On the treatment of malignant skin neoplasms with X-rays

1927 ◽  
Vol 23 (9) ◽  
pp. 941-946
Author(s):  
M. I. Goldstein

Of the skin diseases amenable to the action of X-rays, malignant neoplasms deserve special attention. The powerful radiant energy of X-rays often brings a complete cure even in those severe, far advanced, non-operable cases where all other treatment methods are powerless. Some favorable reports of this kind date back to the beginning of the X-ray era, when the technique of irradiation was far from being perfect. Since then, the literature on the subject has grown considerably. Nevertheless, we still think it is worthwhile to share the results of our observations, because until very recently, there is far from being a unified, established view both on the biological effect of x-rays and on the method of their application.

1937 ◽  
Vol 33 (5) ◽  
pp. 642-644
Author(s):  
V. Dembskaya

The authors divided infectious diseases to be treated with X-rays into two groups, guided not by the etiological moment, but by their sensitivity and receptivity in relation to radiant energy. From this point of view, the first group included: early localized forms of erysipelas in adults, boils, granulomas, infected hemangiomas, a certain type of cellulitis and lymphangitis, Mikulich's disease, parotitis and rhinophyma. The second: carbuncles, blastomycosis and sporotrichosis.


1922 ◽  
Vol 35 (4) ◽  
pp. 475-485 ◽  
Author(s):  
Waro Nakahara ◽  
James B. Murphy

A study has been made of the biological effect of a small dose of soft x-rays given off by a special water-cooled tube with a window of thin glass, operated at ½ inch spark-gap and 11 milliamperes. Mice exposed for 1 minute show 2 days later in the blood an increase in the number of lymphocytes and in the lymphoid organs an increased number of mitotic figures. There occurs also a marked dilatation of the vessels of the suprarenals, particularly between the cortex and medulla. The latter condition did not appear until after 24 hours and was still present 14 days after the treatment. No change was detected in other organs. Mice treated in this way showed a high degree of resistance to cancer transplants. The amount of resistance varied with the time of the inoculation after the treatment. The resistance was not increased before 3 days after and was at its highest point 10 days after the treatment.


Bakerian Lectures dealing with astronomical topics have occurred roughly every ten years during this century. They have therefore something of the character of reports on progress and one need read no further back than Hoyle’s ‘Review of recent developments in cosmology’ (Hoyle 1968) and Ryle’s ‘The nature of the cosmic radio sources’ (Ryle 1958) to discover the background against which are to be seen the dramatic changes of the ensuing period. It stretches from the conception of X-ray astronomy through its birth, with the discovery of the first non-solar source (Giacconi et al . 1962), to its maturity with the availability of satellites to provide long exposures. Nor is it any accident that the root κóσμoς is prominent in the titles of recent lectures for while those of Jeans, Eddington, Milne and Blacket were concerned with our Galaxy, the drama is now truly cosmic. Cosmic X-ray astronomy grew out of the study of the Sun and for this reason its founding father is Herbert Friedman. Giacconi describes well the early history of the subject (Giacconi & Gursky 1974) and tells how, in June 1962, having been interested in the idea by Rossi in September 1959, he and his colleagues detected flux coming neither from the Sun nor from the Moon. Friedman had discussed as early as 1956 ‘how his group obtained puzzling results, which might have been due to celestial X-ray fluxes’, and reported this at the I. A. U. meeting in Moscow in 1958. Stimulated by our solar studies with the Skylark rocket, similar thinking was taking place under the auspices of this Society. Mention of this was made at a conference in the United States in June 1961 (Boyd 1962) but a meeting of the Astronomy Working Group of the British National Committee on Space Research (N. C. S. P./34, 1959 a ) had discussed, in May 1959, the possibility, of mounting ‘Directive X-ray counters’ on the proposed U. K. -I satellite. The minute read ‘Current theories suggested that there may be objects in the sky with strong X-ray emission although inconspicuous visually. A search for these is a matter of great interest and importance.’ It is noteworthy that Hoyle, who had discussed Friedman’s speculations with him, was present at the meeting.


1937 ◽  
Vol 33 (2) ◽  
pp. 246-247

Four patients with malignant neoplasms were treated with X-rays.


The efficiency of many elements as emitters of soft X-rays has been investigated by Richardson and Robertson and others, using a photoelectric method. The X-ray exciting voltages used ranged up to 6000 volts and several metals were used as photoelectric detectors. Some phenomena observed in large thermionic valves indicated a need for information about the photoelectric emission from tungsten and molybdenum in particular, under the action of X-rays from copper at rather higher exciting voltages than those previously studied, and for this investigation it was decided to follow the technique developed by Professor Richardson and Mr. Robertson to whom I am indebted for helpful discussion of the subject and guidance in the design of the apparatus. The present results, therefore, form a continuation of the earlier work and extend it in several directions, principally the following: (1) the voltage range goes up to 20,000 volts; (2) tungsten and molybdenum were used as photoelectric detectors for X-rays from copper; and (3) an absorption screen, included in our apparatus, gave some indication of the quality of the radiation most effective in producing the emission. The effect of heat treatment of the photoelectric plates was also investigated and showed that the photoelectric emission is sensitive to the surface condition, but whether heat treatment produces an increase or a decrease in the emission depends on the previous treatment of the metal.


1988 ◽  
Vol 123 ◽  
Author(s):  
J.S. Olin ◽  
D.W. Von Endt ◽  
Y.T. Cheng ◽  
M. Ligeza

Neutron-induced autoradiography is a further step in the development of techniques for the examination of paintings that complements x-ray radiography and often yields unique information that cannot be obtained by other means. After exposure to a field of thermal neutrons (<0.3eV), selected elements in the painting form radioactive nuclides that in turn decay at known half-lives with the emission of gamma rays and charged particles. The charged particles, mainly electrons, expose radiographic film that is held in close contact with the painting by a very slight vacuum. Unlike x-ray radiography, which involves detecting x-rays that have passed through the painting to expose a film, autoradiography uses one activation with neutrons followed by sequential film exposures to capture the images of activated elements that have different half-lives. The autoradiographs show the distribution patterns of the pigments in which the elements occur. These pigments may be on the surface and visible in the painting or they may be beneath the surface. Often autoradiography uncovers the preliminary sketch or underpainting preceding the rough blocking in of the subject and the subsequent paint layers that create the final image. X-rays reveal almost exclusively the presence of pigments containing heavy elements such as lead and barium; autoradiography identifies the presence of activated pigments and distinguishes the fine details of paint application as well as changes in composition.


2021 ◽  
pp. 219-222
Author(s):  
Rubina Rubina ◽  
Baig M.Q ◽  
Kumar Dev

Many years after the discovery of X-ray's and gamma rays. They have been used empirically in medicine, later on realized that this approach was dangerous mainly in radiotherapy and up to some extent in diagnostic radiology. Thus Means of measuring x-ray/γ-rays had to be found in terms of unit of x-rays quantity dened and accepted. The magnitude of the biological effect desirable in case therapy and undesirable in case of diagnosis. It depends upon how much radiation energy is absorbed by irradiated material. X-ray dosimetry is the measurement of energy absorbed in any material particularly in different tissues of the body.


That sterility follows prolonged exposure to X-rays appears to have first been shown in 1903 by Albers-Schonberg (1) who obtained this result by irradiating rabbits and guinea-pigs. About the same time, Frieben (8) reported atrophy of the testes as the result of exposure. In the following year the histological results of irradiation were the subject of a very careful investigation by Bergonié and Tribondeau (3) on the rat. These authors found that whereas complete degeneration of the germ cells is caused by prolonged exposure to X-rays, the Sertoli cells and the interstitial tissue are not damaged and may even show increased proliferation. These results were confirmed almost immediately by Villemin (23) who also agreed with Bergonié and Tribondeau in finding that resumption of spermatogenic activity may occur where the damage has been insufficient to destroy all the spermatogonia. Simmonds (21) later recorded that some tubules seem to show greater resistance to X-rays destruction. That interruption of the spermatogenic function follows exposure to X-rays was again shown in the rat by Wakelin, Barratt and Arnold (24) and by Regaud (18) on the cat. Therapeutic and accidental exposure of the human subject also seems to lead to similar results. Philipp (17) records two cases of therapeutic exposures to X-rays which resulted in sterility. Brown and Osgood (5) collected 18 cases of abnormality among X-ray workers, all who had done X-ray work for more than three years showing complete azoospermia.


It is now well established that from the point of view of the theory of X-ray reflection, the majority of crystals can be divided into those which are relatively perfect and those which are relatively imperfect or mosaic. The intensity of reflection of X-rays by the former has been much less extensively studied than by the latter and hitherto no really satisfactory agreement appears to have been found between the observed intensities of reflection from highly perfect crystals such as diamond and the results predicted by the theoretical treatment of the subject. It will be shown in what follows that this lack of agreement is very largely removed when the atomic scattering factor, f , which plays such an important part in the theory of reflection by mosaic crystals, is taken into account for perfect crystals.


Sign in / Sign up

Export Citation Format

Share Document