scholarly journals Computational Approach to Investigation of Crack Behaviour under Vehicular Loading of A Typical Concrete Pavement (A Case Study of Mbagathi Road in Nairobi)

2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Njiru Joseph Mwaura ◽  
◽  
Siphila Wanjiku Mumenya
Author(s):  
Ian Rouse ◽  
David Power ◽  
Erik G. Brandt ◽  
Matthew Schneemilch ◽  
Konstantinos Kotsis ◽  
...  

We present a multiscale computational approach for the first-principles study of bio-nano interactions. Using titanium dioxide as a case study, we evaluate the affinity of titania nanoparticles to water and biomolecules through atomistic and coarse-grained techniques.


2019 ◽  
Vol 5 (1) ◽  
pp. 444-467
Author(s):  
Katherine A. Crawford

AbstractOstia, the ancient port of Rome, had a rich religious landscape. How processional rituals further contributed to this landscape, however, has seen little consideration. This is largely due to a lack of evidence that attests to the routes taken by processional rituals. The present study aims to address existing problems in studying processions by questioning what factors motivated processional movement routes. A novel computational approach that integrates GIS, urban network analysis, and agent-based modelling is introduced. This multi-layered approach is used to question how spectators served as attractors in the creation of a processional landscape using Ostia’s Campo della Magna Mater as a case study. The analysis of these results is subsequently used to gain new insight into how a greater processional landscape was created surrounding the sanctuary of the Magna Mater.


1999 ◽  
Vol 11 (4) ◽  
pp. 309-316 ◽  
Author(s):  
Angela D. Rogers ◽  
Pearl Lee-Sullivan ◽  
Theodore W. Bremner
Keyword(s):  

2018 ◽  
Vol 171 ◽  
pp. 198-208 ◽  
Author(s):  
Xueliang Yuan ◽  
Yuzhou Tang ◽  
Yue Li ◽  
Qingsong Wang ◽  
Jian Zuo ◽  
...  

2021 ◽  
Author(s):  
Amanda Kowalczyk ◽  
Omotola Gbadamosi ◽  
Kathryn Kolor ◽  
Jahree Sosa ◽  
Claudette St Croix ◽  
...  

AbstractRecent advances in genome sequencing have led to the identification of new ion and metabolite transporters, many of which have not been characterized. Due to the variety of subcellular localizations, cargo and transport mechanisms, such characterization is a daunting task, and predictive approaches focused on the functional context of transporters are very much needed. Here we present a case for identifying a transporter localization using evolutionary rate covariation (ERC), a computational approach based on pairwise correlations of amino acid sequence evolutionary rates across the mammalian phylogeny. As a case study, we find that poorly characterized transporter SLC30A9 (ZnT9) uniquely and prominently coevolves with several components of the mitochondrial oxidative phosphorylation chain, suggesting mitochondrial localization. We confirmed this computational finding experimentally using recombinant human SLC30A9. SLC30A9 loss caused zinc mishandling in the mitochondria, suggesting that under normal conditions it acts as a zinc exporter. We therefore propose that ERC can be used to predict the functional context of novel transporters and other poorly characterized proteins.


Author(s):  
Rianne Conijn ◽  
Emily Dux Speltz ◽  
Evgeny Chukharev-Hudilainen

AbstractRevision plays an important role in writing, and as revisions break down the linearity of the writing process, they are crucial in describing writing process dynamics. Keystroke logging and analysis have been used to identify revisions made during writing. Previous approaches include the manual annotation of revisions, building nonlinear S-notations, and the automated extraction of backspace keypresses. However, these approaches are time-intensive, vulnerable to construct, or restricted. Therefore, this article presents a computational approach to the automatic extraction of full revision events from keystroke logs, including both insertions and deletions, as well as the characters typed to replace the deleted text. Within this approach, revision candidates are first automatically extracted, which allows for a simplified manual annotation of revision events. Second, machine learning is used to automatically detect revision events. For this, 7120 revision events were manually annotated in a dataset of keystrokes obtained from 65 students conducting a writing task. The results showed that revision events could be automatically predicted with a relatively high accuracy. In addition, a case study proved that this approach could be easily applied to a new dataset. To conclude, computational approaches can be beneficial in providing automated insights into revisions in writing.


Author(s):  
B. Addison ◽  
N. Sarigul-Klijn ◽  
R. Roberto ◽  
A. Jamali ◽  
M. Thompson

This paper presents a high fidelity computational approach to be used in validation of biomechanics experimental measurements. As a demonstration, a case study involving a spinous process implant to correct scoliosis is presented. The biomechanical behavior of the spinous process and implant under tensile loading is investigated using experiments and computations. The experimental study examined the ultimate strength of calf thoracic and lumbar spinous processes in three pullout directions. A statistical analysis was performed on the experimental results to reveal relationships and variations between pullout direction and vertebral type. The finite element high fidelity computational analysis was performed to validate the experimental results. In the process, the material properties of cortical and trabecular bone were elucidated for calf spinous processes. Good comparisons are obtained. The high fidelity computational approach detailed here should serve useful in validation of experimental values from spine biomechanics experimental.


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