Chimie ◽

10.37358/rc.17.5.5594 ◽

2017 ◽

Vol 68 (5) ◽

pp. 977-981

Author(s):

Laura Elisabeta Checherita ◽

Elena Rezus ◽

Maria Magdalena Leon ◽

Ovidiu Stamatin ◽

Elena Mihaela Carausu

Keyword(s):

Drug Treatment ◽

Temporomandibular Joint ◽

Diclofenac Sodium ◽

Symptomatic Treatment ◽

Daily Dose ◽

Before And After ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Prosthetic Complications ◽

Important Objective

Affections of temporomandibular joint (TMJ) can lead to imbalances and disfunctions named algodisfunctional syndrome. One of the affections that we will take into consideration in this study is the temporal-mandibular arthrosis, which is, in fact, the frequent pathology at this level, and to which we will measure the pain before and after the administration of the anti-inflammatory therapy: Etoricoxib vs. Dyclofenac.The important objective of this study is to investigate this type of drug treatment over TMJ. The class of drug called non-steroidal anti-inflammatory drugs (NSAIDs)�so called to distinguish this class of drug from steroids, which have similar but additional effects�make NSAIDs one of frequently used drugs for the symptomatic treatment of many common conditions. Etoricoxib is clinically effective in the therapy of TMJ providing a magnitude of effect comparable to that of the maximum recommended daily dose of Diclofenac.

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