scholarly journals COMPARATIVE STUDY OF THE EFFICACY OF BONE MARROW ASPIRATION, TREPHINE BIOPSY AND IMPRINT CYTOLOGY IN THE DIAGNOSIS OF BONE MARROW INVOLVEMENT IN LYMPHOMA

2019 ◽  
Vol 6 (16) ◽  
pp. 1240-1245
Author(s):  
Shubham Bhattacharya ◽  
Barnali Maiti ◽  
Sudipta Bhattacharyya ◽  
Arghya Bandyopadhyay
Keyword(s):  
Bone Marrow ◽  
Comparative Study ◽  
Bone Marrow Involvement ◽  
Bone Marrow Aspiration ◽  
Imprint Cytology ◽  
Trephine Biopsy

scholarly journals Bone marrow trephine biopsy in Haematological diseases: a study of 53 cases

2015 ◽  
Vol 22 (2) ◽  
pp. 207-210
Author(s):  
Hazera Khatun ◽  
Salma Afrose ◽  
Mohiuddin Ahmed Khan ◽  
Tasneem Ara ◽  
Mohammad Sirajul Islam ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Involvement ◽  
Bone Marrow Aspiration ◽  
Polycythaemia Vera ◽  
Safe Procedure ◽  
Trephine Biopsy ◽  
Lymphoid Aggregate ◽  
Medical College ◽  
Bone Marrow Trephine Biopsy ◽  
Adults And Children

Bone marrow aspiration (BMA) and biopsy (BMTB) are important investigations for diagnosis of haematolgical malignancies and non-malignant diseases both in adults and children. BMA and BMTB are complementary and if both are done a comprehensive analysis of bone marrow involvement is possible. 53 cases of BMTB were studied in order to underscore the indications and importance of BMTB. BMTB was done to determine cellularity in aplastic anaemia (AA) (33.96%, n=18) and in cases of failure of aspiration (32.08%, n=17). Failure of aspiration was attributable to bone marrow (BM) fibrosis (76%, n=13) due to acute leukaemia (35.30%, n=6) and myelofibrosis (43.17%, n=7). BMTB upstaged non Hodgkin’s lymphoma (NHL) from IIIB to IVB in 22.22% cases. 1 case of AA showed focal lymphoid aggregate which later evolved into acute lymphoblastic leukaemia (ALL). BMTB is a safe procedure and increased bleeding was noted only in a case of polycythaemia vera. DOI: http://dx.doi.org/10.3329/jdmc.v22i2.21544 J Dhaka Medical College, Vol. 22, No.2, October, 2013, Page 207-210

scholarly journals Haematoma caused by bone marrow aspiration and trephine biopsy

2011 ◽  
Vol 3 (3) ◽  
Author(s):  
Maria Sarigianni ◽  
Efthymia Vlachaki ◽  
Sofia Chissan ◽  
Filippos Klonizakis ◽  
Evaggelia Vetsiou ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Aspiration ◽  
Trephine Biopsy

A comparative study of bone marrow aspirate with trephine biopsy in pancytopenia disorders

2021 ◽  
Vol 6 (3) ◽  
pp. 201-206
Author(s):  
Kavya J ◽  
Kalpana Kumari MK
Keyword(s):  
Bone Marrow ◽  
Sensitivity And Specificity ◽  
Megaloblastic Anemia ◽  
Tertiary Care ◽  
Bone Marrow Aspiration ◽  
Bone Marrow Examination ◽  
Care Hospital ◽  
Trephine Biopsy ◽  
Hematological Disorders ◽  
Hematoxylin And Eosin

Pancytopenia is commonly reported in clinical hematology practice. Due to its varied marrow pathology and underlying ailments, diagnosis is often misleading and delayed. Bone marrow examination would provide a comprehensive diagnosis of both blood and bone marrow, since aspirate investigates the cytological morphology and biopsy evaluates the cellularity, architecture, and compact marrows.To compare bone marrow aspiration and trephine biopsy results in the diagnosis of pancytopenia, and to determine the sensitivity and specificity of aspirate examination in pancytopenia diagnosis.This prospective study was conducted at a tertiary care hospital from July 2014 to June 2016. A total of 320 samples were received at the department of pathology for bone marrow examination (aspirate and biopsy). Romanowsky (Leishman) stain was used to investigate aspirate samples. All biopsy samples were processed into 3-5 μ blocks and stained using hematoxylin and eosin after decalcification with 5.5% EDTA. Data analysis was performed using SPSS19.Pancytopenia constituted 56 (18.7%) cases with the mean age of 41.79 years. Of the total pancytopenia cases, hematological disorders constituted 50 (89.3%) cases and 6 (10.7%) were non-hematological cases. Aspirate and biopsy diagnosis positively correlated in 76.79% of cases. A 100% sensitivity and specificity of aspirate diagnosis was observed in, acute myeloid leukemia, hypersplenism, myelodysplastic syndrome, megaloblastic anemia, hematological malignancy in remission and negative for lymphoma infiltrate. Aspirate had no role in diagnosis of uremic osteodystrophy and myelofibrosis, whereas leishmaniasis was diagnosed on aspirate alone.Pancytopenia includes multiple underlying ailments which requires a differential diagnosis approach. Combining both aspirate and biopsy for diagnosis would benefit the patient in prognosis as they are complementary to each other.

scholarly journals Comparison of bone marrow aspiration cytology with bone marrow trephine biopsy histopathology: An observational study

2017 ◽  
Vol 9 (03) ◽  
pp. 182-189
Author(s):  
Meenu Gilotra ◽  
Monika Gupta ◽  
Sunita Singh ◽  
Rajeev Sen
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Aspiration ◽  
Bone Marrow Examination ◽  
Final Diagnosis ◽  
Trephine Biopsy ◽  
Additional Advantage ◽  
Hematological Disorders ◽  
Bone Marrow Trephine ◽  
Bone Marrow Trephine Biopsy ◽  
Underlying Disorder

Abstract INTRODUCTION: Bone marrow examination is a useful investigative tool for the diagnosis of many hematological and nonhematological disorders. Bone marrow aspiration (BMA) provides information about the numerical and cytological features of marrow cells, whereas bone marrow trephine biopsies (BMB) provide excellent appreciation of spatial relationships between cells and of overall bone marrow structure. We conducted this study with the objective of comparing the accuracy of BMA with BMB in the diagnosis of various hematological disorders. MATERIALS AND METHODS: Both BMA and BMB were performed on a total of 130 cases and a comparative evaluation was performed in 100 cases to see the complementary role of both the procedures. However, 30 cases were excluded due to inadequate BMA, BMB, or both. Immunohistochemistry (IHC) was employed whenever required. RESULTS: In our study of 100 cases, 87% of cases were confirmed on bone marrow biopsy and in remaining 13% of cases final diagnosis was achieved with the help of other ancillary investigations. These cases were excluded for calculation of concordance rate between BMA and BMB. The concordance and disconcordance rate between BMA and BMB was 72.4% and 27.6%, respectively. CONCLUSION: BMA cytology and trephine biopsy histopathology complement each other and the superiority of one method over the other depended on the underlying disorder. Furthermore, application of ancillary techniques such as flow cytometery and IHC proved to be an additional advantage in further typing of various diseases.

Clinical features and treatment of patients with lung adenocarcinoma with bone marrow metastasis

2019 ◽  
Vol 105 (5) ◽  
pp. 388-393
Author(s):  
Di Wang ◽  
Yang Luo ◽  
Di Shen ◽  
Lin Yang ◽  
Hui-Ying Liu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Lung Adenocarcinoma ◽  
Survival Time ◽  
Kinase Inhibitor ◽  
Bone Marrow Involvement ◽  
Bone Marrow Aspiration ◽  
Best Supportive Care ◽  
Bone Marrow Metastasis ◽  
Platinum Based Chemotherapy ◽  
Targeted Drug

Background: Bone marrow metastasis occurs in lung adenocarcinoma patients with a poor prognosis due to the late course and lack of definitive treatments, although reports on this are limited. This study analyzed the clinical manifestation, laboratory examination, treatment, and prognosis of patients with lung adenocarcinoma with bone marrow metastasis. Methods: All patients were confirmed to have bone marrow infiltration by bone marrow aspiration. The clinical data of 12 patients with lung adenocarcinoma with bone marrow metastasis were analyzed retrospectively. The prognostic factors were analyzed by Kaplan-Meier statistics. Results: The common biomarker abnormalities in 12 patients were elevated carcinoembryonic antigen in 12 cases (100%), elevated lactate dehydrogenase in 9 cases (75%), increased alkaline phosphatase and anemia in 8 cases each (66.7%), and thrombocytopenia in 4 cases (33.3%). After diagnosis of bone marrow metastasis, 5 patients were treated with platinum-based chemotherapy, 3 patients received chemotherapy and targeted drug tyrosine kinase inhibitor (TKI) therapy, 2 patients received simple TKI therapy, and 2 patients received only best supportive care (BSC) therapy. The median duration of survival after the diagnosis of bone marrow involvement was 422 days. The survival time of patients receiving TKI therapy after bone marrow metastasis was significantly better than that of patients receiving only BSC and chemotherapy (χ2=4.636, P=0.031). Conclusions: The survival period of patients with lung adenocarcinoma with bone marrow metastasis is short, and targeted drug TKI treatment can prolong the survival time for patients with EGFR mutation–carrying lung adenocarcinoma with bone marrow metastasis.

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