Tactical approaches to the treatment of arterial hypertension in the European part of the Russian Federation. EPOHA study 2017

Aim. Analysis of antihypertensive treatment among different groups of patients with arterial hypertension from “EPOCHA” study 2017. Materials and methods. EPOCHA study is a representative sample of the European part of the Russian Federation was created in 2002 and re-examined in 2017. Results. 34.6% of the effectively treated (ET) patients had one antihypertensive drug and 32,2% of the ineffective treatment (IT) patients, p=0.16. Two-component antihypertensive therapy was 45.9% and 44.9%, respectively, p=0.56. Three antihypertensive drugs had 17.9% of the ET patients and 20.7% of the IT patients, p=0.05. Four antihypertensive drugs had 1.6% of the ET patients and 2.2% of the IT patients. The frequency of use of renin-angiotensin-aldosterone system blockers in the group of ET patients was 85.0%, which was significantly lower than 91.6% in the group of IT patients, р<0.0001. Conclusion. EPOCHA study shows that structure of antihypertensive therapy does not differ between ET and IT patients what is caused lack of medical supervision for patients with hypertension in real clinical practice.

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EPOCHA-AH 1998–2017. Dynamics of prevalence, awareness of arterial hypertension, treatment coverage, and effective control of blood pressure in the European part of the Russian Federation

Kardiologiia ◽

10.18087/cardio.2445 ◽

2019 ◽

Vol 59 (1S) ◽

pp. 34-42 ◽

Cited By ~ 9

Author(s):

Yu. V. Badin ◽

I. V. Fomin ◽

Yu. N. Belenkov ◽

V. Yu. Mareev ◽

F. T. Ageev ◽

...

Keyword(s):

Blood Pressure ◽

Arterial Hypertension ◽

Russian Federation ◽

Representative Sample ◽

Antihypertensive Drugs ◽

Pilot Project ◽

European Part ◽

Effective Control ◽

Treatment Coverage ◽

The Russian Federation

Aim.To perform a repeated epidemiological study of a representative sample in the European part of the Russian Federation in 2017 and to compare the dynamics of arterial hypertension (AH) prevalence with the eﬀectiveness of blood pressure (BP) control in the population compared to 1998, 2002, and 2007.Materials and methods.A representative sample of the European part of the Russian Federation was created in 2002 and re-examined in 2007 and 2017. In 1998, a pilot project was performed for examining a representative sample for the Nizhniy Novgorod region.Results.During 19 years of follow-up, the AH prevalence increased from 35.5 to 43.3%. Te awareness and treatment coverage reached 76.9 and 79.3%, respectively, in 2017. Achievement of the target BP with a single measurement also increased among patients receiving antihypertensive medication from 14.3 to 34.9%. For the treatment of AH, medium-acting antihypertensive drugs are used, ofen at suboptimal doses.Conclusion.Epidemiological indices of awareness, treatment coverage, and number of eﬀectively managed patients with AH have improved. However, the AH prevalence has increased by 7.8% for 19 years, which indicates inefciency of the primary prevention of this disease.

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The possibility of a new receptor blocker to angiotensin in improving control of hypertension. Non-intervention international multicenter observational prospective study of the use azilsartan medoxomil in patients with arterial hypertension and overweight or obesity in the Russian Federation and the Republic of Kazakhstan

Systemic Hypertension ◽

10.26442/sg29130 ◽

2016 ◽

Vol 13 (3) ◽

pp. 6-12

Author(s):

Yu V Zhernakova ◽

I E Chazova

Keyword(s):

Arterial Hypertension ◽

Russian Federation ◽

Antihypertensive Drugs ◽

Antihypertensive Agents ◽

Cardiovascular Complications ◽

Receptor Blocker ◽

The Russian Federation ◽

The Republic ◽

Azilsartan Medoxomil ◽

Overweight Or Obesity

Currently, there is evidence of a rather low efficacy of antihypertensive therapy, especially in patients with obesity and metabolic disorders that indicate the need for the search of new highly effective antihypertensive agents that have additional features to prevent destruction of target organs and cardiovascular complications. On the Russian pharmaceutical market antihypertensive drugs presents receptor blocker to angiotensin - azilsartan medoxomil (Edarbi®). The article is published design of study of the effectiveness of azilsartan medoxomil in patients with arterial hypertension and overweight or obesity in daily clinical practice of the Russian Federation and the Republic of Kazakhstan.

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Polyclinic doctors’ knowledge of clinical recommendations regarding indications to administration of antihypertensive drugs

Perm Medical Journal ◽

10.17816/pmj36571-75 ◽

2019 ◽

Vol 36 (5) ◽

pp. 71-75

Author(s):

Ya. P. Sandakov ◽

V. V. Kochubei

Keyword(s):

Correlation Analysis ◽

Arterial Hypertension ◽

Frequency Analysis ◽

Russian Federation ◽

Antihypertensive Drugs ◽

Maximum Score ◽

Clinical Recommendations ◽

Analysis Calculation ◽

The Russian Federation ◽

The Mean

Aim. To study the knowledge of clinical recommendations of the Ministry of Healthcare of the Russian Federation, acquired by doctors providing dispensary observation regarding contraindications to administration of antihypertensive drugs. Materials and methods. Questioning of 146 doctors, providing dispensary observation of adults using the standard questionnaire, containing 14 questions-tests. There was implemented the frequency analysis, calculation and comparison of the mean score, Median, Mode in relation to all the group and groups, singled out by the following two signs: work at the hospital for the recent 5 years and awareness of the content of clinical recommendations of the Ministry of Healthcare of RF. Correlation analysis between scores and age was conducted. Results. The mean score was 3.6 3.3 with maximum 14, Median 1, Mode 1. Nobody from respondents got the maximum score, the best result 12 scores was received by 0.7 % of respondents, 0 scores 3 %. No correlation between scores and age (r = 0.1, p = 0.4) was revealed. In the group of doctors, working at the hospital for the recent 5 years, during half a year the mean score 5.4 3.5 was significantly higher (t = 3.8, p = 0.001) than in the group of those who did not work 2.9 2.7. In the group of respondents, who indicated their knowledge of the content of clinical recommendations, the mean score 3.6 3.4 (t = 0.4, p = 0.89) did not significantly differ from the mean score 3.5 3.3 in the group of doctors who were not aware of clinical recommendations on arterial hypertension in adults. Conclusions. The knowledge of clinical recommendations, confirmed by the Ministry of Health of the Russian Federation, should be regularly estimated among the doctors, providing dispensary observation. Practice-oriented training of clinical recommendations is also needed.

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Epizootiological Monitoring of Natural Focal Infections in the South of the European Part of the Russian Federation in 2017

Problems of Particularly Dangerous Infections ◽

10.21055/0370-1069-2019-2-45-49 ◽

2019 ◽

pp. 45-49

Author(s):

N. F. Vasilenko ◽

O. V. Maletskaya ◽

D. A. Prislegina ◽

E. A. Manin ◽

O. V. Semenko ◽

...

Keyword(s):

Russian Federation ◽

Q Fever ◽

Hemorrhagic Fever ◽

European Part ◽

The South ◽

Hemorrhagic Fever Virus ◽

Granulocytic Anaplasmosis ◽

Control Research ◽

The Russian Federation ◽

Human Monocytic Ehrlichiosis

Objective– analysis of epizootiological manifestations of natural focal infections in the territory of the south of the European part of the Russian Federation in 2017.Materials and methods. Statistical documentation data from the Rospotrebnadzor Administrations, Centers of Hygiene and Epidemiology in the constituent entities of the Russian Federation, and Plague Control Research Institutes and Stations were used. The information was processed using Microsoft Excel 2010 software.Results and discussion. Epizootiological survey for 19 nosological forms of natural focal infections in the territory of the south of the European part of the Russian Federation was conducted. The total of 70155 samples of field material was tested; markers of 14 pathogens of natural focal infections were identified. The circulation of Crimean-Congo hemorrhagic fever virus was revealed in 11 constituent entities, tularemia and Lyme borreliosis pathogens – in 8 entities, West Nile virus – in 7. Markers of leptospirosis, Q fever, human granulocytic anaplasmosis and human monocytic ehrlichiosis pathogens were detected in 6 constituent entities, markers of the agent of hemorrhagic fever with renal syndrome – in 5 entities; markers of intestinal yersiniosis pathogen – in 3 constituent entities of the Russian Federation, pathogens of tick spotted fevers group, tick-borne viral encephalitis and pseudotuberculosis – in 2. The circulation of the virus Sindbis was identified in the Rostov Region.

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Human babesiosis: clinical cases in the european part of the Russian Federation

Terapevticheskii arkhiv ◽

10.26442/00403660.2019.11.000405 ◽

2019 ◽

Vol 91 (11) ◽

pp. 60-65

Author(s):

A K Tokmalaev ◽

V B Chentsov ◽

V A Malov ◽

V V Maleyev ◽

G M Kozhevnikova ◽

...

Keyword(s):

Differential Diagnosis ◽

Russian Federation ◽

Clinical Picture ◽

Epidemiological Data ◽

European Part ◽

Laboratory Studies ◽

Direct Supervision ◽

Clinical Observations ◽

The Russian Federation ◽

Human Babesiosis

The article describes four clinical observations of patients with babesiosis detected in the European part of the Russian Federation, two of whom were under the direct supervision of the authors. The analysis of epidemiological data, clinical picture, results of laboratory studies in the dynamics of the disease. Differential diagnosis and treatment are discussed.

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Stem Volume Tables by Height Classes of Willow Trees in the Northern Taiga Region of the European Part of the Russian Federation

Lesnoy Zhurnal (Forestry Journal) ◽

10.37482/0536-1036-2021-6-69-78 ◽

2021 ◽

pp. 69-78

Author(s):

Andrey A. Paramonov ◽

◽

Sergey V. Tretyakov ◽

Sergey V. Koptev ◽

Aleksandr P. Bogdanov ◽

...

Keyword(s):

Russian Federation ◽

Forest Inventory ◽

Information Source ◽

Northern Taiga ◽

European Part ◽

Stem Volume ◽

Analytical Technique ◽

Height Class ◽

The Russian Federation ◽

Willow Trees

In order to improve the accuracy of forest inventory works, tables of stem volume by height classes of willow trees in the northern taiga region of the European part of the Russian Federation were created. Forest inventory standards have not previously been developed for this species in the northern taiga region. The analytical technique proposed by I.I. Gusev in 1971 for spruce forests of the European North was used in compiling the height class volume tables. It was later adopted for the description of other tree species as well. Diameters and heights of trees were measured at 41 sample plots laid out in the Verkhnyaya Toyma and Arkhangelsk forestries of the Arkhangelsk region; 105 model trees were sampled. In most cases, sample plots were laid out in mixed plantations with the predominance of willow. The data obtained on the sample plots served to determine the parameters of the height class scale. The information source for stem volume of willow trees used to be the stem volume tables for aspen trees. A comparative analysis of the tables compiled for willow trees stems with the tables for aspen taken from the Forest Valuation Handbook for the Northeast of the European part of the Russian Federation was carried out. The analysis shows significant discrepancy in the scales for willow and aspen. The use of aspen height class volume tables for willow leads to a systematic overestimation of wood volumes. Tables of stem volumes by height classes of willow trees are used to determine stand stock with the enumeration data by 4-centimeter diameter classes. The developed tables meet the forest practice requirements. The volume tables by height classes are used to calculate timber reserves when laying out sample plots; to determine the damage level in case of stand damage; and for other practical purposes. For citation: Paramonov A.A., Tretyakov S.V., Koptev S.V., Bogdanov A.P., Tsvetkov I.V. Stem Volume Tables by Height Classes of Willow Trees in the Northern Taiga Region of the European Part of the Russian Federation. Lesnoy Zhurnal [Russian Forestry Journal], 2021, no. 6, pp. 69–78. DOI: 10.37482/0536-1036-2021-6-69-78

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Antibiotic resistance of Helicobacter pylori in the European part of the Russian Federation: first results

Terapevticheskii arkhiv ◽

10.26442/00403660.2020.08.000761 ◽

2020 ◽

Vol 92 (8) ◽

pp. 24-28

Author(s):

I. V. Maev ◽

D. N. Andreev ◽

V. M. Govorun ◽

E. N. Ilina ◽

Yu. A. Kucheryavyy ◽

...

Keyword(s):

Helicobacter Pylori ◽

Antibiotic Resistance ◽

Russian Federation ◽

European Part ◽

Diffusion Method ◽

Rapid Urease Test ◽

Urease Test ◽

First Results ◽

The Russian Federation ◽

H Pylori

Aim. Determine the primary antibiotic resistance of Helicobacter pylori (H. pylori) strains isolated from patients living in the European part of the Russian Federation. Materials and methods. As part of a clinical laboratory study, from 2015 to 2018, 27 gastrobiopsy samples obtained from H. pylori-infected patients were analyzed. H. pylori infection was verified using a rapid urease test or a 13C-urea breath test. The values of the minimum inhibitory concentration (MIC) of antibiotics were determined by the diffusion method using E-test strips (BioMerieux, France) according to the recommendations of the manufacturer. The sensitivity of the isolates was determined for 6 antibacterial drugs (amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, rifampicin). Results. According to the data obtained, resistance to amoxicillin was 0%, clarithromycin 11.1%, metronidazole 59.3%, levofloxacin 3.7%, tetracycline 0%, and rifampicin 14.8%. Dual resistance to clarithromycin and metronidazole was recorded in two isolates (7.4%). Conclusion. Thus, the first results of the evaluation of H. pylori antibiotic resistance in the European part of the Russian Federation indicate a low resistance of the microorganism to clarithromycin and quite high to metronidazole.

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