scholarly journals Mortality in COPD: Comparison of Different Predictors in Patients Seeking a Pulmonary Rehabilitation Program

2019 ◽  
Vol 21 (4) ◽  
pp. 390
Author(s):  
Thamyres Spositon da Silva ◽  
Antenor Rodrigues ◽  
Juliiana Fonseca Micheleti ◽  
Nidia Aparecida Hernandes ◽  
Fabio Pitta ◽  
...  
Keyword(s):  
High Risk ◽  
Prognostic Value ◽  
Research Council ◽  
Medical Research Council ◽  
Chronic Obstructive ◽  
Walk Test ◽  
Obstructive Pulmonary Disease ◽  
Risk Of Death ◽  
Bode Index ◽  
Indice Bode

Resumo É clinicamente relevante identificar fatores preditores de mortalidade isolados ou multidimensionais em pacientes com Doença Pulmonar Obstrutiva Crônica (DPOC). O objetivo desse esuto foi comparar diferentes fatores na identificação de pacientes classificados em alto risco de morte e identificar o valor prognóstico de fatores isolados frente ao índice BODE. Foram avaliados pacientes quanto a fatores associado a mortalidade: função pulmonar com a medida do volume expiratório forçado (VEF1); índice de massa corpórea (IMC); índice de massa magra corporal (IMMC); Incremental Shuttle Walk Test (ISWT) com a estimativa do consumo máximo de oxigênio (VO2máx); teste de caminhada de seis minutos (TC6min); escala Medical Research Council; índice BODE e tempo sedentário. Pontos de corte previamente associados com mortalidade foram utilizados para calcular a proporção de pacientes em alto risco. Análise de curva ROC foi utilizada para testar o valor prognóstico das variáveis isoladas frente ao BODE. Foram incluídos 162 pacientes (86 homens, idade 67±8 anos). As proporções de pacientes classificados em alto risco variaram de 12,6% até 76,5% de acordo com os oito fatores analisados (P<0,05 vs todos). A área sob a curva (AUC) desses fatores testados isoladamente frente ao índice BODE indicou insatisfatória capacidade discriminativa (0,26 < AUC < 0,44). Existe uma variabilidade expressiva na proporção dos pacientes classificados como “alto risco” de acordo com cada fator preditor de mortalidade. Além disso, a avaliação prognóstica do paciente obtida com o índice BODE não pode ser substituída pela avaliação de um único fator preditor. Palavras-chave: Doença Pulmonar Obstrutiva Crônica. Mortalidade. Exercício. AbstractIt is clinically relevant to identify isolated factors or multidimensional predictors of mortality in patients with Chronic Obstructive Pulmonary Disease (COPD). To compare different factors in the identification of patients classified as high risk of death and to identify the prognostic value of isolated factors against the BODE index. Patients were evaluated considering the factors associated with mortality: pulmonary function with forced expiratory volume (FEV1); body mass index (BMI); body mass index (LMWI); Incremental Shuttle Walk Test (ISWT) with estimation of maximal oxygen consumption (VO2max); six-minute walk test (6MWT); Medical Research Council scale; BODE index and sedentary time. Cut-off points previously associated with risk of death were used to calculate the proportion of patients at high risk of death. ROC curve analysis was used to test the prognostic value of each variable against the BODE index. A total of 162 patients (86 men, age 67 ± 8 years) were included. The proportions of patients classified as high risk ranged from 12.6 to 76.5% according to all eight factors analyzed (P <0.05 vs all). The area under the curve (AUC) of each factor analyzed against the BODE index indicated insufficient discriminative capacity (0.26 < AUC < 0.44). Conclusion: There is an expressive variability of patients classified as "high risk" according to each predictor factor. Moreover, the prognostic evaluation of the patient using the BODE index cannot be replaced by the assessment of a single predictive factor. Keywords: Chronic Obstructive Pulmonary Disease, Mortality, Exercise.

scholarly journals Chronic obstructive pulmonary disease Assessment Test na avaliação de pacientes com doença pulmonar obstrutiva crônica em reabilitação pulmonar: há relação com nível de dispneia nas atividades de vida diária e com índice preditor de mortalidade? Estudo transversal

2013 ◽  
Vol 20 (4) ◽  
pp. 379-386
Author(s):  
Júlia Gianjoppe-Santos ◽  
Samantha Maria Nyssen ◽  
Bruna Varanda Pessoa ◽  
Renata Pedrolongo Basso-Vanelli ◽  
Mauricio Jamami ◽  
...  
Keyword(s):  
Daily Living ◽  
Research Council ◽  
Medical Research Council ◽  
Airflow Obstruction ◽  
Disease Assessment ◽  
Chronic Obstructive ◽  
Activity Of Daily Living ◽  
Obstructive Pulmonary Disease ◽  
Copd Assessment Test ◽  
Indice Bode

O objetivo do estudo foi investigar se há relação entre o impacto da Doença Pulmonar Obstrutiva Crônica (DPOC) no estado de saúde com o nível de dispneia nas atividades de vida diária (AVD) e o índice preditor de mortalidade em pacientes em reabilitação pulmonar (RP). Trata-se de um estudo transversal, em que foram avaliados 32 pacientes com DPOC moderada a muito grave (23 homens; 66,6±12,0 anos; VEF1: 40,6±15,6% previsto) por meio do COPD Assessment Test (CAT), Índice de Massa Corpórea (IMC), Teste de Caminhada de Seis Minutos (TC6), London Chest Activity of Daily Living Scale (LCADL), modified Medical Research Council (mMRC) e Índice BODE (Body mass index, airflow Obstruction, Dyspnea and Exercise capacity). Observaram-se correlações positivas moderadas do CAT com o questionário mMRC (r=0,35; p=0,048), a pontuação total da LCADL (r=0,60; p<0,001) e com a porcentagem da pontuação total da LCADL (r=0,57; p=0,001). Apenas a pontuação total da LCADL é capaz de predizer independentemente a pontuação do questionário CAT (p<0,05; r²=0,61). Não foram constatadas correlações significativas entre o CAT e o Índice BODE, IMC, TC6 e VEF1. Dessa forma, quanto maior o nível de dispneia nas AVD, maior o impacto da DPOC no estado de saúde do paciente, entretanto, o mesmo não ocorre em relação ao prognóstico de mortalidade nos pacientes com DPOC em RP.

scholarly journals Hubungan Antara Hitung Jenis Leukosit dengan Derajat Penyakit Paru Obstruktif Kronik Berdasarkan Gejala Klinis dan Gold 2019 pada Pasien Penyakit Paru Obstruktif Kronik Stabil di Rumah Sakit Islam Jakarta Sukapura

2020 ◽  
Vol 1 (1) ◽  
pp. 1
Author(s):  
Nayla Sa’adah Alawiyah ◽  
Muhammad Fachri
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Medical Research ◽  
Pulmonary Disease ◽  
Research Council ◽  
Medical Research Council ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Global Initiative

Latar belakang: Penyakit Paru Obstruktif Kronik (PPOK) merupakan penyakit tidak menular yang menjadi salah satu masalah kesehatan di Indonesia diperkirakan terdapat 4,8 juta orang dengan prevalensi 56%. Tujuan: tujuan penelitian ini untuk mengetahui hubungan antara hitung jenis leukosit dengan derajat PPOK berdasarkan gejala klinis dan PPOK GOLD 2019 pada pasien PPOK stabil di Rumah Sakit Islam Jakarta Sukapura periode September 2018 – September 2019. Metode: studi ini merupakan penelitian kuantitatif dengan metode deskriptif analitik. Desain penelitian yang digunakan yaitu cross sectional. Teknik pengambilan sampel dalam penelitian ini yaitu teknik total sampling. Jumlah pasien PPOK stabil yang diteliti sebanyak 35 pasien. Penilaian gejala pada pasien PPOK menurut Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) 2019 dapat menggunakan kuesioner yang sudah divalidasi yaitu COPD Assesment Test/CAT dan Modified Medical Research Council/MMRC. Hasil: Hasil pemeriksaan hitung jenis leukosit terbanyak memiliki nilai eosinofil normal, nilai basofil normal, nilai neutrofil meningkat, nilai monosit normal, dan nilai limfosit normal. Kesimpulan: hasil penelitian menunjukkan kecenderungan peningkatan nilai leukosit pada setiap derajat PPOK, namun secara statistik tidak terdapat hubungan yang signifikan antara hitung jenis leukosit dengan derajat PPOK berdasarkan gejala klinis dan GOLD 2019 pada pasien PPOK stabil di RSIJ Sukapura.

scholarly journals Confirmatory Evaluation of the Modified Medical Research Council Questionnaire for Assessment of Dyspnea in Patients with Chronic Obstructive Pulmonary Disease in Portugal

2021 ◽  
Vol 34 (13) ◽  
Author(s):  
Soraia Ribeiro ◽  
Carlos Seiça Cardoso ◽  
Margarida Valério ◽  
João Machado ◽  
José Costa ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Medical Research ◽  
Pulmonary Disease ◽  
Research Council ◽  
Medical Research Council ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Language Version ◽  
British Medical Research Council ◽  
Kappa Agreement

Introduction: The Modified British Medical Research Council Questionnaire is considered an adequate and simple measure of breathlessness in chronic obstructive pulmonary disease. It is widely used in clinical practice in Portugal, but it still lacks confirmatory evaluation for the Portuguese setting. The aim of this study was to perform a cultural adaptation and validation of the Modified British Medical Research Council Questionnaire so that its most suitable version can be made available to researchers and clinicians in Portugal.Material and Methods: We performed a cross-sectional descriptive study involving patients with chronic obstructive pulmonary disease aged 40 years or older. We applied the Modified British Medical Research Council Questionnaire and the previously validated Portuguese-language version of the clinical questionnaire for chronic obstructive pulmonary disease between January and June 2019. We determined the agreement between the two questionnaires with kappa agreement, with a 95% confidence interval, and we used Spearman correlation to find a correlation between two scores.Results: The study included 65 patients managed in a hospital pulmonology clinic (aged 68 ± 7 years; with predicted FEV1 of 49.86% ± 16.5%). The Modified British Medical Research Council scale correlated significantly with all the domains and the overall score of the clinical questionnaire for chronic obstructive pulmonary disease (0.46 < r < 0.68; p < 0.001). In bilingual patients, interclass correlation coefficient was 0.912 (p < 0.001).Discussion: Our study showed that the Portuguese-language version of the Modified British Medical Research Council Questionnaire is feasible and externally valid when compared with a traditional and previously validated instrument.Conclusion: The Portuguese version of the Modified British Medical Research Council Questionnaire is a valid instrument for measurement of breathlessness in chronic obstructive pulmonary disease.

scholarly journals The responsiveness of the Manchester Chronic Obstructive Pulmonary Disease Fatigue Scale to pulmonary rehabilitation

2019 ◽  
Vol 10 ◽  
pp. 204062231988220 ◽  
Author(s):  
Abebaw Mengistu Yohannes ◽  
Sheila Dryden ◽  
Nicola Alexander Hanania
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Pulmonary Rehabilitation ◽  
Medical Research Council ◽  
Chronic Obstructive ◽  
Walk Test ◽  
Obstructive Pulmonary Disease ◽  
St George's Respiratory Questionnaire ◽  
The Mean

Background: We examined the responsiveness of the Manchester Chronic Obstructive Pulmonary Disease (COPD) Fatigue Scale (MCFS) in patients with COPD following 8 weeks of pulmonary rehabilitation (PR). Methods: Patients ( n = 273) with clinically stable COPD completed 8 weeks of outpatient multidisciplinary PR, comprising 2 h (1 h exercise and 1 h education) weekly. Anxiety, exercise capacity, quality of life, dyspnea, fatigue were measured pre- and post-PR, utilizing the Anxiety Inventory for Respiratory Disease (AIR), Incremental Shuttle Walk Test (ISWT), St. George’s Respiratory Questionnaire (SGRQ), and modified Medical Research Council (mMRC) scale and MCFS, respectively. Results: The mean (SD) age of participants was 72 (8) years, and 50% were women. Total MCFS score fell after PR mean (95% confidence interval) −4.89 (–7.90 to −3.79) as did domain scores: physical −1.89 (–2.33 to −1.46), cognition −1.37 (–1.65 to −1.09), and psychosocial −1.62 (–2.00 to −1.62). Total MCFS effect size (ES) was 0.55; and for domains, physical was 0.52, cognition was 0.59, and psychosocial was 0.51. The ES for AIR was 0.30, mMRC was 0.38, SGRQ was 0.66, and ISWT was 1.19. MCFS changes correlated with changes in both SGRQ ( p < 0.002) and AIR ( p < 0.004), but not ISWT ( p = 0.30) or mMRC ( p = 0.18). The AIR, SGRQ, mMRC, and ISWT all improved after PR (all, p < 0.001). Conclusion: The MCFS scale is a valid and responsive scale to measure fatigue in patients with COPD after pulmonary rehabilitation.

scholarly journals Gender Differences in Chronic Obstructive Pulmonary Disease Using the Lung Information Needs Questionnaire

2019 ◽  
Vol 5 ◽  
pp. 237796081983146
Author(s):  
Ritsuko Wakabayashi ◽  
Takashi Motegi ◽  
Kozui Kida
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Gender Differences ◽  
Mental State ◽  
Information Needs ◽  
Research Council ◽  
Mini Mental State Examination ◽  
Medical Research Council ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
State Examination

Aim: To investigate gender-related information needs in patients with chronic obstructive pulmonary disease (COPD) using the Lung Information Needs Questionnaire (LINQ). Design: Cross-sectional, prospective cohort study. Methods: Patients with COPD receiving standardized self-management education including information regarding disease knowledge, medications, avoidance of exacerbation, smoking cessation, exercise, and nutrition were included. Gender differences were assessed by pulmonary function tests, 6-minute walking test, modified Medical Research Council dyspnea scale, Mini-Mental State Examination, St. George's Respiratory Questionnaire, and LINQ. Results: A total of 122 patients were enrolled. Females displayed significantly higher information needs for total LINQ score ( p < .001), avoidance of exacerbation ( p < .03), and nutrition ( p < .006). Significant correlations were seen between total LINQ score and gender ( p = .001), forced expiratory volume in 1 second, % predicted ( p = .003), and Mini-Mental State Examination ( p = .002) for male patients. In females, modified Medical Research Council dyspnea scale was correlated with the total LINQ score ( p = .04).

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