Association of metabolic syndrome with complicated gall stone disease: our experience

Background: Gall stone disease is the most common biliary pathology and frequently encountered in our daily practice. Patients with gall stone that experienced at least one attack of acute cholecystitis is defined as complicated gall stone disease (CGSD). Aim of this study was to find out the association between complicated gall stone disease and the metabolic syndrome.Methods: This prospective, observational study was done from 1st March 2017 to 30th November 2018 in department of general surgery, SMS hospital Jaipur. All patients with cholelithiasis admitted in general surgery department were included. Metabolic syndrome was defined by adult treatment panel III (ATP III) criteria. All patients were divided in two groups: complicated gall stone disease (CGSD) and uncomplicated gall stone disease (UGSD).Results: Mean age was 47.2 years in CGSD group and 46.7 year in UGSD group. Female to male ratio was 8.2:1 in CGSD group and 4:1 in UGSD. Metabolic syndrome was presented in 64 patients (58.2%) of CGSD group and 24 patients (21.8%) of UGSD patients, which was statistically significant (OR 4.986, CI 2.763-8.995, p value <0.001). Five components of metabolic syndrome were compared in both CGSD group and UGSD group. Lower serum HDL-C level and hyperglycemias was statistically significant in CGSD group as compared to UGSD group.Conclusions: Metabolic syndrome can be use to predict complicated gall stone disease. Hyperglycaemia and lower HDL-C associated with CGSD. One should be aware about possible metabolic syndrome background when dealing with gall stone disease patients.

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Etiology and chemical composition of gall stone disease: a prospective observational study from the developing world

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20210997 ◽

2021 ◽

Author(s):

Syed Mushtaq Ahmed Shah ◽

Tahir Saleem Khan ◽

Ravi Kumar ◽

Tajddin Wani ◽

Adil Shadab Indrabi

Keyword(s):

Calcium Carbonate ◽

Chemical Composition ◽

Observational Study ◽

Prospective Observational Study ◽

Gall Stone ◽

Stone Disease ◽

Common Component ◽

Calcium Bilirubinate ◽

Gall Stones ◽

Gall Stone Disease

Background: Aim of the study was to assess the etiology and determine the chemical composition of gallstones in our population.Methods: This was a prospective observational study conducted at GMC Srinagar from 2018 to 2020. One hundred patients having gall stone disease were enrolled into the study and after cholecystectomy was performed the stones chemical composition was analyzed by fourier-transform infrared (FTIR) spectroscopy. The data was collated and analysed.Results: 54 patients had mixed stones with chemical composition of cholesterol, calcium carbonate and calcium bilirubinate; 39 had cholesterol stones and 7 patients had pigmented stone with chemical composition of cholesterol, calcium carbonate and calcium bilirubinate.Conclusions: Our results suggest that cholesterol, either singularly or in combination with calcium carbonate or bilirubin is a common component of gall stones in our population.

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An observational study on the association of nonalcoholic fatty liver disease and metabolic syndrome with gall stone disease requiring cholecystectomy

Annals of Medicine and Surgery ◽

10.1016/j.amsu.2017.03.015 ◽

2017 ◽

Vol 17 ◽

pp. 7-13 ◽

Cited By ~ 8

Author(s):

Farah Ahmed ◽

Qamaruddin Baloch ◽

Zahid Ali Memon ◽

Iqra Ali

Keyword(s):

Metabolic Syndrome ◽

Liver Disease ◽

Observational Study ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Gall Stone ◽

Stone Disease ◽

Nonalcoholic Fatty Liver ◽

Gall Stone Disease

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Metabolic Syndrome: An Indicator of Complicated Gall Stone Disease?

Cureus ◽

10.7759/cureus.3659 ◽

2018 ◽

Cited By ~ 1

Author(s):

Monis J Ahmed ◽

Rasheeqa Mahmood ◽

Roshane S Rana ◽

Muhammad T Pirzada ◽

Jahanzaib Haider ◽

...

Keyword(s):

Metabolic Syndrome ◽

Gall Stone ◽

Stone Disease ◽

Gall Stone Disease

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Is hypothyroidism a risk for gall stone disease? a study to assess the association

International Surgery Journal ◽

10.18203/2349-2902.isj20173406 ◽

2017 ◽

Vol 4 (8) ◽

pp. 2665

Author(s):

Yawar Zahoor Watali ◽

Rahul Jain ◽

Rajandeep Singh Bali ◽

Ankul Mittal

Keyword(s):

Gall Stone ◽

Stone Disease ◽

Control Group ◽

P Value ◽

Case Group ◽

Endocrine Disorders ◽

Gall Stones ◽

Significant Difference ◽

Gall Stone Disease ◽

Thyroid Profile

Background: Gall stones are one of the most common problems affecting the digestive tract requiring hospitalization. The disease frequently occurs in young, otherwise healthy people with a prevalence of 11-36 % on autopsy report. Thyroid diseases are, arguably, among the commonest endocrine disorders worldwide. In the present study, we have tried to determine an association between gall stone disease, and previously diagnosed and undiagnosed hypothyroidism in patients presenting to our hospital for treatment. The aim of this study was to determine association between gallstones and hypothyroidism and to study the prevalence of previously undiagnosed hypothyroidism in all patients of gallstones.Methods: The study was a hospital based cross sectional, observational study conducted on 200 patients with upper abdominal pain attending the Surgery OPD and Emergency over a period of 1 years. Patients were divided into 2 groups: Case group (100 patients) with gall stones on ultrasound and Control group (100 patients) without gall stones on ultrasound. Thyroid profile along with other biochemical investigations was done and both the groups were compared for the parameters.Results: Both groups were comparable for age and sex of the patients. On considering the thyroid profile of the patients in both the groups we observed that 14% of patients were hypothyroid in case group and 8% of the patients in control group. On comparing the two groups, there was no statistically significant difference in the prevalence of hypothyroidism (p value 0.175) between the two groups. There was a significant difference when serum cholesterol and bilirubin levels were compared between the two groups. 7 patients out of 100 cholelithiasis had Choledocolithiasis too, these patients had significantly raised cholesterol and deranged liver function tests.Conclusions: No significant relation between gallstones and hypothyroidism was found in this study (p value=0.175) and need further evaluation. Among the hypothyroid patients the incidence of gall stones was highest among 51-60 years of age so we recommend that TSH level should be measured for every patient with gallstone disease in this age range.

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An evaluation of open versus laparoscopic cholecystectomy in tertiary centre

International Surgery Journal ◽

10.18203/2349-2902.isj20193319 ◽

2019 ◽

Vol 6 (8) ◽

pp. 2797

Author(s):

Kanwar Singh Goel ◽

Sapna Goel ◽

Sham L. Singla ◽

Pawan Tiwari

Keyword(s):

Laparoscopic Cholecystectomy ◽

Gall Stone ◽

Age Groups ◽

Stone Disease ◽

Average Hospital ◽

Medical College ◽

Tertiary Centre ◽

Gall Stone Disease ◽

Open Versus ◽

Surgery Department

Background: Cholecystectomy is a method of treatment for acute or chronic cholecystitis with cholelithiasis or any other diseases of gall bladder. The diagnosis of gall stone disease depends on an accurate history, physical examination, supporting lab investigations and a proper ultrasound of abdomen. After the advent of lap cholecystectomy there is revolution in minimally invasive surgery. Because of better technological innovations, the lap cholecystectomy has become gold standard presently.Methods: This prospective observational study was performed in Surgery Department in SGT Medical College, Budhera, Gurugram, over a period of 2 years from January 2017 to January 2019. Patients were taken from both sexes and all age groups from different units of surgery. A total of 100 patients were taken for study who underwent cholecystectomy.Results: Mean age of patients in our study was 38.64 years. Most patients were females. Procedure adopted was open in 18% patients and lap cholecystectomy in 74% patients. Conversion from laparoscopic to open was done in 8% patients. In 8% patients there were operative complications. Average hospital stay was much less for lap cholecystectomy.Conclusions: After the advent of laparoscopic cholecystectomy, most of the surgeons are performing more and more of laparoscopic cholecystectomy. Here incision is small, pain is less, and hospitalization is shorter. Even in acute cholecystitis, in experienced hand, lap cholecystectomy can be performed safely. The author’s inclination is totally in favour of lap cholecystectomy, except the cases where lap cholecystectomy is contraindicated.

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Diagnostic value of upper gastrointestinal endoscopy prior to elective laparoscopic cholecystectomy for symptomatic cholelithiasis

International Surgery Journal ◽

10.18203/2349-2902.isj20175549 ◽

2017 ◽

Vol 5 (1) ◽

pp. 105

Author(s):

Indira Khedkar ◽

Dinesh Prasad ◽

Achal Datta

Keyword(s):

Laparoscopic Cholecystectomy ◽

Gall Stone ◽

Gastrointestinal Symptoms ◽

Stone Disease ◽

P Value ◽

Upper Gastrointestinal Endoscopy ◽

Complete Relief ◽

Gastrointestinal Lesions ◽

Gall Stone Disease ◽

Symptomatic Gall Stone

Background: Laparoscopic cholecystectomy is gold standard surgery for symptomatic gall stone disease which is the commonest disease needs surgical management. Present study was conducted to contribute UGI endoscopy as routine preoperative investigation and the importance of UGI endoscopy to evaluate the association between gastrointestinal symptoms with gallstones and reduce the prevalence of post cholecystectomy pain.Methods: Patients with Ultrasonography suggestive of single or multiple gall stones were included and investigated as per proforma. Upper GI Scopy was done 1 to 2 days prior to laparoscopic cholecystectomy as per inclusion and exclusion criteria. All patients above 18years, with ultrasonographically proven diagnosis of cholelithiasis and with symptoms (typical and atypical) were included.Results: In present study, author have evaluated the different OGD pathologies the most common site of pathology was stomach (72.5%) that was gastritis. Followed by oesophagitis (55%), and Hiatus hernia (16.5) The most common duodenal pathology was duodenitis (6.25%). In present study, 71 patients had pain in epigastrium at presentation which gradually subsided with no complains of pain in 3 months. Statistically significant reduction in pain was appraised at the end of first week itself (p-value <0.0001).Conclusions: Certain symptoms associated with gallstones are not alleviated by cholecystectomy itself and requires further exploration, therefore, patients presenting with symptomatic gall stone disease should undergo routine OGD prior to cholecystectomy as many gastrointestinal lesions may coexist which prevents the complete relief of the symptoms after cholecystectomy.

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Investigation of the Lith1 candidate genes ABCB11 and LXRA in human gall stone disease

Zeitschrift für Gastroenterologie ◽

10.1055/s-2006-950845 ◽

2006 ◽

Vol 44 (08) ◽

Author(s):

C Schafmayer ◽

J Tepel ◽

JH Egberts ◽

A Franke ◽

S Buch ◽

...

Keyword(s):

Candidate Genes ◽

Gall Stone ◽

Stone Disease ◽

Gall Stone Disease

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Early experience of laparoscopic cholecystectomy in acutely inflamed gallbladder

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v9ispl1.1283 ◽

2018 ◽

Vol 9 (SPL1) ◽

Author(s):

Ali Abdul Hussein Handoz ◽

Ahmed Kh Alsagban

Keyword(s):

Laparoscopic Cholecystectomy ◽

Acute Cholecystitis ◽

Gall Stone ◽

The Elderly ◽

Stone Disease ◽

Definitive Treatment ◽

Adjacent Structures ◽

Common Causes ◽

Gall Stone Disease ◽

Male To Female

Gallstones are now among the most important disease in the era of surgery. Definitive treatment of gall stone disease remains cholecystectomy. One of the common causes of emergency surgical referral is acute cholecystitis of which 50-70% cases are seen in the elderly patients.50 patients were treated with laparoscopic cholecystectomy from October 2013 to October 2015. The patient’s age was from 20 to 65 years old with a mean age of 34 ±3 years old. The patients received in the emergency unit and their attack not more than 72 hrs of acute gall stone inflammation were included in this study.From the 50 patients,15 were males (34%) and females were 35 (74%) so the ratio of 1:2of male to female. Problems and complications that facing in this study at time of laparoscopy were mainly adhesions to the adjacent structures like stomach, colon, and omentum. Adhesion into CBD also considered.Early intervention for acute cholecystitis of calculus type by laparoscopy now regarding safe and gold standard approach that should be kept in mind when dealing with such cases.

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