scholarly journals Serum magnesium level and QTc interval prolongation in acute myocardial infarction patients and its correlation with arrhythmias

2019 ◽  
Vol 7 (11) ◽  
pp. 4015
Author(s):  
Laxmi Mohanani ◽  
Kuldeep Deopujari ◽  
Rangvendra Singh Meena ◽  
T. N. Dubey
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Serum Magnesium ◽  
Myocardial Cell ◽  
Magnesium Level ◽  
Qtc Interval ◽  
Serum Magnesium Level ◽  
Interval Prolongation ◽  
Low Magnesium ◽  
Qtc Interval Prolongation

Background: Arrhythmias commonly occur early in acute myocardial infarction and remain a common cause of sudden death in AMI. Magnesium has been implicated in the pathogenesis of acute myocardial infarction and its complication like arrhythmia. Magnesium improves myocardial metabolism, inhibits calcium accumulation and myocardial cell death. It improves vascular tone, peripheral vascular resistance, after load and cardiac output and reduces cardiac arrhythmias. The objective of this study to investigate the serum magnesium level and QTc interval prolongation in AMI and its correlation with arrhythmias.Methods: In this study, 200 patients of AMI were enrolled. ECG and cardiac parameters were examined. Serum magnesium level is measured and the QTc interval was calculated.Results: MI was more prevalent in the male patients (63.3%) and age group of 41-50 years. Hypertension (35.7%), smoking (34.2%), and diabetes (23.1%) were the major risk factor for MI. Mean serum magnesium level was 1.64±0.37 among those having arrhythmia that is significantly low as compared to those having no arrhythmia among which mean serum magnesium level was 2.28±0.31 (p<0.001). Mean QTc was higher (546.88 ms vs. 404.33ms) in patients documented with arrhythmia compared with those who had no arrhythmia (p<0.001).Conclusions: In acute myocardial infarction, patients with low magnesium levels and prolonged QTc interval are more prone to get arrhythmias. So magnesium treatment can be considered in patients of acute myocardial infarction with low magnesium levels.

scholarly journals Association of low Serum Magnesium level with occurrence of Ventricular Arrhythmia in patients with Acute Myocardial Infarction

2020 ◽  
Vol 35 (1) ◽  
pp. 39-46
Author(s):  
Nizam Uddin ◽  
Abdul Wadud Chowdhury ◽  
Mohsin Ahmed ◽  
Md Khalequzzaman ◽  
Gaffer Amin ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Ventricular Arrhythmia ◽  
Serum Magnesium ◽  
Magnesium Level ◽  
Serum Magnesium Level ◽  
Mortality And Morbidity ◽  
Group A ◽  
Group B ◽  
Plasma Magnesium

Background: Acute Myocardial Infarction is the leading cause of morbidity and mortality throughout the world. Its prevalence among developing countries has increased significantly over the past two decades. Acute myocardial infarction is associated with electrolyte imbalance most commonly hypomagnesemia and hypokalaemia. Both are associated with ventricular arrhythmia which can lead to increase hospital mortality and morbidity. Objectives: To find out association of hypomagnesemia with ventricular arrhythmia in patients with acute myocardial infarction. Methods: Patients with acute myocardial infarction admitted in the department of Cardiology, DMCH, within the study period and who fulfilled the inclusion and exclusion criteria were taken as study sample. Informed consent was taken from all patients and then the patients were evaluated by detailed history, clinical examination and relevant investigations. Serum magnesium level was measured after admission. The sample population was Grouped into Group A(Acute myocardial infarction with normal serum magnesium) and Group B(Acute myocardial infarction with hypomagnesemia). Patients were followed up regularly till discharge or death for evidence of ventricular arrhythmia. Then the obtained data was analysed with SPSS 22.0. Results: Among 110 patients of Acute MI, 44 patients were in Group A who had plasma magnesium level e”0.7 mmol/ l and 66 patients were in Group B who had plasma magnesium level <0.7 mmol/l. Incidence of hypoagnesemia was 60% and more common in male. Male vs female percentage of hypomagnesemia were 61% vs 39%. Mean age was 54.16±11.72 yrs vs 57.52±10.59 yrs in group A vs group B. On admission serum magnesium level was 0.9218 vs 0.523 mmol/L( group A vs group B). The study showed that group B patients were more haemodynamically unstable and mean SBP and DBP were found 89.39±19.93 and 60.67±11.56 mm-Hg respectively. Troponin I was markedly increased in group B than A (i.e 4.7±1.79 vs 14.6±4.3 vs ng/ml). Adverse cardiac events such as cardiogenic shock (group A vs group B = 11.36% vs 28.27%) and ventricular arrhythmias(group A vs group B = 34% vs 72.73%) were also higher in group B than group A. Mean hospital stay for group B patient was higher than group A(6.78±0.85 vs 5.31±0.35 days). The study result showed that ventricular arrhythmia is negatively correlated with serum magnesium and the correlation coefficient was - 0.541. It also showed that serum Magnesium is positively correlated with Potassium(r= 0.831, p<0.01) and Calcium(r= 0.902, p<0.001). Multiple logistic regression analysis showed that hypomagnesemia is an independent risk factor for ventricular arrhythmia. Conclusions: This study showed that in patients with acute myocardial infarction, hypomagnesemia is common and it is significantly associated with ventricular arrhythmia. So the presence of hypomagnesemia should alert the physicians to adopt corrective measures as it increases both mortality and morbidity. Bangladesh Heart Journal 2020; 35(1) : 39-46

scholarly journals An evaluation of the serum magnesium levels in acute myocardial infarction: a hospital based cross sectional study

2020 ◽  
Vol 8 (11) ◽  
pp. 4071
Author(s):  
M. Poorna Chandran ◽  
J. Kumanan
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Myocardial Infarct ◽  
Serum Magnesium ◽  
Cross Sectional Study ◽  
Inferior Wall ◽  
Sectional Study ◽  
Cross Sectional ◽  
Acute Myocardial Infarct ◽  
Low Magnesium

Background: Magnesium has been implicated in the pathogenesis of acute myocardial infarction and its complication like arrhythmia. Magnesium improves myocardial metabolism, inhibits calcium accumulation and myocardial cell death. Objective was to know the relationship between the serum magnesium levels and arrhythmias in patients with acute myocardial infarction.Methods: It was a hospital based cross sectional study. By using simple random method, 50 cases of acute myocardial infarction, admitted in a tertiary care hospital in Chennai for the period of two years. Simple descriptive analysis was done to find out frequencies and percentages. For the test of significance the Chi-square test was used.Results: In our study group of 50 subjects, 28 (56%) of patients developed arrhythmias and 22 (44%) of patients recovered without any complications. Variation in type of Myocardial Infarction among our study 50 patients were 22 (44%) had anterior wall MI, 21 (42%) patients had Inferior wall MI and 7 (14%) patients had anteroseptal MI. The mean Mg level for the arrhythmias patients for the day 1 and day 5 were 1.70±0.16 and 1.76±0.51 and 2.10±0.19 and for patients without arrhythmias 2.26±0.20. There is a significant difference in the magnesium levels in patients with arrhythmias and without arrhythmias.Conclusions: In acute myocardial infarct ion, patients with low magnesium levels are more prone to get arrhythmias. So magnesium treatment can be considered in patients of acute myocardial infarct ion with low magnesium levels.

scholarly journals Dynamics of magnesemia levels, structural-functional heart parameters and arrhythmia syndrome features in patients with myocardial infarction and undifferentiated connective tissue dysplasia against the background of drug correction with magnesium

2018 ◽  
Vol 17 (6) ◽  
pp. 20-25
Author(s):  
E. P. Miroshnichenko ◽  
A. V. Ushakov
Keyword(s):  
Myocardial Infarction ◽  
Connective Tissue ◽  
Serum Magnesium ◽  
Left Ventricular ◽  
Magnesium Level ◽  
Serum Magnesium Level ◽  
Pronounced Increase ◽  
Basic Therapy ◽  
Group I ◽  
Connective Tissue Dysplasia

Aim. To assess the relationship of serum magnesium levels with the structural-functional heart parameters and the arrhythmic syndrome features in patients with myocardial infarction (MI) and undifferentiated connective tissue dysplasia (UCTD) against the background of drug correction with magnesium.Material and methods. The study included 112 patients with Q-wave MI. Group I (n=22) consisted of patients with MI and UCTD, who, in addition to the standard basic therapy, from 1st day of IM took the magnesium drug. Group II (n=30) — patients with MI and UCTD who received only basic therapy. Group III (n=60) — patients with MI without UCTD who received standard basic therapy. The control group (n=32) — patients without cardiovascular pathology and without UCTD. For assessment we used clinical and phenotypic examinations, echocardiography and daily monitoring of the electrocardiogram, determination of serum magnesium level in the course of MI.Results. We observed a decrease in serum magnesium level in patients with MI in all study groups on the 1st day of MI. Moreover, this tendency persisted for 28 days in the II and III groups. In the first group of patients against the background of the medical correction, an increase in the magnesium level was observed by the 28th day of MI. MI patients with UCTD revealed a more pronounced increase of left ventricular cavity dimensions, a decrease in its pumping ability. We also noted a tendency to a less pronounced increase in the left ventricular mass index compared with the group of patients with MI without UCTD. In addition, the development of MI in patients with UCTD compared with patients without UCTD is characterized by a higher frequency of paroxysmal supraventricular rhythm disturbances and paroxysmal ventricular tachycardia. Magnesium addition to MI treatment in patients with UCTD reduces the frequency of supraventricular arrhythmias.Conclusion. In patients with MI, which occur on the background of UCTD, the initially existing hypomagnesaemia is associated with the development of a disadaptive version of the post-infarction cardiac remodeling. Magnesium use in patients with MI and UCTD helps to reduce the severity of hypomagnesaemia and the frequency of supraventricular cardiac rhythm disorders.

scholarly journals Serum Magnesium in Acute Myocardial Infarction: Observation from Bangladeshi Patients

2020 ◽  
Vol 14 (2) ◽  
pp. 71-73
Author(s):  
Mohammad Rezaul Quader ◽  
Sharmin Rahman ◽  
Nasima Sultana ◽  
Suranjit Kumar Saha
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Serum Magnesium ◽  
Serum Magnesium Level ◽  
Control Groups ◽  
Mean Values ◽  
Medical College ◽  
Important Trace Element ◽  
The Mean ◽  
And Control

Dyslipidemia is an established risk factor of acute myocardial infarction (AMI), but measurement of macro metals like magnesium can be helpful in the prevention and better management of AMI. The aim of this study was to estimate serum magnesium in AMI. This is a case control type of study carried out in the Department of Biochemistry, Dhaka Medical College, Dhaka during the period of January 2015 to December 2015 with a total number of 100 study subjects. Acute myocardial infarction patients were selected as case (50) from coronary care unit (CCU), Department of Cardiology, Dhaka Medical College Hospital. Normal healthy individuals were selected as control (50) from the attendants of patients, relatives and doctors. Serum level of magnesium were assessed for both case and control groups. The mean values of the variable were compared between them by statistical analysis using SPSS version 16. For all the statistical analysis P<0.05 was considered as significant. The mean values of serum magnesium were 1.63±0.27mg/dl in cases. The mean values of serum magnesium were 2.35±0.28 mg/dl in control group. Significant differences were found in mean values between case and control groups and differences were highly significant (p<0.001). In AMI, serum magnesium level was found to be lower in this study. Serum magnesium is an important trace element that act as cofactor in many biochemical reactions. Decrease level of this important trace element may contribute to pathogenesis of AMI. So with other biochemical risk parameters, routine assessment of serum magnesium level is advocated, which might be helpful for prevention and better management of AMI. Faridpur Med. Coll. J. Jul 2019;14(2): 71-73

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