scholarly journals Impact of CD4 count in the development of mycobacterium tuberculosis in patients with HIV infection in a tertiary care centre

2018 ◽  
Vol 5 (2) ◽  
pp. 340
Author(s):  
Satyanarayan T. B. ◽  
Manjunath M. P. ◽  
Ranganath M. ◽  
Mahendra M.
Keyword(s):  
Hiv Infection ◽  
Opportunistic Infections ◽  
Tertiary Care ◽  
Cd4 Count ◽  
Cell Mediated Immunity ◽  
Pulmonary Medicine ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Cd4 Counts ◽  
Immunodeficiency Virus

Background: Patients with Human Immunodeficiency Virus (HIV) infection are predisposed to numerous opportunistic infections due to decreased cell mediated immunity, Tuberculosis being most common. Low CD4 count is associated with low immunity and higher risk of tuberculosis.Methods: Author conducted a retrospective study in the department of Pulmonary medicine in a tertiary care teaching hospital during January to December 2017. Author collected data of all the patients with HIV diagnosed with Tuberculosis from the ART centre. Author collected demographic details including age, sex, symptoms at presentation, details of diagnosis of TB including type of tuberculosis, CBNAAT results, CD4 count at the diagnosis of TB, details of ART therapy and ATT therapy and outcomes of treatment.Results: Eighty one patients with HIV-TB co- infection were included in the study. Males (70.37%) were more affected than females. Mean age of the study group was 39.97±10 years. Sixty one patients (75.4%) were diagnosed with Pulmonary Tuberculosis and 20 (24.6%) patients were diagnosed with extra pulmonary TB. Mean CD4 counts of the cohort was 226±110/µl. Eighty percent of patients developed Tuberculosis with CD4 count <250/µl.Conclusions: Author found in this study higher proportions of tuberculosis (80.2%) in patients with HIV infection with CD4 count <200/µl. Author also found higher proportion of pulmonary Koch’s in patients with low CD4 count (CD4 <200/µl).

scholarly journals STUDY OF LYMPH NODE CYTOLOGY IN HIV INFECTED PATIENTS

2021 ◽  
Vol 5 (10) ◽  
Author(s):  
Abhijeet Ramesh Dhawale
Keyword(s):  
Human Immunodeficiency Virus ◽  
Lymph Node ◽  
Hiv Infection ◽  
Opportunistic Infections ◽  
Tertiary Care ◽  
Cd4 Count ◽  
Axillary Lymph ◽  
Immunodeficiency Virus ◽  
Neoplastic Lesions ◽  
Granulomatous Lymphadenitis

Background and Aim: Human immunodeficiency virus (HIV) infection has become a global pandemic. Persistent generalized lymphadenopathy (PGL) is very common manifestation of HIV infection. Moreover, different opportunistic infections such as tuberculosis (TB) and malignancies may present with lymphadenopathy. This study was performed to evaluate the role of FNAC as a cytological investigative tool in the diagnosis of various lesions in HIV lymphadenopathy. Material and Methods: This study was carried out in Tertiary care Institute of India, over a period of one year. Total 50 cases of HIV lymphadenopathy patients were participated in the study after having signed the Informed Consent Form. Diagnosis of HIV was done by enzyme linked immunosorbant assay (ELISA) test, followed by the CD4 counts by BD FACS Count system in HIV positive patients. FNAC procedure was performed as an OPD procedure in cytology OPD of pathology department. Results: Most common site of HIV lymphadenopathy is cervical lymph node 40 (80%), followed by supraclavicular 6(12%) followed by axillary lymph node 4(8%). The most common lesion found was mycobacterial infection 22(44%), followed by reactive lymphadenitis 15(30%). Non-specific chronic granulomatous lymphadenitis in 10(22%) and 3(6%) cases of acute suppurative lymphadenitis. CD4 count more than 500 cells/ µL was seen in 9 (18%) cases of reactive lymphadenitis and 4 (8%) cases of chronic granulomatous lymphadenitis. Patients with tubercular infection had CD4 count between 200- 499 cells/ µL in 12 (24%) cases and less than 200 in 10 (20%) cases. Conclusion: FNAC is relatively inexpensive and valuable tool for identification of opportunistic infections, neoplastic lesions and non-neoplastic lesions. It may spare patients lymph node excision and enable immediate treatment of specific infection. This procedure is readily repeatable and can be used for follow up during and after treatment. Keywords: Human immunodeficiency virus, lymphadenopathy, Non-specific chronic granulomatous lymphadenitis, tuberculosis

CUTANEOUS MANIFESTATIONS OF HIV IN PEOPLE LIVING WITH HIV/AIDS AT TERTIARY CENTRE

2021 ◽  
pp. 70-72
Author(s):  
Anubhav Agrawal ◽  
Simmi Dube ◽  
Aditya Tejwani
Keyword(s):  
Cell Count ◽  
Tertiary Care ◽  
Skin Lesions ◽  
Cd4 Count ◽  
People Living With Hiv ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Cutaneous Manifestations ◽  
Cd4 Cell Count ◽  
Cd4 Cell

BACKGROUND-The study was conducted to describe systematic clinical manifestations among HIV in PLHA at tertiary care centre. METHODOLOGY- This study was designed as cross sectional study at Department of Medicine, tertiary care centre. A total of 100 HIV infected patients were included detailed enquiry about presence of skin lesions along with CD4 cell count was obtained and entered in pretested questionnaire RESULTS-The mean age of patients with HIV was 43.9±10.2 years and Slight female preponderance was observed with male: 3 female ratio of 0.89:1. Mean CD4 count was 243.2±103.2 cells/mm . Majority of patients had CD4 count in the range of less than 3 200 cells/mm (64%) Staphylococcal skin infections were the most common skin lesions observed in 34% patients. All the patients with cutaneous manifestations presented in present study had low CD4 cell count. However, no statistically signicant association between CD4 count and cutaneous manifestations could be documented (p>0.05). CONCLUSION-Cutaneous manifestations are more prevalent in patients with lower CD4 counts and can also be observed with normal CD4 count levels amongst patients with HIV. Occurrence of cutaneous manifestations was higher in patients with lower CD4 count but the observed difference was not statistically signicant.

Prevalence of HIV Infection among Blood Donors at a Tertiary Care Centre in Gwalior, India

2015 ◽  
Vol 4 (4) ◽  
pp. 1-8 ◽  
Author(s):  
Dharmesh Sharma ◽  
Arun Jain ◽  
Poonam Woike ◽  
Sunita Rai ◽  
Lokesh Tripathi ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Blood Donors ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre

scholarly journals The effect of nevirapine vs efavirenz containing regimens on clinical outcomes among HIV patients on ART: a comparative study

2017 ◽  
Vol 4 (3) ◽  
pp. 768
Author(s):  
Jeetam Singh Rajput ◽  
Manoj Kumar Mathur ◽  
Ajeet Kumar Chaurasia ◽  
Smriti Singh ◽  
Alankar Tiwari
Keyword(s):  
Clinical Outcome ◽  
Observational Study ◽  
Comparative Study ◽  
Reverse Transcriptase ◽  
Opportunistic Infections ◽  
Tertiary Care ◽  
Care Centre ◽  
Reverse Transcriptase Inhibitors ◽  
Tertiary Care Centre ◽  
Antiretroviral Drug

Background: The present study has been conducted to compare regimens containing either of nevirapine (NVP) and efavirenz (EFV) and two or more nucleoside reverse transcriptase inhibitors (NRTIs) among HIV infected patients in respect to clinical outcome and to compare incidence of opportunistic infections among these patients.Methods: This study was an observational study conducted at a tertiary care centre over 105 patients, who were evenly matched and received three antiretroviral drug one of the drug was either nevirapine (NVP) or efavirenz (EFV) and these patients were followed up for 6 months for occurrence of any opportunistic infections during these 6 months.Results: 105 patients were followed for 6 months, the maximum incidence of opportunistic infection (OI’s) was found among patients who were on ZLN (zidovudine, lamivudine, nevirapine) regime i.e. 60% followed by patients who changed their regime from ZLN to TLE i.e. 36.5%, while the least incidence of OI’s was noted among the patients who were on TLE (tenofovir, lamivudine, efavirenz) regime i.e. 28.5%. These differences were found to be statistically significant (p<0.05).Conclusions: EFV containing antiretroviral regimen was associated with superior clinical outcome than NVP containing regimen.

Sign in / Sign up

Export Citation Format

Share Document