scholarly journals Omalizumab biosimilar, a cost effective option for patients with chronic urticaria: Our initial experience in two cases

2021 ◽  
Vol 7 (1) ◽  
pp. 78-80
Author(s):  
Nidhi Sharma ◽  
Ramanjit Singh ◽  
Anant Patil
2021 ◽  
Vol 9 (6) ◽  
pp. 596
Author(s):  
Murugan Ramasamy ◽  
Mohammed Abdul Hannan ◽  
Yaseen Adnan Ahmed ◽  
Arun Kr Dev

Offshore vessels (OVs) often require precise station-keeping and some vessels, for example, vessels involved in geotechnical drilling, generally use Spread Mooring (SM) or Dynamic Positioning (DP) systems. Most of these vessels are equipped with both systems to cover all ranges of water depths. However, determining which system to use for a particular operational scenario depends on many factors and requires significant balancing in terms of cost-benefit. Therefore, this research aims to develop a platform that will determine the cost factors for both the SM and DP station-keeping systems. Operational information and cost data are collected for several field operations, and Artificial Neural Networks (ANN) are trained using those data samples. After that, the trained ANN is used to predict the components of cost for any given environmental situation, fieldwork duration and water depth. Later, the total cost is investigated against water depth for both DP and SM systems to determine the most cost-effective option. The results are validated using two operational scenarios for a specific geotechnical vessel. This decision-making algorithm can be further developed by adding up more operational data for various vessels and can be applied in the development of sustainable decision-making business models for OVs operators.


2014 ◽  
Vol 136 (2) ◽  
Author(s):  
Brandon J. Hopkins ◽  
Nikhil Padhye ◽  
Alison Greenlee ◽  
James Torres ◽  
Levon Thomas ◽  
...  

Wave-driven reverse osmosis desalination systems can be a cost-effective option for providing a safe and reliable source of drinking water for large coastal communities. Such systems usually require the stabilization of pulsating pressures for desalination purposes. The key challenge is to convert a fluctuating pressure flow into a constant pressure flow. To address this task, stub-filters, accumulators, and radially elastic-pipes are considered for smoothing the pressure fluctuations in the flow. An analytical model for fluidic capacitance of accumulators and elastic pipes are derived and verified. Commercially available accumulators in combination with essentially rigid (and low cost) piping are found to be a cost-effective solution for this application, and a model for selecting accumulators with the required fluidic-capacitance for the intended system is thus presented.


2017 ◽  
Vol 15 (1) ◽  
pp. 71-74 ◽  
Author(s):  
Dharmendra Karn ◽  
Shekhar KC

Background: Quality of life in chronic idiopathic urticaria is hampered as efficacy of H1-antihistamines is limited. Autologous serum containing tolerance-generating anti-idiotype antibodies is a novel and cost-effective therapy. This study was conducted to evaluate the efficacy of autologous serum therapy (AST) among chronic urticaria patients with autologous skin prick test positive and negative status.Methods: Untreated 102 patients of chronic urticaria were enrolled in a non-randomized interventional study. Patients were categorized into two groups based on autologous serum skin prick test as test positive (ASST +) and test negative (ASST -). Patients were then treated with intramuscular injection of 0.05ml per kg body weight of autologous serum weekly for 10 weeks. Urticaria activity scoring (UAS) tool was used for quantification of the symptoms. Weekly recording of UAS (range: 0-42) was made before the therapy (baseline) and during the therapy for 10 weeks.Results: Significant improvement with AST in the mean UAS was noted from baseline to 10 weeks in both the group of patients (14.6 ± 6.3 and 10.2 ± 5.1 for ASST+ group; 16.9 ± 7.8 and 8.6 ± 4.8 for ASST- group; at baseline and 10 weeks, respectively (p-value for both <0.05)). However no statistical significance was found while comparing the efficacy of the therapy against ASST + and ASST - Groups (p-value > 0.05).Conclusions: Irrespective of autologous skin prick test results, autologous serum therapy showed significant improvement in patients with chornic idiopathic urticaria. AST can, thus, be an effective treatment modality for it.


Author(s):  
Thorben Moos ◽  
Amir Moradi

In recent years it has been demonstrated convincingly that the standby power of a CMOS chip reveals information about the internally stored and processed data. Thus, for adversaries who seek to extract secrets from cryptographic devices via side-channel analysis, the static power has become an attractive quantity to obtain. Most works have focused on the destructive side of this subject by demonstrating attacks. In this work, we examine potential solutions to protect circuits from silently leaking sensitive information during idle times. We focus on countermeasures that can be implemented using any common digital standard cell library and do not consider solutions that require full-custom or analog design flow. In particular, we evaluate and compare a set of five distinct standard-cell-based hiding countermeasures, including both, randomization and equalization techniques. We then combine the hiding countermeasures with state-of-the-art hardware masking in order to amplify the noise level and achieve a high resistance against attacks. An important part of our contribution is the proposal and evaluation of the first ever standard-cell-based balancing scheme which achieves perfect data-independence on paper, i.e., in absence of intra-die process variations and aging effects. We call our new countermeasure Exhaustive Logic Balancing (ELB). While this scheme, applied to a threshold implementation, provides the highest level of resistance in our experiments, it may not be the most cost effective option due to the significant resource overhead associated. All evaluated countermeasures and combinations thereof are applied to a serialized hardware implementation of the PRESENT block cipher and realized as cryptographic co-processors on a 28nm CMOS ASIC prototype. Our experimental results are obtained through real-silicon measurements of a fabricated die of the ASIC in a temperature-controlled environment using a source measure unit (SMU). We believe that our elaborate comparison serves as a useful guideline for hardware designers to find a proper tradeoff between security and cost for almost any application.


Sign in / Sign up

Export Citation Format

Share Document