scholarly journals A retrospective study on indications and histopathological analysis of non-oncological hysterectomies in a tertiary care hospital

2020 ◽  
Vol 9 (12) ◽  
pp. 5050
Author(s):  
Ananthi Kasinathan ◽  
Himabindu Nagulapally
Keyword(s):  
Retrospective Study ◽  
Clinical Diagnosis ◽  
Ovarian Cyst ◽  
Preoperative Evaluation ◽  
Tertiary Care ◽  
Pelvic Organ ◽  
Clinical Indication ◽  
Histopathological Analysis ◽  
Histopathological Diagnosis ◽  
Care Hospital

Background: An increase in the number of women undergoing hysterectomy especially in South India is of great concern. Whenever hysterectomy is performed, it is imperative that clinical diagnosis is accurate. The purpose of current study is to assess whether the histopathological diagnosis after surgery is correlated with the clinical diagnosis. Methods: This is a retrospective study conducted in the department of obstetrics and gynaecology at Indira Gandhi medical college and research institute Puducherry, from January 2018 to December 2018. Patients, who underwent hysterectomy for benign causes, were included in the study. Data was collected from the patients' case records. Whether the histopathological diagnosis was in tandem with the clinical diagnosis, was notedResults: Out of the 234 hysterectomies performed, 46.15% were by abdominal route and 53.84% were by vaginal route. 24.7% were TAH with BSO with mean age of 49.72 years. VH with PFR (46.5%) was the most common surgery done. Out of the 80 cases of fibroid, 66 (28.2%) were confirmed on histopathology. Histopathological diagnosis corroborated the clinical diagnosis in patients with ovarian cyst, fibroid with ovarian cyst and DUB. Adenomyosis was validated in 7 of 9 cases. Endometriosis of ovary was confirmed in 4 (1.7%) cases. In patients with pelvic organ prolapse, histopathology showed atrophic changes.Conclusions: Accurate clinical diagnosis, supported by in-depth preoperative evaluation and a sound clinical knowledge helps to avoid unnecessary hysterectomies. It is imperative to study the histopathology of the operated specimen and confirm the appropriateness of the clinical indication.

scholarly journals Histopathological analysis of hysterectomy specimens in a tertiary care centre: study of 160 cases

2019 ◽  
Vol 6 (8) ◽  
pp. 2856
Author(s):  
Roopali Jandial ◽  
Mehnaz Choudhary ◽  
Kuldeep Singh
Keyword(s):  
Clinical Diagnosis ◽  
Tertiary Care ◽  
Life Time ◽  
Total Abdominal Hysterectomy ◽  
Clinical Indication ◽  
Histopathological Analysis ◽  
Histopathological Diagnosis ◽  
Cervical Lesions ◽  
Tertiary Care Centre ◽  
Wide Range

Background: Hysterectomy is the most commonly performed gynaecological surgery as the female reproductive system has been affected by various non-neoplastic and neoplastic conditions during the life time of a woman.Methods: This retrospective study was conducted on 160 hysterectomy specimens reported to Department of Pathology. They were compared in terms of age of the patients and pathology of hysterectomy specimens. The histopathological findings of hysterectomy specimens was noted and these findings were then correlated with clinical diagnosis. The aim of the study was to evaluate the wide range of pathological lesions, commonest pathology involved and correlation of the preoperative clinical diagnosis with the histopathological diagnosis in the hysterectomy specimens.Results: The most common type of hysterectomy was total abdominal hysterectomy with bilateral salpingo-ophorectomy with 102 cases (63.7%). Peak incidence at 5th decade of life in 92 cases (57.5%) was noted. The most common clinical indication was fibroid uterus in 81 cases (50.6%). Proliferative phase of endometrium was the commonest finding in 87 cases (54.3%). In case of myometrium, 95 leiomyomas were noted. On histomorphological study of cervical lesions, chronic cervicitis was commonest finding in 75 (46.8%) cases.Conclusions: Few double pathologies can be missed clinically so clinico-pathological correlation in all cases of hysterectomy has been proved to be important to improve the clinical outcome and post-operative management.

scholarly journals A retrospective clinico-pathological study of hysterectomy cases in a tertiary care hospital in India – a review of 950 cases.

2018 ◽  
Vol 17 (1) ◽  
pp. 88-92
Author(s):  
Pal Subrata ◽  
Chakrabarti Srabani ◽  
Sinha Anuradha ◽  
Phukan Jyoti Prakash ◽  
Bose Kingshuk ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Medical Science ◽  
Abdominal Hysterectomy ◽  
Uterine Bleeding ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Dysfunctional Uterine Bleeding ◽  
Common Indication

Introduction: Hysterectomy is the most commonly performed gynaecological surgery in India as well as in abroad. It is frequently done in myometrial and endometrial pathologies and rarely for other causes. Hysterectomy is definitive management for diseases like fibroid, adenomyosis, dysfunctional bleeding, prolapsed uterus and malignant lesions of uterus and adenexa. We aimed our study to observe incidence of different pathologies of uterus and other reproductive organs in hysterectomy specimens and retrospective correlation between clinical diagnosis and histopathological finding of hysterectomy cases.Materials and Methods: Retrospective data were collected from our routine histopathological laboratory. Detailed history, clinical examination and operative findings and provisional diagnosis of all 950 hysterectomy cases were recorded during study period of 2 years. Histopathological diagnosis was correlated with clinical and preoperative diagnosis.Observations: Abdominal hysterectomy (734 cases, 77.26%) was the most common route of approach during surgery. Common pre-operative diagnoses were fibroid uterus (32%), dysfunctional uterine bleeding (28.95%), uterine prolapsed (22.74%). Other causes included uterine polyps (1.6%), complications of pregnancy (2.74%), ovarian tumours (8.42%), cervical carcinomas (2.97%) etc. Common pathologies on histology were leiomyoma (32%), adenomyosis (20.32%), atrophic endometrium (17.26%) and endometrial pathology (8.95%).Discussion: Our study has been correlated with other studies of India and other south Asian countries. Most common indication of hysterectomy in our study is dysfunctional uterine bleeding (32%) but Gupta et al and Jha R et al found utero-vaginal prolapse as most common indication. Leiomyoma was the most common histology diagnosed in the present series. Clinical diagnosis was possible in 67.57% cases in our study similar to Khan et al (70.51%).Conclusions: Histopathological examination of hysterectomy specimens helps to detect the exact causes and underlined pathology.Bangladesh Journal of Medical Science Vol.17(1) 2018 p.88-92

scholarly journals Necessity of routine histopathological examination of gall bladder specimens after elective cholecystectomy: An experience at Tertiary Care Hospital of Southern Punjab Pakistan

2020 ◽  
Vol 27 (06) ◽  
pp. 1171-1175
Author(s):  
Sadaf Shafique ◽  
Raheel Khan ◽  
Raees Abbas ◽  
Bakhtawer Mehmood
Keyword(s):  
Gall Bladder ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Pathological Examination ◽  
Histopathological Analysis ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Benign Diseases ◽  
Selective Approach ◽  
Elective Cholecystectomy

Objectives: Few centers adopt a selective approach in sending these specimens to pathology department for histopathology whereas it is a routine procedure in our setup. In our study, few unexpected cases of adenocarcinoma of gall bladder were seen during investigation of results of pathological examination of gall bladder specimens. Study Design: A retrospective histopathological analysis of gall bladder specimens removed during elective cholecystectomy for benign diseases was done. Setting: Department of Pathology, Quaid-e-Azam Medical College/Bahawal Victoria Hospital Bahawalpur. Period: 1st January 2018 to 31st December 2018. Material & Methods: The demographic properties of the patients were evaluated from the past records and their association was seen with the histopathological diagnosis and frequency of unexpected cases of gall bladder carcinoma. Results: Total of 840 cases were reviewed with mean age of the patient 42.48±14.8 years. The most frequent diagnosis was chronic cholecystitis with cholelithiasis (n=806) which was associated with upper abdominal pain (p<0.01). It was more prevalent among females sex (n=742). Six patients (0.7%) showed evidence of adenocarcinoma of gall bladder which had no gross abnormality on macroscopic examination. Conclusion: It is very significant to do routine histopathological examination of all the gall bladder specimens removed for benign diseases during elective cholecytectomies which incidentally may also be associated with carcinoma gall bladder and may require further surgical intervention.

A STUDY TO EVALUATE CD44 EXPRESSION IN INVASIVE BREAST CARCINOMA AND ITS CORRELATION WITH HISTOLOGIC GRADE AND PTNM STAGING

2021 ◽  
pp. 33-35
Author(s):  
Anish kumar Rakshit ◽  
Krishnendubikas Bag ◽  
Gopinath Barui
Keyword(s):  
Breast Carcinoma ◽  
Large Population ◽  
Tertiary Care ◽  
Small Sample ◽  
Invasive Breast Carcinoma ◽  
Histopathological Analysis ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Tumour Grade ◽  
Cd44 Expression

Introduction: The class mammalian is remarkable for the evolution of modied skin appendages that provide complete nourishment and immunological protection to the young. The breasts form a secondary sexual feature of females and are the source of nutrition for the neonate. They are also present in a rudimentary form in males. Aims And Objectives: Histomorphological study of invasive breast carcinoma on mastectomy specimens and its categorization on the basis ofhistologic grading and PTNM staging. Expression prole of immunohistochemical marker CD44 on invasive breast carcinoma. Correlation between CD44 expression with tumour grade and PTNM staging. Microscopic diagnosis and histopathological analysis of invasive breast carcinoma and its categorization on histologic grading and PTNM staging. Expression of CD44 in invasive breast carcinoma after histopathological diagnosis. Correlation of CD44 expression with that of tumour grade and PTNM staging. Materials And Methods: This study was conducted on a group of patients admitted in Department of General Surgery in collaboration with the Department of Pathology, R G Kar Medical College & Hospital, Kolkata over a period of 18 months. Cross sectional observational descriptive study. Conclusion: The main strength of our study was tertiary care hospital set-up, having infrastructure supportive enough to enable us to study invasive breast carcinoma from various socio-economic background, with diverse mode of presentation. We were able to do the necessary investigations in each case. There were some limitations in our study as limited duration of time, small sample size, unable to follow up results. This study needs to be extrapolated to a large population based sample with nancial support sufcient enough to nd relationship of expression of biomarker with grade and stage of tumour. In short, the present study has revealed various facets of breast carcinomas keeping comparable results with different studies. These ndings need to be conrmed by a larger prospective cohort.

scholarly journals Gynecological profile of patients undergoing laparoscopy/laparotomy in a tertiary care hospital

2017 ◽  
Vol 6 (6) ◽  
pp. 2475
Author(s):  
Sitalakshmi V. ◽  
Alpana Bansal
Keyword(s):  
Clinical Diagnosis ◽  
Ovarian Cyst ◽  
Elective Surgery ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Institutional Ethics ◽  
Abdominal Emergencies

Background: Laparoscopy is not only used in the elective surgery but also used in the emergency surgery. It is also found to be useful in the acute abdominal emergencies. It is useful in removing any diagnostic doubts. It is also useful in the treatment of diseases. The objective of the study was to study the gynecologic profile of patients undergoing laparoscopy/laparotomy in gynecology department of a tertiary care hospitalMethods: A hospital based cross sectional study was carried out at department of Obstetrics and Gynecology of S. V. Medical College, Tirupati from September 2014 to February 2015, for a period of six months. A total of 36 patients were evaluated for gynecological problems during the study period based on the inclusion and exclusion criteria. They were evaluated for menstrual complaints, chief presenting complaints, clinical diagnosis, scan diagnosis and laparotomy evaluation. Institutional Ethics Committee permission was taken before the start of the study. Informed consent was taken from all patients after explaining them about the nature of the study.Results: Ovarian cyst was the most common presentation which constituted more than half of the patients (55.6%). All patients i.e. 36 (100%) had menorrhagia as the complaint of menstrual irregularity. Out of 9 cases, clinical diagnosis differed in all cases, thus giving zero percent of accuracy for clinical diagnosis. Scan diagnosis matched with laparotomy confirmation in only 3 (33.3%) of cases. One case which was labeled as normal was found to have bilateral functional ovarian cyst on laparotomy confirmation. One case which was labeled as left ovarian cyst was found to have no cyst on laparotomy confirmation.Conclusions: Thus, laparoscopy is a useful tool for diagnosis and therapeutic accuracy in gynecological disease in routine as well as in emergencies. It is safe, effective, less time consuming, economical and patient friendly.

TO DETERMINE THE ROLE OF CA125 IN THE DIAGNOSIS OF ACUTE APPENDICITIS

2020 ◽  
Vol 4 (7) ◽  
Author(s):  
Vinod Kumar ◽  
Bhupen Songra ◽  
Richa Jain ◽  
Deeksha Mehta
Keyword(s):  
Acute Appendicitis ◽  
Clinical Diagnosis ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Ca 125 ◽  
Care Hospital ◽  
Serum Samples ◽  
Roc Curve Analysis ◽  
Surgery Department

Background: the present study was under taken to determine the role of CA-125 in the diagnosis of acute appendicitis (AA), to prevent its complications and also in preventing negative appendicectomies in tertiary care hospital. Methods: The study was conducted at a tertiary care and research center between 01/03/2018 to 30/06/2019. Patients admitted to the surgery department with diagnosis of AA were considered for the study. After informed consent, a, standardized history was obtained as a case Performa. Serum samples from all the cases with clinical diagnosis of AA were obtained and stored. Only the cases with histopathologically approved AA were included in the study. Cases operated for clinical diagnosis of AA, but not histopathologically proven AA was not included in the study. CA125 levels in cases with definitive diagnosis of AA were measured. Results: In present study, ROC curve analysis revealed the sensitivity of 87.27 % and specificity of 90.91 % when the CA 125 cut-off value of > 16.8 was taken to diagnose acute appendicitis. AUC was 0.911 with a standard error of 0.0292. Conclusion: In this study we have observed that CA125 showed a positive correlation with acute appendicitis, that was statistically not significant (P>0.05). We didn’t evaluate the correlation with the disease severity. We consider that CA125 can be used as a marker in acute appendicitis cases although further research is still needed. Keywords: CA125, Acute Appendicitis, Surgery.

A RETROSPECTIVE STUDY ON ANTIBIOTIC USAGE IN A TERTIARY CARE HOSPITAL

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Anna Joy ◽  
Aparna Anand ◽  
Arathy R Nath ◽  
Meera S Nair ◽  
Dr. K. G. Prasanth
Keyword(s):  
Retrospective Study ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
Sensitivity Test ◽  
Actual Process ◽  
Care Hospital ◽  
Rational Use ◽  
Antibiotic Susceptibility Test ◽  
Antibiotic Sensitivity Test ◽  
Rational Use Of Antibiotics

Antibiotics are one of the most commonly prescribed drugs today. Rational use of antibiotics is therefore extremely important as their injudicious use can adversely affect the patient. Drug Utilization Evaluation (DUE) is a system of ongoing systematic criteria based evaluation of drug that will help to ensure that medicines are used appropriately. It is drug/disease specific and can be structured so that it will assess the actual process of prescribing, dispensing, or administration of drug. The retrospective study was conducted At Pk Das Institute of Medical Sciences, Palakkad, Kerala for a duration of 6 months (February 2017 - January 2018). A source of data includes Patient case sheets &medication charts, nursing charts, culture & sensitivity reports. The inclusion criterion includes Patients aged between 18- 80 year, prescribed with oral and parenteral antibiotics. . On analyzing the gender, male gender (n= 111, 55.5%) were higher in numbers as compared to female counterparts (n=89, 44.5%). In our study the majority of the patients prescribed with antibiotics were with the clinical assessment of COPD (n=39, 19.5%), UTI (n=37, 18.5%) and LRTI (n=28, 14%), Bronchial asthma (n=19, 9.5%) respectively. On analyzing the data based on antibiotic sensitivity test, antibiotic test were performed and followed in (n=64,32%)prescriptions and in (n=47,23.5%)prescriptions were test is not followed respectively. In (n=89,44.5%) prescriptions, antibiotic sensitivity test is not performed. On analysis of antibiotics prescribed, the most commonly prescribed antibiotics were cephalosporins, of these ceftriaxone was highly prescribed of all (n=95). The high percentage of antibiotic prescriptions may indicate a high probability of irrational use. This study also point out irrational use of antibiotics are more leading to resistance, misuse and serious problems. So certain strategies should be put forward to strengthen rational use of antibiotics. Keywords: Antibiotics, Antibiotic Susceptibility Test, Irrational use, Resistance

A Retrospective Study of the Clinico-pathological Profile of Primary Extra Nodal Lymphomas in a Tertiary Care Hospital

2019 ◽  
Vol V-5 (I-1) ◽  
pp. 1-5
Author(s):  
Babu Janarthan ◽  
Krishna Nikhil ◽  
Dattatreya P.S. ◽  
Nirni S.S. ◽  
Vasini Vindhya
Keyword(s):  
Retrospective Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital

scholarly journals Pattern and prevalence of neuropsychiatric lupus: a retrospective study from a tertiary level hospital in Bangladesh

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Fahima Hossain ◽  
Mohammad Delwer Hossain Hawlader ◽  
Dipak Kumar Mitra ◽  
Mohammad Hayatun Nabi ◽  
Md. Mujibur Rahman
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Retrospective Study ◽  
Cognitive Dysfunction ◽  
Lupus Erythematosus ◽  
Neuropsychiatric Symptoms ◽  
Tertiary Care ◽  
Care Hospital ◽  
Systemic Lupus ◽  
Case Definitions ◽  
American College Of Rheumatology

Abstract Background Neuropsychiatric systemic lupus erythematosus (NPSLE) is well known for its varying presentations and poor outcomes, but little is evident about its distribution and characteristics among the Bangladeshi population. This study aimed to assess the pattern and prevalence of neuropsychiatric symptoms in female systemic lupus erythematosus (SLE) patients of Bangladesh. A retrospective study was conducted at a tertiary care hospital in Dhaka, Bangladesh, between January and December 2018. One hundred female SLE patients were included in the study purposively. Data were collected on sociodemographic and clinical characteristics of diagnosed SLE cases visiting the SLE clinic and indoor medicine department. Neuropsychiatric (NP) syndromes were defined according to the widely accepted American College of Rheumatology (ACR) nomenclature and case definitions. Results A total of 244 NP events were identified in fifty-five patients. Headache was the most frequent symptom (55%), followed by cognitive dysfunction (50%), anxiety (49%), psychosis (43%), seizure (23%), depression (17%), and cerebrovascular disease (ischemic type, 7%). The NP manifestations were more prevalent among urban residents (58.2%), younger patients (41.8%), and patients with graduate-level education (34.5%). Besides, young age at diagnosis (p = 0.038), Raynaud’s phenomenon (p = 0.015), other organ involvement (p < 0.001), and time of NPSLE development (p < 0.001) were found to be significantly associated with the development of these manifestations. Conclusion NP damage is prevalent among Bangladeshi female SLE patients (55%) with headache and cognitive dysfunction being the most common symptoms. Routine screening for neuropsychiatric symptoms among suspected SLE cases and further evaluation with a larger population are warranted.

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