scholarly journals Fatal outcome in acute fatty liver of pregnancy and review of literature

2019 ◽  
Vol 8 (3) ◽  
pp. 1197
Author(s):  
Reena Rani ◽  
Asmita M. Rathore ◽  
Sangeeta Bhasin
Keyword(s):  
Fatty Liver ◽  
Clinical Symptoms ◽  
Fatal Outcome ◽  
Fetal Mortality ◽  
Review Of Literature ◽  
Third Trimester ◽  
Acute Setting ◽  
Clinical Criteria ◽  
Life Threatening ◽  
Acute Fatty Liver

Acute fatty liver of pregnancy (AFLP) is an uncommon life-threatening disorder of pregnancy seen commonly in third trimester. When not diagnosed at right time it can lead to hepatic failure, encephalopathy, coagulopathy, maternal and fetal mortality. The clinical symptoms and signs are nonspecific, and it needs to be identified early in order to prevent poor outcome. The gold standard for diagnosis of AFLP is liver biopsy, which is difficult in an acute setting and in abnormal coagulation profile hence the diagnosis is usually based on clinical criteria   Early termination of pregnancy and good intensive care support are the mainstay of management. The authors here presented a case report where even early delivery and good critical care failed to prevent maternal mortality. Review of literature regarding etiopathogenesis, management and recurrences of AFLP are also discussed.

scholarly journals Acute Fatty Liver of Pregnancy: A Life Threatening Condition

2020 ◽  
Vol 15 (1) ◽  
pp. 79-80
Author(s):  
Sarita Sitaula ◽  
Ajay Agrawal ◽  
Achala Thakur ◽  
Tara Manandhar ◽  
Babauram Dixit Thapa ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Postpartum Hemorrhage ◽  
Post Partum ◽  
High Morbidity ◽  
Third Trimester ◽  
Delay In Diagnosis ◽  
Threatening Condition ◽  
Life Threatening ◽  
Acute Fatty Liver ◽  
Catastrophic Disease

Acute Fatty Liver of Pregnancy (AFLP) is a rare but catastrophic disease affecting women in pregnancy. It usually occurs in the third trimester or post-partum period. Delay in diagnosis is associated with morbid complications with high morbidity and mortality. We report a case of 24 years old female at 38 weeks period of gestation who presented with jaundice, vomiting for 3 days and deranged liver function test. She was diagnosed as acute fatty liver of pregnancy and was delivered by instrumental delivery but required cesarean hysterectomy due to postpartum hemorrhage. She started improving with supportive care and discharged after 4 weeks of hospital stay. Key words: AFLP, Hysterectomy, Postpartum hemorrhage

scholarly journals STEATOSE HEPATIQUE AIGUE GRAVIDIQUE, UNE OBSERVATION ET REVUE DE LA LITTERATURE ACUTE FATTY LIVER OF PREGNANCY, AN OBSERVATION AND REVIEW OF LITERATURE

2020 ◽  
Vol 8 (11) ◽  
pp. 1141-1145
Author(s):  
Ouakasse Samira ◽  
◽  
Driouech Aicha ◽  
Erhaymini Khalil ◽  
Kabba Zineb ◽  
...  
Keyword(s):  
Hepatic Encephalopathy ◽  
Fatty Liver ◽  
Rare Condition ◽  
Symptomatic Treatment ◽  
Rapid Progression ◽  
Review Of Literature ◽  
Third Trimester ◽  
The Third ◽  
Stéatose Hépatique ◽  
Acute Fatty Liver

Acute fatty liver of pregnancy is a rare condition that occurs during the third trimester of pregnancy. Formerly regularly fatal, this pathology currently benefits from a better maternal and fetal prognosis, , due to earlier diagnosis, rapid delivery and symptomatic treatment. An observation is reported of a case which presented at a late stage after having developed a frank cutanocellular jaundice with significant hypertransaminasemia and thrombocytopenia and a drop in PT with a rapid progression to a picture of hepatocellular insufficiency associating a hepatic encephalopathy and hemostasis disorders.

scholarly journals Presumed acute fatty liver of pregnancy following influenza A hepatitis

2017 ◽  
Vol 10 (4) ◽  
pp. 186-188 ◽  
Author(s):  
Adam Morton
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Fatty Liver ◽  
Influenza A ◽  
Fatty Infiltration ◽  
Influenza Virus Infection ◽  
Acid Oxidation ◽  
Reye's Syndrome ◽  
Third Trimester ◽  
Acute Fatty Liver

Acute fatty liver of pregnancy is a rare mitochondrial hepatopathy characterised by microvesicular fatty infiltration, and is believed to be due to impaired fatty acid oxidation. Hepatitis following influenza virus infection is uncommon. Rarely influenza virus infection may be complicated by Reye's syndrome, another hepatic microvesicular fat disease. A case of influenza A hepatitis in third trimester of pregnancy, followed by the evelopment of presumed acute fatty liver of pregnancy is described in this report and a potential mechanism why this may have occurred is discussed.

Acute fatty liver of pregnancy associated with pancreatitis: A life-threatening complication

2004 ◽  
Vol 190 (2) ◽  
pp. 502-505 ◽  
Author(s):  
Julie S. Moldenhauer ◽  
John M. O'Brien ◽  
John R. Barton ◽  
Baha Sibai
Keyword(s):  
Fatty Liver ◽  
Life Threatening ◽  
Acute Fatty Liver ◽  
Life Threatening Complication

scholarly journals Uterine pseudoaneurysm on the basis of deep infiltrating endometriosis during pregnancy-a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tibor Andrea Zwimpfer ◽  
Cécile Monod ◽  
Katharina Redling ◽  
Heike Willi ◽  
Martin Takes ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Arterial Embolization ◽  
Symptomatic Patient ◽  
Interdisciplinary Treatment ◽  
Fetal Mortality ◽  
Deep Infiltrating Endometriosis ◽  
Increased Risk ◽  
Risk Of Rupture ◽  
Life Threatening ◽  
Infiltrating Endometriosis

Abstract Background Pseudoaneurysm of the uterine artery (UPA) is a rare cause of potentially life-threatening hemorrhage during pregnancy and puerperium. It is an uncommon condition that mainly occurs after traumatic injury to a vessel following pelvic surgical intervention, but also has been reported based on underlying endometriosis. There is an increased risk of developing UPA during pregnancy. Diagnosis includes clinical symptoms, with severe abdominal pain and is confirmed by sonographic or magnetic resonance imaging (MRI). Due to its potential risk of rupture, with a subsequent hypovolemic maternal shock and high fetal mortality, an interdisciplinary treatment should be considered expeditiously. Case presentation We present the case of a 34-year old pregnant symptomatic patient, where a large UPA was detected at 26 weeks, based on deep infiltrating endometriosis (DIE). The UPA was successfully treated by selective arterial embolization. After embolization, the pain decreased but the woman still required intravenous analgesics during follow-up. At 37 weeks she developed a sepsis from the intravenous catheter which led to a cesarean section and delivery of a healthy boy. She was discharged 10 days postpartum. Conclusions UPA should be considered in pregnant women with severe abdominal and pelvic pain, once other obstetrical factors have been excluded. DIE might be the underlying diagnosis. It is a rare but potentially life-threatening condition for mother and fetus.

scholarly journals Acute Fatty Liver of Pregnancy

2006 ◽  
Vol 20 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Hin Hin Ko ◽  
Eric Yoshida
Keyword(s):  
Fatty Liver ◽  
Acid Metabolism ◽  
Third Trimester ◽  
Fatal Complication ◽  
The Third ◽  
Early Postpartum Period ◽  
Early Postpartum ◽  
Imaging Results ◽  
Acute Fatty Liver ◽  
Cholestasis Of Pregnancy

Acute fatty liver of pregnancy (AFLP) is a rare, potentially fatal complication that occurs in the third trimester or early postpartum period. Although the exact pathogenesis is unknown, this disease has been linked to an abnormality in fetal fatty acid metabolism. Early diagnosis of AFLP sometimes can be difficult because it shares features with other common conditions such as pre-eclampsia, viral hepatitis and cholestasis of pregnancy. However, a careful history and physical examination, in conjunction with compatible laboratory and imaging results, are often sufficient to make the diagnosis, and liver biopsy is rarely indicated. Supportive care and expeditious delivery are essential to optimal maternal-fetal outcomes and remain as the mainstay treatment for AFLP.

scholarly journals Acute Fatty Liver Disease of Pregnancy in the Second Trimester

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Faraz Afridi ◽  
Michael Feely ◽  
Raju Reddy
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Fulminant Liver Failure ◽  
Second Trimester ◽  
Third Trimester ◽  
Fetal Demise ◽  
The Third ◽  
History Of ◽  
Acute Fatty Liver

Acute fatty liver of pregnancy (AFLP) is a rare disorder that typically presents in the third trimester. We report a case of a 21-year-old woman with a history of intrauterine fetal demise at 19 weeks’ gestation who developed fulminant liver failure 1 week after the fetal demise. She was diagnosed with AFLP as per the Swansea criteria. An orthotopic liver transplant was attempted but was unsuccessful. AFLP usually presents between the 30th to 38th weeks of gestation. However, it can occur in the postpartum period after only 19 weeks of gestation as highlighted in our case.

scholarly journals Liver diseases unique to pregnancy

Medicina ◽  
2008 ◽  
Vol 44 (5) ◽  
pp. 337 ◽  
Author(s):  
Jūratė Kondrackienė ◽  
Limas Kupčinskas
Keyword(s):  
Fatty Liver ◽  
Liver Diseases ◽  
Hyperemesis Gravidarum ◽  
Correct Diagnosis ◽  
Late Pregnancy ◽  
First Trimester ◽  
Third Trimester ◽  
Liver Disorders ◽  
Elevated Liver Enzymes ◽  
Acute Fatty Liver

The aim of this review article is to improve knowledge of the liver disease in pregnancy. The article summarizes the results of own experience and the recent reviews of liver disorders unique to pregnancy. Abnormalities in liver tests occur in 3% of pregnancies with causes ranging from self-limiting to rapidly fatal. In Kaunas University of Medicine Hospital, a retrospective analysis disclosed a rate of 0.52% of liver diseases in 16252 pregnant women over a 5-year period. Several liver diseases occur only during pregnancy and are considered to be associated with the pregnant state. The liver disorders unique to pregnancy have characteristic clinical features and timing of onset. Hyperemesis gravidarum occurs in the first trimester, intrahepatic cholestasis of pregnancy in the second or third trimester, preeclampsia, HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome, and acute fatty liver of pregnancy usually in the third trimester. The disorders of late pregnancy – preeclampsia, HELLP syndrome, and acute fatty liver of pregnancy – may progress to severe liver dysfunction. The correct diagnosis is critical, as any delay can result in morbidity or mortality of both the mother and fetus. Early delivery and advances in supportive management are the only available option for improving the prognosis.

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