scholarly journals Serotonin and cyclic sleep organization in healthy full-term newborns

2021 ◽  
Vol 70 (1) ◽  
pp. 69-76
Author(s):  
Natalia A. Zvereva ◽  
Yulia P. Milyutina ◽  
Inna I. Evsyukova
Keyword(s):  
Umbilical Cord ◽  
Gestational Age ◽  
Platelet Rich Plasma ◽  
Venous Blood ◽  
General Pattern ◽  
Full Term ◽  
Serotonin Content ◽  
Platelet Suspension ◽  
Neuropsychiatric Diseases ◽  
Term Newborns

Relevance: The growth of neuropsychiatric diseases caused by perinatal pathology indicates the need to study the biochemical markers of brain damage in the newborn for the timely prevention of adverse consequences. Serotonin in early ontogenesis provides intensive development of neuronal structures and cortical networks involved in the mechanisms of formation of cyclic sleep organization a fine criterion of morphofunctional development of the brain. aim: The aim of the work is to study the content of serotonin in healthy full-term newborns in comparison with the quantitative and qualitative characteristics of the electropoligraphic sleep pattern. Material and methods: 84 healthy newborns were examined, which, depending on the gestational age, were divided into 3 groups: I 37 weeks (20 people), II 38 weeks (24 people), III 39-40 weeks (40 people). The content of serotonin in platelet-rich plasma of blood from the umbilical cord vein and in platelet suspension prepared from venous blood taken from mothers and children on the first day of life and again on day 5 was determined by high-performance liquid chromatography with electrochemical detection. A quantitative and qualitative analysis of the sleep electropoligram was performed 7-12 hours after birth. Results: The content of serotonin in platelet-rich plasma in umbilical cord blood in children does not depend on the method of birth, is 2 times lower than in the venous blood of mothers (0.379 0.116 microns/l, versus 0.756 0.200 microns/l, but there is a high correlation between the indicators (r = 0.8, p 0.05). At the gestational age of 39-40 weeks, the level of serotonin in platelet-rich plasma and in venous blood platelets is significantly higher than in those born at 37 weeks. In the latter, the increase in the content of serotonin in platelets continues after birth (at day 1, 0.539 0.149 nM/109 Tr, and on day 5 0.846 0.094 nM/109 Tr; p 0.05), whereas the indicators for those born at 39-40 weeks of pregnancy. They do not change (0.797 0.190 nM/109 Tr and 0.749 0.142 nM/109 Tr, respectively). A significant increase in the content of serotonin in the platelet-rich plasma and in the platelets of the child in the period from 37 to 39 weeks, both during intrauterine development and in the first days of life, correlates with an increase in the representation of the orthodox phase in the sleep cycle. Conclusion: The general pattern of changes in serotonin content and cyclic sleep organization in the early neonatal period in healthy newborns, depending on gestational age, indicates the possibility of using the obtained standard values of serotonin as a biochemical marker of functional brain development.

The time of umbilical cord separation in healthy full-term newborns: a controlled clinical trial of different cord care practices

2003 ◽  
Vol 162 (5) ◽  
pp. 350-351 ◽  
Author(s):  
Andrea Guala ◽  
Guido Pastore ◽  
Vasco Garipoli ◽  
Mario Agosti ◽  
Marco Vitali ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Umbilical Cord ◽  
Full Term ◽  
Controlled Clinical Trial ◽  
Cord Care ◽  
Term Newborns ◽  
Care Practices

scholarly journals Head circumference and anterior fontanel measurements in newborns

2012 ◽  
Vol 52 (3) ◽  
pp. 145 ◽  
Author(s):  
Rizal Agus Tiansyah ◽  
Irawan Mangunatmadja ◽  
Aman Pulungan
Keyword(s):  
Gestational Age ◽  
Head Circumference ◽  
Full Term ◽  
Brain Growth ◽  
Anterior Fontanel ◽  
Term Infants ◽  
Head Growth ◽  
Term Newborns ◽  
Male Subjects ◽  
The Brain

Background Head growth and anterior fontanel (AP) closureare passive processes in response to brain growth. The growthof the brain and skull starts in the third week of intrauterinegestation. roth processes run simultaneously as a part of integralgrowth, along 'With increasing gestational age, until post􀀿birth.Measurement of head circumference (He) and AF in newbornsis done to determine if the brain and skull grew normally duringthe intrauterine period.Objectives To investigate the differences in He and AF sizebetween preterm and full􀀿term infants, and the relationshipbetween gestational age (GA) and birth weight (BW) to Heand AF size.Methods This was a descriptive analytic study on preterm andfull􀀿term newborns. Measurement of HC and AF was conductedin three phases: just after birth, 1x24 and 2x24 hours of age.Analysis of HC and AF size differences between preterm and fullterm subjects was performed, as well as analysis of the correlationbetween GA and BW to HC and AF size.Results Two hundred fifty newborns completed the study. Therewere 180 full􀀿term and 70 preterm subjects. Median HC in full􀀿term and preterm male subjects were 34 cm (range 31􀀿37 cm)and 31 cm (27􀀿34 cm), respectively. Median HC in full􀀿termand preterm female subjects were 33 cm (31􀀿36 cm) and 32 cm(27􀀿3S.S cm), respectively. Median AF in full􀀿term and pretermmale subjects were 2.17 cm (1.0SA.6 cm) and 2.22 cm (1.3SA.Scm), respectively, and in full􀀿term and preterm female subjectswere 2.02 cm (lA.1S cm) and 2.22 cm (0.7SA cm), respectively.The HC of preterms were significantly lower than the fullterms(P<O.OOl), however the AF size was not different between these2 groups of newborns (P =0 .28). Correlation test between GA andBW to HC size revealed a positive correlation (r=0.620, P<O.OO 1and r=0.801, P<O.OOl, respectively), but not to AF size (r=􀀿 0.06,p􀁀 0.279 and F- 0.049, P􀁀0.44, respectively).Concl usions We found that the HC size of pre terms wassignificantly lower than thefullterms, but no significant differences in AF size between the two groups. GA and BW were associatedwith HC size, but not associated to AF size. [paediatr lndones.2012;52:145-51].

scholarly journals INTRAUTERINE GROWTH AND THE VITAMIN E STATUS OF FULL-TERM AND PRETERM NEWBORNS

2019 ◽  
Vol 37 (3) ◽  
pp. 291-296 ◽  
Author(s):  
Alyne Batista da Silva ◽  
Jeane Franco Pires Medeiros ◽  
Mayara Santa Rosa Lima ◽  
Amanda Michelly Braga da Mata ◽  
Eva Débora de Oliveira Andrade ◽  
...  
Keyword(s):  
Vitamin E ◽  
Umbilical Cord ◽  
Gestational Age ◽  
Full Term ◽  
Alpha Tocopherol ◽  
Term Infants ◽  
Intrauterine Growth ◽  
Cord Serum ◽  
Low Levels ◽  
Gestational Age At Birth

ABSTRACT Objective: To determine the concentration of alpha-tocopherol in umbilical cord serum of full-term and preterm newborns, in order to assess the nutritional status of both groups in relation to the vitamin and its possible correlation with intrauterine growth. Methods: A cross-sectional observational study conducted with 140 newborns, of which 64 were preterm and 76 were full-term. They did not have any malformations, they came from healthy mothers, who were nonsmokers, and delivered a single baby. Intrauterine growth was evaluated by weight-to-gestational age at birth, using Intergrowth-21st. Thealpha-tocopherol levels of umbilical cord serum were analyzed by High Performance Liquid Chromatography. Results: The mean concentration of alpha-tocopherol in umbilical cord serum for preterm and full-term infants was 263.3±129.5 and 247.0±147.6 µg/dL (p=0.494). In the preterm group, 23% were small for gestational age, whereas in the full-term group, this percentage was only 7% (p=0.017). Low levels of vitamin E were found in 95.3% of preterm infants and 92.1% of full-term infants. There was no correlation between alpha-tocopherol levels and weight to gestational age Z score (p=0.951). Conclusions: No association was found between alpha-tocopherol levels and weight to gestational age at birth. Intrauterine growth restriction was more frequent in preterm infants and most infants had low levels of vitamin E at the time of delivery.

Complete blood count parameters for healthy, small-for-gestational-age, full-term newborns

2006 ◽  
Vol 28 (2) ◽  
pp. 97-104 ◽  
Author(s):  
E. OZYUREK ◽  
S. CETINTAS ◽  
T. CEYLAN ◽  
E. OGUS ◽  
A. HABERAL ◽  
...  
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Blood Count ◽  
Complete Blood Count ◽  
Full Term ◽  
Term Newborns

Umbilical cord serum lipids between early and late clamping in full-term newborns. A systematic assignment treatment group

2014 ◽  
Vol 28 (2) ◽  
pp. 186-189 ◽  
Author(s):  
Jesús Florido ◽  
Catalina de Paco-Matallana ◽  
M. Soledad Quezada ◽  
M. Carmen Garrido-Sánchez ◽  
Carmen Padilla ◽  
...  
Keyword(s):  
Treatment Group ◽  
Umbilical Cord ◽  
Serum Lipids ◽  
Full Term ◽  
Cord Serum ◽  
Term Newborns

Gestational Age and Thyroid Economy at Birth in Full-Term Newborns

1981 ◽  
Vol 13 (07) ◽  
pp. 412-413
Author(s):  
F. De Luca ◽  
M. Gemelli ◽  
T. Arrigo ◽  
R. Melluso ◽  
S. Benvenga ◽  
...  
Keyword(s):  
Gestational Age ◽  
Full Term ◽  
Term Newborns

scholarly journals Optimization of Hypoxic Brain Injuries Diagnostics in Full-Term Newborns

2021 ◽  
Vol 6 (2) ◽  
pp. 133-141
Author(s):  
M. S. Panova ◽  
A. S. Panchenko ◽  
V. A. Mudrov
Keyword(s):  
Cord Blood ◽  
Brain Damage ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Full Term ◽  
Damage Diagnosis ◽  
Hypoxic Brain Damage ◽  
Hypoxic Brain ◽  
Tnf Α ◽  
Term Newborns

The problem of early diagnosis of the central nervous system damage in newborn before the onset of clinical symptoms remains relevant at the present time.The aim of the study was to optimize the hypoxic brain damage diagnosis in full-term newborns by analyzing the concentration of cytokines in the umbilical cord blood.Materials and methods. During the first stage of the study, a prospective analysis of concentrations of interleukins (IL-1β, IL-4, IL-6, IL-8, IL-10), TNF-α and neuron-specific enolase (NSE) in the umbilical cord blood serum of full-term newborns was performed. The second stage of the study included the retrospective analysis of clinical data and instrumental research methods. The main method for diagnosing in the development of hypoxic brain damage in newborns was neurosonography.Results. The development of hypoxic brain damage is evidenced by the concentration of IL-1β over 30.3 pg/ml, IL-4 – over 1.7 pg/ml, IL-6 – over 79.4 pg/ml, IL-8 – over 107.7 pg/ml, NSE – more than 10.3 ng/ml and TNF-α – more than 1.6 pg/ml in umbilical cord blood.Conclusion. The results of the study confirmed that the comprehensive assessment of the cytokines concentration in the umbilical cord blood improves the hypoxic brain damage diagnosis in newborns. Analysis of the level of these markers immediately after the birth will optimize the management tactics of newborns who have undergone hypoxic exposure in antenatal and intranatal period. 

scholarly journals Hepcidin, Serum Iron, and Transferrin Saturation in Full-Term and Premature Infants during the First Month of Life: A State-of-the-Art Review of Existing Evidence in Humans

2020 ◽  
Vol 4 (8) ◽  
Author(s):  
James H Cross ◽  
Andrew M Prentice ◽  
Carla Cerami
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Serum Iron ◽  
Venous Blood ◽  
Transferrin Saturation ◽  
Full Term ◽  
Preterm Neonates ◽  
Postnatal Life ◽  
Reference Ranges ◽  
Blood Concentrations

ABSTRACT Neonates regulate iron at birth and in early postnatal life. We reviewed literature from PubMed and Ovid Medline containing data on umbilical cord and venous blood concentrations of hepcidin and iron, and transferrin saturation (TSAT), in human neonates from 0 to 1 mo of age. Data from 59 studies were used to create reference ranges for hepcidin, iron, and TSAT for full-term-birth (FTB) neonates over the first month of life. In FTB neonates, venous hepcidin increases 100% over the first month of life (to reach 61.1 ng/mL; 95% CI: 20.1, 102.0 ng/mL) compared with umbilical cord blood (29.7 ng/mL; 95% CI: 21.1, 38.3 ng/mL). Cord blood has a high concentration of serum iron (28.4 μmol/L; 95% CI: 26.0, 31.1 μmol/L) and levels of TSAT (51.7%; 95% CI: 46.5%, 56.9%). After a short-lived immediate postnatal hypoferremia, iron and TSAT rebounded to approximately half the levels in the cord by the end of the first month. There were insufficient data to formulate reference ranges for preterm neonates.

Building and Clinical Use of Activated Plasma Clotting Time Test and the Value of APCT on Predicting the Bleeding Due to Leukemia Chemotherapy-Induced Thrombocytopenia.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 3915-3915
Author(s):  
Bao-An Chen ◽  
Jin-Jin Li ◽  
Cheng-Yin Huang ◽  
Feng Gao ◽  
Jian Chen ◽  
...  
Keyword(s):  
Sodium Citrate ◽  
Platelet Rich Plasma ◽  
Venous Blood ◽  
Clinical Use ◽  
Clotting Time ◽  
Platelet Suspension ◽  
Platelet Poor Plasma ◽  
Platelet Counts ◽  
Significant Difference ◽  
Time Test

Abstract Objective This study was aimed to determine the optimal concertration of C-PG in activated plasma clotting time (APCT) test and build the APCT test.To investigate the value of activated plasma clotting time test (APCT) on predicting the bleeding due to Leukemia chemotherapy-induced thrombocytopenia. Method We collected healthy blood donors’venous blood, prepared watched platelet suspension and platelet rich plasma in a normal way to which we add different concertrations of C-PG, then test expression of AnnexinV in the surface of activated platelet by FCM. Prepared platelet rich plasma and platelet poor plasma in a normal way to which we add different concertrations of C-PG, then count the plasma clotting time.Forty-one patients with leukemia chemotherapy, twenty-one patients with petechiae or epistaxis or gum bleeding and twenty patients without bleeding symptoms, were involved in the test. Drawed their venous blood and collected in 3.2% buffered sodium citrate(9:1), the platelet counts and APCT, PT, APTT, TT, Fig were assesed. Result Bleeding group’s APCT was obviously prolonged contrast to the non-bleeding group’s. Platelet counts and APCT of the bleeding group and the non-bleeding group were (7.2±2.9) ×109/L, (105.9±8.1)s and (23.0±12.2) ×109/L,(71.4±9.0)s respectively. There was significant difference between the two groups (P&lt;0.01). Using APCT≥90s as the cut-off point to predict the bleeding caused by chemotherapy-induced thrombocytopenia, the sensibility was 100%, and the specificity was 95.7%. Using platelet counts ≤15*109/L, the sensibility and the specificity was 95.2% and 69.0%. PT, APTT, TT, Fig of the bleeding group and the non-bleeding group were 11.7±1.1)S,(31.5±1.3)S,(11.1±1.2)S,(2.37±0.41)g/L and (12.1±0.8)S,(30.8±2.1)S,(10.7±0.9)S,(2.64±0.27)g/L respectively. The results of the two groups were all not significantly different (P&gt;0.05). Conclusion APCT is a good indication of predicting the bleeding due to leukemia chemotherapy -induced thrombocytopenia.

Association between Magnesium, Calcium, Phosphorus, Copper, and Zinc in Umbilical Cord Plasma and Erythrocytes, and the Gestational Age and Growth Variables of Full-Term Newborns

1992 ◽  
Vol 38 (1) ◽  
pp. 141-143 ◽  
Author(s):  
Michelle Speich ◽  
Bernard Bousquet ◽  
Jean-Louis Auget ◽  
Simone Gelot ◽  
Olivier Laborde
Keyword(s):  
Umbilical Cord ◽  
Gestational Age ◽  
Stepwise Regression ◽  
Full Term ◽  
Age And Growth ◽  
Significant Variable ◽  
Regression Equations ◽  
Cord Plasma ◽  
Copper And Zinc ◽  
Calcium Phosphorus

Abstract We determined reference values in umbilical cord plasma and erythrocytes for magnesium, total calcium, phosphorus, copper, and zinc, and then calculated correlations and stepwise-regression equations in 66 white full-term newborn infants (35 boys, 31 girls). Only infants meeting certain optimal criteria and benefiting from excellent maternal conditions and uncomplicated pregnancies were included. There were no significant sex-related differences at birth among the variables studied. Gestational age was positively correlated with erythrocyte zinc (P less than 0.001), and plasma calcium was positively correlated with erythrocyte copper (P less than 0.001). Plasma copper proved to be the most significant variable in the stepwise-regression equation for birth height as the dependent variable. The most significant regressors accounting for birth weight were erythrocyte zinc followed by plasma zinc.

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