scholarly journals Clinic of infectious hemorrhagic diseases and fevers

2021 ◽  
Vol 43 (1) ◽  
pp. 92-93
Author(s):  
M. A. Zeitlenok
Keyword(s):  
Clinical Manifestations ◽  
Hemorrhagic Fevers ◽  
Laboratory Confirmation

Hemorrhagic fevers are found in various republics and regions of our country, and there is no doubt that the more doctors are aware of the clinical manifestations and methods of laboratory confirmation of this group of diseases, the more complete our ideas about the regions of their distribution will be. The literature on this issue is scattered and not always available to doctors in the periphery. That is why the publication of a monograph by E.A.

scholarly journals Clinical manifestations of hypothyroidism in residents of western region of Nepal: A case control study

2013 ◽  
Vol 2 (1) ◽  
pp. 62-65 ◽  
Author(s):  
B Paudel ◽  
K Paudel ◽  
TL Upadhaya
Keyword(s):  
Clinical Manifestations ◽  
College Teaching ◽  
Signs And Symptoms ◽  
Facial Oedema ◽  
Western Region ◽  
Medical Sciences ◽  
Medical College ◽  
Laboratory Confirmation ◽  
The Difference ◽  
Symptoms And Signs

Background: This study was designed for the evaluation of the difference in the common signs and symptoms of hypothyroidism in our population from already available literature. Methods: In this study we have compared the symptoms and signs of hypothyroid and euthyroid patients visiting to Gandaki Medical College Teaching Hospital (GMCTH) from April 2011 to October 2011. We compared the 18 common signs and symptoms of hypothyroidism in our patients and analyzed by SPSS software. Results: Of the 2483 patients visiting to the GMCTH, 665 patients were included in the study and were examined. After the laboratory investigations, 98 were identified as the cases of hypothyroidism, the rest were declared as euthyroid and selected as controls. Lethargy, cold intolerance, constipation and paresthesia were the commonest symptom while facial oedema and bradycardia were the most prevalent sign in our population. Conclusions: The most common signs and symptoms of hypothyroidism in the western region of Nepal (that is one of the iodine deficient areas in Nepal) were different from other studies. It seems that strong clinical suspicion on the basis of symptoms and signs elicited by physicians and laboratory confirmation are the only reliable methods for diagnosis of hypothyroidism. Nepal Journal of Medical Sciences | Volume 02 | Number 01 | Jan-Jun 2013 | Page 62-65 DOI: http://dx.doi.org/10.3126/njms.v2i1.7655

LABORATORY CONFIRMATION OF THE SPOTTED FEVER GROUP RICKETTSIOSES AMONG PATIENTS WITH TYPICAL AND ATYPICAL CLINICAL MANIFESTATIONS

2020 ◽  
Author(s):  
T.A. Chekanova ◽  
Keyword(s):  
New Species ◽  
Primary Infection ◽  
Spotted Fever ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Spotted Fever Group ◽  
Single Group ◽  
Laboratory Confirmation ◽  
Atypical Manifestations

In the group of patients with typical clinical signs of acute tick-borne rickettsioses, specific IgM and/or IgG with/without IgA were found in 75.6% cases. IgG were low avidity in most cases, which indicated the recent primary infection. More than 20% of sera have single group specific IgA. In patients with atypical manifestations highly avidity IgG were predominant, that along with the presence of IgM and/or IgA may indicate re-infection or infection by new species, which is different from previous pathogen of the tick-borne spotted group rickettsioses.

Hemorrhagic fevers of viral nature. State of the problem and directions for creating effective means of prevention and treatment

2020 ◽  
Vol 22 (3) ◽  
pp. 182-187
Author(s):  
A. V. Stepanov ◽  
A. L. Buzmakova ◽  
A. V. Potapova ◽  
M. A. Yudin ◽  
V. Ya. Apchel
Keyword(s):  
Effective Means ◽  
Clinical Manifestations ◽  
Cellular Level ◽  
Molecular Virology ◽  
Hemorrhagic Fevers ◽  
Prevention And Treatment ◽  
Causative Agents ◽  
Viral Nature ◽  
Information Materials ◽  
Available Information

Abstract. An attempt to summarize the data of available information materials on epidemiological aspects, the state and prospects of prevention and treatment of hemorrhagic fevers was. Hemorrhagic fevers of viral nature-zoonotic diseases caused by viruses containing ribonucleic acid are classified into 4 families: Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae. They are spread all over the world, and their pathogens are easily transmitted from person to person, thereby spreading quickly enough beyond the main focus of biological infection. That is why the causative agents of hemorrhagic fevers are regarded as highly contagious biological agents, and agents bioterrorism. Unfortunately, there are currently no effective means of specific prevention and treatment of these infections, and therapeutic measures are limited to the use of symptomatic means. In this regard, the search for substances with pronounced antiviral activity against pathogens of hemorrhagic fevers that can effectively protect against these infections, as well as prevent their occurrence and spread is one of the priority areas of research in modern Infectology, and with the involvement of modern achievements in the field of molecular Virology and genetic engineering. The data obtained in this regard allow a more in-depth understanding of the pathogenesis of hemorrhagic fevers, the mechanisms of interaction of the pathogen with the host at the cellular level, the mechanisms of intracellular replication of viruses, the formation of the hosts response to viral invasion and clinical manifestations of diseases.

News the treatment of vaginal microbiota in perimenopausal period

2017 ◽  
pp. 98-102
Author(s):  
Z.M. Dubossarska ◽  
Keyword(s):  
High Efficiency ◽  
Antihypertensive Drugs ◽  
Pathological Condition ◽  
Clinical Manifestations ◽  
Integrated Approach ◽  
Vaginal Microbiota ◽  
Lipid Lowering ◽  
Sexually Transmitted ◽  
Laboratory Confirmation ◽  
Degenerative Processes

The aim of the research: to evaluate the clinical efficacy and prevention of relapses of inflammatory and degenerative processes of the vagina in patients in perimenopausal period with the drug Femheal. Materials and methods. The study included 40 women aged from 49 to 56 years in perimenopausal period with clinical and laboratory confirmation of nonspecific vulvovaginitis and degenerative processes of the vagina: held pH meter before the appointment of therapy Femheal, 7 days and 3 months after the application Femheal. According to the severity of menopausal disorders to treatment included menopausal hormonal therapy, lipid-lowering and antihypertensive drugs. Results. The use of complex therapy with the use Femheal helps to restore the vaginal microbiota, which is accompanied by disappearance of clinical manifestations nonspecific vulvovaginal (feeling pain in the abdomen, in the genitals, itching, burning, swelling, discomfort and disperion), by normalization of pH. This therapy was effective in the prevention of recurrence, and with an integrated approach to reproductive aging - improving the quality of life. Conclusion. Practicing obstetrician-gynecologists, introducing the pathogenesis of chronic nonspecific vulvovaginal and related violations, especially in a situation when the pathological condition has completely pathognomonic clinical and laboratory evidence, should exclude bacterial vaginosis, sexually transmitted infections, timely identification of changes in the vaginal environment through pH test. Given the high efficiency Femheal in our study and documented in international publications relative to the positive evaluation reattain of action of the drug in the complex treatment of nonspecific vulvovaginitis and prevention of their recurrence, recommended his application for restoration of the vaginal biotope. Key words: nonspecific vulvovaginitis, perimenopausal period, Femheal.

scholarly journals The COVID-19 Pandemic: A View from New York City

Homeopathy ◽  
2020 ◽  
Vol 109 (03) ◽  
pp. 163-166
Author(s):  
Domenick J. Masiello
Keyword(s):  
United States ◽  
New York ◽  
New York City ◽  
Clinical Practice ◽  
York City ◽  
Clinical Manifestations ◽  
Signs And Symptoms ◽  
The United States ◽  
Short List ◽  
Laboratory Confirmation

AbstractThis article provides a view of homeopathic clinical practice in the New York City area in the first few months of 2020 as the coronavirus disease 2019 (COVID-19) pandemic began to evolve in the United States. Key symptoms used to generate a short list of potentially curative remedies are given, and the pandemic syndrome is viewed as appearing in stages or as having various clinical manifestations each with its own main remedy. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is briefly described, as are the preliminary presenting signs and symptoms of COVID-19 infection. Several clinical examples are given, some with positive laboratory confirmation.

scholarly journals DIAGNOSIS OF ANTIPHOSPHOLIPID SYNDROME IN PEOPLE WITH CLINICAL CRITERIA OF THE DISEASE. EXPERIENCE OF A SEPARATE OUTPATIENT CENTER

2019 ◽  
pp. 92-98
Author(s):  
T. V. Vavilova ◽  
L. A. Isaeva ◽  
K. Yu. Grinchenko ◽  
Ju. D. Bogatenkova ◽  
V. A. Sorokoumov
Keyword(s):  
Antiphospholipid Syndrome ◽  
Laboratory Tests ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Final Diagnosis ◽  
Diagnostic Process ◽  
Clinical Criteria ◽  
Laboratory Confirmation ◽  
Diagnostic Center ◽  
Open Question

Antiphospholipid syndrome (APS) is an immune-mediated violation of coagulation, the diagnosis of which requires mandatory laboratory confirmation. Since the clinical manifestations of APS are extremely diverse, various specialists are involved in the diagnostic process – neurology, cardiologists, surgeons, hematologists, endocrinologists, laboratory medicine specialists, etc. So far, it remains an open question what specialist exactly should make the final diagnosis and supervise patient with APS. The experience of a separate diagnostic center shows the distribution of prescriptions and their compliance with the international recommendations. This study also provides data on the frequency of prescribing laboratory tests to confirm APS, which is 1.2% of all coagulation tests. Among the patients with suspected APS on the basis of clinical signs, only 12.2% of the diagnosis was confirmed. Presents the dangers of obtaining false-positive results that should be taken into account when prescribing laboratory tests.

scholarly journals Pediatric multisystem inflammatory syndrome associated with a new coronavirus infection: unresolved issues

2021 ◽  
Vol 13 (1) ◽  
pp. 13-20
Author(s):  
Yu. V. Lobzin ◽  
A. A. Vilnits ◽  
M. M. Kostik ◽  
M. K. Bekhtereva ◽  
A. N. Uskov ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Number Of Children ◽  
Treatment Regimens ◽  
Almost Everywhere ◽  
Laboratory Confirmation ◽  
High Incidence ◽  
Life Threatening ◽  
Symptom Complex ◽  
Coronavirus Infection ◽  
Inflammatory Syndrome

Since March 2020, the first reports have appeared about the increasing, almost everywhere, number of children who have undergone a new coronovirus infection caused by SARS-Cov-2 with a symptom complex resembling the manifestations of Kawasaki disease. A special feature of the clinical manifestations of this syndrome, which is called “Pediatric multisystem inflammatory syndrome associated with COVID-19”, is the high incidence of life-threatening conditions caused by the sharp development of arterial hypotension against the background of cardiogenic or vasogenic shock.In St. Petersburg, since the end of November 2020, there has been a sharp surge in admissions of children to the ICU of various hospitals with the clinic of Pediatric multisystem inflammatory syndrome, who have laboratory confirmation of the transferred COVID-19.The purpose of this article is to attract the attention of doctors of various profiles, to combine efforts to study this pathology, to determine the criteria for verifying the diagnosis, optimal treatment regimens and dispensary monitoring of patients who have been ill.

Morphologic alteration in the muscles of patients with hypokalemic periodic paralysis or myopathy

1990 ◽  
Vol 48 (3) ◽  
pp. 222-223
Author(s):  
T. Shimizu ◽  
Y. Muranaka ◽  
I. Ohta ◽  
N. Honda
Keyword(s):  
Clinical Manifestations ◽  
Quadriceps Muscle ◽  
Honeycomb Structure ◽  
Periodic Paralysis ◽  
Ultrastructural Changes ◽  
Hypokalemic Periodic Paralysis ◽  
Electron Microscopic ◽  
Tubular Aggregates ◽  
Hypokalemic Myopathy ◽  
Transmission Electron

There have been many reports on ultrastructural alterations in muscles of hypokalemic periodic paralysis (hpp) and hypokalemic myopathy(hm). It is stressed in those reports that tubular structures such as tubular aggregates are usually to be found in hpp as a characteristic feature, but not in hm. We analyzed the histological differences between hpp and hm, comparing their clinical manifestations and morphologic changes in muscles. Materials analyzed were biopsied muscles from 18 patients which showed muscular symptoms due to hypokalemia. The muscle specimens were obtained by means of biopsy from quadriceps muscle and fixed with 2% glutaraldehyde (pH 7.4) and analyzed by ordinary method and modified Golgimethod. The ultrathin section were examined in JEOL 200CX transmission electron microscopy.Electron microscopic examinations disclosed dilated t-system and terminal cistern of sarcoplasmic reticulum (SR)(Fig 1), and an unique structure like “sixad” was occasionally observed in some specimens (Fig 2). Tubular aggregates (Fig 3) and honeycomb structure (Fig 4) were also common characteristic structures in all cases. These ultrastructural changes were common in both the hypokalemic periodic paralysis and the hypokalemic myopathy, regardless of the time of biopsy or the duration of hypokalemia suffered.

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