scholarly journals Beta-lactam antibiotics as a probable cause of acute respiratory distress syndrome

2012 ◽  
Vol 93 (3) ◽  
pp. 550-553
Author(s):  
I M Skipskiy ◽  
N V Efimov
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Fatal Outcome ◽  
Lower Lobe ◽  
Middle Lobe ◽  
Atypical Pneumonia ◽  
Beta Lactam ◽  
Beta Lactam Antibiotics

Described was a case of massive (right upper and middle lobe and basal segments of the left lower lobe) clinically atypical pneumonia, «rapidly» resolving during treatment with beta-lactam antibiotics, but complicated by acute respiratory distress syndrome, acute respiratory failure, infectious and toxic shock, cerebral and pulmonary edema that led to a lethal outcome. No macroscopic pathological signs of pneumonia were found, histologically in one of the sections of the lower lobe of right lung in the alveoli some serous-leukocyte exudate was found. The paradox of the situation (pneumonia almost resolved, but the patient died) became the reason to conduct a retrospective analysis, which showed that over the preceding 10 years, there were 27 cases of progressive pneumonia (3.1% of 873 cases of pneumonia), usually atypical during treatment with beta-lactam antibiotics, four of which, including the described one, had a fatal outcome caused by acute respiratory distress syndrome. The remaining patients in whom beta-lactam antibiotics were changed to macrolides, recovered. This suggests the ability of beta-lactam antibiotics to participate in the pathogenesis of acute respiratory distress syndrome, or even be its cause.

scholarly journals Vitamin D micronutrient and COVID-19: the missing link

2021 ◽  
Vol 8 (3) ◽  
pp. 474
Author(s):  
Sanjukta Mishra ◽  
Amaresh Mishra ◽  
Swarnalata Das
Keyword(s):  
Vitamin D ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Immune Cell ◽  
Wide Spectrum ◽  
Fatal Outcome ◽  
World Health ◽  
Primary Concern

The current onset and expeditious increase of COVID-19, caused by severe acute respiratory distress syndrome coronavirus (SARS-CoV-2), has established a global health predicament. Declared as pandemic and public health emergency by the World Health Organization (WHO), it follows an extremely heterogeneous course from mild flu like symptoms to severe acute respiratory distress syndrome. This outbreak intimidates the public with human to human escalation, which is the primary concern worldwide with a still unforeseeable result. With limited data on plausible therapy and vaccination, it is significant to unravel the virulence mechanism of SARS-CoV-2 to delineate chemoprevention that might curb the fatal outcome. It may be acknowledged here that the primary stage of disease prevention depends on the protective immune response to eliminate the virus. This postulation kindles interest in the intervention of vitamin D micronutrient, which might unfold the feasibility of slowing disease advancement and decreasing the risk of mortality. Taking into account, the wide spectrum of beneficial effects ascribed to vitamin D like antiviral, immunomodulatory, anti-inflammatory, and antioxidant action, it can be administered to affect immune cell proliferation and angiotensin-converting enzyme (ACE) 2 expression, which is the basis of pathogenesis of transmission of SARS-CoV-2. Recently, several observational clinical and epidemiological studies underline the hypothesis regarding mean vitamin D level and COVID-19 mortality. More so some retrospective analysis reported the correlation between vitamin D level and disease severity. Nevertheless, potential clinical researches and randomised control trials are recommended in COVID-19 patients with different levels of disease extremity to appraise the useful outcomes. 

scholarly journals Acute respiratory distress syndrome in a patient with tuberculosis

2020 ◽  
Vol 6 (8) ◽  
pp. FSO601
Author(s):  
Rabih Hallit ◽  
Souheil Hallit
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Rare Complication ◽  
Fatal Outcome ◽  
African American Patient ◽  
Tb Treatment ◽  
American Patient ◽  
Suspicion Index

Tuberculosis (TB) continues to be a major cause of death worldwide and can have varying manifestations. Acute respiratory distress syndrome (ARDS) is a rare complication of the clinical course of TB but carries a high mortality rate. We present a case of a diabetic African-American patient, with acute respiratory failure, rapidly progressing to ARDS secondary to TB, which had a fatal outcome. Clinicians should keep a high suspicion index for TB in the setting of ARDS since the use of empiric anti-TB treatment could potentially reduce mortality in these patients.

scholarly journals Clinical phenotypes from fatal cases of acute respiratory distress syndrome caused by pneumonia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kazuya Ichikado ◽  
Kodai Kawamura ◽  
Takeshi Johkoh ◽  
Kiminori Fujimoto ◽  
Ayumi Shintani ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Prognostic Factors ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Disseminated Intravascular Coagulation ◽  
Distress Syndrome ◽  
Fatal Outcome ◽  
Apache Ii ◽  
Apache Ii Score ◽  
Intravascular Coagulation

AbstractThere have been no report of objective clinical characteristics or prognostic factors that predict fatal outcome of acute respiratory distress syndrome (ARDS) since the Berlin definition was published. The aim of this study is to identify clinically available predictors that distinguish between two phenotypes of fatal ARDS due to pneumonia. In total, 104 cases of Japanese patients with pneumonia-induced ARDS were extracted from our prospectively collected database. Fatal cases were divided into early (< 7 days after diagnosis) and late (≥ 7 days) death groups, and clinical variables and prognostic factors were statistically evaluated. Of the 50 patients who died within 180 days, 18 (36%) and 32 (64%) were in the early (median 2 days, IQR [1, 5]) and late (median 16 days, IQR [13, 29]) death groups, respectively. According to multivariate regression analyses, the APACHE II score (HR 1.25, 95%CI 1.12–1.39, p < 0.001) and the disseminated intravascular coagulation score (HR 1.54, 95%CI 1.15–2.04, p = 0.003) were independent prognostic factors for early death. In contrast, late death was associated with high-resolution computed tomography (HRCT) score indicating early fibroproliferation (HR 1.28, 95%CI 1.13–1.42, p < 0.001) as well as the disseminated intravascular coagulation score (HR 1.24, 95%CI 1.01–1.52, p = 0.039). The extent of fibroproliferation on HRCT, and the APACHE II scores along with coagulation abnormalities, should be considered for use in predictive enrichment and personalized medicine for patients with ARDS due to pneumonia.

scholarly journals Whole-Blood Mitochondrial DNA Copies Are Associated With the Prognosis of Acute Respiratory Distress Syndrome After Sepsis

2021 ◽  
Vol 12 ◽  
Author(s):  
Tamara Hernández-Beeftink ◽  
Beatriz Guillen-Guio ◽  
Héctor Rodríguez-Pérez ◽  
Itahisa Marcelino-Rodríguez ◽  
Jose M. Lorenzo-Salazar ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Whole Blood ◽  
Distress Syndrome ◽  
Cox Regression ◽  
Fatal Outcome ◽  
Sepsis Diagnosis ◽  
The Individual

Acute respiratory distress syndrome (ARDS) is an inflammatory process of the lungs that develops primarily in response to pulmonary or systemic sepsis, resulting in a disproportionate death toll in intensive care units (ICUs). Given its role as a critical activator of the inflammatory and innate immune responses, previous studies have reported that an increase of circulating cell-free mitochondrial DNA (mtDNA) is a biomarker for fatal outcome in the ICU. Here we analyzed the association of whole-blood mtDNA (wb-mtDNA) copies with 28-day survival from sepsis and sepsis-associated ARDS. We analyzed mtDNA data from 687 peripheral whole-blood samples within 24 h of sepsis diagnosis from unrelated Spanish patients with sepsis (264 with ARDS) included in the GEN-SEP study. The wb-mtDNA copies were obtained from the array intensities of selected probes, with 100% identity with mtDNA and with the largest number of mismatches with the nuclear sequences, and normalized across the individual-probe intensities. We used Cox regression models for testing the association with 28-day survival. We observed that wb-mtDNA copies were significantly associated with 28-day survival in ARDS patients (hazard ratio = 3.65, 95% confidence interval = 1.39–9.59, p = 0.009) but not in non-ARDS patients. Our findings support that wb-mtDNA copies at sepsis diagnosis could be considered an early prognostic biomarker in sepsis-associated ARDS patients. Future studies will be needed to evaluate the mechanistic links of this observation with the pathogenesis of ARDS.

scholarly journals Acute respiratory distress syndrome and acute renal failure from Plasmodium ovale infection with fatal outcome

2013 ◽  
Vol 12 (1) ◽  
Author(s):  
Yee-Ling Lau ◽  
Wenn-Chyau Lee ◽  
Lian-Huat Tan ◽  
Adeeba Kamarulzaman ◽  
Sharifah Faridah Syed Omar ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Fatal Outcome ◽  
Plasmodium Ovale

COVID-19 – eine vaskuläre Systemerkrankung

2020 ◽  
Vol 49 (10) ◽  
pp. 418-421
Author(s):  
Christopher Werlein ◽  
Peter Braubach ◽  
Vincent Schmidt ◽  
Nicolas J. Dickgreber ◽  
Bruno Märkl ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome

ZUSAMMENFASSUNGDie aktuelle COVID-19-Pandemie verzeichnet mittlerweile über 18 Millionen Erkrankte und 680 000 Todesfälle weltweit. Für die hohe Variabilität sowohl der Schweregrade des klinischen Verlaufs als auch der Organmanifestationen fanden sich zunächst keine pathophysiologisch zufriedenstellenden Erklärungen. Bei schweren Krankheitsverläufen steht in der Regel eine pulmonale Symptomatik im Vordergrund, meist unter dem Bild eines „acute respiratory distress syndrome“ (ARDS). Darüber hinaus zeigen sich jedoch in unterschiedlicher Häufigkeit Organmanifestationen in Haut, Herz, Nieren, Gehirn und anderen viszeralen Organen, die v. a. durch eine Perfusionsstörung durch direkte oder indirekte Gefäßwandschädigung zu erklären sind. Daher wird COVID-19 als vaskuläre Multisystemerkrankung aufgefasst. Vor dem Hintergrund der multiplen Organmanifestationen sind klinisch-pathologische Obduktionen eine wichtige Grundlage der Entschlüsselung der Pathomechanismen von COVID-19 und auch ein Instrument zur Generierung und Hinterfragung innovativer Therapieansätze.

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