scholarly journals Relationship between iron metabolism and thyroid hormone profile in hypothyroidism

2021 ◽  
Vol 9 (3) ◽  
pp. 790
Author(s):  
Suman Chatterjee ◽  
Phalguni Chakrabarti ◽  
Prasanta Sinhamahapatra
Keyword(s):  
Thyroid Hormone ◽  
Iron Deficiency ◽  
Serum Ferritin ◽  
Iron Metabolism ◽  
Negative Correlation ◽  
Control Group ◽  
Thyroid Peroxidase ◽  
Study Group ◽  
The Mean ◽  
Serum Tsh

Background: Iron and thyroid hormone metabolism are closely related with each other. Iron plays an important role for both the synthesis as well as metabolism of thyroid hormones acting as a component of many enzymes including thyroid peroxidase (TPO). So, iron deficiency can lead to abnormal functioning of thyroid gland. Ferritin is storage form of iron in our body. Several studies in showed that nutritional iron deficiency can significantly decrease the circulating levels of both T4 and T3 and it can also reduce peripheral conversion of T4 to T3. So, the aim of the study is to find out whether there is any relationship between hypothyroidism and iron metabolism.Methods: This cross-sectional descriptive study was conducted at Deben Mahata Government Medical College and Hospital, Purulia on 50 hypothyroid patients and 50 age and sex matched controls after imposing inclusion and exclusion criterias. Blood samples were collected and estimation of Serum TSH, fT4 and fT3, iron, ferritin and TIBC levels were done. Then the data obtained were analysed by proper statistical methods.Results: Out of 100 subjects 68 were male and rest were female. The mean serum TSH level in study population was significantly higher than that of comparison group. While serum fT3 and fT4 level in study group were lower than the control group and both were statistically significant. In the other hand, the mean serum ferritin and iron levels in cases were lower than that in controls and the mean TIBS was higher in study group and all the differences were statistically significant. There were significant correlation between Serum ferritin and serum iron (positive correlation), Serum ferritin and TSH (negative correlation), Serum TSH and fT4 (negative correlation) but there was no significant relationship between serum TSH and iron.Conclusions: The iron metabolism is disturbed in hypothyroidism reflected by low serum ferritin and iron.

scholarly journals Thyroid Status in Patients with Low Serum Ferritin Level

2013 ◽  
Vol 5 (1) ◽  
pp. 5-11
Author(s):  
S Akhter ◽  
ZU Nahar ◽  
S Parvin ◽  
A Alam ◽  
S Sharmin ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Iron Deficiency ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Thyroid Peroxidase ◽  
Hormone Synthesis ◽  
Tissue Iron ◽  
Iron Deficient ◽  
Significant Difference

Iron deficiency is the most important but preventable nutritional problem in Bangladesh. Thyroid peroxidase, an iron containing enzyme, is essential for initial two steps of thyroid hormone synthesis which is a component of tissue iron. Tissue iron diminishes early in the course of iron deficiency. So thyroid hormone level may be altered in iron deficient patients. This case-control study was carried out in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU) from July 2006 to June 2007. This study was done to find out the changes of thyroid hormonal activity in iron deficiency.In this study 72 subjects were selected from the out-patient department of the hospital. Patients with low serum ferritin level <12 mgm/L were selected as cases (n=36) and healthy persons with normal serum ferritin level were taken as controls. Serum ferritin, thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) were measured in all study subjects. Values were expressed as mean ± SD. Unpaired 't' test and Pearson's correlation test were performed to see the level of significance and p value <0.05 was taken as significant. Serum ferritin level in cases and controls were 6.78±4.05 mgm/L and 79.04±28.08 mgm/L respectively which showed significant difference (P<0.0001).Serum TSH concentration in cases and controls were 3.32±1.54 mIU/L and 1.89±0.86 mIU/L respectively. Serum FT4 concentration in cases and controls were 11.66±1.77 pmol/L and 13/10±1.36 pmol/L respectively and that of FT3 were 3.00±0.68 and 3.31±0.61 pmol/L respectively. All showed significant difference between groups.Serum ferritin and Serum TSH showed significant negative correlation in controls whereas in cases they showed negative correlation which was not statistically significant.Both serum FT4 and FT3 revealed positive correlation with serum ferritin but that too was not significant statistically.Though the study failed to show any significant positive correlation between serum ferritin and thyroid hormones, lower level of thyroid status in iron deficient patients suggest that it could be a reflection of disturbed activities of iron dependent enzymes such as thyroid peroxidase that impairs thyroid hormone synthesis. However, a large scale study is recommeded to establish the fact.This study showed that there was significant difference in thyroid hormonal status between iron deficient patients and normal healthy persons. Therefore it can be concluded that iron deficiency may impair normal thyroid hormone status. DOI: http://dx.doi.org/10.3329/bjmb.v5i1.13424 Bangladesh J Med Biochem 2012; 5(1): 5-11

scholarly journals Optimization of Epoetin Therapy with Intravenous Iron Therapy in Hemodialysis Patients

2000 ◽  
Vol 11 (3) ◽  
pp. 530-538
Author(s):  
ANATOLE BESARAB ◽  
NEETA AMIN ◽  
MUHAMMAD AHSAN ◽  
SUSAN E. VOGEL ◽  
GARY ZAZUWA ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Transferrin Saturation ◽  
Intravenous Iron ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
Control Group ◽  
Zinc Protoporphyrin ◽  
Study Group ◽  
Iron Deficient

Abstract. Iron deficiency limits the efficacy of recombinant human erythropoietin (rhEPO) therapy in end-stage renal disease (ESRD) patients. Functional iron deficiency occurs with serum ferritin >500 ng/ml and/or transferrin saturation (TSAT) of 20 to 30%. This study examines the effects of a maintenance intravenous iron dextran (ivID) protocol that increased TSAT in ESRD hemodialysis patients from conventional levels of 20 to 30% (control group) to those of 30 to 50% (study group) for a period of 6 mo. Forty-two patients receiving chronic hemodialysis completed a 16- to 20-wk run-in period, during which maintenance ivID and rhEPO were administered in amounts to achieve average TSAT of 20 to 30% and baseline levels of hemoglobin of 9.5 to 12.0 g/dl. After the run-in period, 19 patients randomized to the control group received ivID doses of 25 to 150 mg/wk for 6 mo. Twenty-three patients randomized to the study group received four to six loading doses of ivID, 100 mg each, over a 2-wk period to achieve a TSAT >30% followed by 25 to 150 mg weekly to maintain TSAT between 30 and 50% for 6 mo. Both regimens were effective in maintaining targeted hemoglobin levels. Fifteen patients in the control group and 17 patients in the study group finished the study in which the primary outcome parameter by intention to treat analysis was the rhEPO dose needed to maintain prestudy hemoglobin levels. Maintenance ivID requirements in the study group increased from 176 to 501 mg/mo and were associated with a progressive increase in serum ferritin to 658 ng/ml. Epoetin dose requirements for the study group decreased by the third month and remained 40% lower than for the control group, resulting in an overall cost savings in managing the anemia. Secondary indicators of iron-deficient erythropoiesis were also assessed. Zinc protoporphyrin did not change in either group. Reticulocyte hemoglobin content increased only in the study group from 28.5 to 30.1 pg. It is concluded that maintenance of TSAT between 30 and 50% reduces rhEPO requirements significantly over a 6-mo period.

scholarly journals The Status of Thyroid Hormones in Iron Deficient Patients in Bangladesh

2013 ◽  
Vol 24 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Shaheen Akhter ◽  
Zeba-un Naher ◽  
Shamima Pervin ◽  
Kamrun Nahar ◽  
Muktar Ali ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Negative Correlation ◽  
Hemoglobin Concentration ◽  
Significant Negative Correlation ◽  
Control Group ◽  
Free T4 ◽  
Iron Deficient ◽  
The Status ◽  
And Control ◽  
Serum Tsh

To determine the relation between iron deficiency and the status of thyroid hormones in iron deficient patients. This case control study was done in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU), during July 2006 to the June, 2007. Iron deficiency patient was considered as case a healthy control subject was considered as control. A total of 80 subjects were selected for study from those who were attended in out patient department of the above mentioned hospital were enrolled in this study. The mean (±SD) age of case and control were 33.48±11.03 years and 35.40±12.30 years with the range of 16-60 years and 15-60 years respectively. Male female ratio was 1:1.6 in the whole study subjects. Hemoglobin concentration, serum ferritin concentration were significantly (p<0.05) higher in control group but serum TSH level was significantly (p<0.05) higher in case group, however, serum FT3 was almost similar between case and control groups. In iron deficient patients, serum ferritin had no significant negative correlation (r=-0212; p>0.05) with serum TSH and no correlation with serum FT4 concentrations and serum FT3 concentration which were (r=0.055; p>0.05) and (r=0.147; p>0.05) respectively. In control subjects, serum ferritin revealed that there was significant negative correlation (r=-0.337; p<0.05) serum TSH. However, serum ferritin with serum FT4 concentration and serum ferritin with serum FT3 level showed no statistically significant correlation which were (r=0.283; p>0.05) and (r=0.145; p>0.05) respectively. On the other hand, there were no significant (p>0.05) correlation of hemoglobin concentration and serum ferritin with serum TSH, free T3 and free T4 concentrations both in case and control group. There were no significant (p>0.05) difference among serum TSH, free T3 and free T4 concentrations between male and female in both groups. Serum TSH level was significantly (p<0.05) higher in iron deficient patients and no significant negative correlation, serum ferritin level. DOI: http://dx.doi.org/10.3329/medtoday.v24i1.13941 Medicine TODAY Vol.24(1) 2012 pp.1-4

scholarly journals ALTERED IRON METABOLISM IN SUBCLINICAL HYPOTHYROIDISM: MYTH OR REALITY

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Yan Naing Soe ◽  
Bhasker Mukherjee ◽  
H S Batra ◽  
Sibin M K ◽  
Pratibha Misra ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Metabolism ◽  
Subclinical Hypothyroidism ◽  
Hormone Deficiency ◽  
Deficiency Anemia ◽  
Control Group ◽  
Study Group ◽  
Early Management ◽  
High Prevalence ◽  
Iron Profile

Introduction: Subclinical hypothyroidism refers to thyroid hormone deficiency in patients who have no apparent clinical features. Both iron deficiency anemia and subclinical hypothyroidism, due to their high prevalence and close interrelation, are significant clinical problems. Aims and Objectives: Association of subclinical hypothyroidism and disordered iron metabolism was studied so that better management of iron deficiency could be advised in these patients. Materials and Methods: 150 newly diagnosed subclinical hypothyroid patients and 150 healthy euthyroid controls were included. Total T3, total T4, TSH, iron, TIBC, transferrin and ferritin were measured. Data was analysed by student‘t’ test and Person’s formula. Results: Mean total T3, total T4, iron, TIBC, transferrin and ferritin values of study group were lower than that of control group (p < 0.05). Mean TSH values of study group was higher than that of control group (p < 0.05). Total T4 and T3 were positively correlated with transferrin (p < 0.05). The patients of subclinical hypothyroidism had altered iron metabolism. Conclusion: Decreased iron profile in subclinical hypothyroidism was significantly high. It was suggestive to regularly investigate iron profile for early detection and its early management in case of subclinical hypothyroidism. Keywords: Subclinical Hypothyroidism, Serum Iron, TIBC, Ferritin, Transferrin

scholarly journals Association between Serum Ferritin and Pre-eclampsia

2019 ◽  
Vol 47 (3) ◽  
pp. 18-24
Author(s):  
Ratna Paul ◽  
Mst Sabrina Moonajilin ◽  
Sujit Kumar Sarker ◽  
Himel Paul ◽  
Swapna Pal ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Deficiency Anemia ◽  
Control Group ◽  
The Mean

Pre-eclampsia (PE) is a major cause of maternal and prenatal morbidity and mortality in developing countries. PE occurs in about 6% of the general women population. It complicates about 5-15% of pregnancies over 20 weeks and is responsible for 16% of maternal mortality. Pre-delivery serum Ferritin concentration was significantly higher in patients with eclampsia than in healthy pregnant women. The serum ferritin was the best sensitive marker of the iron status parameters reflecting the preeclampsia. The aim of the study is to explore the association between serum ferritin and Preeclampsia and to do a comparison of serum ferritin to assess risk of development preeclampsia between case and control.This is a case-control study with laboratory methods. The study was carried out in Sir Salimullah Medical College and Hospital. Serum Ferritin was tested in the department of biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU). The study was carried out from January 2008 to December 2009 and the sample size was 80. A total of 80 pregnant women, comprising of 40 PE and 40 normotensive primi or multigravida in the third trimester were enrolled in the study. The mean Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) were significantly higher in PE group on both occasions compared to normotensive women with similar chronological age gestational age. Out of the 40 cases 65% patients had severe proteinuria (+++) and 17.5% had moderate proteinuria (++) and 17.5% had mild proteinuria. The difference between case and control with respect to proteinuria was highly significant. More than two third (67.5%) of the cases did not have any iron deficiency anemia, while the rest (32.5%) had mild iron deficiency anemia. In the present study, the mean serum Ferritin level of PE group was almost 10 times higher (167.11 ± 10.43 ngm/ml) than that of controls (17.0 ± 3.03 ngm/ml) than that of control (431.0 ± 10.93 gm/dl). More than one-third of the cases showed serum ferritin >210 ngm/ml, compared to none of the control group. Serum Ferritin level is significantly higher in preeclamptic patients than the control group. Bangladesh Med J. 2018 Jan; 47 (3): 18-24

P1375ORAL VITAMIN C EFFECT ON HEPCIDIN LEVEL IN HAEMODIALYSIS PATIENTS WITH FUNCTIONAL IRON DEFICIENCY ANAEMIA

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Maha Abdelmoneim Behairy Said ◽  
Reem Elsharabasy ◽  
Ahmed Gharib ◽  
Mahmoud Zaki
Keyword(s):  
Iron Deficiency ◽  
Vitamin C ◽  
Deficiency Anemia ◽  
Control Group ◽  
Study Group ◽  
Oral Vitamin ◽  
Functional Iron Deficiency ◽  
Hepcidin Level ◽  
Serum Hepcidin ◽  
The Mean

Abstract Background and Aims Hepcidin is a key regulatory peptide in iron homeostasis, inhibiting iron absorption by binding to ferroportin. Inflammatory mediated increase in hepcidin levels and reduced clearance in hemodialysis (HD) patients lead to functional iron deficiency ( FID) and Erythropoiesis-stimulating agent (ESA) resistance. Ascorbic acid (Vitamin C) may be used as adjuvant therapy in FID anemia through its anti-inflammatory and anti-oxidant nature, but there was limited studies investigating the direct relation between vitamin C and hepcidin level in HD patients. We Aimed to test the reducing therapeutic effect of oral vitamin C supplement on hepcidin level among hemodialysis patients with functional iron deficiency anaemia. Method This study is an open label randomized controlled clinical trial that was conducted in hemodialysis units of Ain Shams University hospitals, 48 prevalent HD patients with mean age of 46.48 ± 15.57 years were included ,Group 1 (study group) :31 patients [13(41.9%) males & 18(58.1%) females] who received the conventional treatment of erythropoietin stimulating agents together with oral supplementation of vitamin C 500 mg every other day dose for 3 months. Group 2 (control group): included 17 patients [8(47.1%) males and 9 (52.9%) females] who received only the conventional therapy of erythropoietin stimulating agents according to their Hb levels. The patients enrolled in the study were patients on regular conventional HD for more than 6 months with functional iron deficiency anemia, defined as: hemoglobin level &lt;11 gm/dl, ferritin level &gt;200 ng/ml and TSAT &gt;20 %. Patients with history of non-renal causes of anemia including malignancy, end-stage liver disease, or chronic hypoxia, patients with evidence of active or occult bleeding, patients who received blood transfusion within the last 4 months, history of recent hospitalization or infection requiring antibiotics within the last 4 weeks and patients with evidenced iron deficiency anemia were all excluded from the study .Laboratory parameters including serum hepcidin level, highly sensitive CRP (hsCRP) titer, CBC, kidney function tests and iron indices were measured at baseline and after 3 months . Results Oral vitamin C supplementation in Group 1(study group) resulted in statistically significant reduction in Hepcidin levels in the study group [mean 2506.45± 1320.53 pg/ml to 1748.39 ±1432.28 pg/ml ](P=0.03), and highly significant reduction in hsCRP level [mean 8603.23 ±2547.77 ng/ml to 5611.29 ±2829.27 ng/ml](P=0.001) after 3months of treatment. On comparing the two groups regarding changes in Hepcidin levels during follow up, illustrates that vitamin C together with time resulted in significant reduction of hepcidin levels in the study group (P&lt;0.05) by repeated measure ANOVA test (Figure 1). Comparison between the two groups regarding change in hsCRP levels during follow up showed there was a highly significant change in the mean hsCRP over time, and the mean hsCRP differed significantly between the two groups (Figure 2). A significant reduction in serum iron and ferritin levels was observed in study group after treatment vitamin C but the change of the mean of S. ferritin level didn’t differ significantly in comparison to control group . Decreased EPO requirements and elevation of hemoglobin level were observed in the study group but without a statistical significance compared to the control group, this might be attributed to the short period of vit C supplementation. There was a highly significant correlation between serum hepcidin and hsCRP (r=0.46, P&lt;0.01) . Conclusion : Oral Vitamin C may be promising therapy in decreasing serum hepcidin and hsCRP in prevalent hemodialysis patients with functional iron deficiency anemia.

Effectiveness of neurobic exercise program on memory and depression among elderly residing at old age home

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Divya Raj ◽  
Subramaniam Santhi ◽  
G. J. Sara Sapharina
Keyword(s):  
Old Age ◽  
Depression Scale ◽  
Exercise Program ◽  
The Elderly ◽  
Control Group ◽  
Study Group ◽  
Significant Difference ◽  
The Mean ◽  
Interventional Group ◽  
Old Age Homes

AbstractObjectivesThis study finds out the effectiveness of neurobic exercise program on memory and depression among elderly residing in old age homes.MethodsThe non-probability purposive sampling technique was used for sample selection. Wechsler's memory scale (WMS-IV) and Geriatric depression scale (GDS) were the instruments used to assess the memory and depression among elderly during the pretest and posttest, respectively and the researcher had developed data sheet to collect information about the background variables using interview technique.ResultsThe neurobic exercise program was found to be effective in reducing depression among elderly residing in old age homes. There was a significant difference (p<0.001) in the level of depression had been found during the pretest and posttest in the interventional group. There was a statistically significant difference (p<0.001) found between the study group and in the control group. There was significant correlation (r=0.417, p<0.05) found between the memory and depression during the pretest in the study group among the elderly. A statistically significant association (p<0.05) found in the mean scores of depression and marital status of the elderly during the pretest in the study group and there was a significant association (p<0.01) found in the mean scores of depression and the gender of the elderly during the pretest and posttest in the non interventional group were found.ConclusionsThe findings suggested that neurobic exercise program is an effective intervention in improving memory and reducing depression.

scholarly journals Patients with Achilles Tendon Rupture Have a Degenerated Contralateral Achilles Tendon: An Elastography Study

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Qianru Li ◽  
Qi Zhang ◽  
Yehua Cai ◽  
Yinghui Hua
Keyword(s):  
Achilles Tendon ◽  
Axial Strain ◽  
Achilles Tendon Rupture ◽  
Cross Sectional Area ◽  
Control Group ◽  
Computer Assisted ◽  
Study Group ◽  
Sectional Area ◽  
Cross Sectional ◽  
The Mean

Purpose. To evaluate differences of Achilles tendon (AT) hardness and morphology between asymptomatic tendons in patients with acute AT ruptures on the contralateral side and asymptomatic tendons in healthy people by using computer-assisted quantification on axial-strain sonoelastography (ASE). Methods. The study consisted of 33 asymptomatic tendons in 33 patients (study group) and 34 tendons in 19 healthy volunteers (control group). All the tendons were examined by both ASE and conventional ultrasound. Computer-assisted quantification on ASE was applied to extract hardness variables, including the mean (Hmean), 20th percentile (H20), median (H50) and skewness (Hsk) of the hardness within tendon, and the ratio of the mean hardness within tendon to that outside tendon (Hratio) and three morphological variables: the thickness (THK), cross-sectional area, and eccentricity (ECC) of tendons. Results. The Hmean, Hsk, H20, H50, and Hratio in the proximal third of the tendon body in study group were significantly smaller than those in control group (Hmean: 0.43±0.09 vs 0.50±0.07, p=0.001; Hsk: -0.53±0.51 vs -1.09±0.51, p<0.001; H20: 0.31±0.10 vs 0.40±0.10, p=0.001; H50: 0.45±0.10 vs 0.53±0.08, p<0.001; Hratio: 1.01±0.25 vs 1.20±0.23, p=0.003). The THK and cross-sectional area of tendons in the study group were larger than those in the control group (p<0.05). Conclusions. As a quantitative objective method, the computer-assisted ASE reveals that the asymptomatic ATs contralateral to acute rupture are softer than those of healthy control group at the proximal third and the asymptomatic tendons in people with rupture history are thicker, larger, and rounder than those of normal volunteers especially at the middle and distal thirds of AT body.

scholarly journals Pattern ERG as a predictor in ocular hypertensive

2016 ◽  
Vol 15 (2) ◽  
Author(s):  
Paaraj Dave ◽  
Jitendra Jethani
Keyword(s):  
Amplitude Ratio ◽  
Corneal Thickness ◽  
Visual Fields ◽  
Cross Sectional Study ◽  
Control Group ◽  
Study Group ◽  
Pattern Erg ◽  
Check Size ◽  
Cross Sectional ◽  
The Mean

Purpose: To report the repeatability of Pattern Electrotretinogram (PERG) and its findings in ocular hypertension (OHT) and normal eyes.Methods: A cross-sectional study where PERG responses were compared between the study group comprising of 80 eyes of 80 patients with intraocular pressure (IOP)>21 mmHg and the control group with 80 eyes of 80 normal individuals (IOP≤21mmHg). The optic disc and the visual fields were normal with a visual acuity of ≥ 0.8 in both groups. PERG was recorded twice for each individual in the control group by a single operator on 2 consecutive days to assess the repeatability.Results: The mean age in the study and control groups was 50.05±10.03 and 54.8±7.66 years(p=0.44) respectively. The mean IOP was 26.55±3.9 mmHg for the study group as opposed to 14.45±2.9 mmHg for the controls (p<0.001). The central corneal thickness and the cup-disc ratio was similar between the groups (p>.05). The P50-N95 amplitude (p=0.01) and the P50 latency (p<0.001) was statistically significantly different between both the groups. The intra-class correlation coefficient (ICC) showed poor agreement for all parameters except for N35-P50 0.8 to 16 degree check size amplitude ratio (PERG ratio).Conclusion:  Increase in P50 latency emerges as a new candidate for early glaucoma indicator in addition to reduction in P50-N95 amplitude. PERG parameters suffer from high test-retest variability. Deterioration in PERG recordings should be interpreted with caution. The variability is lesser for the PERG ratio which maybe more meaningful while monitoring for change over time.

scholarly journals True and Pseudo Cholinesterase levels in short and long-term of pesticides exposures

2020 ◽  
pp. 9-12
Author(s):  
Mohammed Abdul Rahman ◽  
Raghunatha Rao D ◽  
Vasantha L
Keyword(s):  
Whole Blood ◽  
Acute Poisoning ◽  
Mean Value ◽  
Serum Cholinesterase ◽  
Control Group ◽  
Study Group ◽  
Chronic Poisoning ◽  
The Mean ◽  
The Difference ◽  
And Control

The present study is aimed to study and analyze the true and pseudo Cholinesterase levels in the subjects exposed to pesticides during short term by intentional or accidental intake and long term exposure due to their occupation were studied at Department of Biochemistry, SVS medical college and hospital mahbubnagar district. Whole blood cholinesterase levels and Pseudo cholinesterase levels were estimated. 150 people were taken as controls who had no medical illness and a total number of 300 cases of pesticide poisoning were selected, aged between 20 to 55 years, which consist of 150 acute poisoning and 150 chronic poisoning subjects in Mahbubnagar district, were taken as case study, the detailed case history and the type of organophosphorus pesticide taken were recorded. Mean and standard deviation (S.D) of all variables were calculated and compared with those of controls. Statistical significance was assessed and P-value <0.05 were considered significant.           During acute poisoning the mean value of Whole blood cholinesterase/True cholinesterase (U / L) in acute poisoning cases on first day was 1.267± 0.612 on 3th day was 1.651±0.647, on 7th day was 2.221±0.684 and at the end of 6 months was 3.970±0.404.The difference between the study group and control group (4.0 ± 0.39) was found to be statistically significant in1st, 3rd, 7th day but not significant at the end of 6 months. The mean value of serum cholinesterase/pseudo cholinesterase (U/L) in acute poisoning cases on first day was 2213.05 ± 1749.81, on 3th day was 2862.3 ± 2025.6, on 7th day was 4008.4 ± 2355.9 and at the end of 6 months was 7708.34 ± 880.72.The difference between the study group and control group (7991.97 ± 1276.5) was found to be statistically significant in1st, 3rd, 7th day but not significant at the end of 6 months. During chronic poisoning (exposure) the mean value of Whole blood cholinesterase (U/L) in controls is 4.0 ± 0.39 as compared to 3.019 ± 0.848 in cases of chronic poisoning. The difference between the study group and control group was found to be statistically significant. The mean value of serum cholinesterase/pseudo cholinesterase (U/L) in controls was 7991.97 ± 1276.5 as compared to 6214 ± 1189 in cases of chronic poisoning. The difference between the study group and control group was found to be statistically significant.

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