scholarly journals Is neutrophil lymphocyte ratio a prognostic marker of acute ST elevation myocardial infarction?

2021 ◽  
Vol 8 (5) ◽  
pp. 728
Author(s):  
Sneha Barkur Sadashiva ◽  
Chenthil K. S.
Keyword(s):  
Myocardial Infarction ◽  
St Elevation Myocardial Infarction ◽  
Cardiac Events ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Pubmed Database ◽  
Coronary Syndromes ◽  
St Elevation ◽  
Prognostic Importance ◽  
Timi Risk Score

Several inflammatory biomarkers have been implicated in the pathogenesis of acute coronary syndromes. The present study aims to determine the prognostic value of neutrophil lymphocyte ratio (NLR) to predict the immediate outcomes in patients with acute ST elevation myocardial infarction and if any correlation exists between NLR and TIMI risk score. A review of articles published in Pubmed database on the prognostic importance of neutrophil lymphocyte ratio in determining major adverse cardiac events (MACE) such as arrhythmias, cardiogenic shock and in hospital mortality was done. NLR was found to be a reliable prognostic tool to assess the immediate outcome in ST elevation myocardial infarction (STEMI) patients.

Is the neutrophil-lymphocyte ratio a good marker for the differential diagnosis of unstable angina pectoris and non-ST elevation myocardial infarction?

2021 ◽  
pp. 13-18
Keyword(s):  
Myocardial Infarction ◽  
Differential Diagnosis ◽  
Angina Pectoris ◽  
Unstable Angina ◽  
St Elevation Myocardial Infarction ◽  
Unstable Angina Pectoris ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Good Marker ◽  
St Elevation

Background: The aim of this study is to investigate the role of the neutrophil-lymphocyte ratio (NLR) in the differential diagnosis of non-ST elevation myocardial infarction (NSTEMI) and unstable angina pectoris (USAP). Material and Method: Patients who had been admitted to the emergency ward with complaints of chest pain and who were diagnosed with USAP and NSTEMI in further examination were retrospectively included in this study. The NLR level was measured for each patient both at the times of application and of discharge. The NLR was calculated by dividing the neutrophil count by the lymphocyte count. Results: WBC (8107.38±1405.5 vs 7452.46±1427.9, p: 0.020), neutrophil (5620 vs 4300, p: 0.001), and NLR (3.86 vs 2.14, p: 0.001) values were higher, whereas the lymphocyte value (1505 vs 2100, p: 0.001) was lower in the NSTEMI versus the USAP group. According to the multivariable logistic regression analysis that was done, NLR appeared to be an independent predictor of NSTEMI. The predictive value of NLR for NSTEMI diagnosis was >3.22 with 61.9% sensitivity and 86.96% specificity (74.3% positive predictive, 78.9% negative predictive) (AUC: 0.761; p< 0.001). Conclusion: As a cheap inexpensive and easy-to-calculate index that can be applied in every medical establishment within the first 20 minutes of application, it is possible to state that NLR is a good marker in distinguishing NSTEMI from USAP patients.

scholarly journals Predictive Value of Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Immediate Outcomes of ST-elevation Myocardial Infarction: A Cross-sectional Study

2021 ◽  
Author(s):  
Sneha Barkur Sadashiva ◽  
KS Chenthil
Keyword(s):  
Myocardial Infarction ◽  
Risk Score ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
St Elevation ◽  
Timi Risk Score

Introduction: There have been various inflammatory markers implicated in the pathogenesis of Acute Coronary Syndromes (ACS). However, the role of the Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) as prognostic markers in ST-elevation Myocardial Infarction (STEMI) remains poorly researched. Aim: To determine the prognostic value of NLR and PLR to predict the immediate outcomes in patients with acute STEMI, and if any association exists between NLR/PLR and Thrombolysis in Myocardial Infarction (TIMI) risk score. Materials and Methods: This was a cross-sectional study conducted at a tertiary care centre, Puducherry, India, where 190 patients who presented to casualty with STEMI were enrolled. The patient co-morbidities, personal and family history were obtained. The routine laboratory parameters including platelets, lymphocytes, neutrophils and their corresponding ratios were calculated. Patients were grouped into low and high NLR/PLR groups and were assessed for occurrence of in-hospital mortality or Major Adverse Cardiovascular Events (MACE). Analysis was made to see if there is an association between NLR/PLR and MACE. Chi-square test and one-way ANOVA test was used for statistical significance. Results: Among 190 subjects, 157 male and 33 female with mean age of 55.72±11.24 years were included. A total of 8.94% patients 8.94% had MACE. NLR was positively associated with MACE (p-value=0.0006), whereas PLR was not associated with MACE. Patients with high NLR had 1.45 times higher odds of having MACE. NLR was significantly associated with TIMI risk score. Both NLR (F ratio=6.341) and PLR (F ratio=4.600) showed significant association with Killip classification, however NLR showed higher association (p-value <0.001). Conclusion: NLR can be used as a powerful prognostic marker for predicting immediate MACE and death in STEMI patients. In addition, NLR showed positive correlation with Killip classification and TIMI risk score.

scholarly journals Assessment of neutrophil and neutrophil/lymphocyte ratio in coronary collateral developed patients with acute coronary syndrome

2020 ◽  
Vol 66 (7) ◽  
pp. 954-959 ◽  
Author(s):  
Asli Kurtar Mansiroglu ◽  
Isa Sincer ◽  
Yilmaz Gunes
Keyword(s):  
Myocardial Infarction ◽  
Acute Coronary Syndrome ◽  
Neutrophil Count ◽  
St Elevation Myocardial Infarction ◽  
Collateral Development ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Coronary Syndrome ◽  
Coronary Collateral ◽  
St Elevation

SUMMARY OBJECTIVE Inflammation-related markers provide diagnostic and prognostic information for coronary artery disease and acute coronary syndrome. We aimed to compare neutrophil count and neutrophil/lymphocyte ratio (NLR) in acute coronary syndrome patients with coronary collateral development in our study. METHODS A total of 426 patients (102 unstable angina pectoris (USAP), 223 non-ST-elevation myocardial infarction (non-STEMI), 103 ST-elevation myocardial infarction (STEMI) were compared regarding hemoglobin, platelet, lymphocyte, neutrophil count, and NLR. RESULTS Neutrophil count and NLR were significantly lower in USAP patients and higher in STEMI patients; 5.14± 1.79 vs. 7.21± 3.05 vs. 9.93±4.67 and 2.92±2.39 vs. 5.19±4.80 vs. 7.93±6.38, p <0.001. Other parameters, i.e., hemoglobin, platelet, and lymphocyte count, were not significantly different between the groups. CONCLUSIONS In our study, it was concluded that there may be a statistically significant difference in the number of neutrophil counts and NLR among the types of acute coronary syndromes with coronary collateral development.

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