scholarly journals Paracetamol induced erythema multiforme major: a rare case report

2021 ◽  
Vol 10 (2) ◽  
pp. 198
Author(s):  
Mukesh Kumar ◽  
. Soni
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Erythema Multiforme ◽  
Rare Case ◽  
Case Reports ◽  
Clinical Feature ◽  
Drug Induced ◽  
Common Drug ◽  
Erythema Multiforme Major ◽  
Rare Case Report

Paracetamol is the most quotidian drug used for fever and pain. Adverse drug reaction to paracetamol in India are rare, at times they can lead to lethal situations like erythema multiforme. The most common drug induced erythema multiforme are due to drugs like barbiturate, NSAIDs, penicillin, sulfonamide, nitrofurantoin, phenothiazines and anticonvulsants. There are very few detailed case reports of erythema multiforme due to use of paracetamol. We report a case of erythema multiforme which occurred due to use of paracetamol. The clinical feature and management of patient are described in brief.

Non-chemotherapy drug-induced agranulocytosis in a tertiary hospital

2015 ◽  
Vol 35 (3) ◽  
pp. 244-250 ◽  
Author(s):  
R Navarro-Martínez ◽  
E Chover-Sierra ◽  
O Cauli
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Tertiary Hospital ◽  
Negative Association ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Drug Induced ◽  
Common Drug ◽  
Low Incidence ◽  
Stimulating Factor

Drug-induced agranulocytosis is a rare haematological disorder considered as severe adverse drug reaction. Due to its low incidence, the number of studies are low and the variability of clinical features and presentation in hospitalized patients is rarely described. Awe performed an observational, transversal and retrospective study in the haematology and toxicology unit in a tertiary hospital located in Spain (Valencia) (1996–2010) in order to assess its incidence, the drugs involved, the management and outcomes of drug-induced agranulocytosis. Twenty-one cases of agranulocytosis were retrieved. All of them presented severe and symptomatic agranulocytosis (fever and infection). The most common drug associated with drug-induced agranulocytosis was metamizole administration but other drugs belonging to different pharmacological classes as well (carbimazol, sulfasalazine, bisoprolol, itraconazole, amitryptiline, ketorolac and claritomicine+cefuroxime). No differences between sex and age were found in relationship with the manifestations or course of agranulocytosis. In contrast, a significantly negative association was found between age of patients and the percentage of increase in neutrophil count. Administration of human granulocyte colony-stimulating factor did not significantly enhance the recovery of the process or the restoration of leucocytes count, suggesting a limited utility in this type of agranulocytosis.

A rare case of clomiphene-induced leukocytoclastic vasculitis

2019 ◽  
Vol 30 (4) ◽  
Author(s):  
Yashika Garg ◽  
Sourabh Jain ◽  
Arun Kumar
Keyword(s):  
Adverse Drug Reaction ◽  
Differential Diagnosis ◽  
Drug Reaction ◽  
Rare Case ◽  
Leukocytoclastic Vasculitis ◽  
Clomiphene Citrate ◽  
First Line ◽  
Drug Induced ◽  
Prednisolone Dose ◽  
Line Drug

Abstract Clomiphene citrate is a first-line drug for the induction of ovulation in infertility cases. Leukocytoclastic vasculitis (LCV) is an extremely rare serious adverse drug reaction to clomiphene. We report here the case of a 30-year-old Indian female patient who presented with generalized petechiae and palpable purpura without fever and sparing the mucosa, temporally related to clomiphene intake and consistent with LCV histologically. Clomiphene was stopped and the patient was treated symptomatically with prednisolone 40 mg/day, oral levocetirizine 5 mg twice daily, and emollients and calamine lotion topically. The patient improved over 3–4 weeks. The prednisolone dose was tapered weekly and withdrawn gradually. To date, drug-induced LCV has not been previously reported with clomiphene. Although rare, clomiphene could be considered a potential cause of drug-induced cutaneous LCV in the differential diagnosis of erythematosus rash with non-blanching petechiae and purpura.

scholarly journals Ertapenem-Induced Encephalopathy in a Patient With Normal Renal Function

2017 ◽  
Vol 5 (1) ◽  
pp. 232470961668937 ◽  
Author(s):  
S. Scott Sutton ◽  
Mark Jumper ◽  
Sean Cook ◽  
Babatunde Edun ◽  
Michael D. Wyatt
Keyword(s):  
Adverse Drug Reaction ◽  
Renal Function ◽  
Drug Reaction ◽  
Normal Renal Function ◽  
Brain Function ◽  
Case Reports ◽  
Altered Mental Status ◽  
Drug Induced ◽  
Diffuse Disease ◽  
The Brain

Drug-induced neurotoxicity is a rare adverse reaction associated with ertapenem. Encephalopathy is a type of neurotoxicity that is defined as a diffuse disease of the brain that alters brain function or structure. We report a patient with normal renal function who developed ertapenem-induced encephalopathy manifesting as altered mental status, hallucinations, and dystonic symptoms. The patient’s symptoms improved dramatically following ertapenem discontinuation, consistent with case reports describing ertapenem neurotoxicity in renal dysfunction. Since clinical evidence strongly suggested ertapenem causality, we utilized the Naranjo Scale to estimate the probability of an adverse drug reaction to ertapenem. Our patient received a Naranjo Scale score of 7, suggesting a probable adverse drug reaction, with a reasonable temporal sequence to support our conclusion.

scholarly journals Rosuvastatin induced gynecomastia: a rare presentation of newer statin

2020 ◽  
Vol 9 (11) ◽  
pp. 1744
Author(s):  
Suman Ruhela ◽  
Manish Ruhela ◽  
Rakesh Kumar Ola ◽  
Mahesh Rao
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Case Reports ◽  
Benign Disease ◽  
Reaction Probability ◽  
Glandular Tissue ◽  
Probability Scale ◽  
Drug Induced ◽  
Rare Presentation ◽  
Progressive Enlargement

Gynecomastia is a common benign disease characterized by the progressive enlargement of the glandular tissue of the male breast. The etiology may vary and may be physiological, pharmacological, pathological, or even idiopathic. Among men, drug induced gynecomastia may account for 10-20% of cases. Several case reports have associated this condition to the use of statins. However, there are few case reports of rosuvastatin induced gynecomastia have been reported in literature. We describe a 45-year-old male who developed bilateral gynecomastia after one month of rosuvastatin therapy, after switching to a different or less potent statin (atorvastatin), his symptoms resolved with-in one month. Use of the Naranjo adverse drug reaction probability scale indicated a possible relationship between the patient’s development of gynecomastia and rosuvastatin therapy.

Linezolid Induced Skin Reactions in a Multi Drug Resistant Infective Endocarditis Patient: A Rare Case

2020 ◽  
Vol 15 (3) ◽  
pp. 222-226 ◽  
Author(s):  
Asha K. Rajan ◽  
Ananth Kashyap ◽  
Manik Chhabra ◽  
Muhammed Rashid
Keyword(s):  
Case Report ◽  
Infective Endocarditis ◽  
Rare Case ◽  
Case Reports ◽  
Multidrug Resistant ◽  
The Body ◽  
Prior History ◽  
Skin Reactions ◽  
Rare Case Report ◽  
Multiple Drugs

Rationale: Linezolid (LNZ) induced Cutaneous Adverse Drug Reactions (CADRs) have rare atypical presentation. Till date, there are very few published case reports on LNZ induced CADRs among the multidrug-resistant patients suffering from Infective Endocarditis (MDR IE). Here, we present a rare case report of LNZ induced CARs in a MDR IE patient. Case report: A 24-year-old female patient was admitted to the hospital with chief complaints of fever (101°C) associated with rigors, chills, and shortness of breath (grade IV) for the past 4 days. She was diagnosed with MDR IE, having a prior history of rheumatic heart disease. She was prescribed LNZ 600mg IV BD for MDR IE, against Staphylococcus coagulase-negative. The patient experienced flares of cutaneous reactions with multiple hyper-pigmented maculopapular lesions all over the body after one week of LNZ therapy. Upon causality assessment, she was found to be suffering from LNZ induced CADRs. LNZ dose was tapered gradually and discontinued. The patient was prescribed corticosteroids along with other supportive care. Her reactions completely subsided and infection got controlled following 1 month of therapy. Conclusion: Healthcare professionals should be vigilant for rare CADRs, while monitoring the patients on LNZ therapy especially in MDR patients as they are exposed to multiple drugs. Moreover, strengthened spontaneous reporting is required for better quantification.

scholarly journals Pleomorphic xanthoastrocytoma at the pineal region: rare case report with successful surgical management

2021 ◽  
Vol 36 (1) ◽  
Author(s):  
Saraj Kumar Singh ◽  
Krishan Kumar Sharma ◽  
Tarun Kumar
Keyword(s):  
Surgical Management ◽  
Rare Case ◽  
Case Reports ◽  
Internal Capsule ◽  
Pleomorphic Xanthoastrocytoma ◽  
Pineal Region ◽  
Low Grade ◽  
Pineal Region Tumors ◽  
Pediatric Age Group ◽  
Rare Case Report

Abstract Background Pineal region tumors are commonly present in the pediatric age group. However, pleomorphic xanthoastrocytoma (PXA) is very rare at this region, and only few case reports have been reported till now in literature. Case presentation Here, we report a rare case of pineal region, juxta-thalamic, pleomorphic xanthoastrocytoma (PXA) in an 11-year-old male child. The child presented with severe headache after which MRI was done. It was suggestive of pineal region low-grade tumor. The patient was operated in Parkbench position with SCIT (supracerebellar approach) in a retractor-free manner. Gross total resection was done. However, the patient developed postoperative left-sided hemiparesis. It got improved in 1 month, and the patient became ambulatory. Histopathology came out as pleomorphic xanthoastrocytoma. Conclusion Surgical management should include careful resection near the internal capsule to avoid postoperative hemiparesis. Also, shunt should be delayed in the cystic cavity created by resection of tumor.

scholarly journals Olanzapine-induced black hairy tongue: a rare case

2017 ◽  
Vol 6 (8) ◽  
pp. 2091
Author(s):  
Vishal P. Giri ◽  
Debranjan Datta ◽  
Parvathi Devi
Keyword(s):  
Bipolar Disorder ◽  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Case Report ◽  
Dopamine Receptors ◽  
Rare Case ◽  
Second Generation Antipsychotic ◽  
Black Hairy Tongue ◽  
Calming Effect ◽  
Prevention Of Relapse

Olanzapine is second generation antipsychotic drug. It alters affinities for serotonin and dopamine receptors and provides mild sedating and calming effect. It is indicated for the treatment of schizophrenia, acute mania and the prevention of relapse in bipolar disorder. We present a case report of a 65- year- old man with bipolar disorder I, who developed black hairy tongue following treatment with olanzapine and completely recovered after withdrawal of treatment. Awareness about this particular adverse drug reaction will ensure proper management and avoid unnecessary investigations.

scholarly journals Amoxicillin Induced Steven Johnson’s Syndrome: A Case Report

2020 ◽  
Vol 10 (4-s) ◽  
pp. 220-222
Author(s):  
R Mahendra Kumar ◽  
Sanatkumar Nyamagoud ◽  
Krishna Deshpande ◽  
Ankitha Kotian
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Case Reports ◽  
The Body ◽  
Stevens Johnson Syndrome ◽  
Hypersensitivity Reactions ◽  
Johnson Syndrome ◽  
Oral Consumption ◽  
Life Threatening

Stevens-Johnson syndrome (SJS) is a very rare, potentially fatal skin reaction that is typically the result of reaction to the drug. In particular, SJS is characterized by extensive skin and mucous membrane lesions (i.e. mouth, nose, esophagus, anus, and genitalia), epidermis detachment, and acute skin blisters. In 95 % of case reports, drugs were found to be an important cause for the development of SJS. This story is a case of A 42 year old male hospitalized with rashes all over the body and fever, after oral consumption of Amoxicillin drug for sore throat. This case study discusses the possibility that serious hypersensitivity reactions with Amoxicillin can rarely occur and can be extremely harmful and life-threatening Menacing. Keywords: Toxic Epidermal Necrolysis, Stevens Johnson Syndrome, Adverse drug reaction, Nikolsky’s sign

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