Clinicopathological study of non-malignant lesions of larynx: a prospective observational study

Background: Non-malignant lesions of the larynx constitute an interesting array of lesions. The significance of non-malignant lesions lies in the fact that it cannot only cause change in voice but, at times, can lead to breathing difficulty or life-threatening stridor.Methods: This was a prospective observational study done between November 2019 - July 2020. All the details were filled up by the principal investigator in a structured study proforma. This proforma contains data regarding essential demographic details, clinical features, ENT examination, flexible video laryngoscopy findings, stroboscopy findings, voice handicap index, diagnosis and management. Statistical method and data analysis in this study we tried to describe the analysis process with appropriate methods and principles of statistics, using the data collected from the patients, participated in this study. Results: The most common non-malignant lesion among the 50 patients studied was vocal cord polyp; second most common being the vocal cord cyst. The relation of hoarseness of voice, difficulty in breathing, smoking or alcohol intake with non-malignant lesions showed a statistically significant result. On interpreting the stroboscopic findings of various lesions, all cases of vocal nodule showed an hourglass-shaped glottic closure.Conclusions: These lesions can create a lot of mental and emotional tension in the patient and the family. Early diagnosis of the lesions can lead to effective management and functional recovery. Stroboscopy is valued for its excellent ability to examine the structure and the function of the glottis during phonation.

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Accuracy of the general practitioner’s sense of alarm when confronted with dyspnoea and/or chest pain: a prospective observational study

BMJ Open ◽

10.1136/bmjopen-2019-034348 ◽

2020 ◽

Vol 10 (2) ◽

pp. e034348 ◽

Cited By ~ 3

Author(s):

Marie Barais ◽

Emilie Fossard ◽

Antoine Dany ◽

Tristan Montier ◽

Erik Stolper ◽

...

Keyword(s):

Chest Pain ◽

Observational Study ◽

Likelihood Ratio ◽

Prospective Observational Study ◽

Positive Likelihood Ratio ◽

Negative Likelihood Ratio ◽

Final Diagnosis ◽

Test Accuracy ◽

Index Test ◽

Life Threatening

ObjectivesDyspnoea and chest pain are symptoms shared with multiple pathologies ranging from the benign to life-threatening diseases. A Gut Feelings Questionnaire (GFQ) has been validated to measure the general practitioner’s (GPs) sense of alarm or sense of reassurance. The aim of the study was to estimate the diagnostic test accuracy of GPs’ sense of alarm when confronted with dyspnoea and chest pain.Design and settingsProspective observational study in general practice.ParticipantsPatients aged between 18 and 80 years, consulting their GP for dyspnoea and/or chest pain, were considered for enrolment. These GPs had to complete the GFQ immediately after the consultation.Primary outcome measuresLife-threatening and non-life-threatening diseases have previously been defined according to the pathologies or symptoms in the International Classification of Primary Care (ICPC)-2 classification. The index test was the sense of alarm and the reference standard was the final diagnosis at 4 weeks.Results25 GPs filled in 235 GFQ questionnaires. The positive likelihood ratio for the sense of alarm was 2.12 (95% CI 1.49 to 2.82), the negative likelihood ratio was 0.55 (95% CI 0.37 to 0.77).ConclusionsWhere the physician experienced a sense of alarm when a patient consulted him/her for dyspnoea and/or chest pain, the post-test odds that this patient had, in fact, a life-threatening disease was about twice as high as the pretest odds.Trial registration numberNCT02932982.

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The performance of the EMS triage (RETTS-p) and the agreement between the field assessment and final hospital diagnosis: a prospective observational study among children < 16 years

BMC Pediatrics ◽

10.1186/s12887-019-1857-0 ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Carl Magnusson ◽

Johan Herlitz ◽

Thomas Karlsson ◽

Maria Jiménez-Herrera ◽

Christer Axelsson

Keyword(s):

Observational Study ◽

Prospective Observational Study ◽

Hospital Setting ◽

Risk Of Death ◽

Computerised Decision Support System ◽

Field Assessment ◽

Hospitalised Patients ◽

Increased Risk ◽

Life Threatening ◽

Triage Level

Abstract Background The rapid triage and treatment system for paediatrics (RETTS-p) has been used by the emergency medical services (EMS) in the west of Sweden since 2014. The performance of the RETTS-p in the pre-hospital setting and the agreement between the EMS nurse’s field assessment and the hospital diagnosis is unknown. The aim of this study was to evaluate the performance of the RETTS-p in the EMS and the agreement between the EMS field assessment and the hospital diagnosis. Methods A prospective observational study was conducted among 454 patients < 16 years of age who were assessed and transported to the PED. Two instruments were used for comparison: 1) Classification of an emergent patient according to predefined criteria as compared to the RETTS-p and 2) Agreement between the EMS nurse’s field assessment and the hospital diagnosis. Results Among all children, 11% were identified as having vital signs associated with an increased risk of death and 7% were diagnosed in hospital with a potentially life-threatening condition. Of the children triaged with RETTS-p (85.9%), 149 of 390 children (38.2%) were triaged to RETTS-p red or orange (life-threatening, potentially life-threatening), of which 40 (26.8%) children were classified as emergent. The hospitalised children were triaged with the highest frequency to level yellow (can wait; 41.5%). In children with RETTS-p red or orange, the sensitivity for a defined emergent patient was 66.7%, with a corresponding specificity of 67.0%. The EMS field assessment was in agreement with the final hospital diagnosis in 80% of the cases. Conclusions The RETTS-p sensitivity in this study is considered moderate. Two thirds of the children triaged to life threatening or potentially life threatening were later identified as non-emergent. Of those, one in six was discharged from the PED without any intervention. Further, one third of the children were under triaged, the majority were found in the yellow triage level (can wait). The highest proportion of hospitalised patients was found in the yellow triage level. Our result is in agreement with previous studies using other triage instruments. A computerised decision support system might help the EMS triage to increase sensitivity and specificity.

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Presentation of life-threatening invasive nontyphoidal Salmonella disease in Malawian children: A prospective observational study

PLoS Neglected Tropical Diseases ◽

10.1371/journal.pntd.0006027 ◽

2017 ◽

Vol 11 (12) ◽

pp. e0006027 ◽

Cited By ~ 8

Author(s):

Calman A. MacLennan ◽

Chisomo L. Msefula ◽

Esther N. Gondwe ◽

James J. Gilchrist ◽

Paul Pensulo ◽

...

Keyword(s):

Observational Study ◽

Prospective Observational Study ◽

Life Threatening

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Skin markings to differentiate benign from malignant lesions: A prospective observational study

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2021.07.075 ◽

2021 ◽

Author(s):

Rachel Manci ◽

Michael A. Marchetti ◽

Stephen W. Dusza ◽

Megan Dauscher ◽

Ashfaq A. Marghoob

Keyword(s):

Observational Study ◽

Prospective Observational Study ◽

Malignant Lesions

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Proportion of Pancreatic Necrosis among Patients with Acute Pancreatitis and Association between High-Density Lipoprotein (HDL Cholesterol) and Pancreatic Necrosis – A Prospective Observational Study from Kerala, South India

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/282 ◽

2021 ◽

Vol 8 (20) ◽

pp. 1489-1494

Author(s):

Jayas Siby ◽

Preetha S ◽

Sindhu R.S

Keyword(s):

Acute Pancreatitis ◽

Observational Study ◽

Prospective Observational Study ◽

Pancreatic Necrosis ◽

Hdl Cholesterol ◽

Government Medical College ◽

Medical College ◽

Low Hdl ◽

Life Threatening ◽

The Mean

BACKGROUND Acute pancreatitis is a very common disease and severe acute pancreatitis is life threatening and needs early identification. Current severity predicting indices in acute pancreatitis are cumbersome. There have been previous reports of low HDL cholesterol in life threatening acute pancreatitis. Previous studies in this regard were done in a single ethnicity population and needed to be validated in other ethnic groups. We wanted to estimate the proportion of pancreatic necrosis among the patients with acute pancreatitis attending Government Medical College, Thiruvananthapuram. We also wanted to compare the mean HDL values in those who developed pancreatic necrosis and those who didn’t develop pancreatic necrosis and evaluate the association between HDL value measured 48 – 72 hours of onset of symptoms and pancreatic necrosis. METHODS This was a prospective observational study conducted among 271 patients diagnosed with acute pancreatitis in Government Medical College Hospital, Thiruvananthapuram. Consecutive sampling method was used. RESULTS There were 42 cases of pancreatic necrosis out of 271 cases. The mean HDL of those patients with pancreatic necrosis was found to be less than those without necrosis (P < 0.001). Mean HDL value among those having pancreatic necrosis was 17.7 whereas those without necrosis was 34.9. CONCLUSIONS Proportion of pancreatic necrosis was 15.5 %. The mean HDL measured at 48 hours of symptom onset among the necrotising pancreatitis patients was significantly low when compared to the non-necrotic group (17.7 vs 34.9). All the patients with pancreatic necrosis had their HDL less than 40. Thus, an inference that low HDL at 48 hours of symptom onset was associated with higher incidence of pancreatic necrosis and severe pancreatitis could be made. KEYWORDS Pancreatitis, HDL, Pancreatic Necrosis

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Nursing workforce activities in the Family Health Program in Brazil: a prospective observational study

The Lancet ◽

10.1016/s0140-6736(14)61876-6 ◽

2014 ◽

Vol 384 ◽

pp. S13 ◽

Cited By ~ 1

Author(s):

Daiana Bonfim ◽

Lianne Jeffs ◽

Fernanda M T Fugulin ◽

Raquel R Gaidzinski

Keyword(s):

Observational Study ◽

Health Program ◽

Prospective Observational Study ◽

Family Health ◽

Nursing Workforce ◽

Family Health Program ◽

The Family

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Drug interactions and creatinine levels are associated with QTc prolongation in intensive care units: a prospective, observational study

Drug Metabolism and Personalized Therapy ◽

10.1515/dmpt-2019-0022 ◽

2019 ◽

Vol 34 (4) ◽

Cited By ~ 1

Author(s):

Zeinab Hosseinpoor ◽

Behrooz Farzanegan ◽

Seyyed Reza Seyyedi ◽

Mehdi Rajabi ◽

Shadi Baniasadi

Keyword(s):

Risk Factors ◽

Intensive Care ◽

Observational Study ◽

Drug Interactions ◽

Prospective Observational Study ◽

High Serum ◽

Qtc Interval ◽

Qtc Prolongation ◽

Icu Admission ◽

Life Threatening

Abstract Background Prolongation of the QTc interval may lead to life threatening arrhythmias. QTc prolongation is common in intensive care unit (ICU) patients. The objectives of this study were to identify the role of drug-drug interactions (DDIs) and other predictors (age, sex, cardiovascular diseases, and electrolyte abnormalities) in life threatening QTc prolongation in patients admitted to medical (M), surgical (S) and emergency (E) ICUs. Methods This prospective, observational study included patients above the age of 18 years who were admitted to SICU, EICU, and MICU at a tertiary respiratory referral center. Electrocardiogram (ECG) monitoring was performed during the first 5 days of ICU admission. Risk factors and DDIs which were anticipated to be associated with the prolongation of the QTc interval were assessed for all patients. Results Two hundred patients were included in the study. QTc prolongation occurred in 10.7% of patients and the majority of patients presenting with QTc prolongation had creatinine levels above 1.3 mg/dL during their 5 days of ICU admission. Incidence of pharmacodynamic (PD) DDIs was significantly higher in patients with QTc prolongation vs. other patients. Creatinine levels above 1.3 mg/dL and PD DDIs were associated with QTc prolongation during 5 days of ICU admission. Conclusions High serum creatinine and PD DDIs can increase the risk of QTc prolongation in patients admitted to the ICU. QTc interval measurements should be performed prior to initiation or after starting any drug that is associated with QT prolongation, specifically in patients with the known risk factors.

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STUDY OF CORRELATION BETWEEN THE CYTOLOGICAL AND HISTOPATHOLOGICAL FINDINGS OF NON-NEOPLASTIC AND NEOPLASTIC BREAST LESION

10.36106/gjra/8900203 ◽

2019 ◽

pp. 1-2

Author(s):

Rina Kumari

Keyword(s):

Observational Study ◽

Invasive Ductal Carcinoma ◽

Gold Standard ◽

Breast Lesion ◽

Prospective Observational Study ◽

Ductal Carcinoma ◽

Benign Lesion ◽

Malignant Lesion ◽

Neoplastic Lesion ◽

Lesion Method

Background: Study of correlation between the cytology and histopathological ndings of nonneoplastic and neoplastic breast lesion. Method : The present prospective observational study was conducated in jlnmc for a period of 6 months from 15th April to 14th Sept. we had studied 100 cases and specimens were received in histopathological section of our department.Gross examination of speciemens did followed by xation ,proper sampling and tissue processing. Result: Total 100 cases were studied of which 38 cases were nonneoplastic, 36 cases were benign neoplastic lesion,5 cases borderline and 21 cases were malignant.Over all broadenoma was most common benign lesion with 18 cases. Invasive ductal carcinoma nos were most common malignant lesion followed by lobular carcinoma.malignant phylloid was the most common nonepithelial malignancy. Conclusion: Histology remains gold standard for diagnosis of breast lesion

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