scholarly journals Relationship between uric acid, blood pressure and anthropometric indices in a healthy Ghanaian adult population

2020 ◽  
Vol 8 (12) ◽  
pp. 4185
Author(s):  
Perez Quartey ◽  
Bright Afriyie Owusu ◽  
Lawrence Marfo ◽  
Emmanuel Appiah
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Waist Circumference ◽  
Serum Uric Acid ◽  
Body Mass ◽  
Statistical Significance ◽  
Anthropometric Indices ◽  
Significant Difference ◽  
Positive Correlations

Background: Age- and sex-dependent variations in the relationship between uric acid and blood pressure and anthropometric indices have been reported in some populations. However, this has not been studied in a Ghanaian adult population.Methods: Body mass index, waist circumference, blood pressure and serum uric acid levels were measured. Categorical differences were analysed with chi-square. Differences between groups were assessed by t-test and one-way analysis of variance. Association between serum uric acid and baseline characteristics of age, body mass index, waist circumference and blood pressure was assessed by Pearson’s correlation. Statistical significance was pegged at p<0.05.Results: Prevalence of hyperuricemia was 3.2%. There was no significant difference in prevalence of hypertension between males (28.6%) and females (28.9%). General obesity and central obesity prevalence were significantly higher among females. In males, serum uric acids levels had statistically non-significant positive correlations with age, blood pressure, waist circumference and body mass index. In females, the results showed that among women less than 45 years, serum uric acid had significant positive correlations with only body mass index and waist circumference. However, significant positive correlations were observed between all the baseline parameters and uric acid among women who are 45 years and above.Conclusions: Increasing serum uric acid levels are significantly associated with higher blood pressure, body mass index and waist circumference. This relationship is stronger in females than in males, with the age group ≥45 years being the main determinant of this relationship.

Changes in Waist Circumference and Body Mass Index in Relation to Changes in Serum Uric Acid in Japanese Individuals

2009 ◽  
Vol 37 (2) ◽  
pp. 410-416 ◽  
Author(s):  
NOBUKAZU ISHIZAKA ◽  
YUKO ISHIZAKA ◽  
AKIKO TODA ◽  
MIZUKI TANI ◽  
KAZUHIKO KOIKE ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Uric Acid ◽  
Regression Analysis ◽  
Waist Circumference ◽  
Postmenopausal Women ◽  
Serum Uric Acid ◽  
Body Mass ◽  
Statistical Significance ◽  
Multivariate Logistic Regression Analysis ◽  
The Relationship

Objective. Studies have shown that obesity is associated with an increase in serum uric acid; and few data are available on the relationship between changes in measures of obesity and changes in uric acid concentrations. We investigated the relationship among percentage changes in waist circumference (%dWC), body mass index (%dBMI), and serum uric acid (%dUA).Methods. The data of 3153 individuals [1968 men, 1185 women (536 premenopausal, 649 postmenopausal)] who underwent general health screening over a 2-year period and were not taking antihyperuricemic medication were analyzed.Results. Stepwise multiple regression analysis showed that %dBMI was associated positively with %dUA in postmenopausal women and men, and the association retained statistical significance after adjustment for changes in blood pressure and in renal function. Association between %dBMI and %dUA was not significant in premenopausal women. In men, %dWC was a predicting factor for %dUA, although it did not remain significant when %dBMI was used as a covariate in the statistical model. Multivariate logistic regression analysis showed that the odds ratio of the association between the lowest %dBMI quartile (%dBMI < –1.86) and the lowest %dUA quartile (%dUA < –7.41) was 2.04 (95% CI 1.35–3.07) in postmenopausal women and 1.46 (95% CI 1.14–1.86) in men.Conclusion. Weight loss may represent an effective nonmedical strategy for reducing serum UA levels, especially in postmenopausal women and men.

scholarly journals Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Wen Cao ◽  
Ren-Dong Zheng ◽  
Shu-Hang Xu ◽  
Yao-Fu Fan ◽  
Hong-Ping Sun ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Uric Acid ◽  
Waist Circumference ◽  
Serum Uric Acid ◽  
Body Mass ◽  
Sex Hormone ◽  
Gonadal Dysfunction ◽  
Male Patients

The association between serum uric acid (SUA) level and sexual dysfunction in patients with diabetes is not well characterized. Type 2 diabetes mellitus (T2DM) causes metabolic disorders, including abnormal serum uric acid (SUA) levels. In this study, we enrolled 205 male patients with T2DM and investigated the relationship between sex hormone levels and SUA. Patients were divided into four groups based on SUA quartiles. On the other hand, based on the total testosterone (TT) level, patients were divided into three groups; SUA and other laboratory indices were determined. Increase in SUA level was significantly associated with decreased levels of TT, luteinizing hormone, follicle-stimulating hormone, sex hormone-binding globulin, and increased levels of dehydroepiandrosterone, age, body mass index (BMI), waist circumference, glycated hemoglobin, serum creatinine, and HOMA-IR levels. SUA, waist circumference, BMI, and HOMA-IR showed a negative correlation with TT level, while age showed a positive correlation with TT level. SUA and body mass index were found to be risk factors for gonadal dysfunction. Therefore, we conclude that hypogonadism of male patients with T2DM is related to SUA level.

Relation Between Circadian Rhythm of Blood Pressure and Serum Uric Acid and Body Mass Index

2011 ◽  
Vol 20 (01) ◽  
pp. 32-37
Author(s):  
Mehmet Kanbay ◽  
Faruk Turgut ◽  
Ayse Isik ◽  
Mustafa Koroglu ◽  
Ali Akcay
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Circadian Rhythm ◽  
Serum Uric Acid ◽  
Body Mass

scholarly journals Associations between BMI, serum uric acid, serum glucose, and blood pressure with urinary tract stone opacity

2015 ◽  
Vol 24 (2) ◽  
pp. 103-8
Author(s):  
Ikhlas A. Bramono ◽  
Nur Rasyid ◽  
Ponco Birowo
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Urinary Tract ◽  
Serum Uric Acid ◽  
Body Mass ◽  
Glucose Level ◽  
Serum Glucose ◽  
Serum Glucose Level ◽  
Urinary Tract Stone

Background: Urolithiasis refers to formation of stone in the kidney, ureter, or bladder. Several studies showed metabolic abnormalities were common in urolithiasis patients. The aim of this study was to describe the association between body-mass-index (BMI), serum uric acid, serum glucose, and blood pressure toward stone opacity in urinary tract stone patients.Methods: This study was done retrospectively by reviewing registry data of urinary tract stone patients that had undergone ESWL on January 2008 – December 2013 in Department of Urology Cipto Mangunkusumo Hospital. Data concerning body mass index, serum uric acid, serum glucose, blood pressure, and urinary tract stone opacity were recorded. Associations between body mass index, serum uric acid, serum glucose and blood pressure with urinary tract stone opacity were analyzed using chi-square test.Results: There were 2,889 patients who underwent ESWL on January 2008 – December 2013. We analyzed 242 subjects with complete data. Mean age was ± 12.78 (48.02 years). Male-to-female ratio was 2.27:1. Mean BMI was ± 3.78 (29.91 kg/m2). High risk BMIs were found in 161 patients (66.52%). The proportion of radioopaque stone was 77.69% (188 patients). Twenty two patients (9.1%) had normal blood pressure. Patients with high serum uric acid were 34.30% (83 patients). We found a significant association between random serum glucose level and stone opacity (p < 0.05).Conclusion: There is an association between random serum glucose level and stone opacity in urolithiasis patients. Hyperglycemia patients tend to have radiolucent stone, whereas normoglycemia patients tend to have radioopaque stone.

Abstract P398: Uric Acid And Prehypertension: Salt Intake in Addition to Insulin Resistance are not Mediators.

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Paulo A Lotufo ◽  
Itamar S Santos ◽  
Isabela M Bensenor
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Blood Glucose ◽  
Serum Uric Acid ◽  
Body Mass ◽  
High Blood Pressure ◽  
Urinary Sodium ◽  
Full Model

Introduction: The association "uric acid and high blood pressure" is still matter of debate. Therefore, to distinguish serum uric acid as an independent factor for high blood pressure can start new trials to prevent hypertension. A paleoantropological rationale for this association was a knockout of uricase occurred during the Miocene among hominids that induced high levels of uric acid. As consequence, during food shortage times, high uric acid had an evolutionary benefit increasing salt-sensitivity for keep blood pressure and rising insulin resistance that maintaining high blood glucose levels provided fuel for the brain. Nowadays, the average levels of uric acid are substantially higher compared to chimpanzees, a uricase-deficient primate, and among remote populations as the yanomamo. Hypothesis: we assessed the hypothesis that the link between uric acid and blood pressure in individuals without hypertension is independent of sex, age, race, salt and alcohol intakes, glucose homeostasis, body-mass index and renal function. Methods: from the 15105 participants of the Brazilian Longitudinal Study for Adult Health (ELSA-Brasil) aged 35-74 years, we selected 7954 individuals (median age = 48 years-old; women =58.1; White = 56.6%) without hypertension, diabetes, previous cardiovascular diseases. The presence or not of prehypertension (7th JNC criteria) was the dependent variable and quartiles (Q) of serum uric acid, the independent variable. We applied an unconditional logistic regression adjusted for age and sex. After this, according to our hypothesis, we added the following variables: (1) 24-hour urinary sodium; (2) log Homeostasis Model Assessment (fasting blood glucose (mg/dL) х fasting insulin (mg/dL)/450), and (3) a full model, adding race, body-mass index, alcohol intake, and glomerular filtration rate by CKD-epi). Results: the uric acid quartiles ranges (md/dL) were Q1 ≤ 4.1; Q2:4.2-5.0; Q3:5.1-6.0; Q4: ≥ 6.1 and the number of participants were Q1= 1909; Q2=2029; Q3=2000; Q4= 2016. Considering Q1 as reference, the age-sex adjusted odds ratios (95% Confidence Interval) through the quartiles were: Q2= 1.22 (1.05-1.41); Q3= 1.40 (1.20-1.63); Q4= 2.03 (1.71-2.39) [P for trend <0.001]. Adding 24 hour urinary sodium, the ORs (95% CI) were: Q2= 1.19 (1.01-1.40); Q3= 1.37 (1.16-1.62); and 1.94 (1.61-2.33) [P for trend <0.001]. Adding HOMA-IR, the ORs (95% CI) were: Q2= 1.14 (0.97-1.34); Q3= 1.25(1.05-1.48); and Q4=1.62(1.34-1.96) [P for trend <0.001]. Finally, for the full model the ORs were Q2= 1.04 (0.88-1.23); Q3= 1.05 (0.88-1.26) and Q4= 1.32(1.08-1.62) [P for trend <0. 01]. Conclusion: Uric acid levels were correlated to prehypertension among a middle-aged urban population. It occurred independently of other variables classically associated to high blood pressure or the origin of higher uric acid in hominids.

scholarly journals Uric Acid Levels in Normotensive Children of Hypertensive Parents

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Ali Yildirim ◽  
Fatma Keles ◽  
Pelin Kosger ◽  
Gokmen Ozdemir ◽  
Birsen Ucar ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Diastolic Blood Pressure ◽  
Pronounced Difference ◽  
Significant Difference ◽  
Anthropometric Characteristics ◽  
History Of ◽  
Positive Correlations ◽  
Lipid Parameters

This study evaluated uric acid concentrations in normotensive children of parents with hypertension. Eighty normotensive children from families with and without a history of essential hypertension were included. Concentrations of lipid parameters and uric acid were compared. Demographic and anthropometric characteristics were similar in the groups. Systolic and diastolic blood pressure were higher in the normotensive children of parents with hypertension without statistically significant difference (P>0.05). Uric acid concentrations were higher in the normotensive children of parents with hypertension (4.61 versus 3.57 mg/dL,P<0.01). Total cholesterol and triglyceride concentrations were similar in the two groups. Systolic and diastolic blood pressure were significantly higher in control children aged >10 years (P<0.01). Uric acid levels were significantly higher in all children with more pronounced difference after age 10 of years (P<0.001). Positive correlations were found between the level of serum uric acid and age, body weight, body mass index, and systolic and diastolic blood pressure in the normotensive children of parents. The higher uric acid levels in the normotensive children of hypertensive parents suggest that uric acid may be a predeterminant of hypertension. Monitoring of uric acid levels in these children may allow for prevention or earlier treatment of future hypertension.

scholarly journals Genetic and Environmental Influences on Cardiovascular Disease Risk Factors: A Study of Chinese Twin Children and Adolescents

2014 ◽  
Vol 17 (2) ◽  
pp. 72-79 ◽  
Author(s):  
Fuling Ji ◽  
Feng Ning ◽  
Haiping Duan ◽  
Jaakko Kaprio ◽  
Dongfeng Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Waist Circumference ◽  
Body Mass ◽  
Environmental Variance ◽  
Waist To Hip Ratio ◽  
Metabolic Traits ◽  
High Heritability

We evaluated the genetic and environmental contributions to metabolic cardiovascular risk factors and their mutual associations. Eight metabolic factors (body mass index, waist circumference, waist-to-hip ratio, systolic blood pressure, diastolic blood pressure, total serum cholesterol, serum triglycerides, and serum uric acid) were measured in 508 twin pairs aged 8–17 years from the Qingdao Twin Registry, China. Linear structural equation models were used to estimate the heritability of these traits, as well as the genetic and environmental correlations between them. Among boys, body mass index and uric acid showed consistently high heritability (0.49–0.81), whereas other traits showed moderate to high common environmental variance (0.37–0.73) in children (8–12 years) and adolescents (13–17 years) except total cholesterol. For girls, moderate to high heritability (0.39–0.75) were obtained for six metabolic traits in children, while only two traits showed high heritability and others mostly medium to large common environmental variance in adolescents. Genetic correlations between the traits were strong in both boys and girls in children (rg = 0.64–0.99 between body mass index and diastolic blood pressure; rg = 0.71–1.00 between body mass index and waist circumference), but decreased for adolescent girls (rg = 0.51 between body mass index and waist-to-hip ratio; rg = 0.55 between body mass index and uric acid; rg = 0.61 between body mass index and systolic blood pressure). The effect of genetic factors on most metabolic traits decreased from childhood to adolescence. Both common genetic and specific environmental factors influence the mutual associations among most of the metabolic traits.

scholarly journals A correlative study of body mass index with oxidative stress parameters (serum uric acid and serum malondialdihyde) in essential hypertension

2019 ◽  
Vol 7 (4) ◽  
pp. 1252 ◽  
Author(s):  
Chanchal Shrivastav ◽  
Paras Arvindbhai Parekh ◽  
G. Indra Kumar
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
Body Mass ◽  
Oxidative Stress Marker ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Background: Hypertension is most commonly documented modifiable risk factor for cardiovascular diseases. A growing body of data proposes an appreciated pathogenic role of an elevated serum uric acid in atherosclerosis and cardiovascular disease (CVD). Increased oxidative stress could be involved in the pathogenesis of hypertension. Oxidative stress marker, serum uric acid (SUA) and serum malondialdyhyde level (S. MDA) are affected by both genetic and environmental factors and related to biological factors as gender, age and body mass. So, the aim of the study is to access the association of body mass index (BMI) with oxidative stress parameters in essential hypertension (EHT).Methods: For the said purpose, this case control study was carried out on a total of 200, age and sex matched 75 hypertensives, 75 prehypertensive and 50 healthy subjects. After diagnosis of cases, SUA was estimated by standard kit method and S. MDA was estimated manually by Buege and Aust method.Results: This study represents that systolic and diastolic blood pressure were increased with increased BMI in all groups. Oxidative stress marker, SUA and S. MDA level increased significantly with increasing BMI in all groups and were positively correlated.Conclusions: Our study indicates that monitoring of the blood pressure, SUA and S. MDA at regular interval and maintaining of the oxidative balance would be helpful in preventing the development of hypertension and associated cardio-vascular morbidities.

scholarly journals Impact of BMI on serum uric acid levels in females in local population.

2019 ◽  
Vol 26 (10) ◽  
pp. 1733-1737
Author(s):  
Sardar Muhammad Al-Fareed Zafar ◽  
Rahat Naseem ◽  
Samia Jawed ◽  
Saima Mukhtar ◽  
Farhat Ijaz ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Body Mass ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Venous Blood ◽  
Local Population ◽  
Significant Difference

Body mass index is the fat content of body whereas hyperuricemia is the condition when serum uric acid level crosses the optimum normal level. Increase in BMI may influence serum uric acid. Objective: To find out the relationship of BMI with serum uric acid level in local population. Study Design: Cross sectional study. Setting: Lady Aitchison hospital Lahore. Period: March 2017- August 2017. Material and Methods: Written informed consent was taken prior to data collection. Detailed history was asked and weight in kilograms and height in meters was noted. Body mass index was calculated. Uric acid was measured by uricase method after taking 1 ml venous blood under aseptic measures. Results: Body mass index and serum uric acid of the subjects were compared with the standard values that were 24.99kg/m2 and 5.7mg/dl and statistical analysis showed a significant difference (p-0.023 and p-0.000) respectively. Simple linear regression revealed 0.391 units change in serum uric acid level with one unit change in BMI. Conclusion: Serum uric acid increased with increase in BMI.

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