Effects of age and knee osteoarthritis on the modular control of walking: A pilot study

Background Older adults and individuals with knee osteoarthritis (KOA) often exhibit reduced locomotor function and altered muscle activity. Identifying age- and KOA-related changes to the modular control of gait may provide insight into the neurological mechanisms underlying reduced walking performance in these populations. The purpose of this pilot study was to determine if the modular control of walking differs between younger and older adults without KOA and adults with end-stage KOA. Methods Kinematic, kinetic, and electromyography data were collected from ten younger (23.5 ± 3.1 years) and ten older (63.5 ± 3.4 years) adults without KOA and ten adults with KOA (64.0 ± 4.0 years) walking at their self-selected speed. Separate non-negative matrix factorizations of 500 bootstrapped samples determined the number of modules required to reconstruct each participant’s electromyography. One-way Analysis of Variance tests assessed the effect of group on walking speed and the number of modules. Kendall rank correlations (τb) assessed the association between the number of modules and self-selected walking speed. Results The number of modules required in the younger adults (3.2 ± 0.4) was greater than in the individuals with KOA (2.3 ± 0.7; p = 0.002), though neither cohorts’ required number of modules differed significantly from the unimpaired older adults (2.7 ± 0.5; p ≥ 0.113). A significant association between module number and walking speed was observed (τb = 0.350, p = 0.021) and individuals with KOA walked significantly slower (0.095 ± 0.21 m/s) than younger adults (1.24 ± 0.15 m/s; p = 0.005). Individuals with KOA also exhibited altered module activation patterns and composition (which muscles are associated with each module) compared to unimpaired adults. Conclusion These findings suggest aging alone may not significantly alter modular control; however, the combined effects of knee osteoarthritis and aging may together impair the modular control of gait.

A feedback control architecture for bioelectronic devices with applications to wound healing

Bioelectronic devices can provide an interface for feedback control of biological processes in real-time based on sensor information tracking biological response. The main control challenges are guaranteeing system convergence in the presence of saturating inputs into the bioelectronic device and complexities from indirect control of biological systems. In this paper, we first derive a saturated-based robust sliding mode control design for a partially unknown nonlinear system with disturbance. Next, we develop a data informed model of a bioelectronic device for in silico simulations. Our controller is then applied to the model to demonstrate controlled pH of a target area. A modular control architecture is chosen to interface the bioelectronic device and controller with a bistable phenomenological model of wound healing to demonstrate closed-loop biological treatment. External pH is regulated by the bioelectronic device to accelerate wound healing, while avoiding chronic inflammation. Our novel control algorithm for bioelectronic devices is robust and requires minimum information about the device for broad applicability. The control architecture makes it adaptable to any biological system and can be used to enhance automation in bioengineering to improve treatments and patient outcomes.

Parametric and Implicit Features-Based UAV–UGVs Time-Varying Formation Tracking: Dynamic Approach

Flexible and robust Time-Varying Formation (TVF) tracking of Unmanned Ground Vehicles (UGVs) guided by an Unmanned Aerial Vehicle (UAV) is considered in this paper. The UAV–UGVs system control model is based on leader-follower approach, where the control scheme consists of two consecutive tasks, namely, deployment task and TVF tracking. Accordingly, two novel nonlinear controllers are proposed for controlling the UGVs formation. First, unlike the classical frameworks on UGVs formation tracking, for which only particular shapes are handled (e.g. circle, square, ellipse), we propose a UGVs deployment-controller ensuring to reach free-formation shapes. The key feature is in using the estimated implicit representation of the desired formation shape as a potential function to generate the UGVs reference trajectory. Second, in the TVF tracking task, a robust cascaded velocity/torque controller for UGVs is proposed based on kinematic and dynamic models. Differently from the classical backstepping framework, the key idea is in introducing an auxiliary control input, in such a way that the overall UGV dynamics is converted into a simpler and modular control structure. As such, the auxiliary input is used to control indirectly the actual UGVs velocity vector. A signum term is added to the torque-input to compensate for the unknown external disturbances and unmodeled dynamics. Numerical simulation shows the effectiveness of the proposed formation controllers compared with the case when the perfect velocity-tracking assumption holds. Experimental results are further provided using three festos Robtino robots to show the validity of the proposed TVF tracking velocity-control scheme.

Distance course: features of development and use

In 2013, the Regulation on Distance Learning came into force, probably then no one could have imagined that distance learning would be as popular around the world as it is now. In general, the purpose of developing distance education was to provide the opportunity to receive education in another city or country, but without the direct presence of a person, presence only in the most necessary circumstances, including state exams, thesis defense, and so on. Apropos, even before 2013, distance learning was used in the most famous institutions of higher education in the world. The present is impossible to imagine without distance learning. What has only recently become an isolated phenomenon has become widespread. But at the same time there is a problem of how to effectively organize the educational process using distance learning technologies. The solution to this problem is to use an educational platform, in particular, the Moodle platform. The creation of courses on the Moodle platform with a description of the main stages is characterized. The possibilities of the Moodle educational platform are described and the developed distance courses on the Moodle platform are presented, in particular "Computer networks and the Internet", "Computer graphics and design of polygraphic editions", "Computer design and multimedia", "Programming Internet-oriented applications", which consist of such sections as instructional, which also contains a chat and a forum, lectures, laboratory (practical) works, independent work, modular control work, exam, individual training. The advantages and disadvantages of using distance learning are presented.