scholarly journals Pediatric multisystem inflammatory syndrome associated with a new coronavirus infection: unresolved issues

2021 ◽  
Vol 13 (1) ◽  
pp. 13-20
Author(s):  
Yu. V. Lobzin ◽  
A. A. Vilnits ◽  
M. M. Kostik ◽  
M. K. Bekhtereva ◽  
A. N. Uskov ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Number Of Children ◽  
Treatment Regimens ◽  
Almost Everywhere ◽  
Laboratory Confirmation ◽  
High Incidence ◽  
Life Threatening ◽  
Symptom Complex ◽  
Coronavirus Infection ◽  
Inflammatory Syndrome

Since March 2020, the first reports have appeared about the increasing, almost everywhere, number of children who have undergone a new coronovirus infection caused by SARS-Cov-2 with a symptom complex resembling the manifestations of Kawasaki disease. A special feature of the clinical manifestations of this syndrome, which is called “Pediatric multisystem inflammatory syndrome associated with COVID-19”, is the high incidence of life-threatening conditions caused by the sharp development of arterial hypotension against the background of cardiogenic or vasogenic shock.In St. Petersburg, since the end of November 2020, there has been a sharp surge in admissions of children to the ICU of various hospitals with the clinic of Pediatric multisystem inflammatory syndrome, who have laboratory confirmation of the transferred COVID-19.The purpose of this article is to attract the attention of doctors of various profiles, to combine efforts to study this pathology, to determine the criteria for verifying the diagnosis, optimal treatment regimens and dispensary monitoring of patients who have been ill.

scholarly journals Clinical Characteristics of Rheumatic Diseases and Children Multisystem Inflammatory Syndrome Associated With COVID-19

2021 ◽  
Vol 7 (11) ◽  
pp. 170-183
Keyword(s):  
Connective Tissue ◽  
Clinical Manifestations ◽  
Pathological Process ◽  
Favorable Effect ◽  
Systemic Diseases ◽  
Clinical Observations ◽  
Symptom Complex ◽  
Coronavirus Infection ◽  
Almost All ◽  
Inflammatory Syndrome

With a new coronavirus infection, almost all organism systems are involved in the pathological process, which leads to development during the disease or post-COVID period of both new diseases and complications of existing chronic diseases requiring treatment or rehabilitation. The remaining after the suffered disease symptom complex complaints and clinical manifestations can be disturbed without conducting therapy and rehabilitation over many months. Purpose of the study. Present on their own observations of the laws of the clinical picture and therapies of the treatment of children’s multisystem inflammatory syndrome and systemic diseases of the connective tissue associated with COVID-19. Research results. Presented in Kyrgyzstan series of own clinical observations of 31 patients with children’s multisystem inflammatory syndrome and 23 patients with systemic diseases of the connective tissue associated with COVID-19, and 29 — with exacerbation of the systemic diseases of the connective tissue due to the transferred coronavirus infection, demonstrates the etiological and pathogenic significance SARS COV2 in the emergence of a severe system of inflammatory response. Timely anti-inflammatory treatment of children’s multisystem inflammatory syndrome is crucial and must be adapted for each patient in order to achieve the most favorable effect. Patients of the systemic diseases of the connective tissue account for a risk group with regard to the disease COVID-19 and the unfavorable disease.

scholarly journals Clinical case of SARS-CoV-2-associated multisystem inflammatory syndrome

2021 ◽  
pp. 51-54
Author(s):  
Ye.Ye. Pohorila ◽  
Keyword(s):  
Clinical Course ◽  
Clinical Manifestations ◽  
Ethics Committee ◽  
Probable Case ◽  
General Weakness ◽  
Symptom Complex ◽  
Coronavirus Infection ◽  
Helsinki Declaration ◽  
Course Features ◽  
Inflammatory Syndrome

The clinical course, features of diagnostic examinations and difficulties in verification of the new nosology of multisystem inflammatory syndrome associated with SARS-CoV-2 in 15-year-old girls are described. The girl was taken to the Kyiv Regional Children's Hospital No. 2 with complaints of fever, intoxication syndrome, general weakness, dizziness, vertigo, lack of urine during the day. The child was examined by a consilium of doctors, examined in the laboratory and instrumentally, after a carefully collected epidemiological history revealed possible contact with a patient with coronavirus infection at the place of study and identified a probable case of multisystem inflammatory syndrome associated with SARS-CoV-2. According to the results of our own observations during the pandemic, this nosology was found in patients who relapsed into coronavirus infection in clinical or subclinical form and for the period of hospitalization had a clinical symptom complex of Kawasaki with similar symptoms. This disease is new today, has a variety of clinical manifestations and pathological features that are a problem for clinicians. After all, at present there are no unified protocols for the diagnosis and treatment of MIS-C (multisystem inflammatory syndrome) and each doctor relies on their own experience and previously described cases. This case of multisystem inflammatory syndrome will help practicing clinicians in the early stages to diagnose the disease and provide qualified care to patients. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of all participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the author. Key words: multisystem used for setting fire syndrome, 15-year-old girl, kawasaky-like symptoms, SARS-CoV-2, intravenous immunoprotein, acetophene, glucocorticosteroids.

Bowel Symptoms

2017 ◽  
Author(s):  
Kimberly Chow ◽  
Lauren Koranteng
Keyword(s):  
Bowel Obstruction ◽  
Clinical Manifestations ◽  
Advanced Practice ◽  
Comorbid Disease ◽  
Medication Treatment ◽  
Global Issues ◽  
Treatment Regimens ◽  
Bowel Symptoms ◽  
Life Threatening

Constipation, diarrhea, and bowel obstruction are three common and distressing symptoms in palliative care patients. These symptoms rarely occur without other clinical manifestations of disease, and their management must be considered in light of comorbid disease. Constipation, diarrhea, and bowel obstruction affect a person’s quality of life, eligibility for certain therapies, and may even be life-threatening. This chapter discusses the advanced practice registered nurse (APRN)’s role in the assessment, prevention, and management of these common bowel symptoms. as well as the global issues surrounding management. The causes and pharmacological treatment of these three bowel symptoms are discussed and detailed medication treatment regimens are presented in tabular form.

A Review of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19

2020 ◽  
Vol 24 (4) ◽  
Author(s):  
Alireza Ghodsi ◽  
Abdolreza Malek ◽  
Sara Ghahremani
Keyword(s):  
Clinical Presentation ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Organ Involvement ◽  
High Morbidity ◽  
Laboratory Findings ◽  
Persistent Fever ◽  
Number Of Children ◽  
Relevant Evidence ◽  
Inflammatory Syndrome

: The coronavirus disease 2019 (COVID-19) pandemic, with a high morbidity and mortality rate, has affected all age groups. COVID-19 infection in children usually has minimal symptoms, but the number of children with the inflammatory syndrome with clinical features similar to the Kawasaki disease has increased during the COVID-19 pandemic. Information about this emerging COVID-19 manifestation also called the multisystem inflammatory syndrome in children (MIS-C), is still incomplete. Patients typically present with persistent fever, followed by shock or multi-organ involvement. Laboratory findings and clinical presentation of this multi-organ involvement is part of the diagnostic criteria. Early treatment and multidisciplinary referral to pediatric specialists are essential. The prognosis of MIS-C is not yet fully understood. Although most children survive, several deaths have also been reported. Based on relevant evidence, this study aimed to review the pathophysiology, clinical manifestations, laboratory and imaging findings, diagnosis, treatment recommendations, and prognosis of MIS-C associated with COVID-19.

Features of mahagment of a patient with a new coronaviral infection in the observator on the basis of student’s dormitory

2020 ◽  
Vol 24 (2) ◽  
pp. 45-51
Author(s):  
Olga Yu. Kuznetsova ◽  
Alexandr V. Meltser ◽  
Anna V. Lubimova ◽  
Zhanna V. Pleshanova ◽  
Olga S. Zamyatina ◽  
...  
Keyword(s):  
Young Patients ◽  
Clinical Manifestations ◽  
Hypochromic Anemia ◽  
Lung Damage ◽  
Outpatient Basis ◽  
History Of ◽  
Complicated Course ◽  
Coronavirus Infection ◽  
Inflammatory Syndrome ◽  
Severe Weakness

The article is devoted to the peculiarities of clinical manifestations and the severity of a new coronary virus infection in a university student transferred to an observatory organized in a hotel-type hostel to prevent the spread of COVID-19 among students living in hostels. The data on the epidemiological history of the patient, the results of clinical observation and examination are provided. The tactics of managing a patient with a suspected of COVID-19 on an outpatient basis, symptoms that determine the indications for hospitalization, the results of examination and treatment in a hospital, and further observation at the observatory are considered. A new coronavirus infection can lead to a rapid deterioration in the condition of young patients, which does not correlate with indicators indicating lung damage on the 5th day of the disease. Persistent hyperthermia and severe weakness with anorexia can be indicators of the complicated course of the disease, including the development of hyperactive inflammatory syndrome. Hypochromic anemia can be another disease, which is an unfavorable background for the development of COVID-19. The course of the new coronavirus infection in young patients requires careful attention and further study.

NEW CORONAVIRUS INFECTION COVID-19: FEATURES OF THE COURSE IN CHILDREN IN THE RUSSIAN FEDERATION

2020 ◽  
Vol 99 (6) ◽  
pp. 57-62
Author(s):  
A.V. Gorelov ◽  
◽  
S.V. Nikolaeva ◽  
V.G. Akimkin ◽  
◽  
...  
Keyword(s):  
Russian Federation ◽  
Disease Onset ◽  
Clinical Manifestations ◽  
Final Diagnosis ◽  
Upper Respiratory Tract ◽  
Number Of Children ◽  
Coronavirus Infection ◽  
The Russian Federation ◽  
Upper Respiratory ◽  
Tract Infections

Objective of the research: to determine clinical and epidemiological features of the course of the new coronavirus infection (COVID-19) caused by SARS-CoV-2 in children in the Russian Federation (RF). Materials and methods: a retrospective analysis of all confirmed COVID-19 cases in children in the first half of 2020 in the Russian Federation was performed. Information about patients (age, sex, examination date, place of residence, disease severity final diagnosis, etc.) was taken from the database containing the Rospotrebnadzor report form № 970 «Information on cases of infectious diseases in persons with suspected new coronavirus infection» January – June 2020 across the Russian Federation. Research results were processed using the IBM SPSS Statistics 26 program. To assess the differences in nominal indicators (proportions), the Pearson χ2 test was used. The results were considered statistically significant at p<0,05. Results: in the RF, the total number of children infected with COVID-19 in the first half of 2020 amounted to 8,4% among all patients with this infection. Children of all ages get sick with COVID-19, and boys are slightly more likely than girls (52,2% versus 47,8%, p>0,05). In children, the maximum number of cases is registered in family foci – 75%. Upper respiratory tract infections were diagnosed in 72,1% of patients. The proportion of pneumonia was 1,8%, and 2/3 of children were over 3 years old (p<0,001). In almost 1/3 of patients, the infection course had no clinical manifestations. 18,2% of children at the disease onset had increased body temperature, while only 3,5% of children had hyperthermia above 390 C. Cough was registered in 50,8% of cases. Rhinitis/rhinopharyngitis developed only in every 4th child. Symptoms pathognomonic for COVID-19, such as loss of smell (anosmia) and taste (ageusia), were recorded only in 17% of cases. 41,3% of patients received treatment in a hospital, and among them children under 3 years of age predominated. Conclusion: in children in the RF, the new coronavirus infection COVID-19 is generally favorable.

TUBERCULOSIS UNDER CONDITIONS OF NOVEL CORONAVIRUS INFECTION

2021 ◽  
Vol 100 (2) ◽  
pp. 153-157
Author(s):  
A.A. Starshinova ◽  
◽  
A.M. Malkova ◽  
A.Ya. Starshinova ◽  
V.E. Karev ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Diagnostic Value ◽  
Skin Tests ◽  
High Incidence ◽  
Treatment Facilities ◽  
Coronavirus Infection ◽  
The One ◽  
Novel Coronavirus ◽  
Made In

Tuberculosis (TB) remains an important medical and social problem up to today. In recent years, great strides have been made in the fight against tuberculosis infection (TI) in reducing TB morbidity and mortality, especially in the Russian Federation. Emergence of new COVID-19 infection in the world has led to the need for long-term isolation of the population, on the one hand, and the need to resort to personal protective equipment, on the other. The spread of COVID-19 may have an impact on the increase in TB morbidity, despite the decrease in the incidence rate, which is related to objective difficulties in detecting TB and complexity of the structure of clinical manifestations of the disease against the background of coronavirus infection and severe complications after COVID-19. The use of immunosuppressive therapy in the treatment of COVID-19 may cause immunosuppression, which will affect the results of TI immunodiagnostics using skin tests. At the same time, IGRA tests can be useful in these conditions, since they are of great diagnostic value. Equally important is the reduction of patient visits to treatment facilities in the context of a pandemic or a high incidence of COVID-19.

scholarly journals Hereditary angioedema. Clinical guidelines. (D84.1)

2021 ◽  
Vol 18 (2) ◽  
pp. 77-114
Author(s):  
Elena A. Bliznetz ◽  
Ekaterina A. Viktorova ◽  
Elena A. Vishneva ◽  
Eliso M. Dzhobava ◽  
Natalya I. Il'ina ◽  
...  
Keyword(s):  
Hereditary Angioedema ◽  
Clinical Guidelines ◽  
Clinical Care ◽  
Clinical Manifestations ◽  
Acute Therapy ◽  
Treatment Regimens ◽  
Classification Of Diseases ◽  
International Statistical Classification ◽  
Life Threatening ◽  
And Gender

Hereditary angioedema is a rare, potentially life-threatening genetic disease that manifests with skin and mucous/submucosal swelling that occurs under the influence of bradykinin. The clinical guidelines for hereditary angioedema (code for the International Statistical Classification of Diseases and Related Health Problems D84.1) were developed in December 2020 by the Russian Association of Allergology and Clinical Immunology, Association of Medical Geneticists, National Association of Experts in the Field of Primary Immunodeficiencies, Union of Pediatricians of Russia. In December 2020, the project was approved at a meeting of the Scientific and Practical Council of the Ministry of Health of the Russian Federation (December 10, 2020 No. 743/12). The clinical guidelines are devoted to optimizing the clinical care of patients with hereditary angioedema. The topic is relevant owing to the under-diagnosis of hereditary angioedema and insufficient awareness of doctors of various specialties about this problem, as well as the difficulties in managing this category of patients. The clinical guidelines contain information about the epidemiology, etiology, classification, pathogenesis, and common clinical manifestations of hereditary angioedema. Thus, the paper described actual diagnostic approaches and differential diagnosis of hereditary angioedema and established its diagnostic criteria. Medical care algorithms to patients with hereditary angioedema at the prehospital and hospital stages are also described. The principles of pharmacotherapy, including long-term prophylaxis, short-term prophylaxis, and acute therapy, for hereditary angioedema are also presented. Treatment regimens are stratified according to patients age and gender. Non-drug measures for the prevention hereditary angioedema attacks are considered. Sections were also added in the edition of the new clinical guidelines of hereditary angioedema. Clinical guidelines for hereditary angioedema are intended for practicing doctors of all specialties, students and teachers of medical universities, residents, graduate students of medical universities.

scholarly journals Laboratory parameters of hemostasis in patients with COVID-19

2021 ◽  
Vol 20 (3) ◽  
pp. 147-155
Author(s):  
E. A. Seregina ◽  
E. M. Koltsova ◽  
F. I. Ataullakhanov ◽  
A. G. Rumyantsev
Keyword(s):  
Respiratory Failure ◽  
Clinical Outcomes ◽  
Laboratory Tests ◽  
Clinical Manifestations ◽  
New Developments ◽  
Laboratory Parameters ◽  
Common Disorder ◽  
Life Threatening ◽  
Coronavirus Infection ◽  
Severity Of The Disease

The new coronavirus infection (currently classified as COVID-19), first identified in December 2019 in Wuhan, China, has contributed to a significant increase in global mortality. Coagulopathy is a common disorder in COVID-19 patients, which develops in parallel with respiratory failure. Currently, COVID-19 continues to be a life-threatening disease and requires new developments and solutions to define preventive and curative strategies. Studies often report an abnormality in the balance of coagulation and fibrinolytic systems in COVID-19, but there is still no adequate set of laboratory tests that could provide a diagnosis of coagulopathy in COVID-19. This review analyzes current studies on the clinical manifestations of COVID-19 coagulopathy, and also analyzes the informativeness of laboratory hemostasis tests in relation to the severity of the disease and clinical outcomes.

scholarly journals Mucocutaneous Involvement in Behçet’s Disease: How Systemic Treatment Has Changed in the Last Decades and Future Perspectives

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Cinzia Rotondo ◽  
Giuseppe Lopalco ◽  
Florenzo Iannone ◽  
Antonio Vitale ◽  
Rosaria Talarico ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Clinical Manifestations ◽  
Unknown Etiology ◽  
Behcet's Disease ◽  
Current State ◽  
Life Threatening ◽  
Symptom Complex ◽  
Appropriate Therapy

Behçet’s disease (BD) is a multisystemic disorder of unknown etiology characterized by the “triple symptom complex” consisting of recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis. Recurrent mucocutaneous lesions are generally considered the hallmark of the disease, being the most common symptoms presenting at the onset of disease. Although the improvement of knowledge about the pathogenetic mechanism added important changes in the treatment management of BD clinical manifestations, thus avoiding the appearance of serious life-threatening complications which are disease related, the mucocutaneous lesions are still the most nagging clinical manifestations to be treated. In this work we reviewed the current state of knowledge regarding the therapeutic approaches for mucocutaneous lesions of BD mainly based on controlled studies to provide a rational framework for selecting the appropriate therapy for treating these troublesome features of the disease.

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