The efficacy and safety of a 70% glycolic acid peel with vitamin C for the treatment of photoaging

<p>Glycolic acid peels have been shown in many studies to improve the appearance of photoaged skin. Vitamin C is known to be a potent natural antioxidant and plays an important role in the collagen biosynthetic pathway. In this study, we report our clinical experience with 70% glycolic acid peel added with vitamin C. We found that all parameters of photoaging, in particular the composite wrinkling score, discolouration score and the global photoaged score, showed statistically significant improvement. Patient satisfaction also revealed improvement in keeping with the physician assessment. It is also associated with an excellent safety profile. In conclusion, a combination of 70% glycolic acid with vitamin C chemical peel is a well-tolerated effective treatment of photoaging in Asian skin.</p>

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The efficacy and safety of a 70% glycolic acid peel with vitamin C for the treatment of acne scars

Journal of Surgical Dermatology ◽

10.18282/jsd.v2.i4.94 ◽

2017 ◽

Vol 2 (4) ◽

Author(s):

Heng Jun Khee ◽

Liau MeiQi May ◽

Yang Shiyao Sam ◽

Aw Chen Wee Derrick ◽

Ho Sue-Ann

Keyword(s):

Psychological Distress ◽

Adverse Effects ◽

Vitamin C ◽

Safety Profile ◽

Glycolic Acid ◽

Efficacy And Safety ◽

Common Complication ◽

The Third ◽

Acne Scarring ◽

Excellent Safety Profile

<div><p>Acne scarring is a common complication associated with significant psychological distress. Both glycolic acid (GA) and vitamin C are known to improve the appearance of acne scarring.<strong> </strong>We performed a review of 13 patients treated with three 70% GA peels with vitamin C at four weeks apart.<strong> </strong>There was a statistically significant` improvement in acne scarring and post-inflammatory hyperpigmentation from the baseline. Maximal effects were noted four weeks after the third chemical peel. It has an excellent safety profile with no permanent adverse effects noted. A combination of 70% glycolic acid with vitamin C chemical peel is an efficacious, well-tolerated treatment of acne scarring in Asian skin. </p></div>

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Cyclosporine-A for severe childhood atopic dermatitis: clinical experience on efficacy and safety profile

TURKISH JOURNAL OF MEDICAL SCIENCES ◽

10.3906/sag-1711-7 ◽

2018 ◽

Vol 48 (5) ◽

pp. 933-938 ◽

Cited By ~ 2

Author(s):

Hayriye SARICAOĞLU ◽

Serkan YAZİCİ ◽

Özge ZORLU ◽

Emel BÜLBÜL BAŞKAN ◽

Kenan AYDOĞAN

Keyword(s):

Atopic Dermatitis ◽

Clinical Experience ◽

Cyclosporine A ◽

Safety Profile ◽

Efficacy And Safety

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Efficacy and safety of trifluridine/tipiracil (FTD/TPI) in patients (pts) with metastatic gastric cancer (mGC) with or without prior gastrectomy: Results from a phase III study (TAGS).

Journal of Clinical Oncology ◽

10.1200/jco.2019.37.4_suppl.3 ◽

2019 ◽

Vol 37 (4_suppl) ◽

pp. 3-3 ◽

Cited By ~ 1

Author(s):

David H. Ilson ◽

Aliaksandr Prokharau ◽

Hendrik-Tobias Arkenau ◽

Michele Ghidini ◽

Kazumasa Fujitani ◽

...

Keyword(s):

Effective Treatment ◽

Treatment Option ◽

Safety Profile ◽

Metastatic Gastric Cancer ◽

Best Supportive Care ◽

Phase Iii ◽

Efficacy And Safety ◽

Effective Treatment Option ◽

Phase 3 ◽

Heavily Pretreated

3 Background: The phase 3 study TAGS demonstrated that the novel oral therapy FTD/TPI (TAS-102) represents an effective treatment option with a manageable safety profile for pts with heavily pretreated mGC. In an earlier single-arm Japanese phase 2 trial in mGC, no differences were found in the pharmacokinetics of either FTD or TPI in pts with or without prior gastrectomy. We evaluated the efficacy and safety of FTD/TPI in pts with or without prior gastrectomy within the TAGS study. Methods: In this global phase 3 study of adult pts with mGC who had received ≥ 2 prior regimens of chemotherapy, pts were randomized 2:1 to receive FTD/TPI (35 mg/m2 BID on days 1–5 and 8–12 of each 28-day cycle) or placebo, plus best supportive care. We performed a preplanned analysis of efficacy and safety endpoints in pt subgroups with or without prior gastrectomy. Results: Of 507 randomized pts, 221 (44%) had a prior gastrectomy (FTD/TPI, 147/337; placebo, 74/170). Baseline pt characteristics were balanced across pt subgroups. FTD/TPI prolonged survival versus placebo regardless of gastrectomy (table). The frequency of neutropenia/leukopenia appeared to be higher among FTD/TPI-treated pts with vs without gastrectomy, but this did not result in more treatment discontinuations (table). Conclusions: In the TAGS study, subgroup analysis demonstrated that FTD/TPI is an effective treatment option with a manageable safety profile for pts with heavily pretreated mGC, regardless of prior gastrectomy. Clinical trial information: NCT02500043. [Table: see text]

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Long-term efficacy and safety of cladribine (2-CdA) in adult patients with mastocytosis

Blood ◽

10.1182/blood-2014-12-614743 ◽

2015 ◽

Vol 126 (8) ◽

pp. 1009-1016 ◽

Cited By ~ 63

Author(s):

Stéphane Barete ◽

Olivier Lortholary ◽

Gandhi Damaj ◽

Isabelle Hirsch ◽

Marie Olivia Chandesris ◽

...

Keyword(s):

Effective Treatment ◽

Safety Profile ◽

Systemic Mastocytosis ◽

Adult Patients ◽

Efficacy And Safety ◽

Acceptable Safety Profile ◽

Key Points ◽

Cutaneous Mastocytosis ◽

Indolent Systemic Mastocytosis

Key Points 2-CdA is an effective treatment with a long-term acceptable safety profile in patients with mastocytosis. 2-CdA is effective and safe in indolent systemic mastocytosis and cutaneous mastocytosis refractory to multiple symptomatic therapies.

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