scholarly journals Single dose versus multiple dose prophylactic antibiotic in laparoscopic cholecystectomy: a comparative study

2016 ◽  
pp. 633-636
Author(s):  
Pinakin Sutariya ◽  
Pukur Thekdi
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Single Dose ◽  
Comparative Study ◽  
Multiple Dose ◽  
Prophylactic Antibiotic

Single-dose antibiotic prophylaxis compared with multiple-dose protocol in clean pediatric neurosurgical interventions: a nonrandomized, historically controlled equivalence trial

2021 ◽  
pp. 1-8
Author(s):  
Esmaeil Mohammadi ◽  
Sina Azadnajafabad ◽  
Mehrdad Goudarzi ◽  
Keyvan Tayebi Meybodi ◽  
Farideh Nejat ◽  
...  
Keyword(s):  
Single Dose ◽  
Multiple Dose ◽  
Antimicrobial Prophylaxis ◽  
Meta Analysis ◽  
Prophylactic Antibiotic ◽  
Surgical Site Infections ◽  
Pediatric Neurosurgery ◽  
Total Cohort ◽  
Neurosurgical Patients ◽  
Tertiary Center

OBJECTIVE Guidelines recommend antimicrobial prophylaxis (AMP) preoperatively for "clean" spinal and cranial surgeries, while dose and timing remain controversial. The use of multiple-dose AMP for such surgeries is under debate in the pediatric context. In this clinical study, the authors aimed to compare single-dose with multiple-dose prophylactic antibiotic usage in cranial and spinal neurosurgical interventions of pediatric patients. METHODS All neurosurgical patients aged 28 days to 18 years who underwent surgery at a single tertiary center were assessed. Three cohorts (noninstrumented clean spinal, noninstrumented cranial, and instrumented cranial interventions), each of which comprised two 50-patient arms (i.e., single-dose AMP and multiple-dose AMP), were included after propensity score–matched retrospective sampling and power analysis. Records were examined for surgical site infections. Using a previously published meta-analysis as the prior and 80% acceptance of equivalence (margin of OR 0.88–1.13), logistic regression was carried out for the total cohort and each subcohort and adjusted for etiology by consideration of multiple-dose AMP as reference. RESULTS The overall sample included 300 age- and sex-matched patients who were evenly distributed in 3 bi-arm cohorts. There was no statistical intercohort difference based on etiology or type of operation (p < 0.05). Equivalence analysis revealed nondiscriminating results for the total cohort (adjusted OR 0.65, 95% CI 0.27–1.57) and each of the subcohorts (noninstrumented clean spinal, adjusted OR 0.65, 95% CI 0.12–3.44; noninstrumented cranial, adjusted OR 0.52, 95% CI 0.14–2.73; and instrumented cranial, adjusted OR 0.68, 95% CI 0.13–3.31). CONCLUSIONS No significant benefit for multiple-dose compared with single-dose AMPs in any of the pediatric neurosurgery settings could be detected. Since unnecessary antibiotic use should be avoided as much as possible, it seems that usage of single-dose AMP is indicated.

scholarly journals A PROSPECTIVE COMPARATIVE STUDY OF SINGLE DOSE PROPHYLACTIC ANTIBIOTIC VERSUS EMPIRICAL POST-OPERATIVE ANTIBIOTICS IN PREVENTION OF SSI

2017 ◽  
Vol 6 (09) ◽  
pp. 684-686
Author(s):  
Sankarlingam Sankarlingam ◽  
Lakshmypathy Lakshmypathy ◽  
Alex Franklin ◽  
Arikrishnan Vaithiswaran ◽  
Sathish Kailasam
Keyword(s):  
Single Dose ◽  
Comparative Study ◽  
Prophylactic Antibiotic ◽  
Prospective Comparative Study

A Comparative Study of Single Dose and Multiple Dose Antibiotic Prophylaxis In Caesarean Section

2021 ◽  
Vol 8 (3) ◽  
pp. 89-93
Author(s):  
Dr. Poorvi Agarwal ◽  
Dr. Harshal Nimbannavar ◽  
Dr. Prajakta Khose ◽  
Dr. Supraja Subramanian ◽  
Dr. Himadri Bal
Keyword(s):  
Single Dose ◽  
Caesarean Section ◽  
Antibiotic Prophylaxis ◽  
Multiple Dose ◽  
Prophylactic Antibiotic ◽  
Dose Schedule ◽  
Antibiotic Use ◽  
Skin Incision ◽  
Significant Difference ◽  
Group B

Background: Rampant antibiotic use brought about its own set of problems like the rise in incidence of antibiotic resistant strains, allergies and other complications of antibiotic use. Unfortunately in many of our set ups we are still stuck in prolonged post-operative antibiotic regimes. This study aims to fill that lacunae and thereby aid our gradual shift away from over reliance on prolonged antibiotic usage in prevention of SSI. Hence we decided to investigate the efficacy of the use of a single prophylactic intravenous dose of antibiotic vis a vis multiple doses in reducing post-operative infective morbidity in caesarean sections. Methods: The study included 200 patients at term, satisfying the inclusion and exclusion criteria, reporting to the labour room and undergoing caesarean section. The patients were then divided into two groups of 100 each by simple randomization. Patients in Group A were given a single dose of Inj. Cefotaxime 1gm IV + Inj. Metronidazole 500 mg IV infusion 30 minutes before the skin incision. Group B cases were given the first dose of Inj. cefotaxime 1g IV + Inj. metronidazole 500 mg IV 30 minutes before the skin incision followed by injectables for 2 days: Inj. cefotaxime 1g IV BD and Inj. metronidazole 500mg IV TDS. Subsequently for the next 3 days Tablet Cefixime 200mg BD and Tablet Metronidazole 400mg TDS were administered orally. Results:  The present study did not show any significant difference in the post operative infection incidence between the single dose and multiple dose schedule. Conclusion: our study makes an important observation regarding use of antibiotic prophylaxis and its duration for prevention of post operative infections in mothers without compromising any safety aspects of either the mother or the child.  As noted in our study, there was no difference in the outcome as regards post operative infectious morbidity in patients of both the groups. Hence, based on the findings of our study we conclude that single dose prophylactic antibiotic should be the norm for caesarean sections.

scholarly journals Comparative study on prophylactic antibiotic versus empirical antibiotic in prevention of surgical site infection

2019 ◽  
Vol 9 (2) ◽  
pp. 9-13
Author(s):  
S Rajarajan ◽  
T.H. Sreelekshmi Devi ◽  
Neeshma Mariam Simon ◽  
K.R. Navin Shankar ◽  
V. Ganesan
Keyword(s):  
Single Dose ◽  
Comparative Study ◽  
Surgical Site Infection ◽  
Hospital Stay ◽  
Prophylactic Antibiotic ◽  
Operative Therapy ◽  
Prophylactic Antibiotics ◽  
Control Group ◽  
P Value ◽  
Site Infection

The main aim of the study was to comparative study of single dose prophylactic antibiotic versus empirical postoperative antibiotics in prevention of surgical site infection. The study was a prospective observational study conducted over a period of 8months. A total of 100 number of surgery cases were selected randomly, to groups of 50 each. The study group received a single dose of antibiotic preoperatively while the control group received 3 to 5 days of empirical antibiotic therapy. Data analysis and statistical analysis was done with the help of graph pad prism trial version software. Student t test was carried out for paired analysis to find P value. There was no significant association of surgical site infection, grades of infection, and other complications. The hospital stay of patients, cost to the patients, and number of antibiotics used in patients were significantly more. The single dose prophylactic antibiotics are better than empirical post operative therapy in reducing the hospital stay and hospital cost to patients. Since the complete eradication of surgical site infection is not possible, only the reduction in infection rate can be achieved to a minimal level. Keywords: Prophylactic antibiotics, surgical site infection, surgical complications, post operative antibiotics.

Results of a multicenter comparative study of single-dose cefotetan and multiple-dose cefoxitin as prophylaxis in patients undergoing cesarean section

1988 ◽  
Vol 155 (5) ◽  
pp. 86-90 ◽  
Author(s):  
Rudolph P. Galask ◽  
Benedict B. Benigno ◽  
F. Gary Cunningham ◽  
John P. Elliott ◽  
Edgar Makowski ◽  
...  
Keyword(s):  
Single Dose ◽  
Cesarean Section ◽  
Comparative Study ◽  
Multiple Dose

scholarly journals Efficacy of Single Dose versus Multiple Dose of Pre-Operative Antibiotic: Teaching Hospital Based Study

2020 ◽  
Vol 3 (2) ◽  
pp. 25-29
Author(s):  
Kamta Prasad Gupta ◽  
Dinesh Pratap Singh
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Single Dose ◽  
Surgical Site Infection ◽  
Prophylactic Antibiotic ◽  
Invasive Procedure ◽  
Anesthesia Induction ◽  
Site Infection ◽  
Time Period ◽  
Study Results ◽  
Elective Laparoscopic Cholecystectomy

Background: The major crisis in any type of surgery is understood to be Surgical Site Infection (SSI). Although laparoscopic cholecystectomy is a nominally invasive procedure, there is a dominant prevalence of SSI in patients. It is also believed that prophylactic antibiotic has major impact in reducing SSI. Subjects & Methods: Seventy cases were enrolled in this study with knowledgeable consent. The study was carried out over a time period of ten months. The subjects acknowledge for elective laparoscopic cholecystectomy were incorporated in our study. Results: Out of the 70 randomized patients, 35 were allotted in single dose (SD group) while 35 patients were allotted in multiple doses (MD group), who got planned treatments and were then investigated. Of the 70 patients, female patients were 58(82.9%) and males were 12(17.1%). Total 43.62 12.18 years was the mean age of patients having symptomatic cholelithiasis, with 18 years as minimum and 77 years as maximum age. The peak of disease was documented in the age group of 30 to 39 years (28.6%). Conclusion: Utility of single antibiotic dose before anesthesia induction in laparoscopic cholecystectomy was likewise efficient as the use of multiple antibiotics doses in surgical site infection of postoperative periods.

scholarly journals Single vs Multiple Dose of Cefazolin Prophylaxis in Elective Cesarean Section

2017 ◽  
pp. 60
Author(s):  
Sigit Purbadi ◽  
Muhamad Fadli
Keyword(s):  
Single Dose ◽  
Multiple Dose ◽  
Obstet Gynecol ◽  
Prophylactic Antibiotic ◽  
Clinical Findings ◽  
Elective Cesarean Section ◽  
Maternal Infection ◽  
Elective Cesarean ◽  
Single Blind

Introduction: Caesarean section (CS) is one of port d’ entrée from infection in women and it is related to maternal morbidity during puerpureal period. Until now, there is still lack of consensus regarding prophylactic antibiotic protocol before CS procedure. This study aims to determine the comparative efficacy between single dose and multiple doses of cefazolin prior incision toward the incidence of maternal infection. Methods: This was a single-blind, randomized, clinical trial study with two methods of intervention including 2-gram single dose cefazolin at 30 minutes’ prior incision and 2-gram single dose cefazolin at 30 minutes’ prior incision continued 1-gram cefazolin after 8 hours of procedure. We recruited women undergone elective CS at Fatmawati and Anna Hospital, Jakarta from January to March 2016. The primary outcomes were surgical site infection, urinary tract infection, and endometritis based on clinical findings during 30 days of follow-up period. Results: A total of 46 subjects were recruited which 23 of them were in single dose cefazolin group and the other 23 subjects were in multiple dose of cefazolin group. There were 9 subjects having infection (19.6%). There was no statistical difference in the incidence of infection between two groups (p=1.00; relative risk 0.80, 95% CI 0.25-2.61). Conclusion: Single dose of cefazolin shows similar rates of infection incidence to multiple dose. Therefore, single dose of cefazolin can be a protocol in CS based on its efficacy and efficiency. [Indones J Obstet Gynecol 2017; 5-1: 60-65] Keywords: cefazolin, maternal infection, multipe dose, single dose

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