scholarly journals A cross-sectional study on autologous: serum skin test in chronic urticaria in a tertiary care centre

2017 ◽  
Vol 3 (3) ◽  
pp. 418
Author(s):  
Dharani D. ◽  
Krishnan S. ◽  
Manobalan K.
Keyword(s):  
Chronic Urticaria ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Autologous Serum ◽  
Clinical Test ◽  
Sectional Study ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Autoimmune Urticaria ◽  
Significant Difference

<p class="abstract"><strong><span lang="EN-US">Background:</span></strong><span lang="EN-US"> Urticaria persisting daily for more than six weeks is termed as chronic urticaria. A significant number of them have an autoimmune basis, where ASST is </span>used for detection of chronic autoimmune urticaria (CAU). <span lang="EN-US">The aim and objective of the study was </span>to determine the frequency of autoimmunity with ASST in chronic urticaria patients.</p><p class="abstract"><strong><span lang="EN-US">Methods:</span></strong>This was a hospital based cross sectional study, 100 patients with chronic urticaria fulfilling the inclusion and exclusion criteria were enrolled in the study. Detailed history, physical examination and routine investigations were recorded and ASST was done for all patients.</p><p class="abstract"><strong><span lang="EN-US">Results:</span></strong>Thirty seven (37%) out of 100 CU patients were ASST positive. Statistical analysis of the clinical variables did not show significant difference between ASST positive and negative patients except for dermographism and mean duration of the disease.</p><p class="abstract"><strong><span lang="EN-US">Conclusions:</span></strong>ASST is a simple <em>invivo</em> clinical test for detection of basophil histamine releasing activity. Diagnosing CAU is important as these patients may need high doses of anti-histamines, systemic corticosteroids and/or immunomodulatory drugs. Autologous serum therapy itself has a therapeutic role in treatment of CAU patients.</p>

scholarly journals Association between Clinico-epidemiological Features in Chronic Urticaria with Autologous Serum Skin Test: A Cross-sectional Observational Study

2021 ◽  
Author(s):  
Usha Rani Tirupathi ◽  
Bhagya Rekha Manchiryala ◽  
Sruthi Kareddy
Keyword(s):  
Skin Test ◽  
Chronic Urticaria ◽  
Autologous Serum ◽  
Clinical Test ◽  
Cross Sectional ◽  
Autologous Serum Skin Test ◽  
Epidemiological Features ◽  
Chronic Inducible Urticaria ◽  
Autoimmune Urticaria ◽  
Significant Difference

Introduction: Urticaria is a frequent and heterogeneous skin disease characterised by the development of wheals (hives), angioedema, or both. Chronic urticaria is characterised by the occurrence of wheals lasting less than 24 hours, with or without angioedema occurring daily or almost daily lasting more than six weeks. The two subtypes of chronic urticaria are Chronic Spontaneous Urticaria (CSU) and Chronic Inducible Urticaria (CIU). Autologous Serum Skin Test (ASST) is the simplest and the best in-vivo clinical test for the detection of basophil histamine- releasing activity. ASST has a sensitivity of approximately 70% and a specificity of 80%. Aim: To study the association between clinico-epidemiological features of CSU with positive and negative ASST. Materials and Methods: The cross-sectional study was conducted on 80 clinically diagnosed cases of CSU attending the Department of Dermatology Venereology Leprology Outpatient Department at Mahatma Gandhi Memorial Hospital (Kakatiya Medical College), Warangal, Telangana, India; during the period of January 2016 to September 2017. The detailed history was taken; complete physical and cutaneous examination and laboratory investigations like Complete Blood Picture (CBP), Absolute Eosinophil Count (AEC), Erythrocytic Sedimentation Rate (ESR), Thyroid Function Test (TFT) were carried out. ASST was done and read after 30 minutes. Chi- square test was applied and the results analysed using Statistical Package for the Social Sciences (SPSS) version 10.0. Results: Out of total 80 patients included in the study, ASST was positive in 36 (45%) and negative in 44 (55%). ASST positive patients showed longer duration of the disease with increased frequency of attacks and longer duration of wheals. However, both ASST positive and negative groups did not show statistically significant difference in the age of occurrence, gender, angioedema, dermographism. Conclusion: Autoimmune urticaria has no distinctive clinical features. ASST positive, autoimmune urticaria patients have more severe disease with greater impact on quality of life. Thus, they may need more aggressive treatment.

scholarly journals Knowledge and attitude about leprosy among medical students and interns at tertiary care centre of central India: a cross-sectional study

2019 ◽  
Vol 6 (8) ◽  
pp. 3602
Author(s):  
Ashok R. Jadhao ◽  
Hitesh C. Tayade ◽  
Abhijit N. Kherde ◽  
Punam M. Dambhare
Keyword(s):  
Medical Students ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
National Program ◽  
Sectional Study ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Significant Difference ◽  
Knowledge And Attitude ◽  
Lack Of Knowledge

Background: Leprosy has been known to the Indians since the Vedic period. Leprosy is synonymous with social stigma due to reasons like mystery around its transmission, lack of knowledge on available treatment, deformities and religious views. Prejudice and lack of knowledge about leprosy exist even among medical practitioners and healthcare professionals around the world. Considering above mentioned facts, this study was conducted to study knowledge and attitude of medical students and interns towards leprosy.Methods: A cross-sectional study was conducted at IGGMC, Nagpur, among Third MBBS part one of 7th semester medical students who were exam going for community medicine and interns of IGGMC between October 2018 to January 2019. Questionnaire comprised of 27 knowledge-based and 22 attitude–oriented questions. In all total 210 subjects, 99 Interns and 111 students were enrolled for the study.Results: Mean age of interns was 23.52±0.66 years and that of students was 21.45±0.85 years. There was no significant difference in knowledge regarding cause and modes of transmission and clinical features of leprosy between interns and student however interns were having significant higher knowledge regarding diagnosis, treatment, prevention of deformity limitation and precaution to be taken against leprosy. Only 13(6.19%) participants were having knowledge regarding targets of NLEP that was to be achieved by year 2017. Though both interns and students both showed good attitude towards leprosy but only 34 interns and 31 students had ever rendered service or donated money for cause of leprosy.Conclusions: Knowledge regarding national program is limited in both groups, curriculum should be strengthen pertaining to National program.

scholarly journals “A STUDY OF MICROALBUMINURIA IN NON DIABETIC HYPERTENSIVE PATIENTS”

2020 ◽  
pp. 1-3
Author(s):  
Anup Latne ◽  
Prabhakar Jirvankar
Keyword(s):  
Cardiovascular Risk ◽  
Tertiary Care ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
Low Grade ◽  
Major Public Health Problem ◽  
Sectional Study ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Hypertensive Patients

Hypertension is a major public health problem all over the world. The incidence of hypertension is increasing year after year and the prevalence of hypertension is increasing day by day due to increased life expectancy and aging population and their sedentary lifestyle. Hypertension is known to cause microvascular changes and increased cardiovascular risk from it. Microalbuminuria possibly reflects a state of increased renal endothelial permeability and is an easily measured marker of rather diffuse endothelial dysfunction, low grade inflammation and vascular disease burden2. Microalbuminuria has been determined as an important prognostic indicator and has been reported to be associated with increased cardiovascular risk and progressive renal damage. Reliable data on the prevalence of microalbuminuria in the general population and its association with cardiovascular risk factors is limited. Till now, there is little data available regarding screening and early treatment of hypertensive patients with microalbuminuria, as in the case of microalbuminuric non diabetic subjects. With these perspective this cross sectional study of microalbuminuria in non-diabetic hypertensive patients was undertaken to study prevalence of microalbuminuria in Non Diabetic hypertensive patients. Objectives: To determine the prevalence of microalbuminuria in non-diabetic hypertensive patients and to correlate the presence of microalbuminuria with the patients of different clinical profiles. Materials and Methods: This was observational, cross sectional study of Patients diagnosed with hypertension either admitted in ward or attending OPD of Medical College and Tertiary Care Centre. Urine microalbumin creatinine ratio was used for estimation of microalbuminuria. Conclusion: It was proved that microalbuminuria prevalence was directly proportional to the duration of hypertension, the stage of hypertension. Prevalence of microalbuminria was low in ACE inhibitor and ARB treated hypertensive patients.

scholarly journals Study on Clinico-Demographic Characteristics of Orthopaedic Cases in a Tertiary Care Centre: A Descriptive Cross-sectional Study

2020 ◽  
Vol 58 (232) ◽  
Author(s):  
Badri Rijal ◽  
Krishna Rana ◽  
Srijana KC ◽  
Jamuna Lamsal
Keyword(s):  
Bone Fracture ◽  
Chronic Back Pain ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Implant Removal ◽  
Sectional Study ◽  
Tertiary Care Centre ◽  
Night Time ◽  
Cross Sectional ◽  
Forearm Bone

Introduction: Orthopedic conditions include a range of condition varying from traumatic injuries, congenital anomalies, chronic back-pain, arthritis, rheumatologic conditions, and other. In Nepal, approximately 2.35 million people are living with musculoskeletal conditions in which 175,000 people are suffering with MSD from non-traumatic causes. The aim of the study is to observe the clinical and demographic pattern of orthopedic problems presenting in the hospital. Methods: A descriptive cross-sectional study was done in All Nepal Hospital Private Limited in the month of November. The data from the medical record section was retrospectively collected. Sample size of 384 was included and convenience sampling technique was used. The descriptive statistical analysis was done. Results: Eight hundred forty four cases were included in the study. Implant removal was the main condition for admission in the hospital 105 (12.44%) followed by Forearm Bone Fracture 84 (9.95%) and Cut Injury 64 (7.58%). Most cases presented during the time 6 PM to 12 AM 312 (36.96%). Conclusions: Most of the orthopedic cases presented in the evening and night time. Implant removal, forearm bone fracture and cut injury form the major bulk of the cases.

scholarly journals A cross sectional study on demographic factors affecting low birth weight

2019 ◽  
Vol 6 (11) ◽  
pp. 4896
Author(s):  
Renu Sulakhe Vasant ◽  
Lavanya K. M. Rao ◽  
Nageswara Rao V.
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Tertiary Care ◽  
Income Group ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Factors Affecting

Background: Low birth weight (LBW) is one of the commonest cause for infant and childhood morbidity and mortality. The majority of low birth weight in developing countries is due to intrauterine growth retardation, while most low birth weight in industrialized countries is due to preterm birth. LBW is the single most important factor determining the survival chances of the child. The objectives of the study were to assess the proportion of low birth weight among babies delivered by mothers at a tertiary care hospital and to analyse the relationship between low birth weight and certain socio-demographic factors.Methods: A cross-sectional study conducted in a tertiary care centre for a period of six months.Results: The prevalence of LBW was 23.5%. The proportion of mothers having low birth weight was maximum in women aged less than 18 years (35%) and more than 30 years (26.5%). Muslim women had a higher proportion of LBW (28.8%). LBW was more in women belonging to joint family (30.0%), low per capita income group and illiterates.Conclusions: The prevalence of LBW still continues to be high, almost one fourth of the babies are LBW. Different socio-demographic characteristics of the population are still the important factors determining the occurrence of LBW.

scholarly journals CARDIAC MANIFESTATIONS IN DENGUE FEVER: A CROSS SECTIONAL STUDY FROM A TERTIARY CARE CENTRE OF NORTH INDIA

2019 ◽  
Vol 6 (17) ◽  
pp. 1300-1305
Author(s):  
Mansi Singh ◽  
Ajay Kumar ◽  
Sanjay Mehrotra ◽  
Virendra Atam ◽  
Ravi Mishra ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
North India ◽  
Care Centre ◽  
Sectional Study ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Cardiac Manifestations
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