scholarly journals An unusual case of cervical leiomyosarcoma in an adoloscent girl

2020 ◽  
Vol 9 (12) ◽  
pp. 5121
Author(s):  
Sangeeta Pahwa ◽  
Arshdeep Kaur ◽  
Preet K. Kaur ◽  
Tavleen Kaur
Keyword(s):  
Smooth Muscle ◽  
Uterine Cervix ◽  
Adolescent Girl ◽  
Unusual Case ◽  
Rare Tumor ◽  
Reproductive Outcome ◽  
Mesenchymal Tumour ◽  
Excessive Bleeding ◽  
Malignant Mesenchymal Tumour ◽  
Primary Leiomyosarcoma

Primary leiomyosarcoma of the uterine cervix is an exceedingly rare tumor. It is malignant mesenchymal tumour of smooth muscle origin. We report a case of 15-year-old adolescent girl who presented with complain of excessive bleeding per vaginum off and on since 3-4 months and was diagnosed as leiomyosarcoma of cervix. Patient was advised further management but father refused as according to them when bleeding has stopped completely then what is the need of further treatment. In this article we want to highlight the points: what is prognosis and survival of such patient whose mass was removed completely and patient is not willing for further treatment inspite of knowing the aggressive nature of tumor and if hysterectomy is the answer what about the reproductive outcome in such young girls and what is the prospect of uterine transplant surgery.  

Primary thyroid leiomyosarcoma: a diagnostic and therapeutic challenge

2021 ◽  
Vol 14 (4) ◽  
pp. e236399
Author(s):  
Mohammed Talha Bashir ◽  
Tom Bradish ◽  
Usman Rasul ◽  
Muhammad Shakeel
Keyword(s):  
Smooth Muscle ◽  
Thyroid Cancer ◽  
Cervical Lymphadenopathy ◽  
Rare Condition ◽  
Ultrasound Scan ◽  
Thyroid Lobe ◽  
Mesenchymal Tumour ◽  
History Of ◽  
Left Thyroid Lobe ◽  
Malignant Mesenchymal Tumour

Leiomyosarcoma is a malignant mesenchymal tumour of smooth muscle origin. It is extremely rare as a primary thyroid cancer with only 33 cases previously described in the literature. We present the case of a 69-year-old Caucasian man who presented with a 5-month history of left cervical lymphadenopathy and a suspicious mass in the left thyroid lobe on ultrasound scan. Left hemithyroidectomy confirmed the diagnosis of leiomyosarcoma. A review of current understanding and approaches to management of this rare condition are discussed.

A Rare Case of Cardiac Mesenchymal Hamartoma and Comprehensive Review of the Literature With Emphasis on Histopathology

2021 ◽  
pp. 106689692110022
Author(s):  
Soma Jobbagy ◽  
Simmi Patel ◽  
Charles Marboe ◽  
Jie-Gen Jiang ◽  
Zsolt Jobbagy
Keyword(s):  
Smooth Muscle ◽  
Unusual Case ◽  
Smooth Muscle Actin ◽  
Cell Lineage ◽  
Left Ventricular ◽  
Mesenchymal Hamartoma ◽  
Neoplastic Lesions ◽  
Intramuscular Hemangioma ◽  
Immunohistochemical Studies ◽  
Adipose Cells

Hamartomas are primary, benign neoplastic lesions that most commonly derive from a single variably differentiated cell lineage. Here, we report an unusual case of a cardiac hamartoma. A 62-year-old woman presented with chest pain and palpitations. Serial imaging revealed a large slowly growing and highly vascularized left ventricular mass, which required surgical resection. Microscopically, the lesion was composed of nodular fibrovascular proliferation with haphazardly embedded muscle bundles and peripheral calcifications. Immunohistochemical studies revealed prominent muscle-specific actin positive and smooth muscle actin positive muscle fiber bundles within a disorganized fibrovascular stroma. This characterization is most consistent with cardiac mesenchymal hamartoma. Relevant differential diagnoses for this lesion include hamartoma of mature cardiac myocytes (HMCMs) and intramuscular hemangioma. The prominent smooth muscle differentiation of muscle bundles was incompatible with defining features of HMCM. Absence of S100-positive nerve and mature adipose cells distinguished this lesion from the recently defined, heterogeneous cardiac mesenchymal hamartoma. Forty-seven cases of cardiac hamartoma reported from 1970 to 2020 were reviewed to provide histopathologic context.

scholarly journals Extrarenal angiomyolipoma in uterine cervix: rare presentation in unusual site

2019 ◽  
Vol 8 (1) ◽  
pp. 367
Author(s):  
Rashmi Monteiro ◽  
Shikha Sharma ◽  
Sonal Gupta ◽  
Indu Choudhary
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Blood Vessels ◽  
Uterine Cervix ◽  
Abdominal Mass ◽  
Muscle Cells ◽  
Renal Angiomyolipoma ◽  
Rare Presentation ◽  
Unusual Site ◽  
Hmb 45

Angiomyolipoma is a benign neoplasm composed of variable admixture of blood vessels, smooth muscle cells and adipose tissue. Cervical angiomyolipoma are extremely rare and to the best of our knowledge only five cases of angiomyolipoma in cervix have been reported in the literature till date. Authors are presenting a case of angiomyolipoma arising from the uterine cervix. 43 years old female presented with mass descending per vagina for 6 months. This case had no association with tuberous sclerosis. Microscopic examination showed an ill-defined polypoidal, non-encapsulated lesion covered by keratinized stratified epithelium. The lesion is made up of three components, predominantly by fascicles of spindle shaped cells, varying sized blood vessels and multiple foci of mature adipocytes with no evidence of atypia or increased mitotic activity. Smooth muscle component showed strong immunoreactivity to SMA and absence of elastic fibres in the blood vessels were confirmed by histochemistry. Non-vascular smooth muscle cells were negative for HMB-45 in contrast to renal and other extra-renal angiomyolipoma in which HMB-45 immunoreactivity in seen in these cells. To conclude, the differential diagnosis of lower abdominal mass and dysfunctional uterine bleeding should include the angiomyolipoma, even though the uterine cervix is an extremely rare location where they occur.

scholarly journals An unusual case of delivery with central rupture of perineum and intact introitus

2019 ◽  
Vol 8 (6) ◽  
pp. 2556
Author(s):  
Priyanka Mathe ◽  
Manisha Meena ◽  
Rekha Bharti
Keyword(s):  
Unusual Case ◽  
Institutional Delivery ◽  
Rectal Mucosa ◽  
New Delhi ◽  
Excessive Bleeding ◽  
Operation Theatre ◽  
Satisfactory Condition ◽  
Vaginal Deliveries ◽  
Perineal Injuries ◽  
Antenatal Visits

Most women experience some degree of tear during childbirth and in some these can be extensive. Obstetrics injuries contribute 0.5-15% of vaginal deliveries. Here authors present a case of 23-year-old primigravida who presented at Safdarjung hospital New Delhi, Delhi, India with complaint of pain in perineum and excessive bleeding per vaginum. On examination, introitus was intact and there was central rupture of perineum which involved anal sphincter proximally and rectal mucosa distally. Patient was shifted to operation theatre for exploration and repair. She received 2 units of blood transfusion, antibiotics and laxatives. Patient was discharged on post-operative day 5 in satisfactory condition. Thus, authors emphasise the need of institutional delivery and prevention of perineal injuries which would further obviate the need for surgical repair and associated morbidity. In present era of easy communication and transport we still receive cases of unsupervised deliveries which gives us a strong motive to spread awareness for antenatal visits and care among this population.

scholarly journals Recurrent vaginal discharge: an unusual presentation of embryonal rhabdomyosarcoma of uterine cervix in an adolescent girl

2019 ◽  
Vol 8 (5) ◽  
pp. 2129
Author(s):  
Divya Sarin ◽  
Urmila Singh ◽  
Seema Mehrotra ◽  
Vandana Solanki
Keyword(s):  
Medical Treatment ◽  
Uterine Cervix ◽  
Adolescent Girl ◽  
Vaginal Discharge ◽  
Histopathological Examination ◽  
Female Genital Tract ◽  
Reproductive Function ◽  
Embryonal Rhabdomyosarcoma ◽  
Management Challenge

Embryonal rhabdomyosarcoma (ERMS) is a rare tumor of the female genital tract. It tends to occur during childhood in the vagina and rarely it can arise in the uterine cervix, with a peak incidence in the second decade. We report a case of 15 year old adolescent girl who presented with recurrent vaginal discharge not responding to medical treatment. Examination under anesthesia showed friable growth arising from the cervix. Histopathological examination revealed embryonal rhabdomyosarcoma (botyroid variant) of the cervix. Patient underwent local excision of growth followed by IRS-4 protocol based chemotherapy and now patient is under follow up at our side and pediatric oncology and doing well. Young girls presenting with recurrent vaginal discharge not responding to medical treatment must undergo proper clinical examination and EUA and any suspicious lesions should be examined so as to avoid missing rare but aggressive etiology like rhabdomyosarcoma. Due to the young age of affected patients, embryonal rhabdomyosarcoma (sarcoma botyroides) poses a management challenge as the preservation of hormonal, sexual and reproductive function is essential. Awareness of such as uncommon lesion and its clinical implications is important for the counseling and management of the patient.

scholarly journals Primary epithelioid rhabdomyosarcoma of the stomach: a case report and review of literature

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Yangkun Wang ◽  
Pei Guo ◽  
Zhishang Zhang ◽  
Runde Jiang ◽  
Zuguo Li
Keyword(s):  
Tumor Cells ◽  
Unusual Case ◽  
Histopathological Examination ◽  
Gastroesophageal Junction ◽  
Rare Tumor ◽  
Review Of Literature ◽  
Ki 67 ◽  
Case Presentation ◽  
Cytoplasmic Content ◽  
Mitotic Figures

Abstract Background Epithelioid rhabdomyosarcoma is a rare tumor that generally occurs in the bladder, the parotid gland, or the skin of the neck. We describe an unusual case of primary epithelioid rhabdomyosarcoma of the stomach and review the literature. Case presentation A 64-year-old woman presented with a lesion at the gastroesophageal junction. Histopathological examination showed irregularly sized round cells with low cytoplasmic content and eccentric nuclei. Mitotic figures were present. Fibrovascular septa and areas of necrosis were observed between tumor cells. Tumor cells were strongly positive for MyoD1, desmin, and myogenin, and weakly positive for actin, CD56, and PGP9.5. The ki-67 index was ≥90%. Conclusions Primary epithelioid rhabdomyosarcoma of the stomach is extremely rare. Better awareness of this entity is necessary for early diagnosis and treatment.

scholarly journals Lipoleiomyosarcoma an extremely unusual sarcoma of uterus: A case report

1970 ◽  
Vol 2 (1) ◽  
pp. 67-70 ◽  
Author(s):  
Abhimanyu Jha ◽  
Gita Sayami ◽  
Deepti Adhikari
Keyword(s):  
Smooth Muscle ◽  
Abdominal Pain ◽  
Case Report ◽  
Postmenopausal Woman ◽  
Unusual Case ◽  
Histopathological Examination ◽  
Abdominal Mass ◽  
Lower Abdominal Pain ◽  
First Case ◽  
Well Differentiated

Uterine lipoleiomyosarcoma is a heterologous sarcoma composed of variable proportions of malignant lipoblasts histologically corresponding to well differentiated liposarcoma and malignant smooth muscle cells corresponding to leiomyosarcoma. Finding of benign lipomatous component in a typical leiomyoma (lipoleiomyoma) is not an uncommon, however, lipoleiomyosarcoma is an extremely rare malignant tumor and only very few cases have been reported so far. We report a case of lipoleiomyosarcoma of uterine corpus in a postmenopausal woman presenting with lower abdominal pain and abdominal mass. Diagnosis of lipoleiomyosarcoma was confirmed by histopathological examination of hysterectomy specimen. This is the first case of lipoleiomyosarcoma of uterus reported from Nepal. Keywords: Lipoleiomyosarcoma, uterus, histopathology, unusual case.   doi:10.3126/njog.v2i1.1482    N. J. Obstet. Gynaecol Vol. 2, No. 1, p. 67 - 70 May -June 2007

scholarly journals Intraplacental Leiomyoma in a Case of Second-Trimester Intrauterine Fetal Demise

2020 ◽  
Vol 13 ◽  
pp. 2632010X2092832
Author(s):  
Selene C Koo ◽  
Fang Bu
Keyword(s):  
Smooth Muscle ◽  
Umbilical Cord ◽  
Incidental Findings ◽  
Adverse Outcome ◽  
Implantation Site ◽  
Rare Tumor ◽  
Second Trimester ◽  
Histological Findings ◽  
Fetal Demise ◽  
Intrauterine Fetal Demise

Intraplacental leiomyomas are extremely rare and are generally incidental findings in term placentas. We present the first reported case of a placental leiomyoma associated with preterm intrauterine fetal demise, with histological findings providing the cause of adverse outcome. This was an intrauterine fetal demise detected at 26 weeks gestation with a placental finding of a 2.8-cm leiomyoma. Histological findings in the placenta and fetus were consistent with intrauterine fetal demise of weeks. The umbilical cord was markedly hypercoiled, with 6 twists per 10 cm. Features of maternal vascular malperfusion were evident in the placenta, including villous hypermaturity, an infarct adjacent to the leiomyoma, and retention of smooth muscle in spiral arterioles within the decidua overlying the leiomyoma. Implantation-site trophoblasts invaded into the leiomyoma and the overlying decidua. We hypothesize that incorporation of the leiomyoma into the placenta contributed to fetal demise due to disordered placental implantation, implying that these tumors may not be as benign and incidental as previously described. The finding of implantation-site changes in the leiomyoma may also suggest a potential cause for this rare tumor.

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