scholarly journals Anaphylaxis to Glatiramer Acetate

2015 ◽  
Vol 8 (1) ◽  
pp. 23-25 ◽  
Author(s):  
By Stefan Wöhrl ◽  
Felix Wantke ◽  
Wolfgang Hemmer
Keyword(s):  
Multiple Sclerosis ◽  
Skin Prick Test ◽  
Glatiramer Acetate ◽  
Intradermal Test ◽  
Positive Skin Prick Test ◽  
Positive Skin ◽  
Prick Test ◽  
Asthma Attack ◽  
Anaphylactoid Reactions ◽  
Ige Mediated

Glatiramer acetate (Copaxone, Teva Pharma) and interferon beta are the two only disease-modifying therapies for multiple sclerosis. Glatiramer acetate is known for frequently simulating mild, anaphylactoid reactions while true, IgEmediated allergic reactions have been hardly reported so far. Herein, we report two females suffering from multiple sclerosis who experienced rapidly aggravating hypersensitivity-reactions upon treatment with glatiramer acetate. Patient one experienced an asthma attack, patient two an exacerbation of her urticaria and angioedema. An IgE-mediated mechanism could be demonstrated by a positive intradermal test to a 1:1000 dilution in the first 31-year old and by a positive skin prick test to a 1:10 diluted skin prick test in the second 32-year old second woman.

scholarly journals Study of common aeroallergens in children with wheeze: a hospital based cross sectional study

2019 ◽  
Vol 6 (5) ◽  
pp. 1971
Author(s):  
Kalavathy Jasmine Masillamoni ◽  
Nayantara R. Gandra
Keyword(s):  
Skin Prick Test ◽  
Age Groups ◽  
Intradermal Test ◽  
P Value ◽  
Positive Skin Prick Test ◽  
Indoor Allergens ◽  
Observation Study ◽  
Cross Sectional ◽  
Positive Skin ◽  
Prick Test

Background: Prevention of diseases of the allergic origin depends upon the early identification of aeroallergens. Vaccine for allergy may not be required in all cases. but when treatment is not successful, then there is requirement of the vaccine. Objective of study allergens responsible for inducing recurrent wheezingMethods: A cross sectional observation study was carried out at Departmetn of Pediatric, Shadan Institue of Medical Sciences, Peerancheru, Hyderabad, Telangana, India from June 2017 to June 2018 among 100 children with recurrent (4 or more episodes of wheezing in past one year) ages between 2 yrs to 10 yrs. Using the guidelines for skin prick test as per the European committee, the skin prick test was carried out. Insulin syringe was used for the intradermal test. It is done using standardized allergen extracts (Creative Diagnostic Medicare pvt ltd) were done for our cases.Results: Out of 100 children studied, 67 children were found to be sensitive to at least one of the aeroallergen and 33 children were found to be negative for all the aeroallergens. A statistically significant correlation is seen between the age groups and sensitivity (p value 0.025). Out of 67 children with a positive skin prick test, 66 children showed the sensitivity to indoor allergens. The association between the indoor allergens and the wheezing is statistically significant (P value <0.0001)Conclusion: In children the sensitivity to indoor allergens is more prevalent than sensitivity to outdoor allergens. Sensitivity to pollen was found in older children more than 5 years of age.

scholarly journals Is Atopy Related to Neuroticism, Stress, and Subjective Quality of Life?

2009 ◽  
Vol 60 (1) ◽  
pp. 99-107 ◽  
Author(s):  
Biserka Radošević-Vidaček ◽  
Adrijana Košćec ◽  
Marija Bakotić ◽  
Jelena Macan ◽  
Jasminka Bobić
Keyword(s):  
Quality Of Life ◽  
Skin Prick Test ◽  
Life Events ◽  
Stressful Life Events ◽  
Stressful Life ◽  
Positive Skin Prick Test ◽  
Subjective Quality Of Life ◽  
Positive Skin ◽  
Prick Test

Is Atopy Related to Neuroticism, Stress, and Subjective Quality of Life?Different psychosocial characteristics have been associated with allergic disorders. The aim of this study was to examine whether atopic constitution and reports of allergic symptoms were related to personality trait of neuroticism, exposure to stressful life events and estimates of quality of life. Atopy was determined by skin prick test and reports of nasal and pulmonary allergy-related symptoms. Actively working individuals of both genders took part in the study (n=145, age range: 20 to 66 years). The participants were divided in three groups. The first group was composed of those with negative skin prick test and without symptoms (n=57), the second of those with positive skin prick test but without symptoms (n=28), and the third of those with positive skin prick test and symptoms (n=60). The groups did not differ significantly in neuroticism, exposure to stressful life events, or quality of life. Women reported more pronounced neuroticism and anxiety, higher exposure to stressful life events, and were less satisfied with their environment than men. In our sample of active workers we found no association of neuroticism, exposure to stressful life events, and quality of life with atopy and allergic symptoms.

Identification of patatin as a novel allergen for children with positive skin prick test responses to raw potato

1999 ◽  
Vol 103 (1) ◽  
pp. 165-171 ◽  
Author(s):  
Ulla Seppälä ◽  
Harri Alenius ◽  
Kristiina Turjanmaa ◽  
Timo Reunala ◽  
Timo Palosuo ◽  
...  
Keyword(s):  
Skin Prick Test ◽  
Positive Skin Prick Test ◽  
Positive Skin ◽  
Prick Test

scholarly journals Food allergies in children: a comparison of parental reports and skin prick test results

2018 ◽  
Vol 58 (2) ◽  
pp. 59-65
Author(s):  
Camilia Metadea Aji Savitri ◽  
Azwin Mengindra Putera Lubis ◽  
Gatot Soegiarto
Keyword(s):  
Skin Prick Test ◽  
Skin Prick Testing ◽  
Food Allergies ◽  
P Value ◽  
Positive Skin Prick Test ◽  
Test Results ◽  
Cross Sectional ◽  
Positive Skin ◽  
Prick Test ◽  
Parental Reports

Background Food allergy is common in children and its prevalence is generally on the rise. Imprecise parental reports about reactions to particular foods can lead to unnecessary restrictions. Since children have specific growth requirements, such nutritional restrictions may have disturbing effects on children’s growth and development.Objective To compare parental reports on food reactions to skin prick test results in their children.Method Retrospective, cross sectional study using patient’s medical record data during one-year study period. Data were analyzed manually and statistically, to assess the degree of agreement (Kappa’s coefficient) and significance (P).Results We collected data from 154 subjects aged 0-18 years. For every allergen assessed, parents reported more food reactions than positive skin prick test results. Allergy incidence were caused, in order, by cow’s milk and chicken (25.3%), eggs (22.1%), chocolate (20.1%), fruits (14.3%), seafood (13%), and saltwater fish (1.9%). Kappa coefficient are all poor (<0.2) and P value are all >0.05 except for chicken (P=0.02).Conclusion Most parents tend to overestimate which food cause reactions in their children, as reactions reported were not necessarily allergenic. Therefore, every patient experiencing allergy reactions should undergo skin prick testing to confirm the possibility of allergy.

Atopy and Quality of Life in Pediatric Chronic Rhinosinusitis

2019 ◽  
Vol 33 (5) ◽  
pp. 586-590 ◽  
Author(s):  
Anamika Anamika ◽  
Arunabha Chakravarti ◽  
Raj Kumar
Keyword(s):  
Quality Of Life ◽  
Skin Prick Test ◽  
Chronic Rhinosinusitis ◽  
Cross Sectional Study ◽  
Endoscopic Examination ◽  
Positive Skin Prick Test ◽  
Cross Sectional ◽  
Positive Skin ◽  
Prick Test

Background Atopy has been suggested in the development of chronic rhinosinusitis (CRS), as allergic rhinitis (AR) is common coexisting disease in pediatric and adult patients with CRS. The contribution of AR to CRS is less clear till date. Objectives The objectives of this study were to determine atopic profile of children with CRS and impact of atopic status on disease severity and quality of life. Methods One hundred ten patients, aged between 7 and 18 years of age, diagnosed with CRS based on history, detailed clinical examination including nasal endoscopic examination were included in this cross-sectional study. Scoring of CRS was done according to Lund Mackay Endoscopic Appearance Score. Patients underwent skin prick test against 65 common aeroallergens (1:10 w/v, 50% glycerinated) for evidence of atopy. SN-5 Sinus and Nasal Quality of Life Survey was used to assess the quality of life in the study subjects. Results Positive skin prick test to at least one of the common aeroallergens was present in 58 (52.7%) patients. Most common aeroallergen sensitivity was seen with insects in 48 (43.6%) patients. Patients of CRS with atopy had higher mean Lund Mackay endoscopic score and SN-5 score than nonatopic patients which was statistically significant. Conclusion In conclusion, we recommend that testing for aeroallergen sensitivity and assessment of quality of life should be included in the protocol for diagnosis and management of pediatric patients with CRS. Early diagnosis and treatment of allergy may halt the progression of CRS and also the development of asthma and other allergic multimorbid disorders.

scholarly journals Prevalence of allergen sensitization, most important allergens and factors associated with atopy in children

2013 ◽  
Vol 131 (5) ◽  
pp. 301-308 ◽  
Author(s):  
Raquel Prudente de Carvalho Baldacara ◽  
Maria de Fatima Marcelos Fernandes ◽  
Leonardo Baldacara ◽  
Wilson Tartuce Aun ◽  
Joao Ferreira de Mello ◽  
...  
Keyword(s):  
Family History ◽  
Skin Prick Test ◽  
Cesarean Delivery ◽  
Atopic Disease ◽  
Dermatophagoides Pteronyssinus ◽  
Outpatient Clinics ◽  
Positive Skin Prick Test ◽  
Positive Skin ◽  
Prick Test ◽  
History Of

CONTEXT AND OBJECTIVE: Knowledge of the profile of allergen sensitization among children is important for planning preventive measures. The objective of this study was to assess the prevalence and profile of sensitization to inhaled allergens and food among children and adolescents in an outpatient population in the city of Palmas. DESIGN AND SETTING: Cross-sectional study at outpatient clinics in Palmas, Tocantins, Brazil. METHODS: Ninety-four patients aged 1-15 years who were attending two pediatric outpatient clinics were selected between September and November 2008. All of the subjects underwent clinical interviews and skin prick tests. RESULTS: A positive skin prick test was observed in 76.6% of the participants (72.3% for inhalants and 28.9% for food allergens). The most frequent allergens were Dermatophagoides pteronyssinus (34%), cat epithelium (28.7%), dog epithelium (21.3%), Dermatophagoides farinae (19.1%), Blomia tropicalis (18.1%), cow's milk (9.6%) and grasses (9.6%). A positive skin prick test correlated with a history of atopic disease (odds ratio, OR = 5.833; P = 0.002), a family history of atopic disease (OR = 8.400; P < 0.001), maternal asthma (OR = 8.077; P = 0.048), pet exposure (OR = 3.600; P = 0.012) and cesarean delivery (OR = 3.367; P = 0.019). CONCLUSION: Dermatophagoides pteronyssinus was the most frequent aeroallergen and cow’s milk was the most prevalent food allergen. There was a positive correlation between a positive skin prick test and several factors, such as a family history of atopic disease, maternal asthma, pet exposure and cesarean delivery.

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