scholarly journals Renal cell carcinoma at the time of presentation: a 5-year radiological survey at a tertiary care cancer hospital

2020 ◽  
Vol 7 (5) ◽  
pp. 1657
Author(s):  
Muhammad Omer Altaf ◽  
Asma Riaz ◽  
Mehreen Shafqat ◽  
Hamd Zahra ◽  
Naila Iqbal ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tertiary Care ◽  
Developed Countries ◽  
Nodal Metastasis ◽  
Male Predominance ◽  
Cancer Hospital ◽  
Stage 1 ◽  
Time Of Presentation

Background: Renal cell carcinoma (RCC) is associated with highest mortality rates of all the genitourinary tumors with increased incidence in the past few decades. It is heterogenous tumor with several histological types. Main diagnostic approach is radiological imaging followed by histopathology.Methods: It is a retrospective study conducted at a tertiary care cancer hospital in Pakistan. We reviewed the record of all the RCC patients in terms of age, gender, radiological manifestation of tumor size, polarity, laterality, stage including nodal status, metastasis and histological type.Results: Our study included 149 patients of RCC. Mean age of presentation was 57 years with a male predominance. The most common stage of presentation was stage 3 seen in 41% patients followed by stage 1 in 37% patients. nodal metastasis was observed in around 13% patients and distant metastasis in 8% patients. Also, majority of the patient had histological subtype of clear cell CA (63%) followed by papillary CA (33%).Conclusions: Epidemiological features of renal cell CA are observed over a period of 5 years representing our population. The current trends show variation from those observed in developed countries depicting the struggle of healthcare awareness in developing countries.

scholarly journals Epidemiology and Clinicopathological Profile of Renal Cell Carcinoma

2021 ◽  
Vol 8 (1) ◽  
pp. 1-6
Author(s):  
Likhiteswer Pallagani ◽  
Gautam Ram Choudhary ◽  
Himanshu Pandey ◽  
Vijay Kumar Sarma Madurri ◽  
Mahendra singh Tanwar ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tertiary Care ◽  
Tertiary Care Centre ◽  
Number Of Patients ◽  
Clinicopathological Profile ◽  
Laboratory Investigations ◽  
Genetic And Environmental Factors ◽  
Stage 1

Renal cell carcinoma (RCC) accounts for 3% of all adult cancers and 85% of all kidney tumours. Incidence of RCC is lower in Asian region, particularly in India, probably due to lack of reporting. Most of the data about RCC are from Western countries; and data from India are scarce, especially regarding para-neoplastic syndromes. We sought to determine the epidemiology, clinicopathological profile and management of RCC in a tertiary care centre in Western India.This was a retrospective study that involved data analysis of records of RCC patients who presented to our institution from April 2016 to Feb-ruary 2020. Laboratory investigations, including tests for paraneoplastic syndrome (PNS), and relevant radiologic investigations were performed and treatment was offered according to the stage, patient factors and available modalities.A total 142 RCC patients were included in the study. The median age of presentation was 58 years. Most of the patients (67%) were symptom-atic, and 33% of the patients were asymptomatic, and the RCC was diagnosed incidentally. A large number of patients (56.3%) had PNS. The most common histopathologic type of RCC was clear cell carcinoma (68.8%), followed by papillary (20%) and chromophobe (8%) carcinoma. 40% of carcinomas with sarcomatoid differentiation were seen in patients under 50 years of age. Two cases of multicystic RCC were both seen in patients less than 50 years of age. 65.5% of the patients presented at Stage 1 and 2. Most surgeries (71.2%) were done in a minimally invasive manner.A significant number of patients were asymptomatic, in which RCC was detected incidentally. The age of presentation was earlier, yet the patients had a higher tumour stage. More than half of the patients had PNSs. Despite growing trend towards Western data, the significantly higher number of patients with PNSs and early age of presentation suggest inherent differences in tumour biology, possibly related to differences in genetic and environmental factors.

scholarly journals Decadal Experience of Renal Cell Carcinoma from a Tertiary Care Teaching Institute in North India

2018 ◽  
Vol 9 (4) ◽  
pp. 558-564
Author(s):  
Singh Kawaljit ◽  
Sinha Rahul Janak ◽  
Gupta Ashok ◽  
Singh Vishwajeet
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tertiary Care ◽  
North India ◽  
Care Teaching

scholarly journals Renal Cell Carcinoma Metastatic to the Sinonasal Cavity: A Review and Report of 8 Cases

2018 ◽  
Vol 97 (9) ◽  
pp. E6-E12 ◽  
Author(s):  
Pierre-Louis Bastier ◽  
Dorothée Dunion ◽  
Guillaume de Bonnecaze ◽  
Elie Serrano ◽  
Ludovic de Gabory
Keyword(s):  
Renal Cell Carcinoma ◽  
Overall Survival ◽  
Cell Carcinoma ◽  
Nasal Obstruction ◽  
Survival Data ◽  
Renal Cell ◽  
Tertiary Care ◽  
Local Treatment ◽  
Initial Presentation ◽  
Local Response

Renal cell carcinoma (RCC) metastatic in the sinonasal cavity is rare. In many cases, it represents the initial presentation of RCC. We conducted a retrospective chart review to report the clinical presentation, imaging, and treatment of RCC metastases in the sinonasal cavity at two tertiary care referral centers. Our population was made up of 8 patients—6 men and 2 women, aged 55 to 86 years (mean: 66.9; median: 63.5)—who had been diagnosed with cancer in the sinonasal cavity. The most common complaints were epistaxis, nasal obstruction, and diplopia. Cancers were located in the ethmoid sinus (n = 3), nasal cavity (n = 2), sphenoid sinus (n = 2), and maxillary sinus (n = 1). Local treatment involved resection and adjuvant radiotherapy in 4 patients, surgery alone in 2 patients, and radiotherapy alone in the other 2. The lesion was embolized before surgery in 4 cases. We also performed a critical review of similar published cases. Our literature review covered 53 cases of RCC metastatic to the sinonasal cavity, including ours. Metastases were the first presentation of RCC in 24 of these cases (45.3%); in our series, the metastases led to the diagnosis of the primary RCC in 3 cases (37.5%). In the 53 reported cases, metastatic resection was performed on 35 patients (66.0%). Survival data were available for 22 of these operated patients, and 17 of them achieved a complete local response. Adjunctive radiotherapy was not associated with a better local response. Overall survival was significantly better in patients who had an isolated metastasis rather than multiple metastases (p = 0.013). There was no difference in overall survival between patients whose metastasis represented the initial presentation of RCC and those whose metastasis did not (p = 0.95). We recommend that sinonasal metastasis be suspected in the event of unilateral nasal bleeding or nasal obstruction in patients diagnosed with RCC. Embolization may prevent abundant bleeding during removal. Surgery may improve the quality of life of these patients while decreasing nasal obstruction and bleeding.

scholarly journals Papillary renal cell carcinoma: what is missing in research? A case report and a review of literature

2019 ◽  
Vol 7 ◽  
pp. 2050313X1986947 ◽  
Author(s):  
Ihab Eldessouki ◽  
Ola Gaber ◽  
Mahmoud A Shehata ◽  
Tariq Namad ◽  
Joseph Atallah ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Growth Factor Receptor ◽  
Papillary Renal Cell Carcinoma ◽  
Type I ◽  
Renal Cell Carcinomas ◽  
Cancer Statistics ◽  
Male Predominance ◽  
Endothelial Growth Factor

The incidence of renal cell carcinomas in adults ranges has been increasing over the past decades in both men and women. Once the incidence was 2.9%, now is reported to have increased to 3%–5% with male predominance according to the most recent reports of cancer statistics. The disease typically describes a group of different histopathological subtypes; the most common is clear cell carcinoma which accounts for 70%–80% of the diagnosed cases, while papillary renal cell carcinoma and chromophobe types represent 20% and 5%, respectively. In 1996, the renal cell carcinomas Heidelberg classification was introduced by Delahunt et al. It divides renal cell tumors into benign and malignant parenchymal neoplasms, excluding Wilm’s tumor and secondary metastases and limiting each subcategory to the most commonly documented genetic abnormalities, if applicable. In this report, we discuss a case of metastatic type I papillary renal cell carcinoma treated with the anti-vascular endothelial growth factor receptor sunitinib and showing marked long-term clinical response. Through this case, we highlight the importance of re-classifying papillary renal cell carcinoma subtypes to prioritize the clinical management of these cases.

Value of Tumor Size in Predicting Survival from Renal Cell Carcinoma Among Tumors, Nodes and Metastases Stage 1 and Stage 2 Patients

1994 ◽  
Vol 152 (5 Part 1) ◽  
pp. 1389-1392 ◽  
Author(s):  
Paul V. Targonski ◽  
Walter Frank ◽  
David Stuhldreher ◽  
Patrick D. Guinan
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Size ◽  
Renal Cell ◽  
Stage 1

scholarly journals Image-guided percutaneous renal cryoablation for stage 1 renal cell carcinoma with high surgical risk

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Xiang Yan ◽  
Mingxin Zhang ◽  
Xiaoxiang Chen ◽  
Wang Wei ◽  
Rong Yang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Surgical Risk ◽  
Image Guided ◽  
High Surgical Risk ◽  
Stage 1
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