scholarly journals Spirometry and mannitol bronchial challenge test among firefighters in Bhuj district: a questionnaire based study

2017 ◽  
Vol 4 (5) ◽  
pp. 1434
Author(s):  
Kashyap Buch ◽  
Vinayak Chauhan
Keyword(s):  
Nitric Oxide ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Respiratory Symptoms ◽  
Challenge Test ◽  
Shortness Of Breath ◽  
Chest Tightness ◽  
Bronchial Challenge ◽  
Challenge Tests ◽  
Skin Prick Tests

Background: Asthma is a common chronic lung disease that inflames and narrows the airways. It causes recurring period of wheezing, chest tightness, shortness of breath and coughing.Methods: A questionnaire, spirometry, direct and indirect airway challenge tests, exhaled nitric oxide, and skin-prick tests were administered prospectively to 100 out of 120 firefighters employed in Bhuj district, Gujarat, India. Asthma was defined as the combination of respiratory symptoms with airway hyper responsiveness.Results: Twenty out of 100 firefighters (12%) had physician-diagnosed asthma, which could be confirmed in 8 firefighters. In contrast, asthma was diagnosed in 28% (28 of 100 firefighters). Wheezing was the most sensitive symptom for the diagnosis of asthma (sensitivity, 88%; specificity, 90%).Conclusions: Asthma was considerably under diagnosed in firefighters. The combination of a structured symptom questionnaire with a bronchial challenge test allows identifying patients with asthma and should routinely be used in the assessment of active firefighters and may be of help when evaluating candidates for this profession.

scholarly journals Diagnostic value of exhaled nitric oxide and bronchial challenge tests

2005 ◽  
pp. 70-76
Author(s):  
O. A. Meliashkevich ◽  
P. Ahrens ◽  
V. Gerein
Keyword(s):  
Nitric Oxide ◽  
Challenge Test ◽  
Allergic Inflammation ◽  
Diagnostic Value ◽  
Test Results ◽  
Impulse Oscillometry ◽  
Bronchial Challenge ◽  
Challenge Tests ◽  
Positive Groups ◽  
Feno Level

The reported practical work shows a significance of detection the exhaled fraction of nitric oxide (FENO) compared with bronchial challenge tests to diagnose the allergic inflammation and to determine the inflammatory activity in the airways. Methods: 30 bronchial challenge tests were performed in 24 children aged 5 to 16 yrs with different degrees of sensitization detected by the pricktest. The challenge tests were performed with various allergens, the lung function was examined by spirometry or pneumotachometry, the airway resistance was studied by impulse oscillometry. The FENO was measured using a chemiluminescent gas analyzer. The FENO levels obtained after the challenge tests allowed to divide the patients with positive test results in 2 groups and those with negative test results in 3 groups. Two negative and the positive groups had the similar FENO levels and only the third negative group had different FENO level. Therefore, the FENO allows detecting the allergy imflammation including its latent form even if the challenge test is negative.

Predictive value of non-specific bronchial challenge testing for respiratory symptoms and lung function in aluminium smelter workers

2020 ◽  
Vol 77 (8) ◽  
pp. 535-539
Author(s):  
Michael J Abramson ◽  
Stella May Gwini ◽  
Nicholas H de Klerk ◽  
Anthony Del Monaco ◽  
Martine Dennekamp ◽  
...  
Keyword(s):  
Lung Function ◽  
Predictive Value ◽  
Respiratory Symptoms ◽  
Challenge Test ◽  
Airflow Limitation ◽  
Chest Tightness ◽  
Bronchial Challenge ◽  
Challenge Testing ◽  
Aluminium Smelter ◽  
Increased Risk

ObjectiveTo assess the predictive value of bronchial hyper-responsiveness (BHR) for the subsequent development of respiratory symptoms, airflow limitation and decline in lung function among aluminium smelter workers.MethodsAn inception cohort study of new employees at two Australian aluminium smelters was conducted. Participants completed a modified British Medical Research Council respiratory questionnaire, spirometry and a methacholine bronchial challenge test at baseline and at annual follow-up reviews. BHR was defined as PD20 ≤4000 µg. Poisson and mixed effects models were fitted to respiratory symptoms and lung function (forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC)).ResultsBaseline interview and lung function testing were completed by 278 workers, who were followed for a median of 4 years. BHR at baseline, present in 82 workers, was not associated with incident wheeze risk ratio (RR)=1.07 (95% CI 0.74 to 1.55) and cough RR=0.78 (95% CI 0.45, 1.35), but there was some increased risk of chest tightness RR=1.40 (95% CI 0.99, 1.98) after adjustment for age, sex, smoking and atopy. BHR at baseline was associated with lower FEV1 and FVC, although the rate of annual decline in FEV1 or FVC was similar between those with or without BHR. The specificity of BHR was 77% for wheeze, 70% for cough and 77% for chest tightness, but the sensitivity was poor, at 33%, 24% and 39%, respectively.ConclusionMethacholine challenge testing at entry to employment was not sufficiently predictive of later adverse respiratory outcomes, and notwithstanding the study limitations is unlikely to be a useful pre-employment or preplacement screening test in the aluminium smelting industry.

scholarly journals Diagnostic value of exhaled nitric oxide and bronchial challenge tests

2005 ◽  
pp. 59-65
Author(s):  
A. A. Meliashkevich ◽  
P. Ahrens ◽  
V. Gerein
Keyword(s):  
Nitric Oxide ◽  
Challenge Test ◽  
Allergic Inflammation ◽  
Diagnostic Value ◽  
Test Results ◽  
Bronchial Challenge ◽  
Prick Test ◽  
Challenge Tests ◽  
Positive Groups ◽  
Feno Level

The reported practical work shows a significance of detection the exhaled fraction of nitric oxide (FENO) compared with bronchial challenge tests to diagnose the allergic inflammation and to determine the inflammatory activity in the airways. Methods: 30 bronchial challenge tests were performed in 24 children aged 5 to 16 yrs with different degrees of sensitization detected by the prick-test. The challenge tests were performed with various allergens, the lung function was examined by spirometry or pneumotachometry, the airway resistance was studied by impulse oscillometry. The FENO was measured using a chemiluminescent gas analyzer. The FENO levels obtained after the challenge tests allowed to divide the patients with positive test results in 2 groups and those with negative test results in 3 groups. Two negative and the positive groups had the similar FENO levels and only the third negative group had different FENO level. Therefore, the FENO allows detecting the allergy imflammation including its latent form even if the challenge test is negative.

scholarly journals Surfactant Composition and Function in a Primate Model of Infant Chronic Lung Disease: Effects of Inhaled Nitric Oxide

2006 ◽  
Vol 59 (1) ◽  
pp. 157-162 ◽  
Author(s):  
Philip L Ballard ◽  
Linda W Gonzales ◽  
Rodolfo I Godinez ◽  
Marye H Godinez ◽  
Rashmin C Savani ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Inhaled Nitric Oxide ◽  
Primate Model ◽  
Surfactant Composition ◽  
And Function

scholarly journals ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing

2018 ◽  
Vol 52 (5) ◽  
pp. 1801033 ◽  
Author(s):  
Teal S. Hallstrand ◽  
Joerg D. Leuppi ◽  
Guy Joos ◽  
Graham L. Hall ◽  
Kai-Håkon Carlsen ◽  
...  
Keyword(s):  
Airway Hyperresponsiveness ◽  
Task Force ◽  
Challenge Test ◽  
Technical Standard ◽  
Bronchial Challenge ◽  
Airway Narrowing ◽  
Airway Function ◽  
Challenge Testing ◽  
Challenge Tests ◽  
Indirect Tests

Recently, this international task force reported the general considerations for bronchial challenge testing and the performance of the methacholine challenge test, a “direct” airway challenge test. Here, the task force provides an updated description of the pathophysiology and the methods to conduct indirect challenge tests. Because indirect challenge tests trigger airway narrowing through the activation of endogenous pathways that are involved in asthma, indirect challenge tests tend to be specific for asthma and reveal much about the biology of asthma, but may be less sensitive than direct tests for the detection of airway hyperresponsiveness. We provide recommendations for the conduct and interpretation of hyperpnoea challenge tests such as dry air exercise challenge and eucapnic voluntary hyperpnoea that provide a single strong stimulus for airway narrowing. This technical standard expands the recommendations to additional indirect tests such as hypertonic saline, mannitol and adenosine challenge that are incremental tests, but still retain characteristics of other indirect challenges. Assessment of airway hyperresponsiveness, with direct and indirect tests, are valuable tools to understand and to monitor airway function and to characterise the underlying asthma phenotype to guide therapy. The tests should be interpreted within the context of the clinical features of asthma.

Exercise, physical activity, and asthma

2017 ◽  
Author(s):  
Helge Hebestreit ◽  
Susi Kriemler ◽  
Thomas Radtke
Keyword(s):  
Physical Activity ◽  
Challenge Test ◽  
Well Being ◽  
Physical Activities ◽  
Shortness Of Breath ◽  
Chest Tightness ◽  
Exercise Challenge ◽  
Typical History ◽  
Children With Asthma ◽  
Exercise Induced

The incidence of asthma in children varies among countries and can be estimated to range between 5% and 20%. Exercise-induced asthma (EIA) is common in patients with asthma but can also occur in some children without asthma. Typical symptoms of EIA include cough, chest tightness, and shortness of breath shortly after exercise. The pathophysiology of EIA is not completely understood, but it has been shown that airway cooling and drying with increased ventilation during exercise and airway re-warming after exercise play a pivotal role. In addition, a lack of physical activity may also contribute to EIA. Regular exercise may increase fitness and psychological well-being but may also positively influence airway inflammation in children with asthma. The diagnosis of EIA is based on the typical history and may be verified by an exercise challenge test. Every child with EIA should be able to engage in all type of physical activities.

Lung function and exhaled nitric oxide levels in infants developing chronic lung disease

2007 ◽  
Vol 42 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Olivia Williams ◽  
Gabriel Dimitriou ◽  
Simon Hannam ◽  
Gerrard F. Rafferty ◽  
Anne Greenough
Keyword(s):  
Nitric Oxide ◽  
Lung Function ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Exhaled Nitric Oxide

Inhaled nitric oxide in infants with developing or established chronic lung disease

1995 ◽  
Vol 84 (10) ◽  
pp. 1188-1192 ◽  
Author(s):  
PA Lonnqvist ◽  
B Jonsson ◽  
P Winberg ◽  
CG Frostell
Keyword(s):  
Nitric Oxide ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Inhaled Nitric Oxide

scholarly journals (P2-81) A Survey of the Health Effects of Bushfire Smoke on Patients Attending Two Sydney Emergency Departments

2011 ◽  
Vol 26 (S1) ◽  
pp. s162-s163
Author(s):  
G.O. Watkins
Keyword(s):  
Emergency Departments ◽  
Respiratory Symptoms ◽  
Medication Use ◽  
Control Group ◽  
Study Group ◽  
Shortness Of Breath ◽  
Chest Tightness ◽  
Respiratory Pathology ◽  
The Subject ◽  
Emergency Department Patients

The objective of this survey was to investigate the incidence of respiratory symptoms reported by emergency department patients during the Christmas 2001–2002 Sydney bushfire disaster. Two hundred and thirty patients attending two Sydney emergency departments for any reason completed questionnaires regarding respiratory symptoms. The symptoms investigated were cough, shortness of breath, chest tightness and wheeze. The same questionnaire was subsequently administered to a similar control group who were not exposed to bushfire smoke. 51% of those surveyed during the bushfires reported one or more of the respiratory symptoms investigated compared to 31% of the control group. This difference was statistically significant (p < 0.01). A significantly higher proportion of respiratory patients in the study group reported an exacerbation of their condition and increased medication use during the bushfires (p < 0.01). The results are consistent with other research on the subject and suggest that exposure to bushfire smoke causes an increased incidence of respiratory pathology.

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