M7 to M2 Pre-congestion Speed Management

This paper explores the development and implementation of the M7 to M2 pre-congestion speed limit management trial conducted on workdays between 26th June 2018 and 31st December 2018. This trial was the first of its kind in NSW and was implemented using a live loop reporting system utilising key trigger values (specific loop metrics) to identify the opportune time to reduce speed limits prior to flow breakdown. Through measuring the rate at which speeds dropped during flow breakdown, the heatmap footprint of congestion, and the instance of congestion related crashes it was established the trial was able to have a calming effect on traffic flow and reduce the overall footprint of congestion.

The aromatherapy formulation of essential oils in reducing stress and blood pressure on human

Unhealthy lifestyles such as low physical activity, unbalanced nutrition consumption, high workloads, and low emotional management make a person vulnerable to stress. The large-scale lockdowns to reduce COVID-19 transmission also exacerbate the stress level. Regarding organic and complementary therapeutic schemes, both increased relaxation and decreased hypertension are carried out using aromatherapy that involves essential oil formulations. This study aims to identify the characteristics and effects of aromatherapy formulations, including benzoin, nutmeg, and citronella essential oils on relaxation and human blood pressure. The study began by identifying local applications of essential oils through interviews with 20 local people who apply essential oil in their remedies. The method included initial and final measurements of blood pressure in aromatherapy application for three consecutive days. To evaluate aromatherapy profiles, forty respondents were selected purposively and asked about their expression after inhalation. The results showed that application of the aromatherapy formulation reduced systolic pressure by 8.5 mmHg and diastolic pressure by 1.2 mmHg. Most of the respondents considered that the aroma of formulated essential oils has a refreshing and calming effect on their mind. These antidepressant effects are obtained from combination of benzyl cinnamate, geraniol, linalool, myristicin, p-cymene etc in formulated essential oils. This research concluded that inhalation of essential oils formulation provided a relaxing effect and reduced hypertension, significantly.

Glucose supply as a way to reduce procedural pain in newborns. Review of research results

Immediately after birth, most newborns undergo a number of medical procedures to assess how the body functions. Some of these procedures are invasive and involve breaking the continuity of the baby's tissues, leading to pain and discomfort. Confirmation of pain sensation by newborns is relatively one of the newer scientific discoveries - this fact was not acceptable until the end of the 1980s. Therefore, analgesia was used very rarely during all medical procedures. Nowadays, medical personnel are aware that the youngest patients also feel pain and should be knowledgeable about its prevention and treatment. The aim of the study is to analyze the available studies on glucose supply as a way to reduce procedural pain in newborns. The non-systematic review of the literature was carried out according to the following keywords: pain, glucose, newborn, prevention, recommendations. Analyzes carried out in neonatal departments and a literature review have shown that pain prevention and treatment still pose many problems, as there are no clear guidelines as to how and methods to administer the therapy. Oral glucose is the most common pain reliever used in neonates during medical interventions. Its mechanism of action remains unclear, but it is believed to have a calming effect and reduce behavioral indicators of pain. The American Academy of Pediatrics recommends the administration of three doses of sucrose appropriate to the gestational age of the newborn, but there is concern about the long-term use of this preventive measure, especially in premature babies, who are at greater risk of hyperglycemia and disturbances in the development of the nervous system.

Pakistan’s emerging regional politico-economic role in the SCO

Shanghai Cooperation Organization (SCO) is presently a Eurasian politico-economic bloc having two South Asian members, Pakistan and India. The aim of the study was to evaluate the prospective role of Pakistan in the SCO with qualitative study based on interviews. On June 2017, Pakistan was granted permanent membership in the SCO during its 16th Heads of State Summit in Astana. By associating itself as a permanent member, summit allows Pakistan to contribute to regional development alongside other key regional players, Russia and China and India. The study gave four findings that how multilateralism was having a calming effect on a regional conflict, Pakistan embracing independence from isolation through Trans-Afghanistan gas pipeline. Through CPEC, Pakistan was offering the SCO member countries an economic hallway. And how the Eurasian politico-economic ambitions to reach the warm waters of the Arabian Sea was perceived as hampering the Western economic interests, thereby offering a major impediment to Pakistan’s emerging role in the SCO. Moreover, SCO participation will help enhance Pakistan's worldwide socio-economic objectives. This study examines the socio-politico and economic aspirations of Pakistan and benefit due to ties with SCO member countries.

A ROLE FOR CORTICAL DOPAMINE IN THE PARADOXICAL CALMING EFFECTS OF PSYCHOSTIMULANTS

Attention deficit hyperactivity disorder (ADHD) affects young children and manifests symptoms such as hyperactivity, impulsivity and cognitive disabilities. Psychostimulants, which are the primary treatment for ADHD, target monoamine transporters and have a paradoxical calming effect, but their mechanism of action, is unclear. Studies using the dopamine (DA) transporter (DAT) knockout mice, which have elevated striatal DA levels and are considered an animal model of ADHD, have suggested that the paradoxical calming effect of psychostimulants might be through the actions on serotonin neurotransmission. On the other hand, newer non-stimulant class of drugs such as atomoxetine and Intuniv suggest that targeting the norepinephrine (NE) system in the PFC might explain this paradoxical calming effect. We sought to decipher the mechanism of this paradoxical effect of psychostimulants through an integrated approach using ex vivo monoamine efflux experiments, monoamine transporter knockout mice, drug infusions and behavior. Our ex vivo efflux experiments reveal that NE transporter (NET) blocker desipramine elevates both norepinephrine and dopamine but not serotonin levels, in PFC tissue slices from wild-type and DAT-KO but not NET KO mice. However, serotonin (5-HT) transporter (SERT) inhibitor fluoxetine elevates only serotonin in all three genotypes. Systemic administration of both desipramine and fluoxetine but local PFC infusion of only desipramine and not fluoxetine inhibits hyperactivity in the DAT-KO mice. In contrast, pharmacological norepinephrine depletion but dopamine elevation using Nepicastat also inhibits hyperactivity in DATKO mice. Together, these data suggest that elevation of PFC dopamine and not norepinephrine or serotonin as a convergent mechanism for the paradoxical psychostimulant effects observe in ADHD therapy.

The features of interaction between mothers and their children aged 15-18 during psycho-emotional outbursts

Annotation. The aim of the study is to analyze the influence of mother's reaction during psycho-emotional outbursts in children aged 15-18 on the development of adolescent aggression. The participants of the study were asked to answer the questions in the questionnaire called “The Questionnaire of Mothers of Teenagers Aged 15-18” which included a separate block of questions namely “What do you do when your child has outbursts of irritability or temper tantrums, when he/she gets extremely angry? Subsequently, the participants’ substantive responses were selected and analyzed. The study covered 864 adolescents aged 15-18 (425 people – a group of aggressive adolescents, 439 respondents – a group of non-aggressive teenagers). The analysis considered the difference in distribution between aggressive and non-aggressive groups when exposed to certain factors. Information base – international program ELSPAC – Ukrainian fragment “Family and Children of Ukraine”. Statistical processing of information – Microsoft Office 2003, 2010, “IBM SPSS Statistics 20.0”, “Microsoft Office Excel 2010”. The difference was determined at p<0.05. The analysis of the methods for raising a child used in an attempt to “quench” emotional outbursts in adolescents showed that among the studied methods of calming down a child were identified those methods that had a positive effect on his psycho-emotional state i.e. allowing him/her to cry (42.9% in the aggressive group and 57.1% in the non-aggressive group); neutral methods, for example, comforting with talking (63.6% and 36.4% by groups, respectively), and methods that had a negative impact i.e. forcing a child to go away (83.3% and 16.7%, respectively); getting into a war of words, shouting at him (71.8% and 28.2%, respectively); leaving a child with someone (65.6% and 34.4%, respectively), threatening a child (75.0% and 25.0%, respectively) or beating him/her (81.4% and 18.6%, respectively). Thus, the study found that the interviewed mothers rarely used parenting methods that have a positive effect, and vice versa, they used approaches that did not have a calming effect, which negatively influenced the psycho-emotional state of adolescents.

AWARENESS OF MOTHER WITH BABY PACIFIER

Introduction: Pacifiers consist of a latex or silicone nipple with a firm plastic shield and handle and are available in different forms and sizes. This is used in infant for colling and calming effect on infant however, it is related to many disadvantage and side effect on teeth of the infants. In this study we aimed to a Assess the interrelation between different on-nutritive sucking habits, pacifier use and thumb/digit sucking. Besides, Investigate the relationships between various non-nutritive sucking habits and occlusion in the primary dentition. Methodology: Following a comprehensive literature review, the questionnaire was designed and used for data collection. Then, a cross‐sectional survey was distributed throughout the internet for two months (October - November 2019) to 200 mothers in Riyadh, Saudi Arabia. The mothers answered 16 questions, where 5 of them were self-administered, while the others followed the pacifier and their effect on Breastfeeding and teeth. Initially, the participants have answered inquiries about the demographic information. Results: The results of our study include 202 mothers in which 55.9 % were between 18 -30 years old while 88.6 % of married while 6.4 % were widowed and the rest were divorced. Moreover, 67.3 % of mothers in this study started breast feeding but stopped it, while 15.3 % still breast feeding partially, 12.9 % still breasting feeding exclusively and 4.5 % never breast fed during the process of the survey. 58.9 % of mothers agree about the use of pacifier with their infants where younger mothers were more intended to agree about using of pacifier. Considering the reason behind using of pacifier, mothers reported that 74.3 % of mothers using pacifier because of its comfort or soothing effect. Moreover, 47.1 % of the sample thought that best time to start using pacifiers is from first week of birth and 49 % of mothers in this study thought that pacifier should be used for 4 hours per day. Finally, most of mother thought that the ideal time of pacifier cessation before the first year (45%). Conclusion: As with all infant care practices, there may be multiple factors influencing the parental decision to use or not use a pacifier for the infant. Some of these factors (e.g., concerns about nipple confusion, dental concerns) may be the result of misinformation. As pacifier use has been associated with a reduced risk for SIDS, it is important for health care providers to understand and be able to address the concerns that parents may have about pacifier use. In the hospital setting, providers should be aware that parents may have strong preferences about getting educated regarding pacifier use and its consequences.

Efficacy and Safety of Butorphanol Use in Patient-Controlled Analgesia: A Meta-Analysis

Objective. This meta-analysis evaluates the efficacy and safety regarding usage of butorphanol in patient-controlled analgesia (PCA). Methods. Several databases such as PubMed, Cochrane Library, Embase, CNKI, and VIP were explored with the help of computer search and manual retrieval. Randomized controlled trial (RCT) was selected, and the meta-analysis was conducted using RevMan 5.1. The primary efficacy endpoint was the postoperative visual analog scale score, postoperative Ramsay sedation scale (RSS), and adverse events. Results. Nine RCTs met the inclusion criteria and were included in this meta-analysis. No significant differences were found between the butorphanol group and nonbutorphanol group at 12 h and 48 h. The postoperative RSS score at 12 h, 24 h, and 48 h was representative of the calming effect of butorphanol. No significant difference was found on the endpoint of the postoperative RSS score at 12 h, 48 h, and 24 h. The RSS score was lower in the butorphanol group in comparison to the nonbutorphanol group. The butorphanol group was also associated with lower rate of nausea, vomiting, itching, and dizziness compared to the nonbutorphanol group. Conclusion. Butorphanol may be used in PCA as a successful postoperative analgesia and is also associated with lower side effects. Further research is needed to verify the efficacy and safety of butorphanol.

Effect of Massage, Soak Feet Warm Water, and Aromatherapy for Decreasing Blood Pressure in Older Adults with Hypertension: A Literature Review

Introduction: The increase in blood pressure that lasts long enough to cause damage to the kidneys, heart, and brain. This is in line with Carol A. Miller's theory regarding the aging process that occurs in the older adults. Miller's functional theory in the development process, the older adults will experience many changes, one of which is the dilated and stiff arteries, this results in reduced vascular recoil capacity. The purpose of this study was to determine the effect of massage, warm water foot soaking, and aromatherapy on lowering blood pressure in hypertensive older adults based on empirical studies of the last ten years.Method: Search for journals or articles using a database through Scopus, ProQuest, PubMed, SAGE, EBSCO, Scient Direct, Research Gate, and Google Scholar. The Center for Review and Dissemination and The Joanna Briggs Institute were used to assess the study's quality. The framework used for the review is PICOS, and the inclusion criteria used are English and Indonesian language journals with a coverage of the last ten years, older adults who lives in nursing home or community older adults, outcomes: decreased to blood pressure, and the study design of quasy-experimental studies, randomized control and trial, qualitative research and cross-sectional studies.Result: After screening twenty-five article, but only Thirteen studies matched the research criteria. Six studies suggest that age is a significant factor in hypertension and seven studies the presence of excess sympathetic activity. Meanwhile, strategies to reduce blood pressure in the older adults include massage, soaking feet in warm water, and aromatherapy.Conclusion: Decreased prevalence of hypertension in the older adults can be carried out pharmacologically and non-pharmacologically. The strategy is entirely sufficient for lowering blood pressure in elderly hypertensive are massage, foot soak warm water, and aromatherapy as inhaled a calming effect. Determines successfully in complementary therapy in lowering blood pressure.

Can traditional Chinese medicine formulas treat BMI-associated hypertension effectively?

The tradition of Chinese Medicine (TCM) has been in use and development for thousands of years, where it has been applied in some form for the treatment of nearly every common illness. TCM is currently undergoing a resurgence in interest and in providing an adjunct to allopathic medical care virtually worldwide. TCM therapeutics may be administered in many forms from capsules, to powders, homogenates, tinctures and decoctions. Si Wu Tang, a derivative of the traditional Chinese including Formulas, is a combination of substances that may function in a synergistic manner to promote a calming effect and an amelioration of symptoms of hypertension. Such formulas are often used in TCM to treat or alleviate a wide range of the common illness and disorders of both Eastern and Western society. Reported beneficial effects include improvements in circulatory, cardiovascular, mood, endocrine metabolic and reproductive disorders. One such TCM formula commonly recommended is the Wu Cao Si Wu Tang [SWT]formula, used to treat the hypertension of obesity and a variety of other disorders. Hypertension is a key risk factor for cardiovascular morbidity and mortality and is a leading cause of end-stage renal disease; over 7 million US deaths per year may be directly attributed to pathophysiologic complications resulting from poor control of blood pressure. While numerous advances in the diagnosis and treatment of hypertension have had a major impact on decreasing the overall risks and an improved management of this chronic disease, a definitive cure for all causes of hypertension has remained elusive to date. To determine the comparative effectiveness of conventional Western treatment vs. drug free Traditional Oriental Therapy for hypertension, we reviewed the data from independent studies. Wu Cao Si Wu Tang was found to be as effective as allopathic medications in controlling blood pressure in a group of moderately hypertensive patients