Prevalence of osteoporosis in hysterectomised as compared to non-hysterectomized women in 7th decade of life

Background: Osteoporosis is considered as a major public health issue with fragility fractures of the hip, vertebrae and distal radius being the most important consequences. It has been said to be an age-related degenerative process. However, postmenopausal women develop this disease due to age-related bone mineral loss as well as due to declining levels of estrogen in the body following menopause leading to increased risk of fractures. Objectives of this study were to find out the prevalence of osteoporosis in hysterectomised and non-hysterectomised postmenopausal women in 7th decade of life.Methods: Descriptive cross-sectional study done on a total of 66 postmenopausal women who were in their 7th decade of life. They were divided into two groups, one consisting of 36 women who underwent natural menopause and the other group of 30 women who had surgical menopause. The bone mineral density of both the groups was measured using DEXA scan and comparison was done between these study groups.Results: Out of 30 hysterectomised subjects, 24 (80%) were found to be having osteoporosis, 6 (20%) had osteopenia and none had normal BMD. While out of 36 subjects in the non-hysterectomised group, 14 (38.88%) had osteoporosis, 16 (44.44%) had osteopenia and 6 (16.66%) subjects had normal BMD. Significant relation (p-value 0.001) was found on comparison of the study groups. In addition, significant positive correlation was between BMD and BMI whereas negative correlation was seen between BMD and parity.Conclusions: Hysterectomy was found to increase the incidence of osteoporosis. Obesity was found to have protective effect against bone mineral loss while increasing parity had a negative relation with BMD.

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Radiographic predictors for bone mineral loss

Bone and Joint Research ◽

10.1302/2046-3758.77.bjr-2017-0332.r1 ◽

2018 ◽

Vol 7 (7) ◽

pp. 468-475 ◽

Cited By ~ 3

Author(s):

Q-F. He ◽

H. Sun ◽

L-Y. Shu ◽

Y. Zhu ◽

X-T. Xie ◽

...

Keyword(s):

Bone Mineral ◽

Distal Femur ◽

Osteoporotic Fractures ◽

The Elderly ◽

The Body ◽

Screening Tools ◽

Mineral Density ◽

T Score ◽

Bone Mineral Loss ◽

Mineral Loss

Objectives Researchers continue to seek easier ways to evaluate the quality of bone and screen for osteoporosis and osteopenia. Until recently, radiographic images of various parts of the body, except the distal femur, have been reappraised in the light of dual-energy X-ray absorptiometry (DXA) findings. The incidence of osteoporotic fractures around the knee joint in the elderly continues to increase. The aim of this study was to propose two new radiographic parameters of the distal femur for the assessment of bone quality. Methods Anteroposterior radiographs of the knee and bone mineral density (BMD) and T-scores from DXA scans of 361 healthy patients were prospectively analyzed. The mean cortical bone thickness (CBTavg) and the distal femoral cortex index (DFCI) were the two parameters that were proposed and measured. Intra- and interobserver reliabilities were assessed. Correlations between the BMD and T-score and these parameters were investigated and their value in the diagnosis of osteoporosis and osteopenia was evaluated. Results The DFCI, as a ratio, had higher reliability than the CBTavg. Both showed significant correlation with BMD and T-score. When compared with DFCI, CBTavg showed better correlation and was better for predicting osteoporosis and osteopenia. Conclusion The CBTavg and DFCI are simple and reliable screening tools for the prediction of osteoporosis and osteopenia. The CBTavg is more accurate but the DFCI is easier to use in clinical practice. Cite this article: Q-F. He, H. Sun, L-Y. Shu, Y. Zhu, X-T. Xie, Y. Zhan, C-F. Luo. Radiographic predictors for bone mineral loss: Cortical thickness and index of the distal femur. Bone Joint Res 2018;7:468–475. DOI: 10.1302/2046-3758.77.BJR-2017-0332.R1.

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Thyroid Function within the Upper Normal Range Is Associated with Reduced Bone Mineral Density and an Increased Risk of Nonvertebral Fractures in Healthy Euthyroid Postmenopausal Women

Yearbook of Medicine ◽

10.1016/s0084-3873(11)00357-9 ◽

2011 ◽

Vol 2011 ◽

pp. 509-511

Author(s):

M. Schott

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Thyroid Function ◽

Bone Mineral ◽

Mineral Density ◽

Normal Range ◽

Nonvertebral Fractures ◽

Increased Risk

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Thyroid Function within the Upper Normal Range Is Associated with Reduced Bone Mineral Density and an Increased Risk of Nonvertebral Fractures in Healthy Euthyroid Postmenopausal Women

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2009-2630 ◽

2010 ◽

Vol 95 (7) ◽

pp. 3173-3181 ◽

Cited By ~ 99

Author(s):

Elaine Murphy ◽

Claus C. Glüer ◽

David M. Reid ◽

Dieter Felsenberg ◽

Christian Roux ◽

...

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Thyroid Function ◽

Bone Mineral ◽

Mineral Density ◽

Normal Range ◽

Nonvertebral Fractures ◽

Increased Risk

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Prevalence of osteoporosis and osteoporotic fractures in postmenopausal women with type 2 diabetes mellitus

Beyond Rheumatology ◽

10.4081/br.2021.71 ◽

2021 ◽

Vol 3 (3) ◽

Author(s):

Lamia Oulkadi ◽

Bouchra Amine ◽

Imane El binoune ◽

Samira Rostom ◽

Rachid Bahiri

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Postmenopausal Women ◽

Mineral Density ◽

Control Subjects ◽

Increased Risk ◽

Significant Difference ◽

Prevalence Of Osteoporosis

Type 2 diabetes mellitus (T2DM) and osteoporosis are chronic diseases with increasing prevalence. The aim of this study was to determine the prevalence of osteoporosis and osteoporotic fracture in women with T2DM and to identify predictive factors of fracture occurrence. The prevalence of osteoporosis and fractures in postmenopausal women with T2DM was 23.1% and 16.9%, respectively. 46.2% of T2DM patients had normal bone mineral density (BMD) (P<0.01) and 58.5% of control subjects had osteopenia (P<0.01). Incidence of fracture in T2DM patients with osteopenia was significantly increased versus control subjects when stratified according the BMD (P=0.009). By stratifying T2DM patients according to fractures, factors that were significantly associated with occurrence included T2DM duration (P=0.038), use of insulin (P=0.017), and lower BMD (P=0.048). Our study suggests that there was a higher prevalence of fracture in T2DM patients compared to control subjects and a significant difference in BMD was found between the groups. We also showed that insulin use, low BMD, and long duration of T2DM are factors associated with an increased risk of bone fracture.

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Association Between moleculars and Osteoporotic Fracture Risk:A systematical review

10.1101/2020.03.31.20049429 ◽

2020 ◽

Author(s):

Jie-Yu Liu ◽

Jia-Xiang Wang ◽

Li Xu ◽

Shu-Feng Lei ◽

Fei-Yan Deng

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Elderly Population ◽

Early Recognition ◽

Osteoporotic Fractures ◽

Middle Aged ◽

Mineral Density ◽

Low Bone Mineral Density ◽

Increased Risk

AbstractOsteoporosis is a systemic chronic skeletal disease, which is characterized by low bone mineral density (BMD) and increased risk to osteoporotic fractures (OFs). OFs are associated with high mortality and morbidity, and seriously affect the life quality of patients. Osteoporosis is prevalent in the middle-aged and elderly population, especially the postmenopausal women. With population aging, osteoporosis becomes a world-wide serious public health problem. Early recognition of the high-risk population followed by timely and efficient intervention and/or treatment is important for preventing OFs. In light of the high heritability and complex pathogenesis of OP, comprehensive consideration of significant biological/biochemical factors is necessary for accurate risk evaluation. For this purpose, we reviewed recent research progress on moleculars which are diagnostic and/or predictive of OFs risk. Future integrative analyses and systematic evaluation of these moleculars may facilitate developing novel methodologies and/or test strategies, i.e., biochips, for early recognition of osteoporosis, hence to contribute to preventing OFs in the world.Graphical AbstractOsteoporosis, which is characterized by low bone mineral density (BMD) and increased risk to osteoporotic fractures (OFs), is prevalent in the middle-aged and elderly population, especially in the postmenopausal women. We focused on several types of important molecules, including proteins/peptides, RNAs, lipids, to gain comprehensive understanding and to generate novel perspectives in predicting and diagnosing OFs.

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Age-Related Bone Mineral Density, Bone Loss Rate, Prevalence of Osteoporosis, and Reference Database of Women at Multiple Centers in China

Journal of Clinical Densitometry ◽

10.1016/j.jocd.2007.05.004 ◽

2007 ◽

Vol 10 (3) ◽

pp. 276-284 ◽

Cited By ~ 37

Author(s):

Xiao-Guang Cheng ◽

Ding-Zhuo Yang ◽

Qi Zhou ◽

Tie-Jun Zhuo ◽

Hua-Chou Zhang ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Loss ◽

Bone Mineral ◽

Loss Rate ◽

Reference Database ◽

Mineral Density ◽

Age Related ◽

Bone Loss Rate ◽

Prevalence Of Osteoporosis

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Thyroid Function within the Upper Normal Range Is Associated with Reduced Bone Mineral Density and an Increased Risk of Nonvertebral Fractures in Healthy Euthyroid Postmenopausal Women

Yearbook of Endocrinology ◽

10.1016/j.yend.2011.05.018 ◽

2011 ◽

Vol 2011 ◽

pp. 107-109

Author(s):

M. Schott

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Thyroid Function ◽

Bone Mineral ◽

Mineral Density ◽

Normal Range ◽

Nonvertebral Fractures ◽

Increased Risk

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Comparison of Bone Mineral Density, T-Scores and Serum Zinc between Diabetic and Non Diabetic Postmenopausal Women with Osteoporosis

Journal of Laboratory Physicians ◽

10.4103/0974-2727.151681 ◽

2015 ◽

Vol 7 (01) ◽

pp. 043-048 ◽

Cited By ~ 7

Author(s):

Priyanka R Siddapur ◽

Anuradha B Patil ◽

Varsha S Borde

Keyword(s):

Bone Mineral Density ◽

Fracture Risk ◽

Postmenopausal Women ◽

Bone Mineral ◽

Mineral Density ◽

T Score ◽

Increased Risk ◽

Serum Zn ◽

Type 2 Diabetic

ABSTRACT Context: Postmenopausal osteoporosis is a public health problem. Diabetics are at increased risk of osteoporosis-related fractures. Zinc (Zn) has a role in collagen metabolism, and its levels are altered in diabetes. Aims: The aim was to compare bone mineral density (BMD), T-score and serum Zn between diabetic and nondiabetic postmenopausal women with osteoporosis to see if they influence increased fracture risk in diabetes. Settings and Design: It is a cross-sectional study conducted at Department of Biochemistry, Jawaharlal Nehru Medical College, Belgaum. Materials and Methods: Thirty type 2 diabetic and 30 age-matched (aged 45-75 years) nondiabetic Dual energy X-ray absorptiometry (DEXA) confirmed postmenopausal osteoporotics were included from January 2011 to March 2012. Serum Zn was analyzed by atomic absorption spectrophotometry. Statistical Analysis Used: Mean and standard deviation of the parameters of the two groups were computed and compared by unpaired Student's t-test. Relationship between variables was measured by Karl Pearson's correlation co-efficient. A statistical significance is set at 5% level of significance (P < 0.05). Results: T-score was significantly higher in diabetics compared with nondiabetics(−2.84 ± 0.42 vs. −3.22 ± 0.74) P < 0.05. BMD and serum Zn of diabetics showed a significant positive correlation with body mass index (BMI). Conclusions: Type 2 diabetic postmenopausal osteoporotics have a higher T-score than the nondiabetics. High BMI in type-2 diabetes mellitus (T2DM) may contribute to high BMD and may be a protective factor against zincuria. Increased fracture risk in T2DM could be due to other factors like poor bone quality due to hyperglycemia rather than BMD. Strict glycemic control is of paramount importance.

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