scholarly journals Correlation of ER PR receptors with other prognostic parameters of breast carcinoma

2021 ◽  
Vol 8 (4) ◽  
pp. 437-442
Author(s):  
Vishrabdha Rahul Pawar ◽  
Nekta Anand ◽  
Shahnaz Zaidi
Keyword(s):  
Breast Carcinoma ◽  
Tumor Size ◽  
Histological Grade ◽  
Tumor Type ◽  
Age Group ◽  
Prognostic Parameters ◽  
Carcinoma Breast ◽  
Poor Predictor ◽  
Size Grade ◽  
Grade Ii

To study the MRM specimens for size, grade of the tumor, LVI and LN metastases and the ER/PR receptors of the tumor. To study the association of ER/PR status with the above mentioned prognostic parameters. This three-year study includes 72 histopathologically confirmed cases of carcinoma breast. The tumor type, grade, LNM, LVE were reported on H & E. The ER-PR study was done of all 72 cases. The tumor size, grade, LNM, LVE were correlated with receptor status. Out of 72 cases majority (53%) of cases were in 41-50 years of age group, and tumor size was between 2-4 cm in (54.16%) cases; majority were of grade II carcinoma (60%) of which 59% were ER-PR positive. Out of 46 cases with negative LNM and LVE, 30 cases (65%) were ER-PR positive. In our observation there is no association between higher histological grade and ER-PR status. No obvious correlation with tumor size was noted. But increase in tumor size could also be a poor predictor of ER-PR status. LNM, LVE is poor predictor of ER-PR status.

scholarly journals Correlation ER/PR status of Breast Carcinoma with Tumor size, Tumor grade, Lymphovascular emboli, Lymph node metastasis and the distant metastasis

2021 ◽  
Vol 6 (3) ◽  
pp. 191-196
Author(s):  
Vaibhav Mane ◽  
Nekta Anand ◽  
Darshana Wakkar
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Size ◽  
Tumor Grade ◽  
Tumor Type ◽  
Receptor Status ◽  
Node Metastasis ◽  
Poor Predictor ◽  
Size Grade

Breast cancer is the most frequent cancer in females in the world and is the second most common cancer in India after cervical cancer. The breast cancer is second most common reason of loss of existence in each developed and additionally most of the growing countries. For the appraisal of prognosis of breast cancer commonly followed is the NOTTINGHAM PROGNOSTIC INDEX (NPI) which includes- tumor size, histological tumor grade, lymph node metastasis and hormone receptor status. These prognostic component help in administration and therapeutic requirement of breast cancer patient.1. To study the MRM specimens for size, grade of the tumor, LVI and LN metastases and the ER/PR receptors of the tumor. 2.To study the association of ER/PR status with the above mentioned prognostic parameters.This three-year study includes 50 histopathologically confirmed cases of carcinoma breast. The tumor type, grade, LNM, LVE were reported on H & E. The ER-PR study was done of all 50 cases. The tumor size, grade, NM, LVE were correlated with receptor status. Out of 50 cases majority (7.5%) of cases were in 41-50 years of age group, and tumor size was between 2-4 cm in (17.5%) cases; majority were of grade II carcinoma (17.5%) of which 13% were ER-PR positive. Out of 35 cases with negative LNM and LVE, 26 cases (13%) were ER-PR positive.In our observation there is no association between higher histological grade and ER-PR status. No obvious correlation with tumor size was noted. But increase in tumor size could also be a poor predictor of ER-PR status. LNM, LVE is poor predictor of ER-PR status.

CLINICAL AND HISTOPATHOLOGICAL REVIEW OF INVASIVE BREAST CARCINOMA IN A TERITARY CARE CENTRE.

2021 ◽  
pp. 18-21
Author(s):  
A. Gomathy ◽  
Muruganantham Arunagirinathan ◽  
I. Nithya
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Cancer Survival ◽  
Histological Grade ◽  
Lymph Node Involvement ◽  
Left Breast ◽  
Invasive Breast Carcinoma ◽  
Indian Women ◽  
Node Involvement ◽  
Grade Ii

BACKGROUND: Breast cancer accounts for 14% of all cancers in Indian women, that can occur at any age. Cancer survival becomes more difcult in higher stages of tumour, hence in order to improve the survival of affected persons, early diagnosis of breast cancer is critical. METHODS: Retrospective study of 48 mastectomy specimens with relevant clinical details and respective H&E stained slides were reviewed. CONCLUSION: This review showed that occurrence of Invasive Breast Carcinoma(IBC) peaks in the age group of 41-50years (35.4% ) with right and left breast being affected equally in the ratio of R:L – 1 : 1. Most of the IBC (91.6%) were of No Special Type (NST), with 75% of tumours were of Histological Grade II. 58.3% of tumours were of tumour stage T along with lymph node involvement in equal number of cases.

scholarly journals Significance of Immunohistochemical Biomarker in Breast Carcinoma from a Single Tertiary Care Hospital of Southern Assam

2021 ◽  
Author(s):  
Naiding Momota ◽  
Choudhury Biswadeep ◽  
Bezbaruah Babul ◽  
Nivedita Dasgupta ◽  
Deuri Biman ◽  
...  
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Tumor Size ◽  
Tertiary Care Hospital ◽  
Histological Grade ◽  
Statistical Significance ◽  
Tertiary Care ◽  
Tumor Grade ◽  
Lymph Node Status ◽  
Care Hospital

Abstract Background: Breast carcinoma is the most common malignancy in female worldwide, leading cause of death in women.immunohistochemistry plays a very important role in the prognostication and treatment determination of breast carcinoma patients. Objective: To analyze the immunohistochemical markers in invasive carcinoma of breast and to correlate the expression of hormonal receptors with age of the patient, tumor size, histological grade and lymph node metastasis.Materials and method: The study was conducted on 88 infiltrating ductal breast carcinoma sample in a tertiary care hospital of Southern Assam for a period of two year (January2018- December 2019). Data including age, tumor size, and histologic grade and lymph node status retrieved from pathology department. Chi- square was used to determine the statistical significance between ER/PR status HER2/neu status along with their correlation with various clinicopathological parametres with respect to infiltrating ductal breast carcinoma.Result: The mean age of the patients was 56.6 years. We observed correlation between ER and PR expression with age, tumor size, tumor grade. There was correlation between HER2/neu expression and age only. None of the markers showed correlation with lymph node involvement (P>0.05).Conclusion: Our findings showed the importance of biomarkers (ER, PR, HER2/neu) expression as prognostic factors for therapeutic decision.

scholarly journals Expression of PDL-1 and Its Correlation with TIL in Triple Negative Cases of Breast Carcinoma

2021 ◽  
Vol 8 (6) ◽  
pp. A136-141
Author(s):  
Neha Sharma ◽  
Akashdeep Singh ◽  
Arshdeep Kaur ◽  
Mridu Manjari
Keyword(s):  
Breast Carcinoma ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Histological Grade ◽  
Breast Carcinomas ◽  
Not Otherwise Specified ◽  
Infiltrating Ductal Carcinoma ◽  
Grade Ii ◽  
Patient Prognosis ◽  
Grade Iii

Background:  In the present study, we aimed to determine the expression of PDL1 and its correlation with TIL in Triple Negative (ER, PR and Her 2neu negative) cases of breast carcinoma (immune-histochemical study)  Methods: Expression of PD-L1 was seen on 40 proven triple negative cases of breast carcinomas (TNBC) and to correlate it with other parameters affecting prognosis of the disease. All the cases were infiltrating ductal carcinoma NOS (not otherwise specified) Result: Maximum cases were Grade III (67.5%) followed by Grade II (32.5%). PD-L1 positivity was seen in 32.5% cases whereas TIL was positive for PD-L1 in 27.5 %. 5 cases were positive for both epithelial cell and TIL. Out of 13 PD-L1 positive tumors, 38.5% cases showed TIL positivity whereas out of 27 PD-L1 negative tumors, only 22.2% were TIL positive. PD-L1 expression in TIL was seen in 38.5% of cases however there was no statistically significant correlation between PD-L1 positivity and TIL positivity. PDL-1 positivity was more in Grade III (33.3%) as compared to Grade II (23%) lesions. Thus, it was observed that PD-L1 positivity increased from grade II to grade III lesions. Conclusion: Intra-tumoral expression of PD-L1 is directly proportional to histological grade, aggressive subtypes in TNBC cases however there was no statistically significant correlation between PD-L1 positivity in tumor cells and TIL positivity. We thus postulate that measurement of PD-L1 expression in TNBC cases could enhance the accuracy of predicting patient prognosis and allow for optimal treatment selection.

STUDY ON RELATION BETWEEN TRADITIONAL PROGNOSIS FACTORS AND HORMONE RECEPTORS STATUS, KI-67, HER2 IN INVASIVE BREAST CARCINOMA

2017 ◽  
pp. 70-76
Author(s):  
Cong Thuan Dang ◽  
Thi Thu Thuy Phan ◽  
Nam Dong Tran ◽  
Cao Sach Ngo ◽  
Thi Hong Van Vo
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Lymph Node Metastasis ◽  
Tumor Size ◽  
Hormone Receptors ◽  
Histological Grade ◽  
Invasive Breast Carcinoma ◽  
Disease Stage ◽  
Ki 67 ◽  
Node Metastasis

Objectives: To examine histopathologic features and hormone receptors status, Ki-67 and HER2 in invasive breast carcinoma at Hue University Hospital to evaluating the relation between tumor size, histological grade, lymph node metastasis status, disease stage and the expression of steroid hormone receptors status, Ki-67 and HER2 in invasive breast carcinoma. Materials and methods: From May 2015 to April 2016, samples were collected from 96 breast carcinoma patients. Histopathologic samples were stained by Hematoxylin-Eosin and immunohistochemistry staining at Pathology Department, Hue University Hospital. R esults: Most invasive breast carcinoma patients were among the age of 50-59 (39.6%), invasive ductal carcinoma (82.3%), tumor size ≤2cm (54.2%), histological grade II (60.2%), lymph node metastasis (53.1%), disease stage II (51%); ER(+) 46.9%, PR(+) 49.0%, Ki-67(+) 77.1%, HER2(+) 30.2% of cases. Conclusion: There were a positive correlation between histological grade with the HER2 expression (p<0.05) in invasive breast carcinoma. Key words: invasive breast carcinoma, immunohistochemistry, tumor size, histological grade, lymph node metastasis, disease stage

scholarly journals Immunohistochemical Analysis of Expression of GATA3 in Carcinoma Breast and its Correlation with Prognostic Parameters

2021 ◽  
Vol 8 (2) ◽  
pp. A26-32
Author(s):  
Tanvi Suri ◽  
Charanjeet Ahluwalia
Keyword(s):  
Histological Grade ◽  
Statistical Significance ◽  
Tumour Size ◽  
Lymph Node Status ◽  
Inverse Association ◽  
Prognostic Parameters ◽  
Tumour Grade ◽  
Carcinoma Breast ◽  
Gata3 Expression ◽  
Her 2

Background: GATA3 plays an essential role in the normal development and function of the mammary gland where it promotes the luminal transcriptional program. Its loss is implicated in the pathogenesis of breast cancer. We proposed to study the expression of GATA3 in carcinoma breast by immunohistochemistry and determine its correlation with prognostic parameters. Methods: The expression pattern of GATA3 was evaluated by immunohistochemistry in 30 cases of invasive breast carcinoma. GATA3 scoring was done and a score of ≥ 1+ was considered positive. Patient characteristics, including age, tumour laterality, tumour size, lymph node status, tumour grade, histological type, molecular subtypes were collected. The relationships between protein expression and clinicopathological variables were analysed. Statistical significance was determined by Pearson’s chi-square test and Mann Whitney U test (for age). Result: 46.7% of cases (14/30) scored positive for GATA3 expression in tumour cells including 63% of luminal subtypes, 14% of Her-2 neu enriched carcinomas and 20% of triple negative carcinomas. Most positive cases (35.7%) demonstrated 3+ staining. GATA3 expression showed an inverse association with histological grade (P = 0.012) and HER-2 overexpression (P = 0.038), and a direct association with ER expression (P =0.017) and PR expression (P =0.009). Conclusion: GATA3 is luminal marker as it shows strong association with ER and PR in breast cancers. High GATA3 expression is also correlated good prognostic parameters like low tumour grade. Our findings advocate for GATA3 as a promising new breast-specific immunomarker.

scholarly journals An analysis of invasive micropapillary breast carcinoma based on hormone receptor and epidermal growth receptor 2 status

2020 ◽  
Author(s):  
Yuting Sun
Keyword(s):  
Breast Carcinoma ◽  
Tumor Size ◽  
Hormone Receptor ◽  
Histological Grade ◽  
Cox Proportional Hazards ◽  
Cancer Specific Survival ◽  
Exact Probability ◽  
Her 2 ◽  
Epidermal Growth ◽  
To Receive

Abstract Background This research aimed to explore the role of combining hormone receptor (HR) with epidermal growth factor receptor 2 (Her-2) status of invasive micropapillary breast carcinoma (IMPC). Methods 1291 IMPC patients were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database of the US National Cancer Institute. The X2 test and Fisher’s exact probability test were used to evaluate differences between qualitative variables. Univariate and multivariate Cox proportional hazards regressions were performed to assess the independent prognostic factors on cancer-specific survival (CSS) and overall survival (OS). The nomogram models were made to predict 3-year survival rate of IMPC using R software. Results Among 1291 patients, HR+/Her-2- subtype accounted for 74.7%, while HR-/Her-2+, HR-/Her-2-, HR+/Her-2 + accounted for 4.7%, 4.0% and 15.6% respectively. The X2 test indicated compared to HR+/Her-2- subgroup, HR-/Her-2- or HR+/Her-2 + subtype IMPC had larger tumor size (T stage) and higher histological grade. Compared to HR+/Her-2- IMPC, HR-/Her-2- and HR+/Her-2 + subtypes were more likely to receive mastectomy than conserving surgery. Furthermore, HR+/Her-2- IMPC had more projections to receive chemotherapy and was less likely to receive radiotherapy compared with HR-/Her-2- subtype. Survival analysis suggested that HR-/Her-2- IMPC had the worst OS and CSS. Conclusion This population-based study provided evidence that HR-/Her-2- IMPC accounted the smallest part of four subtypes, but were more likely to have larger tumor size and more advanced histological grade. Furthermore, HR+/Her-2- IMPC had most unfavorable prognosis among four subtypes.

scholarly journals Correlation Between Breast Tumor Size and Lymph Node Involvement in Patients Referring to the Pathology Department of Rasoul Akram Hospital in Iran

Thrita ◽  
2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Maryam Mohammadhosseini ◽  
Ahmad Majd ◽  
Hamidreza Mirzaei ◽  
Mona Farhadi ◽  
Nasrin Shayanfar
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Breast Carcinoma ◽  
Cancer Progression ◽  
Tumor Size ◽  
Ductal Carcinoma ◽  
Histological Grade ◽  
Lymph Node Involvement ◽  
Ductal Breast Carcinoma ◽  
Node Involvement

Background: Breast cancer has the highest mortality rate, second to gastric cancer, among Iranian women and is one of the most common cancers in the world. The incidence of breast cancer in women is increasing gradually. Meanwhile, ductal breast carcinoma experiences more increases than other malignancies and is one of the most important health problems. Objectives: This study aimed at evaluating women with ductal breast carcinoma because of the significance of pathological factors and their association with breast cancer progression. Methods: This retrospective study was conducted using data of ductal breast carcinoma women during the years 2018 and 2019. In this cross-sectional study, demographic data (age, sex, and pathology of breast mass) of 50 patients referring to Rasoul Akram hospital (Tehran, Iran) were gathered. Then, the data were analyzed by SPSS 26 software using the t test and Levene's test. The results were presented using descriptive statistics. Results: Fifty patients with ductal carcinoma were assessed based on their pathological information. The examination of factors including tumor size, involvement/non-involvement of lymph nodes, histological grade, and age of patients revealed a significant direct relationship between tumor size and lymph node involvement (P

Prognosis in T2N0M0 stage I breast carcinoma: a 20-year follow-up study.

1991 ◽  
Vol 9 (9) ◽  
pp. 1650-1661 ◽  
Author(s):  
P P Rosen ◽  
S Groshen ◽  
D W Kinne
Keyword(s):  
Breast Carcinoma ◽  
Tumor Size ◽  
Malignant Neoplasm ◽  
Risk Groups ◽  
Recurrence Risk ◽  
Tumor Type ◽  
Free Survival ◽  
Node Negative ◽  
Kaplan Meier

In a study of prognosis in node-negative breast carcinoma, we investigated 293 T2N0M0 patients treated by mastectomy and axillary dissection with a median follow-up of 19.8 years. The probability of surviving 20 years considering all causes of death was 41.3% +/- 3.0%. Recurrence-free survival (Kaplan-Meier estimate) was 68.6% +/- 3% at 10 years and 63.2% +/- 3.1% at 20 years. The estimated probability of cure determined by the method of Brinkley and Haybittle was 63% (95% confidence interval [Cl], 55% to 72%). Prognosis was related to primary tumor size with the best separation (P = .06) when tumors from 2.1 to 3.0 cm (33% chance of recurrence at 20 years) and from 3.1 to 5.0 cm (44% chance of recurrence at 20 years) were compared. The histologic tumor type was prognostically important. Recurrence at 20 years was not significantly different for patients with invasive duct (34%) and lobular (42%) carcinoma. Women with special types (medullary, mucinous, papillary, etc) of carcinoma had a 25% chance of recurrence. Subsequent contralateral breast carcinoma was diagnosed in 29 patients, and four of these were fatal, accounting for only 4.6% of breast carcinoma deaths. Thirty-two patients (10.9%) developed a nonmammary malignant neoplasm (NMMN) after the ipsilateral breast carcinoma, and 69% of these lesions were fatal. Although the chances of recurrence at 20 years related to tumor size and type did not differ statistically in the series, there were trends that suggest that T2N0M0 patients can be stratified into recurrence risk groups based on tumor size and histologic type. These factors should be taken into consideration in the design and analysis of clinical adjuvant therapy trials. Measures for the early detection of common NMMNs should be included in the routine follow-up of T2N0M0 breast carcinoma patients.

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