Prospective study of accuracy of C-reactive protein and leucocyte count in diagnosis of acute appendicitis in comparison with histopathology

Background: Acute appendicitis is one of the most common surgical emergencies. Approximately 7.0% of the population will have appendicitis in their lifetime with the peak incidence occurring between the age of 10 and 30 years. The classical history of peri umbilical pain at beginning and later shifting to right iliac fossa is present in only 50% cases. C-reactive protein is an acute phase reactant synthesized by liver in response to tissue injury. Serial measurement of CRP can improve the accuracy of diagnosing acute appendicitis.Methods: A prospective study of 70 cases with clinical diagnosis of acute appendicitis admitted in the department of surgery, B. R. D. Medical College Gorakhpur during a period of one year.Results: There was young age predominance (54.2%) and commonest presenting symptom was RIF pain (100%) followed by nausea/vomiting (66%) and fever (60%). Among 48 cases of histopathology proven appendicitis, CRP was raised in 44 cases (91.6%).Conclusions: Serial measurement of CRP is more sensitive and specific than TLC count and the raised value of CRP is directly related to the severity of inflammation. Combining the TLC and CRP increases the diagnostic accuracy and therefore may reduce rate of negative appendectomy.

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The value of C-Reactive protein in diagnosis of acute appendicitis - A prospective study

Medpusle International Journal of Surgery ◽

10.26611/1061132 ◽

2019 ◽

Vol 11 (3) ◽

pp. 149-152

Author(s):

Ajith Kumar H ◽

◽

Abhinandan B Vandakudri ◽

Praveen Kumar K ◽

◽

...

Keyword(s):

Acute Appendicitis ◽

Prospective Study ◽

C Reactive Protein ◽

Reactive Protein ◽

A Prospective Study

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The value of C-Reactive protein in diagnosis of acute appendicitis - A prospective study

Medpusle International Journal of Surgery ◽

10.26611/10611212 ◽

2019 ◽

Vol 11 (2) ◽

pp. 148-152

Author(s):

Ajith Kumar H ◽

◽

Abhinandan B Vandakudri ◽

Praveen Kumar K ◽

◽

...

Keyword(s):

Acute Appendicitis ◽

Prospective Study ◽

C Reactive Protein ◽

Reactive Protein ◽

A Prospective Study

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Accuracy of Leukocyte Count and C-Reactive Protein in the Diagnosis of Acute Appendicitis –A Prospective Study

International Journal of Anatomy Radiology and Surgery ◽

10.7860/ijars/2016/18067.2129 ◽

2016 ◽

Author(s):

Srikanataiah Hiremath

Keyword(s):

Acute Appendicitis ◽

Prospective Study ◽

Leukocyte Count ◽

C Reactive Protein ◽

Reactive Protein ◽

A Prospective Study

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Alteration of Body Temperature, Erythrocyte Sedimentation Rate, and C-reactive Protein After Reamed Intramedullary Nailing: A Prospective Study

Yearbook of Orthopedics ◽

10.1016/s0276-1092(08)70392-4 ◽

2006 ◽

Vol 2006 ◽

pp. 91

Author(s):

M.F. Swiontkowski

Keyword(s):

Body Temperature ◽

Prospective Study ◽

Erythrocyte Sedimentation Rate ◽

Intramedullary Nailing ◽

Sedimentation Rate ◽

C Reactive Protein ◽

Reactive Protein ◽

Erythrocyte Sedimentation ◽

A Prospective Study

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Comparison of Clinical Features Between Patients with Positive and Negative Appendectomy

10.21203/rs.3.rs-117309/v1 ◽

2020 ◽

Author(s):

Guner Cakmak ◽

Baris Mantoglu ◽

Emre Gonullu ◽

Kayhan Ozdemir ◽

Burak Kamburoglu

Keyword(s):

Acute Appendicitis ◽

Clinical Features ◽

Total Bilirubin ◽

Negative Appendectomy ◽

C Reactive Protein ◽

Future Studies ◽

Female Patients ◽

Reactive Protein ◽

Male Patients ◽

The Mean

Abstract Background: The objective of this study was to retrospectively compare clinical features and prognostic values between the patients who were referred to the general surgery clinic of our hospital with the presumed diagnosis of acute appendicitis and underwent positive or negative appendectomy.Methods: Patients were divided into two groups as positive (PA) (n:362) and negative appendectomy (NA) (n:284) and the data obtained were compared between these two groups.Laboratory investigations were performed in all patients, and white blood cell (WBC), mean platelet volume (MPV), neutrophils count (NEU), neutrophils (%) (NEU%), C-reactive protein (CRP) and total bilirubin (TBIL) values were studied.Results: The mean MPV value was found as 7.88 fl in PA groups and 8.09 fl in NA group, and the mean MPV value was not statistically significantly difference in PA group, compared to NA groups (p=0.012). Laboratory parameters were also compared between genders. Accordingly, the mean MPV value was statistically significantly higher in female patients compared to male patients in PA group (p = 0.04). The mean TBIL value was 0.97 mg/dl in PA group and 0.69 mg/dl in NA group, and the mean TBIL value was statistically significantly higher in PA group (p< 0.001). Finally, TBIL value was statistically significantly lower in female patients compared to male patients in NA and PA group (p < 0.05).Conclusions: According to the results of our study, MPV and T. BIL values differ in PA and NA groups depending on gender. Therefore, these values may not be used as specific biomarkers in predicting positive acute appendicitis. We believe that these results will contribute to the literature and will be guiding for future studies.

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