Red cell distribution width as a prognostic marker in septic neonates versus healthy term newborns

Background: We evaluated the usefulness of RDW (red cell distribution width) as a diagnostic tool in newborn sepsis. Several biomarkers for sepsis have been studied including CRP (C-reactive protein), procalcitonin, interleukins, total WBC count (TC) absolute neutrophil count (ANC), ratio of immature neutrophils to total neutrophils (I/T ratio). An ideal biomarker for sepsis is still elusive. Hence we evaluated RDW as a sepsis marker as it was cheap and available. The objective of the study was to evaluate the role of RDW as a prognostic marker in newborn sepsis compared to healthy newborns.Methods: The study sample comprised of two groups (cases and control group) each with 40 neonates. Group 1 (cases group) comprised 40 newborns with suspected/probable sepsis based on clinical or laboratory parameters. In group 1 (suspected/probable sepsis) RDW was done at the time of suspicion of sepsis along with other relevant investigations. According to the clinical course these parameters were repeated 24-48 hrs after first value. Group 2 (control group) comprised 40 normal newborns in the postnatal ward. For the control group blood sampling for CBC and RDW was done simultaneously along with blood sampling for newborn screening.Results: On comparing the baseline variables there is no significant difference among cases and control group with respect to gender distribution, age in days, gestational age in weeks and birth weight. The mean RDW among the cases group was significantly higher than among the control group. In ROC analysis we obtained a cut off value of RDW of 17.25 is helpful to diagnose sepsis with reasonable sensitivity (70%) and specificity (60%).Conclusions: This study revealed that RDW may also be included in the diagnosis of sepsis in newborns as it is a simple, inexpensive, available and easily repeated test as it is routinely done with a complete blood count.

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The Evaluation of Red Cell Distribution Width in Chronic Hemodialysis Patients

International Journal of Nephrology ◽

10.1155/2014/754370 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 12

Author(s):

Hikmet Tekce ◽

Buket Kin Tekce ◽

Gulali Aktas ◽

Mehmet Tanrisev ◽

Mustafa Sit

Keyword(s):

Serum Albumin ◽

Red Cell Distribution Width ◽

Study Cohort ◽

Red Cell ◽

Cell Distribution ◽

Normal Range ◽

Distribution Width ◽

Iron Storage ◽

Interdialytic Weight Gain ◽

Group 1

Background. Red cell distribution width (RDW) has been used as a marker of iron deficiency; however, it is accepted as a marker of cardiovascular survival. We aimed to study RDW levels in hemodialysis (HD) patients and the association between RDW and inflammatory, nutritional, and volume markers.Methods. We included 296 HD patients with sufficient iron storage and without anemia or hypervolemia. We grouped patients into four groups according to clinical parameters, albumin, and C-reactive protein (CRP).Results. The lowest RDW levels were found in group 1 (13.2%). Although RDW of group 2 was higher than that of group 1, it was still in normal range (14.7% versus 13.2%,P=0.028). RDW levels of groups 3 (17.8%) and 4 (18.5%) were significantly higher than those of groups 1 and 2 and above normal range. A positive correlation was detected between RDW and HD duration, interdialytic weight gain (IDWG), serum phosphate, and CRP levels and a negative correlation was detected with serum albumin. HD duration, CRP, IDWG, and serum albumin have been found as independent predictors of RDW elevation.Conclusions. Results of the present study reflect adverse effects of inflammation, malnutrition, and excess IDWG on RDW elevation in an HD study cohort with sufficient iron storage and without anemia and hypervolemia.

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Red Cell Distribution Width Upon Hospital Admission Predicts Short-Term Mortality in Hospitalized Patients With COVID-19: A Single-Center Experience

Frontiers in Medicine ◽

10.3389/fmed.2021.652707 ◽

2021 ◽

Vol 8 ◽

Author(s):

Christoph C. Kaufmann ◽

Amro Ahmed ◽

Ulrich Brunner ◽

Bernhard Jäger ◽

Gabriele Aicher ◽

...

Keyword(s):

Prognostic Marker ◽

Group Analysis ◽

Study Data ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Short Term ◽

Crude Odds Ratio ◽

Distribution Width ◽

Short Term Mortality

Background: Coronavirus disease (COVID-19) was first described at the end of 2019 in China and has since spread across the globe. Red cell distribution width (RDW) is a potent prognostic marker in several medical conditions and has recently been suggested to be of prognostic value in COVID-19.Methods: This retrospective, observational study of consecutive patients with COVID-19 was conducted from March 12, 2020 to December 4, 2020 in the Wilhelminenhospital, Vienna, Austria. RDWlevels on admission were collected and tested for their predictive value of 28-day mortality.Results: A total of 423 eligible patients with COVID-19 were included in the final analyses and 15.4% died within 28 days (n = 65). Median levels of RDWwere significantly higher in non-survivors compared to survivors [14.6% (IQR, 13.7–16.3) vs. 13.4% (IQR, 12.7– 14.4), P < 0.001]. Increased RDW was a significant predictor of 28-day mortality [crude odds ratio (OR) 1.717, 95% confidence interval (CI) 1.462–2.017; P = < 0.001], independent of clinical confounders, comorbidities and established prognostic markers of COVID-19 (adjusted OR of the final model 1.368, 95% CI 1.126–1.662; P = 0.002). This association remained consistent upon sub-group analysis. Our study data also demonstrate that RDW levels upon admission for COVID-19 were similar to previously recorded, non-COVID-19 associated RDW levels [14.2% (IQR, 13.3–15.7) vs. 14.0% [IQR, 13.2–15.1]; P = 0.187].Conclusions: In this population, RDWwas a significant, independent prognostic marker of short-term mortality in patients with COVID-19.

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Red cell distribution width is a prognostic marker of perioperative stroke in patients undergoing cardiac valve surgery

Interactive Cardiovascular and Thoracic Surgery ◽

10.1093/icvts/ivx216 ◽

2017 ◽

Vol 25 (6) ◽

pp. 925-929 ◽

Cited By ~ 14

Author(s):

Piotr Duchnowski ◽

Tomasz Hryniewiecki ◽

Mariusz Kuśmierczyk ◽

Piotr Szymański

Keyword(s):

Prognostic Marker ◽

Valve Surgery ◽

Cardiac Valve ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

Perioperative Stroke ◽

Cardiac Valve Surgery

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Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction

Coronary Artery Disease ◽

10.1097/mca.0b013e328342c77b ◽

2011 ◽

Vol 22 (3) ◽

pp. 138-144 ◽

Cited By ~ 85

Author(s):

Huseyin Uyarel ◽

Mehmet Ergelen ◽

Gokhan Cicek ◽

Mehmet Gungor Kaya ◽

Erkan Ayhan ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Prognostic Marker ◽

Primary Angioplasty ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width

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Red cell distribution width as a prognostic marker in diabetes; a pilot cross-sectional study

Journal of Nephropharmacology ◽

10.15171/npj.2019.03 ◽

2018 ◽

Vol 8 (1) ◽

pp. 3-3

Author(s):

Saeed Shirali ◽

Sara Bahadoram ◽

Seyed Mohamad Kazem Nourbakhsh ◽

Mohammad Bahadoram ◽

Ali Asghar Valipour ◽

...

Keyword(s):

Prognostic Marker ◽

Cross Sectional Study ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Sectional Study ◽

Cross Sectional ◽

Distribution Width

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Red cell distribution width: an inexpensive and powerful prognostic marker in heart failure

European Journal of Heart Failure ◽

10.1093/eurjhf/hfp147 ◽

2009 ◽

Vol 11 (12) ◽

pp. 1155-1162 ◽

Cited By ~ 89

Author(s):

Yahya Al-Najjar ◽

Kevin M. Goode ◽

Jufen Zhang ◽

John G.F. Cleland ◽

Andrew L. Clark

Keyword(s):

Heart Failure ◽

Prognostic Marker ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width

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Relationship between red cell distribution width and prognosis of patients with osteosarcoma

Bioscience Reports ◽

10.1042/bsr20192590 ◽

2019 ◽

Vol 39 (12) ◽

Cited By ~ 2

Author(s):

Jian Zheng ◽

Xiaopin Yuan ◽

Weichun Guo

Keyword(s):

Poor Prognosis ◽

Survival Curve ◽

Poor Response ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Poor Overall Survival ◽

Distribution Width ◽

Significant Difference

Abstract We retrospectively collected the clinical data and follow-up information of patients with osteosarcoma who were admitted to Department of Orthopedics, RenMin Hospital of Wuhan University from January 2010 to December 2016 and explore the relationship between red cell distribution width (RDW) and prognosis of patients with osteosarcoma. The present study finally included 271 patients with osteosarcoma with median follow-up time of 24.2 months (3–69 months). According to the RDW median, 135 patients belong to the low RDW group and 136 patients belong to high RDW group. Compared with low RDW group, the high RDW group tend to have metastasis (50 vs 32.6%, P=0.004), higher poor response rate to chemotherapy compared with the low RDW group (24.3 vs 7.4%, P=0.000) and higher C-reactive protein (CRP) (7.6 ± 4.9 vs 5.5 ± 4.5, t = 3.727, P=0.000). There was slightly significant difference in the types of pathology (χ2 = 8.059, P=0.045). The Kaplan–Meier analysis indicated survival curve of high RDW group was poorer than that in the low RDW group (P=0.020). The univariate cox analysis indicated that patients with RDW ≥ median had higher risk of poor prognosis compared with those who had RDW level < median (HR = 2.41, 95% confidence interval (CI): 1.51–3.83, P=0.000). After adjusting some potential cofounding factors, the elevated RDW was still associated with poor prognosis (HR = 1.66, 95% CI: 1.07–2.56, P=0.024). The elevated pretreatment RDW was associated with poor overall survival (OS) in patients with osteosarcoma and can be an independent predictor of prognosis.

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