scholarly journals Sustained release of the antitumor drug paclitaxel from poly(3-hydroxybutyrate)-based microspheres

2011 ◽  
Vol 57 (2) ◽  
pp. 232-240 ◽  
Author(s):  
A.P. Bonartsev ◽  
G.M. Soboleva ◽  
K.V. Shaytan ◽  
M.P. Kirpichnikov ◽  
S.G. Yakovlev ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Drug Dosage ◽  
Dosage Forms ◽  
Antitumor Drug ◽  
Sustained Action ◽  
Novel Drug ◽  
Kinetics Of ◽  
Prolonged Drug Release

Development of systems of medicines with sustained action on the basis of biodegradable polymers is a promising trend in modern pharmacology. Polyhydroxyalkanoates (POA) attract increasing attention due to their biodegradability and high biocompatibility, which make them suitable for development of novel drug dosage forms. We obtained microspheres on the basis of poly(3-hydroxybutyrate) (PHB) loaded with the antitumor drug paclitaxel. Morphology, drug release kinetics and effect on tumor cells in vitro of microspheres were studied. The data on the kinetics of drug release, biocompatibility and biological activity of the biopolymer microspheres in vitro showed that the studied system of prolonged drug release had lower toxicity and higher efficiency compared to the traditional dosage forms of paclitaxel.

Fabrication and Release Kinetics of Liposomes Containing Leuprolide Acetate

2021 ◽  
Vol 7 (1) ◽  
pp. 35-38
Author(s):  
Sudipta Das ◽  
Arnab Samanta ◽  
Koushik Bankura ◽  
Debatri Roy ◽  
Amit Nayak
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
In Vitro Release ◽  
Zero Order ◽  
Leuprolide Acetate ◽  
Lipid Film ◽  
In Vitro Drug Release ◽  
Liposomal Formulations ◽  
Kinetics Of

The present work is focused on the preparation and in vitro release kinetics of liposomal formulation of Leuprolide Acetate. In this work, “Thin Lipid Film Hydration Method” was used for preparation of Leuprolide Acetate loaded liposomes. Prepared liposomal formulations of Leuprolide acetate was evaluated by drug entrapment study, in-vitro drug release kinetics and stability studies. The percentage drug entrapment of Leuprolide acetate for F1 and F2 formulations were found to be 78.14 ± 0.67 and 66.70 ± 0.81% respectively. In-vitro drug release study of liposomal formulations had shown zero order release pattern. Regression co-efficient (R2) value of Zero order kinetics for F1 and F2 formulations were 0.9912 and 0.9676 respectively. After storing formulations for 1 month, stability testing was done at 40C.It was found that all batches were stable. These liposomal formulations of Leuprolide acetate can be formulated for parenteral application to treat prostate cancer and in women, to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids.

scholarly journals Application of Mathematical Models in Drug Release Kinetics of Cyanocobalamine Fast Dissolving Sublingual Film

2021 ◽  
pp. 72-81
Author(s):  
Adil Patel ◽  
Ami Kalsariya ◽  
Srushti Patel ◽  
Chandni Patel ◽  
Shreya Patel
Keyword(s):  
Drug Release ◽  
Mathematical Models ◽  
Release Kinetics ◽  
Release Profile ◽  
Suitable Model ◽  
Order Model ◽  
Drug Release Profile ◽  
Casting Technique ◽  
Kinetics Of

The aim of present work is to determine and analyse the kinetics of drug release from the fast dissolving sublingual by employing various mathematical models. A study was done with Cyanocobalamine fast dissolving sublingual films, 1.5 mg/film by employing solvent casting technique using dehydrated banana starch and Gelatin. The in-vitro drug release profile was carried out in pH 6.8 phosphate buffer (900 mL) using USP dissolution apparatus I (Basket) at 50 rpm for 20 mins. The drug release data was obtained, quantitatively correlated and interpreted with various mathematical models viz. Zero order model, first order model, Higuchi model, Hixson-Crowell model and Korsmeyer-Peppas model and evaluated to understand the kinetics of drug release. The criterion for the most suitable model was based on the high degree of coefficient of correlation of drug release profile of Cyanocobalamine fast dissolving sublingual films.

scholarly journals New in vitro model to evaluate kinetics of antimycobacterial drug release from bioresorbable polymeric carriers

2020 ◽  
pp. 10-15
Author(s):  
SN Andreevskaya ◽  
TG Smirnova ◽  
EN Antonov ◽  
LN Chernousova ◽  
SE Bogorodsky ◽  
...  
Keyword(s):  
Drug Release ◽  
Culture Medium ◽  
Culture Media ◽  
Release Kinetics ◽  
Prolonged Release ◽  
Wide Range ◽  
Polymeric Carriers ◽  
The Matrix ◽  
Kinetics Of

Sustained-release drugs against tuberculosis are a promising approach to therapy since they positively affect patient compliance with long regimens, especially when it comes to the multidrug-resistant form of the disease. Conventional UV-visible spectroscopy does not work well with multicomponential culture media used for growing M. tuberculosis. The aim of this study was to develop a method for evaluating the kinetics of anti-tuberculosis drug released from bioresorbable polymeric carriers suitable for screening a wide range of encapsulated prolonged-release drugs and identifying the best performing candidate. While studying the growth dynamics of the laboratory susceptible strain M. tuberculosis H37Rv in the presence of different levofloxacin concentrations (from 0.03 to 0.4 μg/ml), we developed a model, which is essentially a set of 2 parallel experiments evaluating the kinetics of drug release into the culture medium. The results of these 2 experiments conducted on 3 encapsulated forms of levofloxacin loaded onto bioresorbable polymeric PLGA carriers (particles sized 50 μm and 100 μm and the matrix) revealed that release kinetics of the drug largely depended on the type of polymeric carrier. The best encapsulation of the antibiotic and its gradual release into the culture medium was observed for the matrix. All experiments were run in 3 replicates. The obtained data were analyzed using descriptive statistics.

scholarly journals Mouth Dissolving Tablets of Favipiravir using Superdisintegrants: Preparation, Optimization and In-vitro Evaluation

2021 ◽  
pp. 28-39
Author(s):  
D. Avinash ◽  
Madhu Gudipati ◽  
M. V. Ramana ◽  
Pallavi Vadlamudi ◽  
Rama Rao Nadendla
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Wetting Time ◽  
Tablet Dosage ◽  
Kinetics Of ◽  
Hardness Values ◽  
Mouth Dissolving Tablet

To formulate and evaluate the mouth dissolving tablet dosage forms of favipiravir using various superdisintegrants by using wet granulation technique. Batches of favipiravir Mouth dissolving tablets were formulated by using the wet granulation technique. The formulated granules were evaluated for their flow properties as a pre-compression parameter and the friability, hardness, disintegration, wetting ratio, wetting time, dissolution, and drug release parameters were evaluated as post-compression parameters. The effect of the varying concentrations of superdisintegrants on the formulation for disintegration time was ascertained and the results were compared. The tablet had friability and hardness values ranging from 0.60  to 0.68 % and 3.9  to 4.3 (kg/cm2). Tablet weights did not vary significantly but the disintegration time varied from 44.66  to 142.66±2.51 min and the wetting time varied from 45.33  to 144 min and the optimal batch of tablets shows a drug release of 98.8% within 60 min and first-order release kinetics of the formulations are compared.

scholarly journals Preparation and Evaluation of In Vitro Release Kinetics of Theophylline Loaded Matrix Tablet Based on Eudragit NE 30 D and Eudragit RS 30 D

1970 ◽  
Vol 8 (2) ◽  
pp. 153-159
Author(s):  
Mohammad Borhan Uddin ◽  
Jakir Ahmed Chowdhury ◽  
Kazi Rashidul Azam ◽  
Reza-ul Jalil ◽  
Md Selim Reza
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Release Kinetics ◽  
Matrix Tablet ◽  
Matrix System ◽  
Polymeric Systems ◽  
Eudragit Rs ◽  
Kinetics Of ◽  
Preparation And Evaluation

In the present study efficiency of Eudragit NE 30 D and RS 30 D as matrix forming materials was investigated. It was found that theophylline loaded granules prepared with these two polymers could not sustain drug release for a significant period of time. However, compression of these granules into tablets retarded drug release for up to 7 hours. Release was similar with both of the polymers. Effects of fillers and rate modifiers on drug release have been assessed. Incorporation of lactose and starch caused substantial release of theophylline from both the polymeric systems. Avicel PH 101 intensified the retardation effect of both NE 30 D and RS 30 D on theophylline release. Hydrophobic excipients also show retardation of release from both NE 30 D and RS 30 D. Key words: Eudragit RS 30 D; Eudragit NE 30 D; Theophylline; Matrix system; Controlled release DOI: 10.3329/dujps.v8i2.6030 Dhaka Univ. J. Pharm. Sci. 8(2): 153-159, 2009 (December)

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