scholarly journals Molecular organization of the microsomal oxidative system: a new connotation for an old term

2015 ◽  
Vol 61 (2) ◽  
pp. 176-187 ◽  
Author(s):  
D.R. Davydov
Keyword(s):  
Drug Disposition ◽  
Systems Approach ◽  
Cytochromes P450 ◽  
Drug Effects ◽  
Integrated System ◽  
Molecular Organization ◽  
Food Ingredients ◽  
System A ◽  
Integral Systems ◽  
Microsomal Monooxygenase

The central role that cytochromes P450 play in the metabolism of drugs and other xenobiotics makes these enzymes a major subject for studies of drug disposition, adverse drug effects and drug-drug interactions. Although there has been tremendous success in delineating P450 mechanisms, the concept of the drug-metabolizing ensemble as a functionally integrated system remains undeveloped. However, eukaryotic cells typically possess a multitude of different P450 enzymes that are co-localized in the membrane of endoplasmic reticulum (ER) and interact with each other with the formation of dynamic heteromeric complexes (mixed oligomers). Appreciation of the importance of developing an integral, systems approach to the ensemble of cytochromes P450 as an integral system inspired growing interest of researchers to the molecular organization of microsomal monooxygenase, which remained in the focus of research of academician Archakov for over 40 years. Fundamental studies carried out under his guidance have an important impact on our current concepts in this area. Further exploration of the molecular organization of the system of microsomal monooxygenase as an integral multienzyme and multifunctional system will have an essential impact on our understanding of the key factors that determine the changes in human drug metabolism and other P450-related functions in development, aging, and disease, as well as under influence of drugs, food ingredients, and environmental contaminants.

Demagogic populism and media system: A preliminary articulation

2021 ◽  
pp. 026732312199953
Author(s):  
Paul K Jones
Keyword(s):  
Political Communication ◽  
Systems Approach ◽  
Public Communication ◽  
Communication Studies ◽  
Theoretical Frameworks ◽  
Existential Crisis ◽  
System A ◽  
Media System ◽  
Modern Media ◽  
Media Systems

Political communication studies has a long tradition of ‘crisis talk’ regarding the fate of public communication. Now, however, the field itself faces a kind of existential crisis as its core assumptions of ‘normal’ political communication are daily undermined. This ‘liberal normalcy’ shares much with orthodoxies in populism studies, most notably a tendency to bracket out demagogic communication, both in historical fascist regimes and democracies. Yet correcting these failings is not simply a matter of rejecting liberal models for left-populist ones. Rather, both fields need to broaden their historical parameters and deepen their theoretical frameworks. The article draws on the Weberian conception of modern demagogy and its revision in the wake of 'modern media' by Shils and Adorno. It further argues that a critical reworking of Hallin and Mancini’s media systems approach could benefit both fields. For Hallin and Mancini’s socio-historical use of Weberian ideal-typification complements Worsley’s never-completed plan for an ideal-typification of modes of populism and demagogic leadership.

SAT Revisited — A Critical Post-Examination of the Systems Approach to Training

1975 ◽  
Vol 19 (2) ◽  
pp. 271-273
Author(s):  
Robert C. Sugarman ◽  
Steven L. Johnson ◽  
William M. Hinton ◽  
Chester C. Buckenmaier
Keyword(s):  
Developmental Stages ◽  
Systems Approach ◽  
Selection Process ◽  
System Development ◽  
Instructional System ◽  
Society Meeting ◽  
System A ◽  
Instructional System Development ◽  
The Media ◽  
Training Community

A unique application of the Systems Approach to Training (SAT) was carried out for the design of the B-1 aircrew instructional system. A preliminary report was presented at the 1975 Human Factors Society Meeting by Johnson, et aI, (1974) and Sugarman, et aI, (1974). Based on the additional experience, this presentation will share with the training community a look at some of the strengths and weaknesses of the SAT process. The particular application provided a harsh test of the process since the B-1 air vehicle is still in the developmental stages. This resulted in many opportunities to be faced with missing or incomplete data whose criticality to the analysis became more than apparent. The genral state-of-knowledge within Instructional System Development (ISD) itself is incomplete, which also became apparent when applying a highly structured (i.e., internally consistent and documented) SAT process. The major strength of the SAT process is the capability it provides for the justification of many decisions that were hitherto prone to hand-waving. This particular strength comes from the internal documentation for each decision process which is an important feature of SAT. The adequacy of the assumptions underlying the decision processes then becomes subject to scrutiny. The power of the documentation is enhanced by the use of computer aids in data management and economic analysis which facilitate the documentation. Within the present paper, problem areas which weaken the SAT process are also discussed. These include the data bases for the task analysis and economic/policy data, the media selection process, and the development of instructional strategies.

scholarly journals Stability analysis of the banking system: a complex systems approach

2017 ◽  
Vol 10 (3) ◽  
pp. 273-284
Author(s):  
Alan Karaev ◽  
Marina Melnichuk ◽  
Timur Guev ◽  
Grzegorz Mentel
Keyword(s):  
Stability Analysis ◽  
Complex Systems ◽  
Systems Approach ◽  
Banking System ◽  
System A

scholarly journals The implementation of total quality management in Arab universities: A proposed model

2021 ◽  
Vol 8 (7) ◽  
pp. 67-76
Author(s):  
Abdul-Wasea Abdul-Ghani Saif Almekhlafi ◽  
◽  
Keyword(s):  
Quality Management ◽  
Total Quality Management ◽  
Customer Service ◽  
Systems Approach ◽  
Integrated System ◽  
Total Quality ◽  
Academic Leaders ◽  
Intellectual Content ◽  
Final Sample ◽  
Proposed Model

The purpose of this study is to develop a model for the implementation of total quality management in higher educational institutions, Arab universities. This model exceeds the limitations in the implemented current models in various business organizations through implementing the systems approach and process entry in the design that includes inputs, processes, outputs, and goals. This study is a survey-based methodology in which the survey is designed based on the 7 famous models of implementing the total quality with an adaption within the framework of the total quality management concept. The final sample consists of 51 academic leaders at Prince Sattam bin Abdulaziz University who hold various experiences in working with different Arab universities. The results of this study indicate that the proposed model obtained high relative importance that reached at the axis level a high degree ranged between 76.39%-80.78%, and at the overall level reached a percentage of 80.39%. This confirms the importance of the model in expressing the intellectual content of management of total quality as an integrated system of universities as open organizations to their external context. This study recommends that high leaders should believe in the importance of total quality management and encourage its application through the proposed model with its essential criteria and its sub-dimensions and spreading the culture of total quality management and customer service among workers.

An Integrated Systems Approach for Early Warning and Risk Management Systems

2012 ◽  
pp. 55-65
Author(s):  
Walter Hürster ◽  
Thomas Wilbois ◽  
Fernando Chaves
Keyword(s):  
Risk Management ◽  
Environmental Monitoring ◽  
Early Warning ◽  
Power Plants ◽  
Systems Approach ◽  
Integrated System ◽  
Integrated Systems ◽  
Management Systems ◽  
Coastal Protection ◽  
Monitoring And Surveillance

An integrated and interdisciplinary approach to Early Warning and Risk Management is described in this paper as well as the general technical implementation of Early Warning and Risk Management Systems. Based on this systems approach, a concept has been developed for the design of an Integrated System for Coastal Protection. In addition to this, as a prototype implementation of a modern environmental monitoring and surveillance system, a system for the Remote Monitoring of Nuclear Power Plants is presented here in more detail, including a Web Portal to allow for public access. The concept, the architectural design and the user interface of Early Warning and Risk Management Systems have to meet high demands. It is shown that only a close cooperation of all related disciplines and an integrated systems approach is able to fulfil the catalogue of requirements and to provide a suitable solution for environmental monitoring and surveillance, for early warning and for emergency management.

An Integrated Systems Approach for Early Warning and Risk Management Systems

2010 ◽  
Vol 3 (2) ◽  
pp. 46-56 ◽  
Author(s):  
Walter Hürster ◽  
Thomas Wilbois ◽  
Fernando Chaves
Keyword(s):  
Risk Management ◽  
Environmental Monitoring ◽  
Early Warning ◽  
Power Plants ◽  
Systems Approach ◽  
Integrated System ◽  
Integrated Systems ◽  
Management Systems ◽  
Coastal Protection ◽  
Monitoring And Surveillance

An integrated and interdisciplinary approach to Early Warning and Risk Management is described in this paper as well as the general technical implementation of Early Warning and Risk Management Systems. Based on this systems approach, a concept has been developed for the design of an Integrated System for Coastal Protection. In addition to this, as a prototype implementation of a modern environmental monitoring and surveillance system, a system for the Remote Monitoring of Nuclear Power Plants is presented here in more detail, including a Web Portal to allow for public access. The concept, the architectural design and the user interface of Early Warning and Risk Management Systems have to meet high demands. It is shown that only a close cooperation of all related disciplines and an integrated systems approach is able to fulfil the catalogue of requirements and to provide a suitable solution for environmental monitoring and surveillance, for early warning and for emergency management.

The KB System: A Modular Control Panel Concept

1966 ◽  
Vol 8 (4) ◽  
pp. 291-298
Author(s):  
William H. Harkins
Keyword(s):  
Integrated System ◽  
Control Panel ◽  
System Control ◽  
Design And Development ◽  
Modular Control ◽  
Basic Module ◽  
Machine System ◽  
Unlimited Number ◽  
System A ◽  
And Control

This report describes the design and development of an integrated system of manually operable switch modules and related keyboard and control panel components called the KB System. The size of the basic module was based on the standard center-to-center spacing of keys in a conventional keyboard. The system of components and mounting structure based on this module can be assembled in an unlimited number of arrangements to satisfy widely varying man-machine system control and display requirements.

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