Study of common aeroallergens in children with wheeze: a hospital based cross sectional study

Background: Prevention of diseases of the allergic origin depends upon the early identification of aeroallergens. Vaccine for allergy may not be required in all cases. but when treatment is not successful, then there is requirement of the vaccine. Objective of study allergens responsible for inducing recurrent wheezingMethods: A cross sectional observation study was carried out at Departmetn of Pediatric, Shadan Institue of Medical Sciences, Peerancheru, Hyderabad, Telangana, India from June 2017 to June 2018 among 100 children with recurrent (4 or more episodes of wheezing in past one year) ages between 2 yrs to 10 yrs. Using the guidelines for skin prick test as per the European committee, the skin prick test was carried out. Insulin syringe was used for the intradermal test. It is done using standardized allergen extracts (Creative Diagnostic Medicare pvt ltd) were done for our cases.Results: Out of 100 children studied, 67 children were found to be sensitive to at least one of the aeroallergen and 33 children were found to be negative for all the aeroallergens. A statistically significant correlation is seen between the age groups and sensitivity (p value 0.025). Out of 67 children with a positive skin prick test, 66 children showed the sensitivity to indoor allergens. The association between the indoor allergens and the wheezing is statistically significant (P value <0.0001)Conclusion: In children the sensitivity to indoor allergens is more prevalent than sensitivity to outdoor allergens. Sensitivity to pollen was found in older children more than 5 years of age.

Download Full-text

Food allergies in children: a comparison of parental reports and skin prick test results

Paediatrica Indonesiana ◽

10.14238/pi58.2.2018.59-65 ◽

2018 ◽

Vol 58 (2) ◽

pp. 59-65

Author(s):

Camilia Metadea Aji Savitri ◽

Azwin Mengindra Putera Lubis ◽

Gatot Soegiarto

Keyword(s):

Skin Prick Test ◽

Skin Prick Testing ◽

Food Allergies ◽

P Value ◽

Positive Skin Prick Test ◽

Test Results ◽

Cross Sectional ◽

Positive Skin ◽

Prick Test ◽

Parental Reports

Background Food allergy is common in children and its prevalence is generally on the rise. Imprecise parental reports about reactions to particular foods can lead to unnecessary restrictions. Since children have specific growth requirements, such nutritional restrictions may have disturbing effects on children’s growth and development.Objective To compare parental reports on food reactions to skin prick test results in their children.Method Retrospective, cross sectional study using patient’s medical record data during one-year study period. Data were analyzed manually and statistically, to assess the degree of agreement (Kappa’s coefficient) and significance (P).Results We collected data from 154 subjects aged 0-18 years. For every allergen assessed, parents reported more food reactions than positive skin prick test results. Allergy incidence were caused, in order, by cow’s milk and chicken (25.3%), eggs (22.1%), chocolate (20.1%), fruits (14.3%), seafood (13%), and saltwater fish (1.9%). Kappa coefficient are all poor (<0.2) and P value are all >0.05 except for chicken (P=0.02).Conclusion Most parents tend to overestimate which food cause reactions in their children, as reactions reported were not necessarily allergenic. Therefore, every patient experiencing allergy reactions should undergo skin prick testing to confirm the possibility of allergy.

Download Full-text

Atopy and Quality of Life in Pediatric Chronic Rhinosinusitis

American Journal of Rhinology and Allergy ◽

10.1177/1945892419854266 ◽

2019 ◽

Vol 33 (5) ◽

pp. 586-590 ◽

Cited By ~ 4

Author(s):

Anamika Anamika ◽

Arunabha Chakravarti ◽

Raj Kumar

Keyword(s):

Quality Of Life ◽

Skin Prick Test ◽

Chronic Rhinosinusitis ◽

Cross Sectional Study ◽

Endoscopic Examination ◽

Positive Skin Prick Test ◽

Cross Sectional ◽

Positive Skin ◽

Prick Test

Background Atopy has been suggested in the development of chronic rhinosinusitis (CRS), as allergic rhinitis (AR) is common coexisting disease in pediatric and adult patients with CRS. The contribution of AR to CRS is less clear till date. Objectives The objectives of this study were to determine atopic profile of children with CRS and impact of atopic status on disease severity and quality of life. Methods One hundred ten patients, aged between 7 and 18 years of age, diagnosed with CRS based on history, detailed clinical examination including nasal endoscopic examination were included in this cross-sectional study. Scoring of CRS was done according to Lund Mackay Endoscopic Appearance Score. Patients underwent skin prick test against 65 common aeroallergens (1:10 w/v, 50% glycerinated) for evidence of atopy. SN-5 Sinus and Nasal Quality of Life Survey was used to assess the quality of life in the study subjects. Results Positive skin prick test to at least one of the common aeroallergens was present in 58 (52.7%) patients. Most common aeroallergen sensitivity was seen with insects in 48 (43.6%) patients. Patients of CRS with atopy had higher mean Lund Mackay endoscopic score and SN-5 score than nonatopic patients which was statistically significant. Conclusion In conclusion, we recommend that testing for aeroallergen sensitivity and assessment of quality of life should be included in the protocol for diagnosis and management of pediatric patients with CRS. Early diagnosis and treatment of allergy may halt the progression of CRS and also the development of asthma and other allergic multimorbid disorders.

Download Full-text

Prevalence and associated factors of airway hyper- responsiveness in children with recurrent chronic cough

Paediatrica Indonesiana ◽

10.14238/pi44.5.2004.181-7 ◽

2016 ◽

Vol 44 (5) ◽

pp. 181 ◽

Cited By ~ 1

Author(s):

I Gusti Agung Ngurah Sugitha Adnyana ◽

Putu Suwendra ◽

Hendra Santoso

Keyword(s):

Skin Prick Test ◽

Passive Smoking ◽

Chronic Cough ◽

Associated Factors ◽

Positive Skin Prick Test ◽

Cross Sectional ◽

Positive Skin ◽

Cough Variant Asthma ◽

Prick Test ◽

History Of

Background Airway hyper-responsiveness (AH) is a common char-acteristic of asthma. Patient who has recurrent chronic cough withAH is commonly referred as “cough variant asthma”. Histamineprovocation test should be performed to determine whether a pa-tient has “cough variant asthma” or recurrent viral bronchitis.Objective To determine AH prevalence in children with recurrentchronic cough and factors associated with it.Methods A cross sectional study was conducted on 6-12 year-oldchildren with recurrent chronic cough at the Pediatrics OutpatientClinic, Sanglah Hospital Denpasar from September 2002 until June2003Results Twenty one out of 64 (33%) subjects suffering from recur-rent chronic cough without wheezing had AH. Associated factorssignificantly associated with AH were age, allergic rhinitis, pater-nal and maternal history of atopy, passive smoking, use of mos-quito-coil, positive skin prick test, and eosinophilia. Spearman cor-relation analysis between associated factors and AH showed thatpositive skin prick test and passive smoking were moderately cor-related with AH (r=0.56, p<0.0001; r=0.57, p<0.0001, respectively),whereas multivariate regression logistic analysis on associatedfactors found true associated factors, such as positive skin pricktest (p=0.01; OR=14.82), history of atopy in father (p=0.02;OR=22.75), and passive smoking (p=0.03; OR=11.97).Conclusions The prevalence of airway hyper-responsiveness inchildren with recurrent chronic cough without history of wheezingwas 33%. Independent associated factors of AH in recurrent chroniccough children are positive skin prick test, history of atopy in fa-ther, and passive smoking

Download Full-text

Anaphylaxis to Glatiramer Acetate

The Open Allergy Journal ◽

10.2174/1874838401508010023 ◽

2015 ◽

Vol 8 (1) ◽

pp. 23-25 ◽

Cited By ~ 1

Author(s):

By Stefan Wöhrl ◽

Felix Wantke ◽

Wolfgang Hemmer

Keyword(s):

Multiple Sclerosis ◽

Skin Prick Test ◽

Glatiramer Acetate ◽

Intradermal Test ◽

Positive Skin Prick Test ◽

Positive Skin ◽

Prick Test ◽

Asthma Attack ◽

Anaphylactoid Reactions ◽

Ige Mediated

Glatiramer acetate (Copaxone, Teva Pharma) and interferon beta are the two only disease-modifying therapies for multiple sclerosis. Glatiramer acetate is known for frequently simulating mild, anaphylactoid reactions while true, IgEmediated allergic reactions have been hardly reported so far. Herein, we report two females suffering from multiple sclerosis who experienced rapidly aggravating hypersensitivity-reactions upon treatment with glatiramer acetate. Patient one experienced an asthma attack, patient two an exacerbation of her urticaria and angioedema. An IgE-mediated mechanism could be demonstrated by a positive intradermal test to a 1:1000 dilution in the first 31-year old and by a positive skin prick test to a 1:10 diluted skin prick test in the second 32-year old second woman.

Download Full-text

Incidence of sensitization to specific inhalatory allergens in patients suffering from allergic rhinitis

Vojnosanitetski pregled ◽

10.2298/vsp170309071b ◽

2019 ◽

Vol 76 (1) ◽

pp. 50-54

Author(s):

Maja Buljcik-Cupic ◽

Slobodan Savovic ◽

Sanja Hromis ◽

Slobodanka Lemajic-Komazec ◽

Dea Karaba-Jakovljevic

Keyword(s):

Allergic Rhinitis ◽

Skin Prick Test ◽

Allergic Sensitization ◽

Positive Skin Prick Test ◽

Indoor Allergens ◽

Positive Skin ◽

Prick Test ◽

Chronic Rhinitis ◽

Frequent Type ◽

Number Of Patients

Backgound/Aim. Allergic rhinitis is the most frequent type of rhinitis affecting more than 600 million people worldwide. As incidence increases, it is important to know about the characteristics, the allergens that exacerbate it as well as effects of allergic rhinitis on population. The aim of this study was to determine among patients with chronic rhinitis the number of patients positive to standard inhaled allergens, their distribution by sex, age and to determine the type and frequency of allergic sensitization to specific inhalatory allergens. Methods. Data was collected from 514 patients tested for standard inhalatory allergens via the skin prick test from 01.01.2016 to 31.12. 2016. Age, sex and concomitant diseases as well an analysis of type and frequency of hypersensitivity to different allergens were assessed and recorded. Results. Of 514 patients, 307 patients, with an average age of 29.6 ? 8.88 years had a positive skin prick test. The sex ratio was 1.2 : 1 in favor of the females. Outdoor allergens affected 81.2% of all patients while indoor allergens 66.4% of them. Weed pollen (71%), grass pollen (61%) and Dermatophagoides pteronyssinus (46%) were the most common allergens. Most patients were sensitized to 1 (22%) or 2 (22%) allergens, while 20% of patients were simultaneously sensitized to 3 allergens. Conclusion. Most patients with the symptoms of chronic rhinitis had a positive allergic reaction. Those in their third decade of life were the most commonly affected. Outdoor allergens were the most prevalent allergen group, and weed pollen was the most frequent type of allergen.

Download Full-text

Is Atopy Related to Neuroticism, Stress, and Subjective Quality of Life?

Archives of Industrial Hygiene and Toxicology ◽

10.2478/10004-1254-60-2009-1899 ◽

2009 ◽

Vol 60 (1) ◽

pp. 99-107 ◽

Cited By ~ 5

Author(s):

Biserka Radošević-Vidaček ◽

Adrijana Košćec ◽

Marija Bakotić ◽

Jelena Macan ◽

Jasminka Bobić

Keyword(s):

Quality Of Life ◽

Skin Prick Test ◽

Life Events ◽

Stressful Life Events ◽

Stressful Life ◽

Positive Skin Prick Test ◽

Subjective Quality Of Life ◽

Positive Skin ◽

Prick Test

Is Atopy Related to Neuroticism, Stress, and Subjective Quality of Life?Different psychosocial characteristics have been associated with allergic disorders. The aim of this study was to examine whether atopic constitution and reports of allergic symptoms were related to personality trait of neuroticism, exposure to stressful life events and estimates of quality of life. Atopy was determined by skin prick test and reports of nasal and pulmonary allergy-related symptoms. Actively working individuals of both genders took part in the study (n=145, age range: 20 to 66 years). The participants were divided in three groups. The first group was composed of those with negative skin prick test and without symptoms (n=57), the second of those with positive skin prick test but without symptoms (n=28), and the third of those with positive skin prick test and symptoms (n=60). The groups did not differ significantly in neuroticism, exposure to stressful life events, or quality of life. Women reported more pronounced neuroticism and anxiety, higher exposure to stressful life events, and were less satisfied with their environment than men. In our sample of active workers we found no association of neuroticism, exposure to stressful life events, and quality of life with atopy and allergic symptoms.

Download Full-text