A study of the prevalence of hyperuricemia as well as its association with non-alcoholic fatty liver disease in three hundred patients at a tertiary care centre in North-East India

Background: Non-alcoholic fatty liver disease (NAFLD) is a condition defined by excessive fat accumulation in the form of triglycerides (steatosis) in the liver. In recent years, an association between elevated serum uric acid concentrations and NAFLD has been reported. Thus, we intended to perform this cross-sectional study to establish the prevalence of hyperuricemia in NAFLD patients and its association with NAFLD in 300 patients at a tertiary care centre in North-East India.Methods: In this hospital based cross-sectional study, 300 patients presenting in Assam medical college and hospital (AMCH) with diagnosed NAFLD were included during the one year period from July 2015 to June 2016.Results: Hyperuricemia was observed in 99 cases out of a total of 300 cases of NAFLD (33%), and a statistically significant association was observed between the two parameters.Conclusions: The prevalence rate of NAFLD was significantly higher in subjects with hyperuricemia than that in those without hyperuricemia (78.19% versus 40.83%) (p<0.001), and the prevalence rate increased with progressively higher serum uric acid levels (p<0.001).

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Reasons for Cancellation of Elective Surgical Operations: A Cross-sectional Study from a Tertiary Care Centre in North-East India

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/49656.15396 ◽

2021 ◽

Author(s):

Laltanpuii Sailo ◽

Stephen Lalfakzuala Sailo ◽

Nari Mary Lyngdoh ◽

Rajani Thabah ◽

Tridip Jyoti Borah ◽

...

Keyword(s):

Tertiary Care ◽

Surgical Oncology ◽

Cross Sectional Study ◽

Care Centre ◽

Sectional Study ◽

Tertiary Care Centre ◽

Cross Sectional ◽

North East India ◽

North East ◽

Surgical Operations

Introduction: Cancellation of elective surgical operations is defined as an elective operation which is not performed on the scheduled date. The rates and the reasons for cancellation vary in different parts of the world. Cancellation causes increased cost of treatment, loss of daily wage and mental trauma. It also causes under utilisation of hospital resources and loss of training opportunities to surgical trainees. Aim: To estimate the rate of cancellation of elective surgical operations in a tertiary care centre in North-East India and determine the reasons for cancellation. Materials and Methods: A prospective cross-sectional study was conducted at a 500 bedded, North-Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India, from January 2018 to September 2018. All consecutive elective surgical cases scheduled during this period were included in the study. The rate and the reasons for cancellation were noted. Descriptive statistics was used for analysis of the results. Results: Out of 1812 elective surgical operations scheduled during the study period, 491 operations (27.10%) were cancelled. The most common reasons for cancellation were shortage of time (78.62%), medical causes (10.79%) and administrative problems (4.48%). Cancellation rate was highest in the Department of Surgical Oncology (40.23%), followed by Departments of Orthopaedics (34.51%) and Obstetrics and Gynaecology (OG) (31.02%). Conclusion: The rate of cancellation of elective surgical operation was high (27.10%) and the most common reason was shortage of time and Surgical Oncology Department had highest rate of cancellation.

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Correlation Between Anthropometric Measurements and Non-alcoholic Fatty Liver Disease in Individuals With Obesity Undergoing Bariatric Surgery: Cross-Sectional Study

Obesity Surgery ◽

10.1007/s11695-021-05470-2 ◽

2021 ◽

Author(s):

Silênio Souza Reis ◽

Guilherme Hoverter Callejas ◽

Rodolfo Araújo Marques ◽

Martinho A. Gestic ◽

Murillo P. Utrini ◽

...

Keyword(s):

Bariatric Surgery ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Cross Sectional Study ◽

Anthropometric Measurements ◽

Sectional Study ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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Higher Healthy Lifestyle Score is associated with lower presence of non-alcoholic fatty liver disease in middle-aged and older Chinese adults: a community-based cross-sectional study

Public Health Nutrition ◽

10.1017/s1368980021000902 ◽

2021 ◽

pp. 1-9

Author(s):

Yun-yang Deng ◽

Qing-wei Zhong ◽

Hai-li Zhong ◽

Feng Xiong ◽

Yue-bin Ke ◽

...

Keyword(s):

Physical Activity ◽

Liver Disease ◽

Fatty Liver Disease ◽

Healthy Lifestyle ◽

Cross Sectional Study ◽

Sectional Study ◽

Community Based ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Abstract Objective: Previous studies have reported inverse associations between certain healthy lifestyle factors and non-alcoholic fatty liver disease (NAFLD), but limited evidence showed the synergistic effect of those lifestyles. This study examined the relationship of a combination of lifestyles, expressed as Healthy Lifestyle Score (HLS), with NAFLD. Design: A community-based cross-sectional study. Questionnaires and body assessments were used to collect data on the six-item HLS (ranging from 0 to 6, where higher scores indicate better health). The HLS consists of non-smoking (no active or passive smoking), normal BMI (18·5–23·9 kg/m2), physical activity (moderate or vigorous physical activity ≥ 150 min/week), healthy diet pattern, good sleep (no insomnia or <6 months) and no anxiety (Self-rating Anxiety Scale < 50), one point each. NAFLD was diagnosed by ultrasonography. Setting: Guangzhou, China. Participants: Two thousand nine hundred and eighty-one participants aged 40–75 years. Results: The overall prevalence of NAFLD was 50·8 %. After adjusting for potential covariates, HLS was associated with lower presence of NAFLD. The OR of NAFLD for subjects with higher HLS (3, 4, 5–6 v. 0–1 points) were 0·68 (95 % CI 0·51, 0·91), 0·58 (95 % CI 0·43, 0·78) and 0·35 (95 % CI 0·25, 0·51), respectively (P-values < 0·05). Among the six items, BMI and physical activity were the strongest contributors. Sensitivity analyses showed that the association was more significant after weighting the HLS. The beneficial association remained after excluding any one of the six components or replacing BMI with waist circumference. Conclusions: Higher HLS was associated with lower presence of NAFLD, suggesting that a healthy lifestyle pattern might be beneficial to liver health.

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Association of Serum Bilirubin Level with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study of 1672 Obese Children

Journal of Clinical Medicine ◽

10.3390/jcm10132812 ◽

2021 ◽

Vol 10 (13) ◽

pp. 2812

Author(s):

Cristina Bellarosa ◽

Giorgio Bedogni ◽

Annalisa Bianco ◽

Sabrina Cicolini ◽

Diana Caroli ◽

...

Keyword(s):

Metabolic Syndrome ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Serum Bilirubin ◽

Cross Sectional Study ◽

Sectional Study ◽

Obese Children ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

As in adults, obesity also plays a central role in the development of metabolic syndrome (MS) in children. Non-alcoholic fatty liver disease (NAFLD) is considered a manifestation of MS. Not only MS but also NAFLD seem to be inversely associated with serum bilirubin concentrations, an important endogenous tissue protector when only mild elevated. The aim of the study was to evaluate the association between serum bilirubin levels and the prevalence of MS and NAFLD in Italian obese children and adolescents. A retrospective cross-sectional study was performed in 1672 patients aged from 5 to 18 years. Clinical and laboratory parameters were assessed. NAFLD was measured by liver ultrasonography. The study was approved by the Ethical Committee of the Istituto Auxologico Italiano (research project code 1C021_2020, acronym BILOB). MS was present in 24% and fatty liver (FL) in 38% of this population. Bilirubin was not associated with FL and MS as a whole, but it was inversely associated only with selected components of MS, i.e., large WC, high blood pressure and high triglycerides. Our data suggest that bilirubin is not protective against MS and NAFLD in the presence of severe obesity.

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