scholarly journals Decadal Experience of Renal Cell Carcinoma from a Tertiary Care Teaching Institute in North India

2018 ◽  
Vol 9 (4) ◽  
pp. 558-564
Author(s):  
Singh Kawaljit ◽  
Sinha Rahul Janak ◽  
Gupta Ashok ◽  
Singh Vishwajeet
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tertiary Care ◽  
North India ◽  
Care Teaching

scholarly journals Renal Cell Carcinoma Metastatic to the Sinonasal Cavity: A Review and Report of 8 Cases

2018 ◽  
Vol 97 (9) ◽  
pp. E6-E12 ◽  
Author(s):  
Pierre-Louis Bastier ◽  
Dorothée Dunion ◽  
Guillaume de Bonnecaze ◽  
Elie Serrano ◽  
Ludovic de Gabory
Keyword(s):  
Renal Cell Carcinoma ◽  
Overall Survival ◽  
Cell Carcinoma ◽  
Nasal Obstruction ◽  
Survival Data ◽  
Renal Cell ◽  
Tertiary Care ◽  
Local Treatment ◽  
Initial Presentation ◽  
Local Response

Renal cell carcinoma (RCC) metastatic in the sinonasal cavity is rare. In many cases, it represents the initial presentation of RCC. We conducted a retrospective chart review to report the clinical presentation, imaging, and treatment of RCC metastases in the sinonasal cavity at two tertiary care referral centers. Our population was made up of 8 patients—6 men and 2 women, aged 55 to 86 years (mean: 66.9; median: 63.5)—who had been diagnosed with cancer in the sinonasal cavity. The most common complaints were epistaxis, nasal obstruction, and diplopia. Cancers were located in the ethmoid sinus (n = 3), nasal cavity (n = 2), sphenoid sinus (n = 2), and maxillary sinus (n = 1). Local treatment involved resection and adjuvant radiotherapy in 4 patients, surgery alone in 2 patients, and radiotherapy alone in the other 2. The lesion was embolized before surgery in 4 cases. We also performed a critical review of similar published cases. Our literature review covered 53 cases of RCC metastatic to the sinonasal cavity, including ours. Metastases were the first presentation of RCC in 24 of these cases (45.3%); in our series, the metastases led to the diagnosis of the primary RCC in 3 cases (37.5%). In the 53 reported cases, metastatic resection was performed on 35 patients (66.0%). Survival data were available for 22 of these operated patients, and 17 of them achieved a complete local response. Adjunctive radiotherapy was not associated with a better local response. Overall survival was significantly better in patients who had an isolated metastasis rather than multiple metastases (p = 0.013). There was no difference in overall survival between patients whose metastasis represented the initial presentation of RCC and those whose metastasis did not (p = 0.95). We recommend that sinonasal metastasis be suspected in the event of unilateral nasal bleeding or nasal obstruction in patients diagnosed with RCC. Embolization may prevent abundant bleeding during removal. Surgery may improve the quality of life of these patients while decreasing nasal obstruction and bleeding.

scholarly journals Renal cell carcinoma at the time of presentation: a 5-year radiological survey at a tertiary care cancer hospital

2020 ◽  
Vol 7 (5) ◽  
pp. 1657
Author(s):  
Muhammad Omer Altaf ◽  
Asma Riaz ◽  
Mehreen Shafqat ◽  
Hamd Zahra ◽  
Naila Iqbal ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tertiary Care ◽  
Developed Countries ◽  
Nodal Metastasis ◽  
Male Predominance ◽  
Cancer Hospital ◽  
Stage 1 ◽  
Time Of Presentation

Background: Renal cell carcinoma (RCC) is associated with highest mortality rates of all the genitourinary tumors with increased incidence in the past few decades. It is heterogenous tumor with several histological types. Main diagnostic approach is radiological imaging followed by histopathology.Methods: It is a retrospective study conducted at a tertiary care cancer hospital in Pakistan. We reviewed the record of all the RCC patients in terms of age, gender, radiological manifestation of tumor size, polarity, laterality, stage including nodal status, metastasis and histological type.Results: Our study included 149 patients of RCC. Mean age of presentation was 57 years with a male predominance. The most common stage of presentation was stage 3 seen in 41% patients followed by stage 1 in 37% patients. nodal metastasis was observed in around 13% patients and distant metastasis in 8% patients. Also, majority of the patient had histological subtype of clear cell CA (63%) followed by papillary CA (33%).Conclusions: Epidemiological features of renal cell CA are observed over a period of 5 years representing our population. The current trends show variation from those observed in developed countries depicting the struggle of healthcare awareness in developing countries.

scholarly journals Histopathological Spectrum of Nephrectomies - A 10 Year Descriptive Study from a Tertiary Care Center in South India

2020 ◽  
Vol 7 (47) ◽  
pp. 2752-2756
Author(s):  
Bhavya P. Mohan ◽  
Jaylakshmy Payippat Leelamma ◽  
Letha Vilasiniamma ◽  
Suresh Bhat
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Care Center ◽  
Tertiary Care ◽  
Age Distribution ◽  
Age Groups ◽  
Renal Diseases ◽  
Malignant Tumours ◽  
Neoplastic Lesions

BACKGROUND Nephrectomy is the standard surgical treatment of neoplastic and non-neoplastic lesions in the kidney and provides more insight into the detailed histopathology of renal lesions. We wanted to identify the age groups, gender distribution and different histopathological types and subtypes of non-neoplastic and neoplastic lesions in nephrectomy specimens over a period of ten years. METHODS A retrospective analysis was done over a period of ten years (January 2006 to December 2015). All nephrectomy specimens received in the Department of Pathology, Government Medical College, Kottayam were recorded from histopathology registers and analysed with regard to age, gender and histopathological types. RESULTS A total of 532 lesions was encountered in our analysis. Males (61.8 %) were affected more than females (38.2 %). Lesions were more on the left side (50.8 %) than right side (49.2 %). Non-neoplastic lesions (53 %) outnumbered neoplastic lesions (47 %). Inflammatory and obstructive causes constituted the majority (43.8 %) in non-neoplastic lesions and renal cell carcinoma was the commonest neoplasm (71.2 %). CONCLUSIONS There is a wide age distribution of renal diseases in the present study. Inflammatory and obstructive conditions constituted the most common indication for nephrectomy, followed by malignant tumours. KEYWORDS Renal Cell Carcinoma, Nephrectomy, Pyelonephritis, Simple Renal Cyst, Wilms Tumour

scholarly journals Machine Learning Approach to Predict the Probability of Recurrence after Surgery for Renal Cell Carcinoma: Prediction Model Development Study (Preprint)

2020 ◽  
Author(s):  
HyungMin Kim ◽  
Sun Jung Lee ◽  
So Jin Park ◽  
In Young Choi ◽  
Sung-Hoo Hong
Keyword(s):  
Machine Learning ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Large Scale ◽  
Tertiary Care ◽  
Analytical Data ◽  
Machine Learning Algorithms ◽  
High Recurrence Rate ◽  
A Value

BACKGROUND Renal cell carcinoma (RCC) has a high recurrence rate of 20–30 % after nephrectomy for clinically localized disease, and more than 40 % of patients eventually die of the disease, making regular monitoring and constant management of utmost importance. OBJECTIVE The objective of this study was to develop an algorithm that predicts the probability of recurrence within 5 and 10 years of RCC. METHODS Data from 6,849 Korean RCC patients were collected from 8 tertiary care hospitals listed in the KOrean Renal Cell Carcinoma (KORCC) web-based database (DB). To predict RCC recurrence, 2,814 analytical data were extracted from the DB. Eight machine learning algorithms were used to predict the probability of RCC recurrence, and the results were compared. RESULTS Within five years of surgery, the highest area under the receiver operating characteristic curve (AUROC) was obtained from the naive Bayes (NB) model, with a value of 0.836. Within 10 years of surgery, the highest AUROC was obtained from the NB model, with a value of 0.784. CONCLUSIONS An algorithm was developed that predicts the probability of RCC recurrence within 5 and 10 years using the KORCC DB, a large-scale RCC cohort in Korea. It is expected that the developed algorithm will help clinicians manage prognosis and establish customized treatment strategies for patients with RCC after surgery.

scholarly journals MP25-04 OUTCOMES OF METASTATIC RENAL CELL CARCINOMA PATIENTS WITH SARCOMATOID HISTOLOGY - A SINGLE TERTIARY CARE CENTER STUDY IN THE TKI ERA

2019 ◽  
Vol 201 (Supplement 4) ◽  
Author(s):  
Florian Janisch* ◽  
Constantin Fühner ◽  
Christian P. Meyer ◽  
Tobias Hillemacher ◽  
Thomas Klotzbücher ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Center Study

Outcomes in Renal Cell Carcinoma With IVC Thrombectomy: A Multiteam Analysis Between an NCI-Designated Cancer Center and a Quaternary Care Teaching Hospital

2020 ◽  
Vol 86 (8) ◽  
pp. 1005-1009
Author(s):  
Angel E. Alsina ◽  
Daniel Wind ◽  
Ambuj Kumar ◽  
Ebonie Rogers ◽  
Jacentha Buggs ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Hospital Mortality ◽  
Cell Carcinoma ◽  
Teaching Hospital ◽  
Renal Cell ◽  
Cancer Center ◽  
Complication Rates ◽  
Thromboembolic Events ◽  
Care Teaching ◽  
Surgical Teams

Introduction Interteam performance and Clavien-Dindo (C-D) complications in renal cell carcinoma with inferior vena cava thrombectomy (RCC-IVCT) have not been reported. We aimed to describe complications by the degree of complexity and surgical teams in a collaborative effort between a National Cancer Institute-designated Comprehensive Cancer Center and a Quaternary Care Teaching Hospital. Methods Between January 2011 and May 2019, 73 consecutive RCC-IVCT were included. C-D grades III or higher were captured. Teams involved were urologic-oncology, vascular, hepatobiliary/transplant, and cardiothoracic. The Mayo Clinic tumor thrombus classification was used. Results Overall complication rate was 42% (n = 31). Nineteen percent had grade III, 18% had grade IV, and 6% had grade V complications. Patients with level IV thrombus had the highest in-hospital mortality rate (75%). Thrombus level did not show a correlation to complication rates (14% level I, 45% level II, 32% level III, 42% level IV). A positive correlation found between the number of teams involved and complication rates (35% with 2-team, 59% with 3-team, P = .059). Thromboembolic events (6% vs 24%, P = .02) and disposition other than home (22% vs 48%, P = .01) were statistically lower for the 2-team groups. Two-team in-hospital mortality was 1/51 (2%) versus 3-team (3/22,14%, ( P = .07). No statistical differences were found in infections, thromboembolic events, and grades of complications between surgical teams. Conclusions Despite similar interteam performance, the consistency of surgeons in high complexity cases could improve outcomes further. Complexity was higher for hepatobiliary/transplant and cardiothoracic teams. A combination of intraoperative events and patient selection (comorbidities and age) contributed to death. Overall, in-hospital mortality was lower than in most reported series.

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