scholarly journals Prevalence of Celiac Disease in Omani Adults with Iron Deficiency Anemia of Unknown Cause

2021 ◽  
Author(s):  
Safa Ambusaidi ◽  
Al Manar Al Busaidi ◽  
Asma Al Salmani ◽  
Robin Davidson ◽  
Jalila Al Shekaili ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Ferritin Level ◽  
Care Facility ◽  
Health Care Facility ◽  
University Hospital ◽  
Deficiency Anemia ◽  
Primary Health Care Facility ◽  
Serological Screening ◽  
Sultan Qaboos University

Objectives: This study aimed to estimate the serological prevalence of celiac disease in patients with IDA of unknown cause at primary health care facility. Methods: This is a prospective case finding study that was conducted at the primary care clinics in the Sultan Qaboos University Hospital (SQUH) from September 2018 to June 2020. A total of 104 patients aged 18 to 55 years old, with a hemoglobin (Hb) level less than 11.5 g/dl for males and less than 11.0 g/dl for females and a ferritin level less than 30 ng/mL for males and less than 13 ng/mL for females participated in the study. Blood samples were obtained for an initial serological screen using serum IgA level and then those with normal level of IgA, had IgA- Anti-tissue transglutaminase antibody (tTG) and IgA- anti-deamidated gliadin peptide (DGP). Positive IgA-tTG test was confirmed using IgA-endomysial antibodies. Patients with low IgA level were tested using IgG-tTG and IgG-DGP. Results: Eight patients out of the 104 (7.7%) found to have positive serological screening for celiac disease. Three patients out of the eight (37.5%) had a positive IgA tTG. Two of those three (66.7%) had a positive IgA-endomysial antibody as well. The IgA-DGP was positive in seven patients out of the 104 (6.7 %). Out of those seven patients, two also had a positive IgA tTG. Conclusion: Celiac disease is not a rare disorder. There is a need to increase awareness among healthcare professionals about celiac disease and its non-classical manifestations such as IDA.Keywords: cervical smears, conventional slides, ThinPrep slides, cervical organisms.

scholarly journals Prevalence of celiac disease among first degree relatives of Brazilian celiac patients

2008 ◽  
Vol 45 (1) ◽  
pp. 69-72 ◽  
Author(s):  
Patrícia Lopes de Almeida ◽  
Lenora Gandolfi ◽  
Inês Cristina Modelli ◽  
Rita de Cássia Martins ◽  
Rodrigo Coutinho de Almeida ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Antibody Test ◽  
Autoimmune Disorder ◽  
University Hospital ◽  
Serological Tests ◽  
Intestinal Lesion ◽  
Serological Screening ◽  
First Degree Relatives ◽  
Small Intestinal

BACKGROUND: Several studies have shown that celiac disease, an autoimmune disorder that occurs in genetically susceptible individuals, is highly prevalent among relatives of celiac patients. AIM: To determine the prevalence of celiac disease in a group of first degree relatives of Brazilian celiac patients. METHODS: First degree relatives of celiac patients attending the Brasilia University Hospital Pediatric Gastroenterology Outpatient Clinic or the Celiac Disease Investigation Center, Brasília, DF, Brazil, between March 2001 and November 2004 were invited to undergo serological screening for celiac disease applying the IgA anti-endomysium antibody test (IgA-EMA). All positive IgA-EMA sera underwent a second screening using the IgA anti-tissue transglutaminase antibodies test. Duodenal or small intestinal biopsies were performed in all subjects positive to serological testing. Biopsy samples were classified as type (O) normal, (I) infiltrative, (II) infiltrative hyperplastic, (III) flat destructive, and (IV) atrophic hypoplastic. The final diagnosis was ascertained in subjects showing positive serological tests and a grade I to III small intestinal lesion. RESULTS: Nine new cases of celiac disease were found among the 188 first degree relatives tested (4.8%). CONCLUSION: The present study confirms the high prevalence of celiac disease among first degree celiac patients’ relatives and reinforces the need of extensive diagnostic screening in this specific group.

scholarly journals Can public sector community health workers deliver a nurturing care intervention in South Africa? The Amagugu Asakhula feasibility study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Sonja Klingberg ◽  
Esther M. F. van Sluijs ◽  
Stephanie T. Jong ◽  
Catherine E. Draper
Keyword(s):  
South Africa ◽  
Health Care ◽  
Public Sector ◽  
Health Workers ◽  
Care Facility ◽  
Health Care Facility ◽  
Preschool Age ◽  
Primary Health Care Facility ◽  
Community Based ◽  
Primary Health

Abstract Background Nurturing care interventions have the potential to promote health and development in early childhood. Amagugu Asakhula was designed to promote developmentally important dietary and movement behaviours among children of preschool age (3–5 years) in South Africa. An initial formative study in Cape Town found the intervention to be feasible and acceptable when delivered by community health workers (CHWs) linked to a community-based organisation. This study evaluated the delivery of the Amagugu Asakhula intervention by CHWs linked to a public sector primary health care facility in Soweto, as this mode of delivery could have more potential for sustainability and scalability. Methods A qualitative design was utilised to assess feasibility, acceptability, adoption, appropriateness, implementation, fidelity and context. CHWs (n = 14) delivered the intervention to caregivers (n = 23) of preschool-age children in Soweto over 6 weeks. Following the completion of the intervention, focus group discussions were held with CHWs and caregivers. Further data were obtained through observations, study records and key informant interviews (n = 5). Data were analysed using deductive thematic analysis guided by a process evaluation framework. Results The delivery of the Amagugu Asakhula intervention through CHWs linked to a primary health care facility in Soweto was not found to be feasible due to contextual challenges such as late payment of salaries influencing CHW performance and willingness to deliver the intervention. CHWs expressed dissatisfaction with their general working conditions and were thus reluctant to take on new tasks. Despite barriers to successful delivery, the intervention was well received by both CHWs and caregivers and was considered a good fit with the CHWs’ scope of work. Conclusions Based on these findings, delivery of the Amagugu Asakhula intervention is not recommended through public sector CHWs in South Africa. This feasibility study informs the optimisation of implementation and supports further testing of the intervention’s effectiveness when delivered by CHWs linked to community-based organisations. The present study further demonstrates how implementation challenges can be identified through qualitative feasibility studies and subsequently addressed prior to large-scale trials, avoiding the wasting of research and resources.

scholarly journals Knowledge and perception about the ongoing COVID-19 pandemic among patients attending a rural primary health care facility in Delhi

2021 ◽  
Vol 8 (3) ◽  
pp. 1494
Author(s):  
Ekta Arora ◽  
Nidhi Budh ◽  
Rohit Katre ◽  
Bratati Banerjee
Keyword(s):  
Public Perception ◽  
Statistical Tests ◽  
Care Facility ◽  
Health Care Facility ◽  
Primary Health Care Facility ◽  
Preventive Strategies ◽  
Cross Sectional ◽  
Modes Of Transmission ◽  
Correct Knowledge ◽  
Novel Coronavirus

Another decade is suffering from the wrath of another coronavirus. Currently, this pandemic has spread to almost all countries of the world taking lives of millions of people globally. This study has uncovered the perceived facts about COVID-19 by general population as well as the effect of IEC in modulating their perception and presenting right amount of information in a scientific manner. A cross-sectional, descriptive study was carried out at rural health training center, Barwala on patients attending out-patient department at RHTC, for a duration of 2 months. Pre-tested questionnaire for assessing public perception and awareness were used to collect data. Appropriate statistical tests were applied to find out association between different variables. Majority of study subjects (98.5%) were aware about the ongoing pandemic of COVID-19. Out of the total study subjects, 90% of them had correct knowledge about various preventive strategies undertaken to break the chain of transmission. However, only about half of the study subjects (53.1%) had correct knowledge regarding various modes of transmission of novel coronavirus. Motivating the people to report any possible infection and to follow the preventive strategies being recommended by experts on timely basis is an important aspect to curb the ongoing menace of COVID-19.

scholarly journals SEROLOGICAL SCREENING FOR CELIAC DISEASE IN CHILDREN WITH COLCHICINE-RESISTANT FAMILIAL MEDITERRANEAN FEVER

2018 ◽  
Vol 55 (2) ◽  
pp. 175-178
Author(s):  
Yasin ŞAHIN ◽  
Kenan BARUT ◽  
Tufan KUTLU ◽  
Fugen Cullu COKUGRAS ◽  
Amra ADROVIC ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Familial Mediterranean Fever ◽  
Tissue Transglutaminase ◽  
Intestinal Biopsy ◽  
Control Group ◽  
Serological Screening ◽  
Iga Antibodies ◽  
Mediterranean Fever ◽  
Iga Antibody ◽  
Clinical Conditions

ABSTRACT BACKGROUND: Familial Mediterranean fever and celiac disease share some common clinical features such as abdominal pain, diarrhea, arthralgia and arthritis. Also, both of the diseases are associated with many inflammatory and autoimmune diseases. Previous studies have shown the association between familial Mediterranean fever (FMF) and different clinical conditions. OBJECTIVE: We aimed to investigate the relationship between celiac disease and colchicine-resistant familial Mediterranean fever (crFMF) disease. METHODS: This prospective study was conducted at the Department of Pediatric Gastroenterology and Pediatric Rheumatology from October 2015 to August 2016. A total of 24 patients with crFMF were included in the study. We used 60 sex- and age-matched healthy subjects as a control group. Levels of total IgA and tissue transglutaminase (tTG) IgA antibody were measured in both groups. Those with increased level of tTG IgA were tested for anti-endomysium IgA antibodies (EMA). Gastroduodenoscopy and intestinal biopsy were planned for a definite diagnosis of celiac disease in patients with positive EMA. RESULTS: Of the 24 patients in this study, 18 (75.0%) were female. Only 4 (16.6%) of 24 patients were positive for tTG IgA. Patients with positive tTG IgA were then tested for EMA IgA antibodies and none of them had a positive result. Only one (1.6%) subject from the control group was positive for tTG IgA but EMA positivity was not detected. CONCLUSION: We did not found celiac disease in 24 children with crFMF. Since crFMF disease is rarely seen in general population, further studies with more patients are needed to provide more precise interpretation.

scholarly journals Serum retinol in 1–6-year-old children from a low socio-economic South African community with a high intake of liver: implications for blanket vitamin A supplementation

2011 ◽  
Vol 15 (4) ◽  
pp. 716-724 ◽  
Author(s):  
Martha E van Stuijvenberg ◽  
Serina E Schoeman ◽  
Carl J Lombard ◽  
Muhammad A Dhansay
Keyword(s):  
Vitamin A ◽  
Economic Status ◽  
Care Facility ◽  
Health Care Facility ◽  
Significant Negative Correlation ◽  
Primary Health Care Facility ◽  
Serum Retinol ◽  
Cross Sectional ◽  
Vitamin A Supplementation ◽  
Breast Fed

AbstractObjectiveTo assess serum retinol, liver intake patterns, breast-feeding history and anthropometric status in pre-school children of a low socio-economic community where liver is regularly consumed.DesignCross-sectional study.SettingNorthern Cape Province, South Africa.SubjectsChildren aged 1–6 years (n243) who attended the local primary health-care facility and had not received a vitamin A supplement in the 6 months preceding the study. Non-pregnant female caregivers (n225), below 50 years of age, were also assessed.ResultsDespite stunting, underweight and wasting being prevalent in 40·5 %, 23·1 % and 8·4 % of the children, only 5·8 % had serum retinol concentrations < 20 μg/dl, which is in sharp contrast to the national prevalence of 63·6 %. None of the caregivers were vitamin A deficient. Liver was eaten by 89·2 % of children, with 87 % of households eating liver at least once monthly and 30 % eating it at least once weekly; liver was introduced into the diet of the children at a median age of 18 months. Ninety-three per cent of the children were being breast-fed or had been breast-fed in the past; children were breast-fed to a median age of 18 months. A significant negative correlation was found between educational level of the caregiver and frequency of liver intake (r= −0·143,P=0·032). There was no correlation between serum retinol and indicators of anthropometric or socio-economic status.ConclusionsThe blanket approach in applying the national vitamin A supplementation programme may not be appropriate for all areas in the country, even though the community may be poor and undernourished.

scholarly journals COVID-19 Vaccine Acceptability Among Pregnant Women at a Primary Health Care Facility in Durban, South Africa

2020 ◽  
Vol 2 (5) ◽  
Author(s):  
A. M. Hoque ◽  
S. Buckus ◽  
M. Hoque ◽  
M. E. Hoque ◽  
G. Van Hal
Keyword(s):  
South Africa ◽  
Pregnant Women ◽  
Community Health Center ◽  
Care Facility ◽  
Health Care Facility ◽  
Primary Health Care Facility ◽  
Vaccine Acceptability ◽  
Cross Sectional ◽  
Vaccine Acceptance ◽  
Public Health Officials

A vaccine represents the most promising strategy for combatting the COVID-19 pandemic through primary prevention. No study has been reported on the acceptability of the COVID-19 vaccine in South Africa (SA) and in the region. The objective of this study was to determine the acceptance of a COVID-19 vaccine among pregnant women. A cross-sectional, descriptive study was conducted at the Kwadabeka Community Health Center (KCHC), Durban. Logistic regression analysis was performed to determine the factors for vaccine acceptability among pregnant women. About two-thirds of pregnant women (63.3%) may accept COVID-19 vaccination once it becomes available in SA. Participants who were <22 years of age were 72% less likely (OR=0.28, CI: 0.13 -0.62) to accept the vaccine, compared to those who were >39 years old. Women with 0-1 parity were 4.3 times more likely (OR=4.3, CI: 1.98-9.48) to accept the vaccine than those with four or more parity. Single pregnant women were less likely (OR=0.23, CI: 0.10- 0.51) to accept the vaccine than those living with their partners. Employed pregnant women had four times more chances of accepting the vaccine (OR= 4.2, CI: 2.28-7.75) than unemployed pregnant women. It was also found that having a positive attitude towards vaccination increased the chance of accepting the vaccine by four times (OR=4.05, CI: 1.89-8.69). Our study found a 63.3% acceptance of a COVID-19 vaccine, but there were noticeable demographic, knowledge, attitude and practice disparities observed in vaccine acceptance among pregnant women. Before a COVID-19 vaccine is introduced to SA, public health officials and policymakers must prioritize effective COVID-19 vaccine-acceptance messages and mass education for all South Africans, especially for the most vulnerable.

Sign in / Sign up

Export Citation Format

Share Document