scholarly journals Lactate dehydrogenase levels in preeclampsia and its correlation with maternal and perinatal outcome

2019 ◽  
Vol 8 (4) ◽  
pp. 1505
Author(s):  
Nirmala Bhandari ◽  
Anjali Gupta ◽  
Simmi Kharb ◽  
Meenakshi Chauhan
Keyword(s):  
Lactate Dehydrogenase ◽  
Pregnant Women ◽  
Perinatal Outcome ◽  
Serum Lactate Dehydrogenase ◽  
Hypertensive Disorder ◽  
Perinatal Complications ◽  
Maternal Complications ◽  
Singleton Pregnancy ◽  
Intracellular Enzyme ◽  
Potential Marker

Background: Hypertensive disorder of pregnancy occurs in approximately 6-8% of all pregnancies. The most serious consequences for the mother and the baby are the result of preeclampsia and eclampsia. Lactate Dehydrogenase (LDH) is an intracellular enzyme. Recently LDH has been suggested as potential marker to predict severity of pre-eclampsia. The objective of the present study was to compare the serum lactate dehydrogenase levels in women with preeclampsia and normal pregnant women and to correlate lactate dehydrogenase levels with maternal and perinatal outcome in preeclampsia.Methods: An observational prospective study was conducted on 200 antenatal women attending the labour room emergency. Women with singleton pregnancy and cephalic presentation, from 28 weeks onwards were enrolled in the study. Out of 200, 100 were normal pregnant women and 100 were preeclamptic women. Serum LDH levels were measured in all women and maternal and perinatal outcome was assessed in terms of LDH levels.Results: Higher levels of LDH was observed in pregnant women with preeclampsia (627.38±230.04 IU/l) as compared to normal pregnant women (224.43±116.61 IU/l). The maternal complications were found to be maximum in women with LDH > 800 IU/l.  Abruption was the most common complication. The perinatal mortality and neonatal deaths were found to have significant correlation with high LDH levels.Conclusions: Maternal and perinatal complications were associated with higher LDH levels in preeclampsia patients. Serum LDH levels can be offered to all patients of preeclampsia and can be used to predict the prognosis of preeclampsia.

scholarly journals MATERNALAND PERINATAL OUTCOME IN PREECLAMPSIAAND ECLAMPSIA IN RELATION TO LDH LEVELS

2020 ◽  
pp. 53-54
Author(s):  
Priti Singh ◽  
Krishna Sinha
Keyword(s):  
Pregnant Women ◽  
Perinatal Outcome ◽  
Case Control Study ◽  
Perinatal Outcomes ◽  
Common Complication ◽  
Maternal Complications ◽  
Intracellular Enzyme ◽  
Potential Marker ◽  
Severity Of The Disease ◽  
Control Study

Lactate Dehydrogenase (LDH) is an intracellular enzyme. Recently LDH has been suggested as potential marker to predict severity of pre- eclampsia. The aim of present study was to correlate LDH levels in pregnant women and women with Preeclampsia and eclampsia in antepartum period and to correlate maternal and perinatal outcomes with LDH levels. Pregnant women in this study were enrolled in 3rd. trimester from 28 weeks onwards . Case control study was done in 100 women with normal B.P and in another 100 women having Pre-eclampsia and Eclampsia. Serum LDH levels were measured in all women and maternal and perinatal outcome was assessed. A significant positive correlation was found in patients with Pre-eclampsia and Eclampsia . LDH levels gradually increased with increase in the severity of the disease.Regular monitoring of serum LDH levels in such patients may help in detecting severity of the disease and associated end organ damage.The maternal complications were found to be maximum in women with LDH > 800 IU/l. Abruption was the most common complication.

SERUM LACTATE DEHYDROGENASE AS A BIOCHEMIAL MARKER FOR MATERNAL AND PERINATAL OUTCOME IN PRE-ECLAMPSIA

2021 ◽  
pp. 101-106
Author(s):  
Jyotika Singh
Keyword(s):  
Lactate Dehydrogenase ◽  
Pregnant Women ◽  
Perinatal Outcome ◽  
Cell Injury ◽  
Cell Damage ◽  
Serum Lactate Dehydrogenase ◽  
P Value ◽  
Intracellular Enzyme ◽  
Body Tissues ◽  
Severity Of The Disease

Background: Pre-eclampsia affects about 5-10% of all pregnancies and is a major cause of maternal, fetal and neonatal morbidity and mortality, particularly in developing countries. FOGSI and other studies show the incidence of pre eclampsia in India ranges between 11-13%. Lactate Dehydrogenase (LDH) is mainly an intracellular enzyme. LDH is present in many body tissues, especially heart, liver, kidney, skeletal muscle, brain, blood cells and lungs. Its level is increased in the scenario of increased cell injury, hemolysis and cell death. Cellular enzymes in the extracellular space although of no further metabolic function in this space, are still of benet because they serve as indicators suggestive of disturbance of cellular integrity induced by pathological conditions and is used to detect cell damage or cell death.This can be further used as help in making decision, regarding the management strategies to improve the maternal and foetal outcome. Objectives: To compare serum LDH levels in the normal pregnant women and in women with preeclampsia and eclampsia in ante-partum period and to correlate the severity of the disease, maternal and perinatal outcome with Lactic Dehydrogenase (LDH) levels in serum in patients of pre-eclampsia and eclampsia. Material and Methods: A prospective comparative study was conducted in the department of Obstetrics and Gynaecology, Ispat General Hospital, Rourkela. Out of 150 women studied, 50 were normal pregnant women, 32 were of mild preeclampsia, 35 were of severe preeclampsia and 33 of eclampsia. The statistical analysis was done by Chi-square test, Fischer Exact test, analysis of variance and student ''t'' test (two tailed and independent). Results: LDH levels were signicantly elevated in women with preeclampsia and eclampsia (p value <0.001). LDH levels had signicant direct correlation with increasing blood pressure (p value <0.001) as well as poor maternal and perinatal outcome. Conclusion: High serum LDH levels correlate well with the severity of the disease and poor maternal and fetal outcomes in patients of preeclampsia and eclampsia and can be considered as a supportive biochemical and prognostic marker from early third trimester.

scholarly journals Twin pregnancy, the study of maternal and perinatal outcome: what being a twin is like?

2019 ◽  
Vol 8 (11) ◽  
pp. 4457
Author(s):  
Smitha K. ◽  
Jasiya Afreen M. H.
Keyword(s):  
Perinatal Outcome ◽  
Twin Pregnancy ◽  
Mode Of Delivery ◽  
Neonatal Morbidity ◽  
Hyaline Membrane Disease ◽  
Perinatal Complications ◽  
Maternal Complications ◽  
Singleton Pregnancy ◽  
Risk Pregnancy ◽  
Twin Pregnancies

Background: Twin pregnancy is considered as a high-risk pregnancy due to associated high maternal and perinatal morbidity mortality in comparison with singleton pregnancy. The objectives of this study were to study the maternal and perinatal complications in twin pregnancies. To find out various factors that contribute to adverse perinatal outcome.Methods: This retrospective study was conducted at Kempegowda Institute of Medical Sciences Hospital, Bengaluru. 92 women with twin pregnancies admitted in KIMS Hospital from September 2014 to September 2018, both booked and referred patients were studied. Individual patient parameters like age, parity, gestational age, mode of delivery, maternal complications were tabulated. Neonatal morbidity and mortality were noted, data thus obtained was analysed and results studied.Results: In the study the incidence of twin pregnancies was more in second gravida (53%). 72% of the patients were admitted between 28-36 weeks of gestation with preterm labour (23%) as the main cause for admission. Anaemia (8.69%), hypertensive disorders of pregnancies (17.39%), PPROM (21%), single foetal demise (5%) and IUGR (5.4%) were the antenatal complications observed. Out of the 92 patients, 29 (35.4%) patients delivered by vaginal route whereas 53 (64.6%) had to undergo C-section. DCDA twin constituted 66% of twins in the study and mal presentation was the commonest indication for caesarean section (50%). Among the 164 babies out of 92 twin pregnancies 8 babies were still born and 12 babies died by the end of one week due to complications related to prematurity like hyaline membrane disease, IVH.Conclusions: Early detection of twin pregnancies and proper antenatal care reduces both maternal and perinatal complication thereby improving maternal and perinatal outcome.

scholarly journals Serum lactate dehydrogenase (LDH) level in mild and severe preeclampsia as a prognostic marker

2018 ◽  
Vol 7 (10) ◽  
pp. 3969
Author(s):  
Radheshyam Bairwa ◽  
Suhail Iqbal
Keyword(s):  
Lactate Dehydrogenase ◽  
Laboratory Data ◽  
Elevated Serum ◽  
Serum Lactate ◽  
Severe Preeclampsia ◽  
Serum Lactate Dehydrogenase ◽  
Close Monitoring ◽  
Intracellular Enzyme ◽  
Potential Marker ◽  
Control Serum

Background: Lactate Dehydrogenase (LDH) is mainly an intracellular enzyme. Its level is an useful biomarker for cellular injury which may suggested as a potential marker to predict the severity of preeclampsia and indicator for multi-organ involvement have significant role in management of preeclampsia. We conducted this study to examine the relationship between lactate dehydrogenase concentration and the severity of the disease and occurrence of complications. The objective of the present study was to assess role of serum LDH level in mild and severe preeclamptic womenMethods: This prospective study was conducted in the Department of obstetrics and gynecology in Jhalawar medical college from Jan 2017 to Oct 2017 Total 120 pregnant women during third trimester (32-40 weeks) aged 18 to 35 years were selected. Among them 40 were severe preeclampsia and 40 were mild preeclampsia patients and 40 were healthy normotensive control. Serum LDH level was estimated by continuous spectrophotometric method. Demographic, hemodynamic, and laboratory data were compared among the three groups. The symptoms and complications of severe pre-eclampsia along with foetal outcome were analyzed according to the levels of LDH.Results: In this study, serum LDH level was significantly higher (P<0.001) in preeclamptic compared to those of control. Again, this value was significantly higher in severe preeclamptic than those of mild preeclamptic. The symptoms and complications of preeclampsia along with perinatal mortality were increased significantly in patents with LDH> 800IU/I compared with those who had lower levels.Conclusions: From this study, it can be concluded that elevated serum LDH level is associated with severity of preeclampsia. LDH has been evaluated as a biochemical marker for preeclampsia and as a prognosticator of the disease severity. Detection of high-risk patients with increased levels of LDH mandate close monitoring and management to prevent maternal and fetal morbidity and mortality.

scholarly journals Comparison of modified biophysical profile and Doppler ultrasound in prediction of perinatal outcome in high-risk pregnancies

2020 ◽  
Vol 9 (7) ◽  
pp. 2808
Author(s):  
Khushboo Malhotra ◽  
Archana Kumari ◽  
H. P. Anand
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Perinatal Outcome ◽  
Umbilical Artery ◽  
P Value ◽  
Fisher Exact Test ◽  
Perinatal Complications ◽  
Singleton Pregnancy ◽  
Biophysical Profile ◽  
Umbilical Artery Doppler

Background: The objective of this present study was to compare MBPP and umbilical artery Doppler flow in high-risk pregnant women in prediction of perinatal outcome.Methods: A cohort study was done on 150 high-risk pregnant women over 16 months. Antenatal women with singleton pregnancy who delivered within 48 hours of performing MBPP and Doppler USG, with presence of ≥1 high-risk factor like pre-eclampsia/gestational HTN, BOH, post-dated pregnancy, FGR, GDM, maternal heart disease, anaemia, hypothyroidism and IHCP were included in the study. MBPP (NST and AFI) and umbilical artery Doppler was performed. Perinatal outcome was measured in terms of stillbirth/IUD, LBW, Apgar <7 at 5 minutes, admission to NICU, neonatal death within 48 hours of delivery, MSL and neonatal seizures within 24-48 hours. Quantitative variables were compared using independent t-test/Mann Whitney test. Qualitative variables were correlated using Chi square test/Fisher exact test. Sensitivity, specificity, NPV, PPV were calculated and p-value <0.05 was considered statistically significant. Data analysis was done using social sciences (SPSS) licensed version 21.0.Results: Majority belonged to the age group 21-25 years and were between 37-40 weeks of gestation. It was found that highest perinatal complications occurred in those with both abnormal MBPP and Doppler followed by those with only abnormal MBPP (p-value<0.0001).Conclusions: MBPP is a better predictor of perinatal outcome compared to umbilical artery Doppler USG in high-risk pregnant women. MBPP should be done in all high-risk pregnancies even if Doppler is normal. Both the tests must be performed in all high-risk pregnancies to improve perinatal outcome.

scholarly journals A correlation of lactate dehydrogenase enzyme levels in pregnancy induced hypertensive disorders with severity of disease, maternal and perinatal outcome

2017 ◽  
Vol 6 (10) ◽  
pp. 4302 ◽  
Author(s):  
Neha V. Bhave ◽  
Parmanand K. Shah
Keyword(s):  
Lactate Dehydrogenase ◽  
Pregnant Women ◽  
Vascular Function ◽  
Perinatal Outcome ◽  
Gestational Hypertension ◽  
Hypertensive Disorder ◽  
Severity Of Disease ◽  
Hypertensive Disorders ◽  
Dehydrogenase Enzyme ◽  
In Pregnancy

Background: A spectrum of hypertensive disorders in pregnancy contribute to maternal and perinatal morbidity and mortality. For prediction and early diagnosis of preeclampsia various biochemical markers, vascular function test and renal markers have been developed. The objective of the study is to measure the lactate dehydrogenase enzyme (LDH) levels in pregnant women with pregnancy induced hypertensive disorders and correlate the levels with the severity of condition, maternal and the perinatal outcome.Methods: In this prospective observational study, a total of 150 pregnant women were studied. Out of these 150 women, 30 women had normal blood pressure, 30 women had gestational hypertension, 30 women had mild preeclampsia, 30 women had severe preeclampsia and 30 women had eclampsia. The serum LDH levels were measured in third trimester and patients followed up until early postpartum period and babies were followed up till early neonatal period to assess the maternal and neonatal outcomes.Results: Higher lactate dehydrogenase enzyme (LDH) levels were observed in pregnant women with severe form of hypertensive disorder and those who had a poor maternal and perinatal outcome. This is statistically significant (p<0.001).Conclusions: Lactate dehydrogenase enzyme (LDH) level is a useful biochemical marker to assess and predict the severity of disease, maternal and perinatal outcome as higher levels of the enzyme are associated with worsening severity of disease, a poor maternal and perinatal outcome.

scholarly journals Maternal serum lactate dehydrogenase level and adverse pregnancy outcomes in women with hypertensive disorder of pregnancy at a tertiary care centre: a retrospective study

2021 ◽  
Author(s):  
Disha Ajila ◽  
Aishwarya Raja ◽  
Pradeep Ganiga
Keyword(s):  
Retrospective Study ◽  
Lactate Dehydrogenase ◽  
Pregnant Women ◽  
Gestational Hypertension ◽  
Tertiary Care ◽  
Research Centre ◽  
Serum Lactate Dehydrogenase ◽  
Hypertensive Disorder ◽  
Apgar Scores ◽  
Hypertensive Disorder Of Pregnancy

Background: Hypertensive disorder of pregnancy affect 6-8% of all pregnancies, contributing immensely to maternal morbidity and mortality. Thus, presence of lactate dehydrogenase (LDH) signifies tissue damage and haemolysis. The aim of the study was to correlate LDH levels with blood pressure ranges and maternal and foetal outcome in women with gestational hypertension, pre-eclampsia.Methods: This retrospective study was conducted in the department of obstetrics and gynaecology of AJ Institute of Medical Sciences and Research Centre, Mangalore for a period of 1 year (January 2020 to January 2021). Based on the eligibility criteria, 52 hypertensive pregnant women were enrolled as cases.Results: Mean±SD period of gestation at delivery was lowest (34.57±1.39 weeks) for pregnant women with S. LDH levels>800 IU/l, whereas with S. LDH<00 IU/l delivered at around 37 weeks of gestation. Mean Apgar scores were lowest for the babies born to hypertensive pregnant women>800 IU/l, mean±SD Apgar scores at the end of 1 min, 5 minutes and 10 min were 4.42±0.79, 4.75±2.26 and 5.50±2.65 respectively.Conclusions: It can be concluded that S. LDH has the potential to be considered as a screening tool or predictor of the outcome of pregnancy in women with hypertensive disorders of pregnancy. However, studies of larger magnitude may be required to confirm the presence and the strength of association of S. LDH levels with pregnancy outcome.

scholarly journals Antenatal thyroid screening and its clinical correlation

2017 ◽  
Vol 6 (5) ◽  
pp. 1864
Author(s):  
Juhi Sisodia ◽  
Meena Samant
Keyword(s):  
Pregnant Women ◽  
Perinatal Outcome ◽  
Fetal Distress ◽  
First Trimester ◽  
Control Group ◽  
Intrauterine Death ◽  
Perinatal Complications ◽  
Maternal Complications ◽  
Serum Tsh ◽  
In Pregnancy

Background: The study of hypothyroidism in pregnancy was done with the aim of determining the effect of hypothyroidism on maternal and perinatal outcome. This study also aimed to decide whether universal screening of pregnant women for hypothyroidism is justified.Methods: A prospective observational study was done over a period of 1 year from October 2011 to September 2012, on pregnant women attending the OPD of Obs and Gynae department. Serum TSH is the most convenient and best test to diagnose hypothyroidism in pregnancy in first trimester. Ideal serum TSH level during pregnancy is 0.5-2.5µIU/ml in first trimester and 0.5-3µIU/ml in second and third trimester. First trimester booking visit is the ideal time for initial evaluation. Thereafter serum TSH should be measured at 6 weeks interval for necessary dose adjustments. Levothyroxine is the drug of choice. It should be started at 1.6-2µg/kg/day. If serum TSH is raised but fT4 is normal, treatment can be started with 25-75µg/day.Results: Inadequately treated hypothyroid pregnant women had higher incidence of maternal complications in comparison to adequately treated hypothyroid patients, like threatened abortion (11.1% vs 1.5%), antepartum hemorrhage (7.4% vs 1.5%), premature rupture of membrane (14.8% vs 3.0%), preterm labour (18.5% vs 1.5%), postpartum hemorrhage (9.3% vs 4.5%), anemia (16.7% vs 9.1%) and intrauterine death (9.3% vs 0%). Perinatal complications were also higher like fetal distress (33.3% vs 13.6%) and low birth weight (16.7% vs 4.5%).Incidence of caesarean section was higher in hypothyroid women in comparison to control group (29.2% vs 19.2%).Conclusions: This study shows that there is an association between inadequately treated hypothyroidism and adverse maternal and perinatal outcome. Those who were detected early and adequately treated had outcome similar to control group.

scholarly journals Serum Lactate Dehydrogenase Level in Pregnancy Induced Hypertension and Fetomaternal Outcome

2021 ◽  
Vol 23 (4) ◽  
pp. 275-280
Author(s):  
Sarmila Prajapati ◽  
Bekha Laxmi Manandhar ◽  
Suvana Maskey ◽  
Jyoti Sharma
Keyword(s):  
Lactate Dehydrogenase ◽  
University Teaching ◽  
Serum Lactate Dehydrogenase ◽  
Hypertensive Disorder ◽  
Pregnancy Induced Hypertension ◽  
Maternal Complications ◽  
Elevated Liver Enzymes ◽  
Induced Hypertension ◽  
Fetal Complications ◽  
In Pregnancy

Hypertensive disorders complicate 5-10% of all pregnancies and associated with potentially dangerous maternal and fetal complications. Studies have shown that pre-eclamptic patients with higher levels of lactate dehydrogenase (LDH) are at high risk of developing subsequent complications with poor maternal and fetal outcome. So with the aim to correlate serum LDH level in pregnancy induced hypertension (PIH) with fetomaternal outcome this hospital based observational descriptive study was done at Tribhuvan University Teaching Hospital (TUTH) for the duration of 1 year from 15th May, 2018 to 14th May, 2019. Women with PIH fulfilling inclusion criteria were enrolled in the study. Serum LDH level was measured and severity of PIH, maternal and perinatal outcome were studied according to the levels of LDH. Results were analyzed using SPSS 18. The incidence of hypertensive disorder in pregnancy was 4.74% in this study and total 180 cases were enrolled. The mean serum LDH level increased with increase in severity of PIH. Thirty two (17.7%) cases had maternal complications and hemolysis elevated liver enzymes and low platelet (HELLP) syndrome was most common complication. More than 2/3rd (62.5%) of cases with LDH level >800 IU/L had complications. The most common perinatal complication was intrauterine growth restriction (IUGR). The perinatal morbidity and mortality were significantly high in patients with PIH with LDH level >800 IU/l. As with the increase in serum LDH level increase in maternal and fetal complications was observed, LDH can be a useful biochemical marker that reflects the severity of PIH.

scholarly journals Serum lactate dehydrogenase as a biochemical marker for maternal outcome in pre-eclampsia

2021 ◽  
Vol 10 (12) ◽  
pp. 4541
Author(s):  
Gitanjali Kumari ◽  
Vaishali Taralekar ◽  
Suchita Dabhadakr
Keyword(s):  
Lactate Dehydrogenase ◽  
Elevated Serum ◽  
Perinatal Outcomes ◽  
Serum Lactate ◽  
Cellular Damage ◽  
Serum Lactate Dehydrogenase ◽  
Hypertensive Disorder ◽  
Close Monitoring ◽  
Intracellular Enzyme ◽  
Organ Systems

Background: LDH is a cytoplasmic intracellular enzyme present in the heart, kidney, muscle, leukocytes and erythrocytes, of all major organ systems. The presence of LDH in extracellular space points towards cellular damage, endothelial dysfunction. Preeclampsia is a multisystem disorder during pregnancy causing cellular damage or death. Hence, serum LDH levels can be helpful in determining the extent of cell damage and the seriousness of this disease. The present study aimed to correlate the maternal serum lactate dehydrogenase levels with maternal and perinatal outcomes in women with pre-eclampsia.Methods: It was a prospective observational study. A total of 120 antenatal patients diagnosed with hypertensive disorder of pregnancy were included in this study. Serum LDH levels were estimated by enzymatic method on the autoanalyzer. Patients were grouped into 3 categories according to serum LDH levels: a) <600 IU/l, b) 600-800 IU/l c) >800 IU/l. Clinical manifestation of development of complications of hypertensive disease and its relation with serum LDH in respective patients were analyzed.Results: An LDH level of more than 800 IU/l was seen in 19.2% while between 600 to 800 IU/l was seen in 16.7% cases. A significant association was observed between incidence of maternal complications with high LDH levels (p<0.01). High LDH levels were observed to be associated with development of ante-partum haemorrhage, eclampsia and requirement of ICU admission. No significant association was found between different categories of LDH and deep tendon reflexes, levels of proteinuria at the time of admission in these preeclamptic women.Conclusions: Close monitoring and early intervention of the preeclampsia patients with elevated serum LDH levels can help avoid adverse effects of the disease and thereby help improve maternal and perinatal outcomes in pregnant women with preeclampsia.

Sign in / Sign up

Export Citation Format

Share Document