scholarly journals Chromoblastomycosis Caused by Fonsecaea monophora

2014 ◽  
Vol 19 (1) ◽  
pp. 18-24 ◽  
Author(s):  
김병수 ◽  
서무규 ◽  
송승현 ◽  
신동훈 ◽  
최종수 ◽  
...  
Keyword(s):  
Fonsecaea Monophora

scholarly journals The superficial structure of neurofibroma was cleared in Fonsecaea monophora infected skin area

2018 ◽  
Vol 73 ◽  
pp. 67-68
Author(s):  
Jing-Yao Liang ◽  
Jian-Qin Wang ◽  
Xin Tian ◽  
Jian-Bo Ruan ◽  
Xi-Bao Zhang ◽  
...  
Keyword(s):  
Skin Area ◽  
Fonsecaea Monophora ◽  
Infected Skin

Melanin in a Meristematic Mutant of Fonsecaea monophora Inhibits the Production of Nitric Oxide and Th1 Cytokines of Murine Macrophages

2012 ◽  
Vol 175 (5-6) ◽  
pp. 515-522 ◽  
Author(s):  
Junmin Zhang ◽  
Li Wang ◽  
Liyan Xi ◽  
Huaiqiu Huang ◽  
Yongxuan Hu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Murine Macrophages ◽  
Fonsecaea Monophora ◽  
Th1 Cytokines

scholarly journals Murine Model of a Disseminated Infection by the Novel Fungus Fonsecaea monophora and Successful Treatment with Posaconazole

2009 ◽  
Vol 54 (2) ◽  
pp. 919-923 ◽  
Author(s):  
Enrique Calvo ◽  
F. Javier Pastor ◽  
M. Mar Rodríguez ◽  
Emilio Mayayo ◽  
Valentina Salas ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Dose Escalation ◽  
Murine Model ◽  
Antifungal Drugs ◽  
The Novel ◽  
Clinical Role ◽  
Disseminated Infection ◽  
Fonsecaea Monophora ◽  
Fungal Load ◽  
The Relationship

ABSTRACT We have evaluated the efficacy of posaconazole, amphotericin B, and itraconazole in a murine model of disseminated infection by Fonsecaea monophora. Of these three antifungal drugs tested, posaconazole prolonged survival significantly and reduced the fungal load in most of the organs tested. Bioassay studies demonstrated the relationship between posaconazole levels and dose escalation in serum and brain tissue. Posaconazole may have a clinical role in the treatment of disseminated infections by F. monophora.

scholarly journals Agrobacterium tumefaciens-Mediated Transformation of Fonsecaea monophora and Fonsecaea erecta for Host-Environment Interaction Studies

2020 ◽  
Vol 6 (4) ◽  
pp. 325
Author(s):  
Cristina Isabel Ferrer Villena ◽  
Renata Rodrigues Gomes ◽  
Larissa Fernandes ◽  
Camille Silva Florencio ◽  
Amanda Bombassaro ◽  
...  
Keyword(s):  
Environment Interaction ◽  
Bactris Gasipaes ◽  
Invasive Potential ◽  
Brain Infection ◽  
Fonsecaea Monophora ◽  
Confocal Fluorescence ◽  
Causative Agents ◽  
Potential Link ◽  
Foreign Dna ◽  
Etiological Agents

The fungal genus Fonsecaea contains etiological agents of human chromoblastomycosis, a (sub)tropical, (sub)cutaneous implantation disease caused by plant contact. The invasive potential differs significantly between species. Infections by Fonsecaea monophora are believed to originate from the environment and the species has been reported as one of the main causative agents of the disease, but also of cases of primary brain infection. The epidemiology of the disease has not been fully elucidated and questions related to its infection route and virulence are still to be clarified. The environmental species Fonsecaea erecta was isolated from organic material and living plants in endemic areas for chromoblastomycosis in Brazil. The present paper describes Agrobacteriumtumefaciens-mediated transformation (AMT) of the environmental species F. erecta and the pathogenic species F. monophora. We propose the use of Agrobacterium transformation for future gene function studies related to Fonsecaea virulence and pathogenicity. We evaluated the co-cultivation ratios 1:1, 10:1 and 100:1 (Agrobacterium:conidia) at 28 °C during 72 h. pAD1625 and pCAMDsRed plasmids were inserted into both species. Confirmation of transformation was realized by hph gene amplification and Southern blot determined the amount of foreign DNA integrated into the genome. In order to evaluate a potential link between environmental and clinical strains, we obtained red fluorescent transformants after pCAMDsRed insertion. We observed by confocal fluorescence microscopy that both F. monophora and F. erecta were able to colonize the palm Bactris gasipaes, penetrating the epidermis. These results contribute to understanding the ability of Fonsecaea species to adapt to different environmental and host conditions.

A Case of Relapsed Chromoblastomycosis Due to Fonsecaea monophora: Antifungal Susceptibility and Phylogenetic Analysis

2013 ◽  
Vol 176 (1-2) ◽  
pp. 139-144 ◽  
Author(s):  
Tatiane Caroline Daboit ◽  
Cibele Massotti Magagnin ◽  
Daiane Heidrich ◽  
Mauricio Ramírez Castrillón ◽  
Sandra Denise Camargo Mendes ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Antifungal Susceptibility ◽  
Fonsecaea Monophora

scholarly journals In Vitro Activities of Eight Antifungal Drugs against 55 Clinical Isolates of Fonsecaea spp.

2010 ◽  
Vol 54 (4) ◽  
pp. 1636-1638 ◽  
Author(s):  
Mohammad J. Najafzadeh ◽  
Hamid Badali ◽  
Maria Teresa Illnait-Zaragozi ◽  
G. Sybren De Hoog ◽  
Jacques F. Meis
Keyword(s):  
Amphotericin B ◽  
Antifungal Drugs ◽  
Clinical Isolates ◽  
Fonsecaea Pedrosoi ◽  
Fonsecaea Monophora

ABSTRACT The in vitro activities of eight antifungal drugs against clinical isolates of Fonsecaea pedrosoi (n = 21), Fonsecaea monophora (n = 25), and Fonsecaea nubica (n = 9) were tested. The resulting MIC90s for all strains (n = 55) were as follows, in increasing order: posaconazole, 0.063 μg/ml; itraconazole, 0.125 μg/ml; isavuconazole, 0.25 μg/ml; voriconazole, 0.5 μg/ml; amphotericin B, 2 μg/ml; caspofungin, 2 μg/ml; anidulafungin, 2 μg/ml; and fluconazole, 32 μg/ml.

scholarly journals A refractory case of chromoblastomycosis due to Fonsecaea monophora with improvement by photodynamic therapy

2012 ◽  
Vol 50 (6) ◽  
pp. 649-653 ◽  
Author(s):  
Yabo Yang ◽  
Yongxuan Hu ◽  
Junmin Zhang ◽  
Xiqing Li ◽  
Changming Lu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fonsecaea Monophora ◽  
Refractory Case

Chromoblastomycosis Due to Fonsecaea monophora in a Man with Nephritic Syndrome

2015 ◽  
Vol 179 (5-6) ◽  
pp. 447-452 ◽  
Author(s):  
Huan Tan ◽  
Yan Xu ◽  
Xue-mei Lan ◽  
Ya-guang Wu ◽  
Cun-jian Zhou ◽  
...  
Keyword(s):  
Fonsecaea Monophora ◽  
Nephritic Syndrome

Increased virulence of albino mutant of Fonsecaea monophora in Galleria mellonella

2019 ◽  
Vol 57 (8) ◽  
pp. 1018-1023 ◽  
Author(s):  
Yinghui Liu ◽  
Xiaowen Huang ◽  
Hongfang Liu ◽  
Liyan Xi ◽  
Chester R Cooper
Keyword(s):  
Immune Response ◽  
Galleria Mellonella ◽  
Southern China ◽  
Immunological Mechanism ◽  
Fonsecaea Monophora ◽  
Albino Mutant ◽  
Predominant Pathogen ◽  
Cellular Immune ◽  
Albino Strain

Abstract Fonsecaea monophora has been the predominant pathogen of chromoblastomycosis in Southern China, but its pathogenic mechanism remains unclear. New models are needed to study this infection. In the current study, we examined the role of melanin on the pathogenicity of F. monophora in Galleria mellonella model using melanin and albino strain. Interestingly, the albino mutant strain displayed higher pathogenicity compared to the melanin stain and restoration of melanin of albino mutant could reverse the pathogenicity. Histopathology showed that inflammatory nodules were bigger than that infected with albino cells, which suggested that melanized cells could trigger a robust cellular immune response of G. mellonella than albino cells. The activated immune response in G. mellonella induced by melanized cells might explain the decreased virulence of melanized cells in larvae model. While further study was needed to gain full insights into the molecular immunological mechanism in G. mellonella activated by melanin.

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