scholarly journals Industrial vibration and specific functions of the female body

2021 ◽  
Vol 43 (3) ◽  
pp. 93-93
Author(s):  
P. V. Manenkov
Keyword(s):  
Reproductive System ◽  
Female Body ◽  
Rapid Development ◽  
Female Reproductive System ◽  
Professional Work ◽  
Female Labor ◽  
Female Workers ◽  
Production Factors

The rapid development of industry in our country and the involvement of female labor in it urgently require the study of harmful production factors, their influence on the female reproductive system and measures to protect the health of female workers. The peer-reviewed monograph by prof. M. A. Petrova-Maslakova and I. I. Klimets on industrial vibration as a frequent factor encountered in the professional work of many women and its influence on the female reproductive system

RISK-ORIENTED MODEL OF PREVENTION WORKERS’ REPRODUCTIVE HEALTH DISORDERS USING DIGITAL TECHNOLOGIES

2021 ◽  
Author(s):  
M.A. Fesenko ◽  
◽  
P.A. Vuytsik ◽  
A.V. Miskevich
Keyword(s):  
Reproductive System ◽  
Digital Technologies ◽  
Occupational Risk ◽  
Machine Learning Algorithms ◽  
Expert Assessment ◽  
Female Workers ◽  
Production Factors ◽  
Health Disorders ◽  
Combined Impact

Abstract: The article touches the issue of creating programs for assessing occupational risk and predicting violations of the reproductive system of female workers when exposed to harmful production factors, using machine learning algorithms. As a result of long-term research, the production-related nature of a significant number of diseases of the reproductive system has been proven. Based on the data obtained, a formula for calculating the occupational risk of developing diseases of the reproductive system in female workers was proposed, which is based on expert assessment and takes into account the combined impact of working conditions and lifestyle.

Nematodes of the order Rhabditida from India. Description of Diplogasteroides uriceus sp. n. and Rhabditidoides papillatus sp. n. (Diplogastrina)

Nematology ◽  
2009 ◽  
Vol 11 (4) ◽  
pp. 541-550 ◽  
Author(s):  
Md Mahamood ◽  
Irfan Ahmad
Keyword(s):  
New Species ◽  
Reproductive System ◽  
Female Body ◽  
Female Reproductive System ◽  
Two New Species ◽  
Flexible Part

Abstract Two new species of diplogastrid nematodes from India are described and illustrated. Diplogasteroides uriceus sp. n. has a medium-sized body, monoprodelphic reproductive system lacking a post-uterine sac, anteriorly directed muscular vagina and vulva located far posterior; long, slender, arcuate spicules; gubernaculum with proximal thread-like flexible part and nine pairs of genital papillae of which four pairs are precloacal and five pairs postcloacal. The new species resembles D. crassus but can be most easily differentiated by the structure of the cheilorhabdions, shape and structure of the gubernaculum, arrangement of the genital papillae and the complete absence of a bursa. The new species also resembles D. proprius but can be differentiated by stoma structure, more anteriorly located vulva, longer spicules, gubernaculum shape and tail form. Rhabditidoides papillatus sp. n. is characterised by the presence of three pairs of post-deirids in the lateral fields, posteriorly curved tubular stoma, amphidelphic female reproductive system, strongly developed, arcuate spicules with bilobed capitulum and a slender gubernaculum provided with a sleeve distally and anteriorly directed bifid ends proximally. It can be distinguished from R. stigmatus by the structure of the spicule head, gubernaculum shape and arrangement of the genital papillae; from R. mastigurus by spicule structure and the gubernaculum shape; and from R. quercophilus by a more slender female body, stoma structure, absence of a male bursa, spicule form and arrangement of the genital papillae.

FEMALE ENDOCRINE CONTROL MECHANISMS DURING THE NEONATAL PERIOD

1972 ◽  
Vol 70 (2) ◽  
pp. 396-408 ◽  
Author(s):  
K.-D. Schulz ◽  
H. Haarmann ◽  
A. Harland
Keyword(s):  
Protein Synthesis ◽  
Reproductive System ◽  
Rna Synthesis ◽  
Neonatal Period ◽  
High Dose ◽  
Female Reproductive System ◽  
Endocrine Control ◽  
Hypothalamic Region ◽  
Rna And Protein Synthesis ◽  
Physiological Dose

ABSTRACT The present investigation deals with the oestrogen-sensitivity of the female reproductive system during the neonatal period. Newborn female guinea pigs were used as test animals. At different times after a single subcutaneous injection of a physiological dose of 0.1 μg or an unphysiologically high dose of 10 μg 17β-oestradiol/100 g body weight, the RNA- and protein-synthesis was examined in the hypothalamic region, pituitary, cerebral cortex, liver, adrenal gland, ovary and uterus. With a physiological dose an increase in organ weight, protein content, RNA-and protein-synthesis was found only in the uterus. These alterations turned out to be dose-dependent. In addition to the findings in the uterus an inhibition of the aminoacid incorporation rate occurred in the liver following the injection of the high oestradiol dose. As early as 1 hour after the administration of 0.1 μg 17β-oestradiol an almost 100% increase in uterine protein synthesis was detectable. This result demonstrates a high oestrogen-sensitivity of this organ during the neonatal period. All the other organs of the female reproductive system such as the hypothalamus, pituitary and ovary did not show any oestrogen response. Therefore the functional immaturity of the uterus during post partem life is not the result of a deficient hormone sensitivity but is correlated with the absence of a sufficient hormonal stimulus at this time. The investigation on the effects of actinomycin resulted in different reactions in the uterus and liver. In contrast to the liver a paradoxical actinomycin effect was found in the uterus after treatment with actinomycin alone. This effect is characterized by a small inhibition of RNA-synthesis and a 50% increase in protein synthesis. The treatment of the newborn test animals with actinomycin and 17β-oestradiol together abolished the oestrogen-induced stimulation of the uterine RNA-and protein-synthesis. Consequently, the effect of oestrogens during the neonatal period is also connected with the formation of new proteins via an increased DNA-directed RNA-synthesis.

Effect of Cryopreserved Placental Explants on Female Reproductive System Under Normal and Pathological Conditions (Experimental study)

2017 ◽  
Vol 27 (3) ◽  
pp. 250-265 ◽  
Author(s):  
Volodymyr Yu. Prokopyuk ◽  
◽  
Olga V. Grischenko ◽  
Oleksandra V. Prokopyuk ◽  
Nadiia O. Shevchenko ◽  
...  
Keyword(s):  
Experimental Study ◽  
Reproductive System ◽  
Female Reproductive System ◽  
Pathological Conditions

ROLE OF ULTRASOUND IN THE DETECTION OF RECURRENT OVARIAN CANCER

2020 ◽  
Vol 6 (1) ◽  
pp. 23-31
Author(s):  
M. Alisherova ◽  
◽  
M. Ismailova
Keyword(s):  
Ovarian Cancer ◽  
Surgical Treatment ◽  
Reproductive System ◽  
Malignant Tumors ◽  
Recurrent Ovarian Cancer ◽  
Primary Diagnosis ◽  
Female Reproductive System

Currently, there are no standard approaches to monitoring patients with ovarian cancer (OC). While the role of ultrasound (US) has been identified in the primary diagnosis of OS, it is still controversial during the subsequent surgical treatment of OC. In world statistics, ovarian cancer is consistently among the four main localizations of malignant tumors of the female reproductive system, along with tumors of the breast, body and cervix.

scholarly journals Species Comparison of the Role of p38 MAP Kinase in the Female Reproductive System

2009 ◽  
Vol 22 (2) ◽  
pp. 109-124 ◽  
Author(s):  
Zaher A. Radi ◽  
Rosemary A. Marusak ◽  
Dale L. Morris
Keyword(s):  
Map Kinase ◽  
Reproductive System ◽  
P38 Map Kinase ◽  
Female Reproductive System ◽  
Species Comparison

scholarly journals Generation of a Novel Mesothelin-Targeted Oncolytic Herpes Virus and Implemented Strategies for Manufacturing

2021 ◽  
Vol 22 (2) ◽  
pp. 477
Author(s):  
Guendalina Froechlich ◽  
Chiara Gentile ◽  
Luigia Infante ◽  
Carmen Caiazza ◽  
Pasqualina Pagano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Reproductive System ◽  
Tumor Cell Line ◽  
Breast Tumors ◽  
Oncolytic Viruses ◽  
Female Reproductive System ◽  
Viral Glycoprotein ◽  
Preclinical Development ◽  
Biological Drugs

Background: HER2-based retargeted viruses are in advanced phases of preclinical development of breast cancer models. Mesothelin (MSLN) is a cell-surface tumor antigen expressed in different subtypes of breast and non-breast cancer. Its recent identification as a marker of some triple-negative breast tumors renders it an attractive target, presently investigated in clinical trials employing antibody drug conjugates and CAR-T cells. The availability of MSLN-retargeted oncolytic viruses may complement the current immunotherapeutic panel of biological drugs against HER2-negative breast and non-breast tumors. Methods: A fully virulent, tumor-targeted oncolytic Herpes simplex virus-1 (MSLN-THV) with a selectivity for mesothelin-expressing cancer cells was generated. Recombineering technology was used to replace an essential moiety of the viral glycoprotein D with antibody fragments derived from clinically validated MSLN monoclonal antibodies, and to allow IL12 cargo expression in infected cells. Panels of breast and female reproductive system cell lines were used to verify the oncolytic potential of the viral constructs. A platform for production of the retargeted viruses was developed in HEK 293 cells, providing stable expression of a suitable chimeric receptor. Results: We demonstrated the selectivity of viral infection and cytotoxicity by MSLN-retargeted viruses in a panel of mesothelin-positive cancer cells, originating from breast and female reproductive system tumors. We also developed a second-generation oncolytic MSLN-THV, encoding IL12, to enhance the immunotherapeutic potential of the viral backbone. A non-tumor cell line expressing a chimeric MSLN/Nectin-1 receptor, de-sensitized from antiviral responses by genetic inactivation of the Stimulator of Interferon Genes (STING)-dependent pathway was engineered, to optimize viral yields. Conclusions: Our proof-of-concept study proposes MSLN-retargeted herpesviruses as potential cancer immunotherapeutics for assessments in preclinical models of MSLN-positive tumors, complementing the available panel of oncolytic viruses to HER2-negative breast tumors.

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