scholarly journals A study on cutaneous adverse drug reactions in a tertiary care center in Rajnandgaon, Chattisgarh

2019 ◽  
Vol 5 (4) ◽  
pp. 839
Author(s):  
Pooja Pandey ◽  
Prabhat Pandey ◽  
Sharad Manore ◽  
Darshan Sandesara
Keyword(s):  
Adverse Drug Reactions ◽  
Care Center ◽  
Tertiary Care ◽  
Age Groups ◽  
Drug Reactions ◽  
Presenting Symptoms ◽  
Causative Agents ◽  
Life Threatening ◽  
Cutaneous Reactions ◽  
The Common

<p class="abstract"><strong>Background:</strong> Cutaneous reactions are one of the most common types of adverse drug reactions which may vary from mildly discomforting to those that are life-threatening.</p><p class="abstract"><strong>Methods:</strong> This prospective, observational study was done in the department of dermatology. Patients with suspected drug rash, of either sex or all age groups were included in the study.<strong></strong></p><p class="abstract"><strong>Results:</strong> A total of 114 patients were enrolled in the study. The most common presenting symptoms of cutaneous adverse drug reactions (CADRs) were itching, burning sensation and pigmentation with 61.31%, 13.87% and 10.22% respectively. A total of 21 different CADRs were observed. The common causative agents were of anti-microbial, nervous system and musculoskeletal class in both outdoor and indoor patients with 51 (37.22%), 21 (15.32%) and 25 (18.24%) respectively.</p><p class="abstract"><strong>Conclusions:</strong> The most common CADR observed in the study was antimicrobials and NSAIDs were the most common causative drugs.</p><p class="abstract"> </p>

scholarly journals 1372. Patient’s Perceptions of Barriers to Tuberculosis Care in Private Sector in India

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S497-S498
Author(s):  
Aparna Yerramilli ◽  
Suneetha Narreddy ◽  
Ravinder N Anisetti ◽  
Angileena Grace K ◽  
Sandhya Rakuditti
Keyword(s):  
Adverse Drug Reactions ◽  
Public Awareness ◽  
Care Center ◽  
Tertiary Care ◽  
Age Groups ◽  
Household Size ◽  
Drug Reactions ◽  
Delay In Diagnosis ◽  
Institutional Ethics ◽  
A Prospective Study

Abstract Background In spite of ambitious plans of all the stakeholders involved there is still a long way to go before Tuberculosis (TB) is eliminated In India due to barriers to care and cure. About half of the population affected with TB gets treated in the private sectors. This study was aimed to assess the patient knowledge on Tuberculosis and identify the barriers perceived by them. Methods A prospective study was conducted in a tertiary care center for a period of 3 months after obtaining approval from the Institutional ethics committee. All adults >18years diagnosed with tuberculosis (pulmonary, extrapulmonary) and receiving treatment in the Infectious Diseases Department were included. Subjects enrolled in the study were fully informed and gave their consent. A questionnaire was used to gather data regarding patient demographics, location, household size, co-morbid conditions, treatment, adverse drug reactions and barriers faced for their treatment. Results A total of 50 patients enrolled in the study. The majority of subjects belonged to age groups of 31–50 years (38%) with postgraduates accounting for 30%. About half (48%) of them were not working and 36 (72%) were married. About 31 (62%) were residing locally. The household size was 3–5 members (72%). Diabetes (13, 26%) and hypertension (11, 22%) were the common comorbid conditions seen. Newly diagnosed cases comprised of 35 (70%). Extrapulmonary TB was seen in 30 cases (60%) with lymph node and spine TB being more common. Adherence to the treatment was seen in 34(68%). Awareness regarding treatment duration and importance of treatment completion was seen in 64% and 82% of the study population, respectively. About 62% had visited more than one doctor for diagnosis with 42% responded that there was a delay in diagnosis. Common Barriers faced were stigma, adverse drug reactions, and transportation in 40 %, 12%, and 6% cases. The other factors faced by the respondents were the cost of diagnosis and treatment, adherence issues and loss of income. Conclusion India has the world’s highest incidence of Tuberculosis. Multifaceted barriers worsen the burden of Tuberculosis. Private sectors treat the majority of the extrapulmonary disease. Intensified efforts by means of public awareness and education are required to prevent the delay in diagnosis and reducing stigma. Disclosures All authors: No reported disclosures.

scholarly journals Status of Geriatric Patients with Abdominal Pain Presented To Emergency Department

2019 ◽  
Vol 9 (2) ◽  
pp. 90-96
Author(s):  
Daya Ram Lamsal ◽  
Jeetendra Bhandari
Keyword(s):  
Emergency Department ◽  
Abdominal Pain ◽  
Care Center ◽  
Tertiary Care ◽  
Medical Officer ◽  
Common System ◽  
Life Expectancy At Birth ◽  
Chief Complaints ◽  
Life Threatening ◽  
The Common

Background: As the development of better health facilities with advanced tools for diagnosis and management our country is not away from global trend. Nepal’s life expectancy at birth is increasing at its pace, it has in­creased in about 30 years in last 4 decades. Among the various problem presenting to ED abdominal pain is one of the common complain elderly patients are greater risk of missing life-threatening causes during evalua­tion and investigation. The aim of the study wasEdit to identify the frequency, cause and outcome of patient presenting in Emergency department with abdominal pain. Methods: It is a retrospective study conducted in tertiary care center at Chitwan, Nepal during the period from 01/09/2017 to 30/08/2018. Elec­tronic data entered by medical officer were retrieved and analyzed. Statis­tical analysis of the record was done using SPSS 16 software. Results: Elderly population who presented with chief complaints of ab­dominal pain was 1160 (21.79%). Among the patient presented with ab­dominal pain 605(52.2%) were male and 555(47.8%) were female. Mean age of patients was 71.72±8.50 years. Most common system involved was gastrointestinal and biliary problem 730(62.93%). Most common diagno­sis was Urinary tract infection 269 (23.2%) among them, 487(41.98%) re­quired hospital admission. Conclusions: Abdominal pain is one of the common presentations of el­derly to emergency department. Disorders of Gastrointestinal and biliary system were among leading causes of emergency visit. Emergency phy­sician should be tactful to identify life threatening conditions and emer­gency management.

scholarly journals Collection and analysis of adverse drug reactions of antiretroviral therapy in a tertiary care hospital in central India

2018 ◽  
Vol 7 (7) ◽  
pp. 1326
Author(s):  
Sandeep Kumar Adwal ◽  
B. L. Bamboria ◽  
Ashutosh Chourishi ◽  
Aditya Bamboria
Keyword(s):  
Adverse Drug Reactions ◽  
Health Care Professionals ◽  
Prospective Observational Study ◽  
Causality Assessment ◽  
Tertiary Care ◽  
Central India ◽  
Treatment Interruption ◽  
Care Hospital ◽  
Drug Reactions ◽  
The Common

Background: The main objective of study is to monitor and analyze the adverse drug reactions (ADRs) of ART and to assess causality and severity of the ADRs detected.Methods: It is a prospective observational study conducted in the ART centre of a tertiary care teaching hospital in central India. The data collected were recorded on standard ADR reporting forms. Causality was assessed by Naranjo’s algorithm. Severity of ADR’s was assessed by modified Hartwig and Seigel scale. Modified Shumock and Thorton criteria used for preventability assessment.Results: In twelve months duration 351 patients on ART were observed for ADRs. Total 166 ADRs detected in 96 patients. Incidence of ADRs was slightly more in female. The common systems involved were gastrointestinal 42.77% followed by nervous system 18.07%, musculoskeletal 15.06% skin/mucous membrane 07.83%, metabolic and nutritional 04.82%, red blood cell disorders 01.20 %, endocrinal 00.60 % and others 09.64%. The causality assessment as per Naranjo’s scale showed that out of 166 ADRs, 28.92% were probable and 71.08% were possible. Severity assessment by modified Hartwig and Siegel scale showed that 83.34% ADRs were mild and 15.66% were moderate. 46.39 % ADRs were probably preventable.Conclusions: Considering the magnitude of ADR related problems, there is a need for greater awareness among health care professionals, to detect and report them. These ADRs if recognized in time and managed properly can prevent treatment interruption.

scholarly journals Adverse drug reactions or events in children with assessment of causality and severity: a retrospective analysis from Bhavnagar

2020 ◽  
Vol 9 (12) ◽  
pp. 1883
Author(s):  
Jayendra R. Gohil ◽  
Aniket B. Sarwade ◽  
Hardik R. Chauhan ◽  
Jay R. Jasani ◽  
Hinal R. Gujrati
Keyword(s):  
Adverse Drug Reactions ◽  
Adverse Drug Events ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Drug Reactions ◽  
Pediatric Age Group ◽  
Skin Redness ◽  
The Common ◽  
Probable Category

Background: Objective was to study the occurrence of adverse drug reactions in pediatric age group in a tertiary care hospital setting.Methods: A retrospective study was undertaken to analyze adverse drug events in pediatrics wards of a tertiary care hospital. Any event marked as ‘suspected adverse drug reaction’ was included in the study and ADR forms were analyzed for causality and severity. Other parameters like age and sex, class of drug, types of ADR, commonly involved systems and polypharmacy were studied.Results: Total 74 cases of admitted patients (13 deaths: 11 infants, 6 neonates) with severe ADR were studied of whom 39% were females. Antimicrobials were the commonest drug class (54%) with Skin most commonly involved. 77% cases were of probable category according to Naranjo’s scale of causality assessment. 11% cases were prescribed polypharmacy.Conclusions: Antibiotics were the class of drug causing maximum ADRs. The commonest system involved was skin. Redness, itching & rashes were the common symptoms. Antimicrobials should be used judiciously. Polypharmacy should be avoided. ADR reporting should be strengthened. Extra vigilance is required for infants and neonate’s prescriptions.

scholarly journals 1253 Adverse Drug Reactions in Children Admitted to a Tertiary Care Center

2010 ◽  
Vol 68 ◽  
pp. 620-621
Author(s):  
S Águeda ◽  
R Jorge ◽  
J Rebelo ◽  
A Maia ◽  
I Azevedo ◽  
...  
Keyword(s):  
Adverse Drug Reactions ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Drug Reactions

scholarly journals Pharmacovigilance in oncology: pattern of spontaneous notifications, incidence of adverse drug reactions and under-reporting

2014 ◽  
Vol 50 (2) ◽  
pp. 411-422 ◽  
Author(s):  
Marília Berlofa Visacri ◽  
Cinthia Madeira de Souza ◽  
Rafaela Pimentel ◽  
Cristina Rosa Barbosa ◽  
Catarina Miyako Shibata Sato ◽  
...  
Keyword(s):  
Adverse Drug Reactions ◽  
Tertiary Care ◽  
Therapeutic Window ◽  
Type B ◽  
Drug Reactions ◽  
Oncology Patients ◽  
Taste Disturbance ◽  
Antineoplastic Treatment ◽  
The Common ◽  
Grade 3

The high toxicity and narrow therapeutic window of antineoplastic agents makes pharmacovigilance studies essential in oncology. The objectives of the current study were to analyze the pattern of spontaneous notifications of adverse drug reactions (ADRs) in oncology patients and to analyze the incidence of ADRs reported by outpatients on antineoplastic treatment in a tertiary care teaching hospital. To compose the pattern of ADR, the notification forms of reactions in oncology patients in 2010 were reviewed, and the reactions were classified based on the drug involved, mechanism, causality, and severity. To evaluate the incidence of reactions, a questionnaire at the time of chemotherapy was included, and the severity was classified based on the Common Terminology Criteria. The profiles of the 10 responses reported to the Pharmacovigilance Sector were type B, severe, possible, and they were primarily related to platinum compounds and taxanes. When the incidence of reactions was analyzed, it was observed that nausea, alopecia, fatigue, diarrhea, and taste disturbance were the most frequently reported reactions by oncology patients, and the grade 3 and 4 reactions were not reported. Based on this analysis, it is proposed that health professionals should be trained regarding notifications and clinical pharmacists should increasingly be brought on board to reduce under-reporting of ADRs.

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