scholarly journals Evaluation of serum ferritin, vitamin B12 and vitamin D levels as biochemical markers of chronic telogen effluvium in women

2021 ◽  
Vol 7 (3) ◽  
pp. 407
Author(s):  
V. A. Belgaumkar ◽  
R. B. Chavan ◽  
N. S. Deshmukh ◽  
P. Patil ◽  
N. Bhatt ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin B12 ◽  
Serum Ferritin ◽  
Hair Loss ◽  
Biochemical Markers ◽  
Past History ◽  
Ferritin Level ◽  
Nutritional Deficiencies ◽  
Normal Range ◽  
Vitamin D Levels

<p class="abstract"><strong>Background: </strong>Diffuse hair loss is a common complaint encountered by dermatologists in clinical practice and can be alarming to the patients. Chronic telogen effluvium (CTE) is characterized by an abrupt onset of diffuse loss of scalp hair persisting for more than six months, predominantly affecting healthy women in their fourth to fifth decade of life. Although CTE is considered to be associated with various nutritional deficiencies, currently the evidence to substantiate this assertion is conflicting.</p><p class="abstract"><strong>Methods: </strong>A cross-sectional study was conducted on 100 adult non-pregnant women with CTE to document serum ferritin, B12 and vitamin D levels in an attempt to validate their role as biochemical markers using Statistical package for social sciences (SPSS) version 25:0 and Fisher’s exact test.</p><p class="abstract"><strong>Results:</strong> Mean ferritin level was 31.17 ng/dL. 23% patients had serum ferritin levels lower than the normal range (13-150 ng/dL). Vitamin D levels (normal range 5.2-60.4 ng/ml, mean 21.41 ng/ml) were low (deficiency range) in 2%. Vitamin B12 levels (normal range 191-663 pg/ml, mean 239.79) were low in 35.7% patients. Other parameters like duration, family history, past history of treatment did not demonstrate any statistically significant correlation.</p><p class="abstract"><strong>Conclusions: </strong>Our study detected low levels of serum ferritin and vitamin B12 in approximately one-fourth and a third of females with chronic telogen effluvium respectively with vitamin D deficiency found in only a small proportion. Although a statistically significant correlation could not be established between these nutrients and participant age or other parameters; we concur with most authors who recommend that all females with diffuse hair loss deserve a thorough screening for nutritional deficiencies to facilitate prompt recognition and timely supplementation.</p>

scholarly journals Female pattern hair loss among Saudi women and hematological changes associated with it - case controlled study

2021 ◽  
Vol 8 (1) ◽  
pp. 1
Author(s):  
Amal O. Al balbeesi
Keyword(s):  
Vitamin D ◽  
Serum Ferritin ◽  
Hair Loss ◽  
Disease Duration ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Control Group ◽  
Saudi Women ◽  
Female Pattern Hair Loss ◽  
Vitamin D Levels

<p class="abstract"><strong>Background:</strong> Female pattern hair loss is a problematic condition. The availability of a rapid indicator is crucial. The current study compared female pattern hair loss patients with healthy controls regarding hematological parameters and vitamin D levels.</p><p class="abstract"><strong>Methods:</strong> We included 78 females with female pattern hair loss and 50 healthy subjects in the control group. We collected a detailed medical history and performed a systematic clinical examination. Blood samples were collected including complete blood count, serum ferritin, and vitamin D.<strong></strong></p><p class="abstract"><strong>Results:</strong> A significant increase in positive family history and acne among the study than the control group. Most patients had mild disease (55.1%). Female pattern hair loss was significantly associated with a reduction in red blood cell count, hemoglobin, hematocrit, mean cell volume, mean cell hemoglobin, mean cell hemoglobin concentration, red cell distribution width, serum ferritin and serum vitamin D. Among the patient’s group, the disease severity was positively correlated with disease duration and patient age. The correlation with duration was moderate (r=0.366). The disease duration was positively correlated with body mass index and negatively correlated with red blood cell count, hemoglobin concentration, hematocrit, red cell indices, ferritin and vitamin D. Disease duration was also inversely correlated with vitamin D levels.</p><p class="abstract"><strong>Conclusions:</strong> Family history, body mass index, acne, hirsutism and irregular period were high among Saudi women. The disease was moderately severe. FPHL was associated with a significant reduction in hematological parameters and lower serum ferritin that indicated iron deficiency could play a crucial role in the development or progression of the disease. As a preventable etiology, restoring iron stores may provide at least an adjunct therapeutic option.</p>

scholarly journals Serum Ferritin and Body Mass Index in Chronic Telogen Effluvium among women attending the main dermatological outpatient clinics in BaghdadSerum Ferritin and Body Mass Index in Chronic Telogen Effluvium among women attending the main dermatological

2020 ◽  
Vol 16 (1) ◽  
pp. 102-109
Author(s):  
Ali Abdulrazak H Al-Nakash ◽  
Yousif Abdul Raheem
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Serum Ferritin ◽  
Hair Loss ◽  
Weight Status ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Case Series ◽  
Nutritional Deficiencies ◽  
Case Series Study

Background: Hair loss is a common distressing disease and challenging problem for many dermatologist. Telogen effluvium is the most common hair loss disease in which nutritional deficiencies may precipitate the disease through their effect on hair structure and growth. Study Aim : Validating role of serum ferritin level and body mass index in Chronic Telogen Effluvium and analyzing association between these factors with socioeconomic, demographic, gynecological factors and weight loss effect. Establishing a nutritional preventive advice to improve treatment successfulness and decrease the disease occurrence.                Methods :  A case series study on 327 chronic telogen effluvium patients (15-65 years old) main teaching dermatological outpatients' clinics in Baghdad. Data were collected by direct interview and questionnaire filling to analyze the associations between variables set in the data collection tool with serum ferritin level and body mass, which in turn may precipitate chronic telogen effluvium. Results :Mean patients' age was 39±9 years, 93.6% of patients had serum ferritin below normal for hair cycle requirement (≤70μg/l). Serum ferritin significantly associated with age (p value= 0.002) and 41.1% of poor socioeconomic patients had serum ferritin ≤20μg/l.  Nearly half of the patients with ≥3 pregnancies, 43.9% of patients on weight-losing diet and 52.7% of those who actually lost weight had low ferritin levels with statistically significant associations. Being obese is a risk factor for having low serum ferritin (OR= 0.297). Conclusion : Serum ferritin found to be ≤ 70μg/l in the majority of chronic telogen effluvium patients, which is significantly associated with patients' socioeconomic status, age, and weight status.

scholarly journals Obesity, oxidative DNA damage and vitamin D as predictors of genomic instability in children and adolescents

2021 ◽  
Author(s):  
Moonisah Usman ◽  
Maria Woloshynowych ◽  
Jessica Carrilho Britto ◽  
Ivona Bilkevic ◽  
Bethany Glassar ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dna Damage ◽  
Genomic Instability ◽  
Oxidative Dna Damage ◽  
Nutritional Deficiencies ◽  
Aetiological Factor ◽  
Enzyme Linked Immunosorbent Assay ◽  
Childhood And Adolescence ◽  
Paediatric Obesity ◽  
Vitamin D Levels

Abstract Background/objectives Epidemiological evidence indicates obesity in childhood and adolescence to be an independent risk factor for cancer and premature mortality in adulthood. Pathological implications from excess adiposity may begin early in life. Obesity is concurrent with a state of chronic inflammation, a well-known aetiological factor for DNA damage. In addition, obesity has been associated with micro-nutritional deficiencies. Vitamin D has attracted attention for its anti-inflammatory properties and role in genomic integrity and stability. The aim of this study was to determine a novel approach for predicting genomic instability via the combined assessment of adiposity, DNA damage, systemic inflammation, and vitamin D status. Subjects/methods We carried out a cross-sectional study with 132 participants, aged 10–18, recruited from schools and paediatric obesity clinics in London. Anthropometric assessments included BMI Z-score, waist and hip circumference, and body fat percentage via bioelectrical impedance. Inflammation and vitamin D levels in saliva were assessed by enzyme-linked immunosorbent assay. Oxidative DNA damage was determined via quantification of 8-hydroxy-2′-deoxyguanosine in urine. Exfoliated cells from the oral cavity were scored for genomic instability via the buccal cytome assay. Results As expected, comparisons between participants with obesity and normal range BMI showed significant differences in anthropometric measures (p < 0.001). Significant differences were also observed in some measures of genomic instability (p < 0.001). When examining relationships between variables for all participants, markers of adiposity positively correlated with acquired oxidative DNA damage (p < 0.01) and genomic instability (p < 0.001), and negatively correlated with vitamin D (p < 0.01). Multiple regression analyses identified obesity (p < 0.001), vitamin D (p < 0.001), and oxidative DNA damage (p < 0.05) as the three significant predictors of genomic instability. Conclusions Obesity, oxidative DNA damage, and vitamin D deficiency are significant predictors of genomic instability. Non-invasive biomonitoring and predictive modelling of genomic instability in young patients with obesity may contribute to the prioritisation and severity of clinical intervention measures.

Effect of vitamin D levels on lipid, glucose, vitamin B12 and C-reactive protein in acute ischemic stroke"

2021 ◽  
Vol 28 (5) ◽  
pp. 879
Author(s):  
Nalan Kozaci ◽  
Cafer Caliskan ◽  
Mustafa Avci ◽  
Gulsum Caliskan ◽  
Ilhan Uysal
Keyword(s):  
Vitamin D ◽  
Ischemic Stroke ◽  
Vitamin B12 ◽  
Acute Ischemic Stroke ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Vitamin D Levels

scholarly journals Biomarkers of Micronutrients in Regular Follow-Up for Tyrosinemia Type 1 and Phenylketonuria Patients

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2011 ◽  
Author(s):  
Kimber van Vliet ◽  
Iris L. Rodenburg ◽  
Willem G. van Ginkel ◽  
Charlotte M.A. Lubout ◽  
Bruce H.R. Wolffenbuttel ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin B12 ◽  
Nutritional Deficiencies ◽  
Micronutrient Deficiencies ◽  
Dietary Restrictions ◽  
Normal Ranges ◽  
Correlation Tests ◽  
Tyrosinemia Type 1

Phenylketonuria (PKU) is treated with dietary restrictions and sometimes tetrahydrobiopterin (BH4). PKU patients are at risk for developing micronutrient deficiencies, such as vitamin B12 and folic acid, likely due to their diet. Tyrosinemia type 1 (TT1) is similar to PKU in both pathogenesis and treatment. TT1 patients follow a similar diet, but nutritional deficiencies have not been investigated yet. In this retrospective study, biomarkers of micronutrients in TT1 and PKU patients were investigated and outcomes were correlated to dietary intake and anthropometric measurements from regular follow-up measurements from patients attending the outpatient clinic. Data was analyzed using Kruskal–Wallis, Fisher’s exact and Spearman correlation tests. Furthermore, descriptive data were used. Overall, similar results for TT1 and PKU patients (with and without BH4) were observed. In all groups high vitamin B12 concentrations were seen rather than B12 deficiencies. Furthermore, all groups showed biochemical evidence of vitamin D deficiency. This study shows that micronutrients in TT1 and PKU patients are similar and often within the normal ranges and that vitamin D concentrations could be optimized.

Decreased serum vitamin B12 and vitamin D levels affect sleep quality in children with familial Mediterranean fever

2017 ◽  
Vol 38 (1) ◽  
pp. 83-87 ◽  
Author(s):  
Rabia Miray Kisla Ekinci ◽  
Sibel Balci ◽  
Mahir Serbes ◽  
Dilek Dogruel ◽  
Derya Ufuk Altintas ◽  
...  
Keyword(s):  
Vitamin D ◽  
Familial Mediterranean Fever ◽  
Sleep Quality ◽  
Vitamin B12 ◽  
Serum Vitamin ◽  
Vitamin D Levels ◽  
Mediterranean Fever

Serum Ferritin and Vitamin D in Female Hair Loss: Do They Play a Role?

2013 ◽  
Vol 26 (2) ◽  
pp. 101-107 ◽  
Author(s):  
H. Rasheed ◽  
D. Mahgoub ◽  
R. Hegazy ◽  
M. El-Komy ◽  
R. Abdel Hay ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Ferritin ◽  
Hair Loss

scholarly journals Micronutrient Status and Child Growth in Mexico: Results From the 2018 National Health and Nutrition Survey (ENSANUT)

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 674-674
Author(s):  
Ximena Palma Molina ◽  
Julia Finkelstein ◽  
Saurabh Mehta ◽  
Teresa Shamah-Levy ◽  
Juan RIvera-Dommarco ◽  
...  
Keyword(s):  
Vitamin D ◽  
Iron Deficiency ◽  
Vitamin B12 ◽  
Serum Ferritin ◽  
National Health ◽  
Child Growth ◽  
Nutrition Survey ◽  
Health And Nutrition ◽  
Micronutrient Status ◽  
Z Scores

Abstract Objectives To examine the associations between micronutrient status and child growth, as part of the National Health and Nutrition Survey in Mexico. Methods Data from the National Health and Nutrition Survey (ENSANUT 2018) were analyzed to examine the association between micronutrient status and child growth in 1,656 children 36 to 59 months of age. Micronutrient biomarkers (serum ferritin (SF), vitamin B12, vitamin D, serum zinc) were measured in venous blood samples via immunoassays. Child weight and height were measured using standardized procedures, and indicators weight-for-age (WAZ), height-for-age (HAZ), weight-for-height (WHZ), and body mass index (BMI) Z-scores were calculated using the WHO Anthro V3.1 and categorized as per WHO Child Growth Standards. Micronutrient biomarkers were natural logarithmically transformed prior to analyses. Iron deficiency was defined as SF &lt; 12.0 μg/L and iron insufficiency was defined as SF &lt; 20.0 μg/L. Vitamin B12 deficiency and insufficiency were defined as &lt; 148 and &lt; 221 pmol/L, respectively. Vitamin D deficiency was defined as &lt; 50 nmol/L, and zinc deficiency was defined as &lt; 65μg/dL. Survey linear regression models were used to examine associations of micronutrient status with WHO Z-scores. Results Serum ferritin concentrations (β [SE]: 0.096 [0.001], p &lt; 0.0001) and vitamin B12 (0.092 [0.003], p &lt; 0.0001) concentrations were associated with higher WHZ. Vitamin B12 (0.171 [0.004], p &lt; 0.0001), vitamin D (0.358 [0.007], p &lt; 0.0001), and zinc (0.122 [0.006], p &lt; 0.0001) concentrations were associated with higher HAZ. Iron deficiency (β [SE]: -0.469 [0.004], p &lt; 0.0001) and zinc deficiency (-0.203 [0.01], p &lt; 0.0001) were associated with lower WHZ, and vitamin B12 (-0.449 [0.002], p &lt; 0.0001), vitamin D (-0.215 [0.001], p &lt; 0.0001) and zinc (-0.216 [0.01], p &lt; 0.0001) deficiencies were associated with lower HAZ. Conclusions Micronutrient deficiencies of vitamin B12, vitamin D, and zinc were associated with lower linear growth in young children in Mexico. Funding Sources ENSANUT was funded by The Ministry of Health of Mexico.

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