scholarly journals A rare case report of bilateral synchronous carcinoma breast

2017 ◽  
Vol 4 (9) ◽  
pp. 3153
Author(s):  
Bhushan Anil Shah ◽  
Nagendra Yadav ◽  
Kandarpa Akhil ◽  
Firoz Alam
Keyword(s):  
Rare Case ◽  
Treatment Guidelines ◽  
Ductal Carcinoma ◽  
Bilateral Breast Cancer ◽  
Conservative Surgery ◽  
Screening Tools ◽  
Bilateral Mastectomy ◽  
Breast Cancer Patients ◽  
Synchronous Carcinoma ◽  
Infiltrating Ductal Carcinoma

Bilateral Breast Carcinoma (BBC) is a rare entity with incidence of synchronous carcinoma being 2-5% of all breast malignancies, which is much less than metachronous carcinoma. Synchronicity/metachronicity are usually associated with local and lymphatic spread and with blood-borne spread to lungs, bones and liver. Moreover, BBC are mostly lobular carcinomas but we report a rare case of Infiltrating Ductal Carcinoma (IDC), medullary type as the primary carcinoma. 56-year-old female who presented with a lump in her right breast for 6 months and lump in her left axilla. There was no e/o palpable lump in her left breast. Trucut biopsy was taken from both the lumps and was s/o infiltrating ductal carcinoma. Different histological subtypes with different grades of tumour in both breasts suggested synchronous primary tumours. Early detection of the contralateral tumour is of utmost importance emphasizing the significance of breast self-examination. Screening tools like MRI have a greater sensitivity compared to Mammography. There are no clear treatment guidelines for bilateral breast cancer. Patients are often treated with bilateral mastectomy, with breast conservative surgery having unclear importance. Meticulous diagnosis and appropriate management help to improve the longevity with an improved quality of life.

Uncommon breast malignancies: Presentation pattern, treatment options and outcome in a single Institution experience

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e22174-e22174
Author(s):  
C. Bareggi ◽  
D. Consonni ◽  
B. Galassi ◽  
D. Gambini ◽  
E. Locatelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma ◽  
Treatment Options ◽  
Radical Mastectomy ◽  
Breast Tumors ◽  
Conservative Surgery ◽  
Stage I ◽  
Stage Ii ◽  
Breast Cancer Patients ◽  
Tubular Carcinoma

e22174 Background: Uncommon breast tumors are often neglected by large clinical trials, even if their incidence is not so low. Methods: We investigated stage, treatment and outcome of 112 patients affected by uncommon breast cancer, out of 2,185 breast cancer patients diagnosed and followed in our Institution from January 1985 to October 2008. Results: Rare subtypes were represented as follows: tubular 2.7% (58 pts), mucinous 1.1% (25 pts), medullary 1% (21 pts), papillary 0.4% (8 pts). Median age at diagnosis was 56.5 years among patients with tubular histotype, 68.9 years for mucinous, 55 and 61.7 years for medullary and papillary, respectively. Stage I tumors were 87.7% among patients with tubular differentiation, 60% for mucinous, 26.3% for medullary and 50% for papillary, (compared to 45.7% in invasive ductal carcinoma: 1,626 pts). Stage II represented 12.3% among patients with tubular carcinoma, 32% for mucinous, 57.9% for medullary and 37.5% for papillary. Surgical option for stage I and stage II was usually conservative surgery (quadrantectomy, lumpectomy) plus local radiotherapy, followed by estrogenic blockade. In stage III radical mastectomy was often performed, followed by hormonal suppression. Median DFS for patients with tubular cancer was 4.1 years, for mucinous 3.7 years, 10.5 and 5.1 years for medullary and papillary, respectively. Median OS for patients with tubular cancer was 4.3 years, whereas for mucinous 4.2 years, for medullary 11 years and 5.3 years for papillary. Conclusions: In our retrospective analysis, uncommon breast tumors are often diagnosed at limited stages, resulting in good prognosis, with standard treatment. Further studies are warranted for a better management of these diseases. No significant financial relationships to disclose.

Analysis of magnetic resonance imaging (MRI) in the detection of mammographically occult breast carcinoma

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 603-603
Author(s):  
L. Vallow ◽  
S. Packianathan ◽  
D. Feigel ◽  
E. DePeri ◽  
S. Buskirk ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma ◽  
Breast Mri ◽  
Breast Disease ◽  
Newly Diagnosed ◽  
Breast Cancer Patients ◽  
Mri Findings ◽  
Index Lesion ◽  
Cancer Management ◽  
Infiltrating Ductal Carcinoma

603 Background: Breast MRI may be useful for detecting mammographically occult ipsilateral carcinoma in newly diagnosed breast cancer. Our initial experience with breast MRI, demonstrated 16% of patients to have additional breast disease detected only by preoperative MRI. We further analyzed our findings to identify an association between patient factors and MRI detected disease. Methods: Preoperative MRI scans of 390 women with newly diagnosed breast cancer were reviewed. Using only patients with pathologic verification, the incidence of mammographically occult ipsilateral cancer was determined. Patient and tumor characteristics were further analyzed to identify factors which may predict pathologically positive MRI findings. Results: Of the 390 women undergoing preoperative MRI, 120 (31%) had ipsilateral findings requiring biopsy. Pathologically verified additional ipsilateral cancer was detected in 62 (16%). Multicentric disease was detected in 32 (52%) and multifocal or more extensive local disease in 30 (48%). The median age of all patients was 62 (27% premenopausal) whereas the median age of those with MRI detected additional carcinoma was 55 (44% premenopausal). Of those with additional disease detected by MRI, 74% had index lesions =1 cm and 63% node negative. The most common histology of the index lesion was infiltrating ductal carcinoma in 64%. In the 62 patients found to have additional disease by MRI the most common histology included infiltrating ductal carcinoma (58%), ductal carcinoma-in-situ (34%) and infiltrating lobular (8%). The histology of the MRI detected additional disease was identical to the index lesion in 71%. Conclusions: In women with newly diagnosed breast cancer, there was a 16% incidence of pathologically proven, mammographically occult ipsilateral disease detected by MRI. Patients found to have additional disease tended to be younger, premenopausal or have index tumors =1cm. The contribution of preoperative MRI in breast cancer management continues to evolve. A lower threshold for obtaining breast MRI may be appropriate in selected subsets of breast cancer patients. No significant financial relationships to disclose.

Proteomics of Grade 3 infiltrating ductal carcinoma in Malaysian Chinese breast cancer patients

2009 ◽  
Vol 52 (3) ◽  
pp. 209 ◽  
Author(s):  
M. Izani Othman ◽  
M. I. A. Majid ◽  
Manjit Singh ◽  
S. Subathra ◽  
Liang Seng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Ductal Carcinoma ◽  
Breast Cancer Patients ◽  
Infiltrating Ductal Carcinoma ◽  
Grade 3 ◽  
Malaysian Chinese

scholarly journals Bilateral breast cancer in a 65-year-old man

2021 ◽  
Author(s):  
Arman Sharbatdaran ◽  
Mohammed Twam ◽  
Hosseine Ghorbane ◽  
Novin Nikbakhsh
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma ◽  
Treatment Plan ◽  
Bilateral Breast Cancer ◽  
Signs And Symptoms ◽  
Bilateral Mastectomy ◽  
Breast Pain ◽  
Advanced Stages ◽  
Grade Ii ◽  
Breast Cancer In Men

Abstract Globally, breast cancer in men is exceedingly uncommon. The misinterpretation of signs and symptoms and lack of a proper medical history can lead to the progression of rare conditions to advanced stages. We report the case of a 65-year-old man who presented to the clinic complaining about progressive bilateral dull breast pain. He had been diagnosed with bilateral grade II invasive ductal carcinoma three months prior, and he underwent bilateral mastectomy followed by chemotherapy as a part of his treatment plan.

Infiltrating ductal carcinoma of male breast: A retrospective study

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10753-10753
Author(s):  
T. Puri ◽  
M. Malik ◽  
G. Gunabushanam ◽  
D. N. Sharma ◽  
P. K. Julka ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Ductal Carcinoma ◽  
Lung Metastases ◽  
Bilateral Breast Cancer ◽  
Radical Mastectomy ◽  
Male Breast ◽  
Single Institution ◽  
Infiltrating Ductal Carcinoma ◽  
Progesterone Receptor Positivity

10753 Background: A single-institution retrospective review of the clinical presentation, treatment and outcome of male breast infiltrating ductal carcinoma (IDC). Methods: Case records of 25 male patients with a histological diagnosis of infiltrating ductal carcinoma (IDC) of breast who were treated in a single institution between 1997 to 2004 were retrospectively reviewed. Results: Patients presented at a mean age of 56 years (range, 34 to 80 years). The presenting complaint was a painless lump in the breast in all the cases. The right breast was involved in 13 cases (52%). There were no cases of bilateral breast cancer. The distribution of patients by stage at presentation are: stage IIA (24%), IIB (20%), IIIA (8%), IIIB (40%), and IV (8%). None of the patients presented with stage I disease. One patient had lung metastases at presentation. Rest of the 24 patients (96%) underwent surgery (modified radical mastectomy, 22 patients; simple mastectomy, 2 patients). Fifteen patients (60%) received adjuvant local radiotherapy. All patients received adjuvant chemotherapy: As per departmental protocol, those presenting before 2000 were treated using a regimen of Cyclophosphamide, Adriamycin and 5-Fluorouracil. After 2000, Ebirubicin was substituted for Adriamycin. Three patients were further administered Docetaxel, the indication being disease progression after first line adjuvant chemotherapy. Estrogen & Progesterone receptor positivity was 64% and 60% respectively. Hormonal therapy (Tamoxifen 14 patients, Anastrozole 2 patients) was administered in these patients. The length of follow-up from time of presentation ranged from 4 to 100 months (mean, 28 months; median, 13 months). At the time of analysis, of the 25 patients, 18 patients (72%) remain disease free, whereas 7 patients (28%) developed progressive disease. Median survival was not reached at the present time. Conclusions: Breast cancer, specifically IDC tends to present at a later stage in males, due to a lack of screening for the disease. In the present series, as a result of the advanced stage of initial presentation, all patients received adjuvant chemotherapy. There is a need to improve awareness among males, of the possibility of a painless breast lump being the first symptom of an underlying malignancy. No significant financial relationships to disclose.

scholarly journals Mixed Mucinous and Invasive Ductal Carcinoma of Male Breast: A Rare Case Report

2017 ◽  
pp. 1-4
Author(s):  
Kuldeep Ananda Vaidhya ◽  
Sukesh
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Ductal Carcinoma ◽  
Histopathological Examination ◽  
Mucinous Carcinoma ◽  
Male Breast ◽  
Rare Entity ◽  
Infiltrating Ductal Carcinoma ◽  
Rare Case Report ◽  
Desmoplastic Stroma

Male breast carcinoma is a rare entity. Here, we present a case of mixed mucinous carcinoma i.e. composite mucinous carcinoma with infiltrating ductal carcinoma component in a 55 year old man. Patient clinically presented with a lump in his right breast. Histopathological examination of the breast mass showed tumor cells arranged in nests, cords, cribriform pattern in a mucinous stroma and a part of tumor was showing features of infiltrating ductal carcinoma with desmoplastic stroma.

scholarly journals Survival Outcomes in Male Breast Cancer – A Single Institution Experience

2018 ◽  
Vol 3 (4) ◽  
pp. 71
Author(s):  
Nisha Hariharan
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Treatment Guidelines ◽  
Ductal Carcinoma ◽  
Radical Mastectomy ◽  
Male Breast ◽  
Survival Outcomes ◽  
Breast Cancers ◽  
Breast Cancer Patients

Introduction: Male breast cancer is an uncommon entity. Due to the scarce numbers, treatment protocolshave largely been extrapolated from available evidence for female breast cancers.Methods: We analysed the clinicopathological features and survival outcomes for male breast cancer patients treated at our institute between January 2010 and June 2016.Results: Of the 5534 women treated at our institute, we screened 40 male breast cancers of whom 33 had available follow up data and were included in the present analysis. Male breast cancer constituted 0.7% of all breast cancers. The median age was 60 years and the median tumor size was 3cm with 66% of patients having nodal disease at presentation. Invasive ductal carcinoma was the most common histology and 97% were hormone receptor positive. Most of the patients (87.8%) underwent an upfront modified radical mastectomy. With a median follow up of 36 months, 10 patients experienced recurrences all of which were distant metastasis (3 to the bone, 1 to the brain, and 6 had visceral metastasis). Of these, 7 patients succumbed to the disease. The 3-year overall survival was 78.7 %.Conclusion: Male breast cancer is a rare clinical entity and current treatment guidelines follow those for women. Due to the lack of awareness, men often present to clinics at an advanced stage. Social support targeted at improving awareness and access to treatment could improve outcomes in this cohort.  

scholarly journals BILATERAL BREAST CANCER - CASE SERIES

2020 ◽  
pp. 1-2
Author(s):  
N. Murugesan ◽  
M. Amudhan ◽  
M.S. Viswanathan ◽  
Bhanumati Bhanumati ◽  
Muthuraj Muthuraj ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma ◽  
Bilateral Breast Cancer ◽  
Case Series ◽  
Breast Cancer Case ◽  
Metastatic Carcinoma ◽  
Primary Carcinoma ◽  
Cancer Case ◽  
Infiltrating Ductal Carcinoma ◽  
Secondary Lesion

This is a presentation of four rare and interesting cases of bilateral breast cancer. The cases vary from Synchronous double primary carcinoma breast, bilateral infiltrating ductal carcinoma, bilateral synchronous metastatic carcinoma and metachronous breast carcinoma. The incidence of developing either primary or metastatic carcinoma in the other breast is increased in patients who already have carcinoma in one side and mammography contributes greatly to the detection of these lesions. (1) It is of significant prognostic value and important in deciding the clinical management based on the classification whether it is a primary or a secondary lesion.

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